Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Endothelial protein C receptor

Gene

PROCR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Blood coagulation, Hemostasis

Enzyme and pathway databases

ReactomeiR-BTA-140875. Common Pathway of Fibrin Clot Formation.
R-BTA-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelial protein C receptor
Alternative name(s):
Activated protein C receptor
Short name:
APC receptor
Endothelial cell protein C receptor
CD_antigen: CD201
Gene namesi
Name:PROCR
Synonyms:EPCR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 13

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 212195ExtracellularSequence analysisAdd
BLAST
Transmembranei213 – 23321HelicalSequence analysisAdd
BLAST
Topological domaini234 – 2418CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence analysisAdd
BLAST
Chaini18 – 241224Endothelial protein C receptorPRO_0000021190Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi49 – 491N-linked (GlcNAc...)Sequence analysis
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence analysis
Disulfide bondi120 ↔ 188By similarity
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence analysis
Glycosylationi174 – 1741N-linked (GlcNAc...)Sequence analysis
Disulfide bondi221 ↔ 234By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ28105.
PRIDEiQ28105.

Expressioni

Tissue specificityi

Expressed in endothelial cells.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010911.

Structurei

3D structure databases

ProteinModelPortaliQ28105.
SMRiQ28105. Positions 30-197.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWW5. Eukaryota.
ENOG41116AV. LUCA.
GeneTreeiENSGT00390000001159.
HOGENOMiHOG000059633.
HOVERGENiHBG005593.
InParanoidiQ28105.
KOiK06557.
OMAiVWHRGNA.
OrthoDBiEOG7F5131.
TreeFamiTF335868.

Family and domain databases

Gene3Di3.30.500.10. 1 hit.
InterProiIPR015669. Endothetial_C_recpt.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PANTHERiPTHR15349. PTHR15349. 1 hit.
PfamiPF16497. MHC_I_3. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28105-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTTLLPLLP LLLPGWALCS QEASDGPWDL HMTQVSYFRN PSQVWHRGNA
60 70 80 90 100
TLGGVLTHVL EGPGRNVSIQ QLQPLQEPDS WALTKIYLNR YLEEFVGLVQ
110 120 130 140 150
VVHQERGVTF PLIIRCFLGC ELPPEGSEAR VFFEVAVNGS SFVNFQPKTA
160 170 180 190 200
SWVAEPHAPS RVVTYTVDQL NKYNRTRYEL REFLQDTCVQ YIQKHITTNN
210 220 230 240
LKGSQTGRSY TSLVLGVLVG CFIVTGVAVG IFLCTGGRRR C
Length:241
Mass (Da):27,010
Last modified:November 1, 1996 - v1
Checksum:iB5129082F86FEE70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39065 mRNA. Translation: AAA87356.1.
BC116074 mRNA. Translation: AAI16075.1.
PIRiB55945.
RefSeqiNP_776862.1. NM_174437.1.
UniGeneiBt.526.

Genome annotation databases

EnsembliENSBTAT00000010911; ENSBTAP00000010911; ENSBTAG00000008291.
GeneIDi282005.
KEGGibta:282005.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39065 mRNA. Translation: AAA87356.1.
BC116074 mRNA. Translation: AAI16075.1.
PIRiB55945.
RefSeqiNP_776862.1. NM_174437.1.
UniGeneiBt.526.

3D structure databases

ProteinModelPortaliQ28105.
SMRiQ28105. Positions 30-197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010911.

Proteomic databases

PaxDbiQ28105.
PRIDEiQ28105.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010911; ENSBTAP00000010911; ENSBTAG00000008291.
GeneIDi282005.
KEGGibta:282005.

Organism-specific databases

CTDi10544.

Phylogenomic databases

eggNOGiENOG410IWW5. Eukaryota.
ENOG41116AV. LUCA.
GeneTreeiENSGT00390000001159.
HOGENOMiHOG000059633.
HOVERGENiHBG005593.
InParanoidiQ28105.
KOiK06557.
OMAiVWHRGNA.
OrthoDBiEOG7F5131.
TreeFamiTF335868.

Enzyme and pathway databases

ReactomeiR-BTA-140875. Common Pathway of Fibrin Clot Formation.
R-BTA-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

NextBioi20805873.

Family and domain databases

Gene3Di3.30.500.10. 1 hit.
InterProiIPR015669. Endothetial_C_recpt.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
[Graphical view]
PANTHERiPTHR15349. PTHR15349. 1 hit.
PfamiPF16497. MHC_I_3. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and expression of murine and bovine endothelial cell protein C/activated protein C receptor (EPCR). The structural and functional conservation in human, bovine, and murine EPCR."
    Fukudome K., Esmon C.T.
    J. Biol. Chem. 270:5571-5577(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Ascending colon.

Entry informationi

Entry nameiEPCR_BOVIN
AccessioniPrimary (citable) accession number: Q28105
Secondary accession number(s): Q1LZD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: November 11, 2015
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.