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Protein

Contactin-1

Gene

CNTN1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion, Notch signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Contactin-1
Alternative name(s):
Neural cell surface protein F3
Gene namesi
Name:CNTN1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000001468321 – 999Contactin-1Add BLAST979
PropeptideiPRO_00000146841000 – 1018Removed in mature formAdd BLAST19

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi65 ↔ 114PROSITE-ProRule annotation
Disulfide bondi158 ↔ 211PROSITE-ProRule annotation
Glycosylationi208N-linked (GlcNAc...)Sequence analysis1
Glycosylationi258N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi263 ↔ 310PROSITE-ProRule annotation
Glycosylationi338N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi352 ↔ 391PROSITE-ProRule annotation
Disulfide bondi436 ↔ 484PROSITE-ProRule annotation
Glycosylationi457N-linked (GlcNAc...)Sequence analysis1
Glycosylationi473N-linked (GlcNAc...)Sequence analysis1
Glycosylationi494N-linked (GlcNAc...)Sequence analysis1
Glycosylationi521N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi526 ↔ 583PROSITE-ProRule annotation
Glycosylationi591N-linked (GlcNAc...)Sequence analysis1
Lipidationi999GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiQ28106.
PRIDEiQ28106.

Interactioni

Subunit structurei

Monomer. Interacts with CNTNAP1 in cis form (By similarity). Binds to the carbonic-anhydrase like domain of PTPRZ1. Interacts with NOTCH1 and TNR. Detected in a complex with NRCAM and PTPRB (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042896.

Structurei

3D structure databases

ProteinModelPortaliQ28106.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini41 – 131Ig-like C2-type 1Add BLAST91
Domaini137 – 223Ig-like C2-type 2Add BLAST87
Domaini241 – 326Ig-like C2-type 3Add BLAST86
Domaini331 – 407Ig-like C2-type 4Add BLAST77
Domaini413 – 500Ig-like C2-type 5Add BLAST88
Domaini504 – 601Ig-like C2-type 6Add BLAST98
Domaini606 – 704Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST99
Domaini709 – 806Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST98
Domaini811 – 906Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST96
Domaini907 – 1000Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ28106.
KOiK06759.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR032991. Contactin-1.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF531. PTHR10489:SF531. 1 hit.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28106-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKMWLLFSLL VIISFKTCLS EFTWHRRYGH GVSEEDKGFG PIFEEQPINT
60 70 80 90 100
IYPEESPEGK VSLNCRARAS PFPVYKWRMN NGDIDLTSDR YSMVGGNLVI
110 120 130 140 150
NNPDKQKDAG IYYCLASNNY GMVRSTEATL SFGYLDPFPP EERPEVRVKE
160 170 180 190 200
GKGMVLLCDP PYHFPDDLSY RWLLNEFPVF ITMDKRRFVS QTNGNLYIAN
210 220 230 240 250
VEASDKGNYS CFVSSPSITK SVFSKFIPLI PLPERTTKPY PADIVVQFKD
260 270 280 290 300
VYALMGQNVT LECFALGNPV PDIRWRKVLE PMPSTAEIST SGAVLKIFNI
310 320 330 340 350
QLEDEGIYEC EAENNRGKDK HQARIYVQAF PEWVEHINDT EVDIGSDLYW
360 370 380 390 400
PCVATGKPIP TIRWLKNGYS YHRGELRLYD VTFENAGMYQ CIAENTHGAI
410 420 430 440 450
YANAELKILA LAPTFEMNPM KKKILAAKGG RVIIECKPKA APKPTFLWSK
460 470 480 490 500
GTERLVNSSR ILIWEDGSLE INNITRSDGG VYTCFVENNK GKANSTGTLV
510 520 530 540 550
ITDPTRIILA PINADITVGE NATMQCAASF DPALDLTFVW SFNGYVIDFN
560 570 580 590 600
KENIHYQRNF MLDSNGELLI RNAQLKHAGR YTCTAQTIVD NSSASADLVV
610 620 630 640 650
RGPPGPPGGL RIEDIRATSV ALTWSRGSDN HSPISKYTIQ TKTILSDDWK
660 670 680 690 700
DAKTDPPIIE GNMEAARAVD LIPWMEYEFR VVATNTLGIG EPSIPSNKIK
710 720 730 740 750
TDGAAPNVAP SDVGGGGGSN RELTITWAPL SREYHYFNNF GYIVAFKPFD
760 770 780 790 800
GEEWKKVTVT NPDTGRYVHK DETMRPSTAF QVKVKAFNNK GDGPYSLTAV
810 820 830 840 850
IHSAQDAPSE APTAVGVKVL SSSEISVHWE HVVEKIVESY QIRYWASHDK
860 870 880 890 900
EAAAHRVQVA SQEYSARLEN LLPDTQYFVE VRACNSAGCG PPSDMTETFT
910 920 930 940 950
KKAPPSQPPR IISSVRSGSR YIITWDHVVA LSNESTVTGY KVLYRPDGQH
960 970 980 990 1000
DGKLYSTHKH SIEVPIPRDG EYVVEVRAHS DGGDGVVSQV KISGASILSP
1010
CLLGFLLPAL GILVYLEF
Length:1,018
Mass (Da):113,385
Last modified:November 1, 1996 - v1
Checksum:i551FC10ED7920341
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32135 mRNA. Translation: BAA06861.1.
PIRiJC4211.
RefSeqiNP_776705.1. NM_174280.2.
UniGeneiBt.349.

Genome annotation databases

GeneIDi281705.
KEGGibta:281705.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D32135 mRNA. Translation: BAA06861.1.
PIRiJC4211.
RefSeqiNP_776705.1. NM_174280.2.
UniGeneiBt.349.

3D structure databases

ProteinModelPortaliQ28106.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000042896.

Proteomic databases

PaxDbiQ28106.
PRIDEiQ28106.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281705.
KEGGibta:281705.

Organism-specific databases

CTDi1272.

Phylogenomic databases

eggNOGiKOG3513. Eukaryota.
ENOG410XSVG. LUCA.
HOGENOMiHOG000059617.
HOVERGENiHBG051047.
InParanoidiQ28106.
KOiK06759.

Family and domain databases

CDDicd00063. FN3. 4 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR032991. Contactin-1.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PANTHERiPTHR10489:SF531. PTHR10489:SF531. 1 hit.
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 2 hits.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
SM00409. IG. 6 hits.
SM00408. IGc2. 5 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 6 hits.
SSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 4 hits.
PS50835. IG_LIKE. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCNTN1_BOVIN
AccessioniPrimary (citable) accession number: Q28106
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.