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Protein

Endothelial protein C receptor

Gene

PROCR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processBlood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-BTA-140875 Common Pathway of Fibrin Clot Formation
R-BTA-202733 Cell surface interactions at the vascular wall

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial protein C receptor
Alternative name(s):
Activated protein C receptor
Short name:
APC receptor
Endothelial cell protein C receptor
CD_antigen: CD201
Gene namesi
Name:PROCR
Synonyms:EPCR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Organism-specific databases

VGNCiVGNC:33359 PROCR

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 212ExtracellularSequence analysisAdd BLAST195
Transmembranei213 – 233HelicalSequence analysisAdd BLAST21
Topological domaini234 – 241CytoplasmicSequence analysis8

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000002119018 – 241Endothelial protein C receptorAdd BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi66N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi120 ↔ 188By similarity
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi174N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi221 ↔ 234By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ28105
PRIDEiQ28105

Expressioni

Tissue specificityi

Expressed in endothelial cells.

Gene expression databases

BgeeiENSBTAG00000008291

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010911

Structurei

3D structure databases

ProteinModelPortaliQ28105
SMRiQ28105
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWW5 Eukaryota
ENOG41116AV LUCA
GeneTreeiENSGT00390000001159
HOGENOMiHOG000059633
HOVERGENiHBG005593
InParanoidiQ28105
KOiK06557
OMAiEFLQDTC
OrthoDBiEOG091G0JCK
TreeFamiTF335868

Family and domain databases

Gene3Di3.30.500.10, 1 hit
InterProiView protein in InterPro
IPR015669 Endothetial_C_recpt
IPR011161 MHC_I-like_Ag-recog
IPR037055 MHC_I-like_Ag-recog_sf
IPR011162 MHC_I/II-like_Ag-recog
PANTHERiPTHR15349 PTHR15349, 1 hit
PfamiView protein in Pfam
PF16497 MHC_I_3, 1 hit
SUPFAMiSSF54452 SSF54452, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTTLLPLLP LLLPGWALCS QEASDGPWDL HMTQVSYFRN PSQVWHRGNA
60 70 80 90 100
TLGGVLTHVL EGPGRNVSIQ QLQPLQEPDS WALTKIYLNR YLEEFVGLVQ
110 120 130 140 150
VVHQERGVTF PLIIRCFLGC ELPPEGSEAR VFFEVAVNGS SFVNFQPKTA
160 170 180 190 200
SWVAEPHAPS RVVTYTVDQL NKYNRTRYEL REFLQDTCVQ YIQKHITTNN
210 220 230 240
LKGSQTGRSY TSLVLGVLVG CFIVTGVAVG IFLCTGGRRR C
Length:241
Mass (Da):27,010
Last modified:November 1, 1996 - v1
Checksum:iB5129082F86FEE70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39065 mRNA Translation: AAA87356.1
BC116074 mRNA Translation: AAI16075.1
PIRiB55945
RefSeqiNP_776862.1, NM_174437.1
UniGeneiBt.526

Genome annotation databases

EnsembliENSBTAT00000010911; ENSBTAP00000010911; ENSBTAG00000008291
GeneIDi282005
KEGGibta:282005

Similar proteinsi

Entry informationi

Entry nameiEPCR_BOVIN
AccessioniPrimary (citable) accession number: Q28105
Secondary accession number(s): Q1LZD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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