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Protein
Submitted name:

CTLA-4 protein

Gene

CTLA-4

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81MannoseCombined sources1
Binding sitei130MannoseCombined sources1

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-BTA-389513. CTLA4 inhibitory signaling.

Names & Taxonomyi

Protein namesi
Submitted name:
CTLA-4 proteinImported
Submitted name:
Cytotoxic T-lymphocyte antigen 4Imported
Submitted name:
Cytotoxic T-lymphocyte-associated protein 4Imported
Gene namesi
Name:CTLA-4Imported
Synonyms:CD152Imported, CTLA4Imported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei160 – 184HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 127Combined sources
Disulfide bondi83 ↔ 101Combined sources
Glycosylationi111N-linked (GlcNAc...)Combined sources1

Expressioni

Gene expression databases

BgeeiENSBTAG00000013170.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000017527.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4KKNX-ray2.25A34-154[»]
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 130Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST101

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni68 – 70Mannose bindingCombined sources3

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IJ05. Eukaryota.
ENOG410YUQR. LUCA.
GeneTreeiENSGT00530000063873.
HOGENOMiHOG000112047.
HOVERGENiHBG057978.
KOiK06538.
OMAiFSKGMHV.
OrthoDBiEOG091G0IGY.
TreeFamiTF335679.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR008096. CTLA4.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07686. V-set. 1 hit.
PRINTSiPR01720. CTLANTIGEN4.
SMARTiView protein in SMART
SM00409. IG. 1 hit.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28090-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MACSGFQSHG TWWTSRTWPC TALFFLVFIP VFSKGMNVTQ PPVVLASSRG
60 70 80 90 100
VASFSCEYES SGKADEVRVT VLREAGSQVT EVCAGTYMVE DELTFLDDST
110 120 130 140 150
CIGTSRGNKV NLTIQGLRAM DTGLYVCKVE LMYPPPYYVG IGNGTQIYVI
160 170 180 190 200
DPEPCPDSDF LLWILAAVSS GLFFYSFLIT AVSLSKMLKK RSPLTTGVYV
210 220
KMPPTEPECE KQFQPYFIPI N
Length:221
Mass (Da):24,433
Last modified:November 1, 1996 - v1
Checksum:i2CAF148422C597AA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DAAA02005638 Genomic DNA. No translation available.
AB910936 mRNA. Translation: BAP25848.1.
AB910937 mRNA. Translation: BAP25849.1.
LC271176 mRNA. Translation: BAX73996.1.
X93305 mRNA. Translation: CAA63708.1.
RefSeqiNP_776722.1. NM_174297.1.
UniGeneiBt.19143.

Genome annotation databases

EnsembliENSBTAT00000017527; ENSBTAP00000017527; ENSBTAG00000013170.
GeneIDi281732.
KEGGibta:281732.

Similar proteinsi

Entry informationi

Entry nameiQ28090_BOVIN
AccessioniPrimary (citable) accession number: Q28090
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported