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Protein

Coatomer subunit epsilon

Gene

COPE

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: GO_Central
  • intra-Golgi vesicle-mediated transport Source: UniProtKB
  • protein transport Source: UniProtKB-KW
  • retrograde vesicle-mediated transport, Golgi to ER Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-6807878. COPI-mediated anterograde transport.
R-BTA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Names & Taxonomyi

Protein namesi
Recommended name:
Coatomer subunit epsilon
Alternative name(s):
Epsilon-coat protein
Short name:
Epsilon-COP
Gene namesi
Name:COPE
Synonyms:COPE1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 7

Subcellular locationi

GO - Cellular componenti

  • COPI vesicle coat Source: UniProtKB
  • nucleoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 308307Coatomer subunit epsilonPRO_0000193849Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei13 – 131PhosphoserineBy similarity
Modified residuei45 – 451PhosphoserineBy similarity

Post-translational modificationi

Polyubiquitinated by RCHY1 in the presence of androgen, leading to proteasomal degradation.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ28104.
PeptideAtlasiQ28104.
PRIDEiQ28104.

Expressioni

Gene expression databases

BgeeiENSBTAG00000000810.

Interactioni

Subunit structurei

Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.

Binary interactionsi

WithEntry#Exp.IntActNotes
COPAQ279545EBI-620457,EBI-620400

Protein-protein interaction databases

IntActiQ28104. 1 interaction.
STRINGi9913.ENSBTAP00000001071.

Structurei

Secondary structure

1
308
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi20 – 278Combined sources
Helixi31 – 4010Combined sources
Helixi46 – 6217Combined sources
Helixi66 – 727Combined sources
Helixi79 – 9214Combined sources
Helixi97 – 10913Combined sources
Helixi117 – 12913Combined sources
Helixi133 – 1408Combined sources
Helixi146 – 15813Combined sources
Helixi162 – 17514Combined sources
Helixi180 – 19314Combined sources
Helixi197 – 21115Combined sources
Helixi216 – 22813Combined sources
Helixi232 – 24514Combined sources
Helixi250 – 26213Combined sources
Helixi267 – 28014Combined sources
Helixi285 – 30420Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MKRX-ray2.60A17-307[»]
ProteinModelPortaliQ28104.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ28104.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi216 – 2194Poly-Leu

Sequence similaritiesi

Belongs to the COPE family.Curated

Phylogenomic databases

eggNOGiKOG3081. Eukaryota.
ENOG410XS5P. LUCA.
GeneTreeiENSGT00390000003478.
HOGENOMiHOG000205825.
HOVERGENiHBG002201.
InParanoidiQ28104.
KOiK17268.
OMAiDAFHIYQ.
OrthoDBiEOG091G0KHF.
TreeFamiTF313390.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006822. Coatomer_esu.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR10805. PTHR10805. 1 hit.
PIRSFiPIRSF016478. Coatomer_esu. 1 hit.
SUPFAMiSSF48452. SSF48452. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28104-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPAPGPAS GGSGEVDELF DVKNAFYIGS YQQCINEAQR VKPSSPERDV
60 70 80 90 100
ERDVFLYRAY LAQRKYGVVL DEIKPSSAPE LQAVRMFAEY LASDSRRDAI
110 120 130 140 150
VAELDREMSR SVDVTNTTFL LMAASIYFYD QNPDAALRTL HQGDSLECMA
160 170 180 190 200
MTVQILLKLD RLDLARKELK KMQDQDEDAT LTQLATAWVS LAAGGEKLQD
210 220 230 240 250
AYYIFQEMAD KCSPTLLLLN GQAACHMAQG RWEAAEGVLQ EALDKDSGHP
260 270 280 290 300
ETLINLVVLS QHLGKPPEVT NRYLSQLKDA HRSHPFIKEY RAKENDFDRL

VLQYAPSA
Length:308
Mass (Da):34,481
Last modified:January 23, 2007 - v3
Checksum:i219385CA17A3B7DA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti94 – 941D → H in CAA54287 (PubMed:8132710).Curated
Sequence conflicti118 – 1181T → N in AAI09964 (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76980 mRNA. Translation: CAA54287.1.
AB042117 mRNA. Translation: BAA94967.1.
BT029899 mRNA. Translation: ABM06145.1.
BC109963 mRNA. Translation: AAI09964.1.
PIRiI46019.
RefSeqiNP_788846.1. NM_176673.1.
UniGeneiBt.4141.

Genome annotation databases

EnsembliENSBTAT00000001071; ENSBTAP00000001071; ENSBTAG00000000810.
GeneIDi338085.
KEGGibta:338085.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76980 mRNA. Translation: CAA54287.1.
AB042117 mRNA. Translation: BAA94967.1.
BT029899 mRNA. Translation: ABM06145.1.
BC109963 mRNA. Translation: AAI09964.1.
PIRiI46019.
RefSeqiNP_788846.1. NM_176673.1.
UniGeneiBt.4141.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3MKRX-ray2.60A17-307[»]
ProteinModelPortaliQ28104.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ28104. 1 interaction.
STRINGi9913.ENSBTAP00000001071.

Proteomic databases

PaxDbiQ28104.
PeptideAtlasiQ28104.
PRIDEiQ28104.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000001071; ENSBTAP00000001071; ENSBTAG00000000810.
GeneIDi338085.
KEGGibta:338085.

Organism-specific databases

CTDi11316.

Phylogenomic databases

eggNOGiKOG3081. Eukaryota.
ENOG410XS5P. LUCA.
GeneTreeiENSGT00390000003478.
HOGENOMiHOG000205825.
HOVERGENiHBG002201.
InParanoidiQ28104.
KOiK17268.
OMAiDAFHIYQ.
OrthoDBiEOG091G0KHF.
TreeFamiTF313390.

Enzyme and pathway databases

ReactomeiR-BTA-6807878. COPI-mediated anterograde transport.
R-BTA-6811434. COPI-dependent Golgi-to-ER retrograde traffic.

Miscellaneous databases

EvolutionaryTraceiQ28104.

Gene expression databases

BgeeiENSBTAG00000000810.

Family and domain databases

Gene3Di1.25.40.10. 1 hit.
InterProiIPR006822. Coatomer_esu.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR10805. PTHR10805. 1 hit.
PIRSFiPIRSF016478. Coatomer_esu. 1 hit.
SUPFAMiSSF48452. SSF48452. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCOPE_BOVIN
AccessioniPrimary (citable) accession number: Q28104
Secondary accession number(s): A1L5B2, Q2TBL7, Q9N286
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.