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Protein
Submitted name:

CTLA-4 protein

Gene

CTLA-4

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-BTA-389513. CTLA4 inhibitory signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
CTLA-4 proteinImported
Submitted name:
Cytotoxic T-lymphocyte antigen 4Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:CTLA-4Imported
Synonyms:CTLA4Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei160 – 18425HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi56 ↔ 127Combined sources
Disulfide bondi83 ↔ 101Combined sources
Glycosylationi111 – 1111N-linked (GlcNAc...)Combined sourcesCAR_5007208313

Expressioni

Gene expression databases

ExpressionAtlasiQ28090. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017527.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KKNX-ray2.25A34-154[»]
SMRiQ28090. Positions 35-159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 130101Ig-like (immunoglobulin-like)InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IJ05. Eukaryota.
ENOG410YUQR. LUCA.
GeneTreeiENSGT00530000063873.
HOGENOMiHOG000112047.
HOVERGENiHBG057978.
KOiK06538.
OMAiFSKGMHV.
OrthoDBiEOG70GMGW.
TreeFamiTF335679.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR008096. CTLA4.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01720. CTLANTIGEN4.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACSGFQSHG TWWTSRTWPC TALFFLVFIP VFSKGMNVTQ PPVVLASSRG
60 70 80 90 100
VASFSCEYES SGKADEVRVT VLREAGSQVT EVCAGTYMVE DELTFLDDST
110 120 130 140 150
CIGTSRGNKV NLTIQGLRAM DTGLYVCKVE LMYPPPYYVG IGNGTQIYVI
160 170 180 190 200
DPEPCPDSDF LLWILAAVSS GLFFYSFLIT AVSLSKMLKK RSPLTTGVYV
210 220
KMPPTEPECE KQFQPYFIPI N
Length:221
Mass (Da):24,433
Last modified:November 1, 1996 - v1
Checksum:i2CAF148422C597AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02005638 Genomic DNA. No translation available.
AB910936 mRNA. Translation: BAP25848.1.
AB910937 mRNA. Translation: BAP25849.1.
X93305 mRNA. Translation: CAA63708.1.
RefSeqiNP_776722.1. NM_174297.1.
UniGeneiBt.19143.

Genome annotation databases

EnsembliENSBTAT00000017527; ENSBTAP00000017527; ENSBTAG00000013170.
GeneIDi281732.
KEGGibta:281732.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02005638 Genomic DNA. No translation available.
AB910936 mRNA. Translation: BAP25848.1.
AB910937 mRNA. Translation: BAP25849.1.
X93305 mRNA. Translation: CAA63708.1.
RefSeqiNP_776722.1. NM_174297.1.
UniGeneiBt.19143.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KKNX-ray2.25A34-154[»]
SMRiQ28090. Positions 35-159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017527.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000017527; ENSBTAP00000017527; ENSBTAG00000013170.
GeneIDi281732.
KEGGibta:281732.

Organism-specific databases

CTDi1493.

Phylogenomic databases

eggNOGiENOG410IJ05. Eukaryota.
ENOG410YUQR. LUCA.
GeneTreeiENSGT00530000063873.
HOGENOMiHOG000112047.
HOVERGENiHBG057978.
KOiK06538.
OMAiFSKGMHV.
OrthoDBiEOG70GMGW.
TreeFamiTF335679.

Enzyme and pathway databases

ReactomeiR-BTA-389513. CTLA4 inhibitory signaling.

Gene expression databases

ExpressionAtlasiQ28090. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR008096. CTLA4.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
PRINTSiPR01720. CTLANTIGEN4.
SMARTiSM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cattle CTLA-4, CD28 and chicken CD28 bind CD86: MYPPPY is not conserved in cattle CD28."
    Parsons K.R., Young J.R., Collins R.A., Howard C.J.
    Immunogenetics 43:388-391(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: HerefordImported.
  3. "Crystal structure of bovine CTLA-4, PSI-NYSGRC-012704."
    Kumar P.R., Casadevall A., Almo S.C.
    Submitted (MAY-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 34-154, GLYCOSYLATION AT ASN-111, DISULFIDE BONDS.
  4. "Increased expression of the regulatory T cell-associated marker CTLA-4 in bovine leukemia virus infection."
    Suzuki S., Konnai S., Okagawa T., Ikebuchi R., Nishimori A., Kohara J., Mingala C.N., Murata S., Ohashi K.
    Vet. Immunol. Immunopathol. 163:115-124(2015) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  5. Ensembl
    Submitted (MAR-2016) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: HerefordImported.

Entry informationi

Entry nameiQ28090_BOVIN
AccessioniPrimary (citable) accession number: Q28090
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.