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Protein

Complement factor H

Gene

CFH

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Complement alternate pathway, Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Complement factor H
Alternative name(s):
H factor 1
Gene namesi
Name:CFH
Synonyms:HF1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 18181 PublicationAdd
BLAST
Chaini19 – 12361218Complement factor HPRO_0000048516Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi21 ↔ 66PROSITE-ProRule annotation
Disulfide bondi52 ↔ 80PROSITE-ProRule annotation
Disulfide bondi85 ↔ 129PROSITE-ProRule annotation
Disulfide bondi114 ↔ 141PROSITE-ProRule annotation
Disulfide bondi146 ↔ 192PROSITE-ProRule annotation
Disulfide bondi178 ↔ 205PROSITE-ProRule annotation
Disulfide bondi210 ↔ 251PROSITE-ProRule annotation
Disulfide bondi237 ↔ 262PROSITE-ProRule annotation
Disulfide bondi267 ↔ 309PROSITE-ProRule annotation
Disulfide bondi294 ↔ 320PROSITE-ProRule annotation
Disulfide bondi325 ↔ 372PROSITE-ProRule annotation
Disulfide bondi355 ↔ 383PROSITE-ProRule annotation
Disulfide bondi387 ↔ 429PROSITE-ProRule annotation
Disulfide bondi414 ↔ 440PROSITE-ProRule annotation
Disulfide bondi446 ↔ 492PROSITE-ProRule annotation
Disulfide bondi475 ↔ 503PROSITE-ProRule annotation
Disulfide bondi507 ↔ 551PROSITE-ProRule annotation
Disulfide bondi534 ↔ 562PROSITE-ProRule annotation
Disulfide bondi567 ↔ 609PROSITE-ProRule annotation
Disulfide bondi595 ↔ 621PROSITE-ProRule annotation
Disulfide bondi629 ↔ 672PROSITE-ProRule annotation
Disulfide bondi658 ↔ 683PROSITE-ProRule annotation
Disulfide bondi690 ↔ 732PROSITE-ProRule annotation
Disulfide bondi718 ↔ 743PROSITE-ProRule annotation
Disulfide bondi752 ↔ 791PROSITE-ProRule annotation
Glycosylationi775 – 7751N-linked (GlcNAc...)Sequence analysis
Disulfide bondi780 ↔ 802PROSITE-ProRule annotation
Disulfide bondi811 ↔ 853PROSITE-ProRule annotation
Disulfide bondi839 ↔ 864PROSITE-ProRule annotation
Disulfide bondi870 ↔ 923PROSITE-ProRule annotation
Disulfide bondi909 ↔ 934PROSITE-ProRule annotation
Disulfide bondi939 ↔ 981PROSITE-ProRule annotation
Disulfide bondi967 ↔ 992PROSITE-ProRule annotation
Disulfide bondi997 ↔ 1040PROSITE-ProRule annotation
Disulfide bondi1026 ↔ 1051PROSITE-ProRule annotation
Disulfide bondi1056 ↔ 1098PROSITE-ProRule annotation
Disulfide bondi1084 ↔ 1109PROSITE-ProRule annotation
Glycosylationi1100 – 11001N-linked (GlcNAc...)Sequence analysis
Disulfide bondi1116 ↔ 1159PROSITE-ProRule annotation
Disulfide bondi1145 ↔ 1170PROSITE-ProRule annotation
Disulfide bondi1174 ↔ 1225PROSITE-ProRule annotation
Disulfide bondi1208 ↔ 1235PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ28085.
PRIDEiQ28085.

Expressioni

Tissue specificityi

Expressed by the liver and secreted in plasma.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029340.

Structurei

3D structure databases

ProteinModelPortaliQ28085.
SMRiQ28085. Positions 20-206, 866-993.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 8264Sushi 1PROSITE-ProRule annotationAdd
BLAST
Domaini83 – 14361Sushi 2PROSITE-ProRule annotationAdd
BLAST
Domaini144 – 20764Sushi 3PROSITE-ProRule annotationAdd
BLAST
Domaini208 – 26457Sushi 4PROSITE-ProRule annotationAdd
BLAST
Domaini265 – 32258Sushi 5PROSITE-ProRule annotationAdd
BLAST
Domaini325 – 38359Sushi 6PROSITE-ProRule annotationAdd
BLAST
Domaini385 – 44258Sushi 7PROSITE-ProRule annotationAdd
BLAST
Domaini444 – 50562Sushi 8PROSITE-ProRule annotationAdd
BLAST
Domaini507 – 56256Sushi 9PROSITE-ProRule annotationAdd
BLAST
Domaini565 – 62359Sushi 10PROSITE-ProRule annotationAdd
BLAST
Domaini627 – 68559Sushi 11PROSITE-ProRule annotationAdd
BLAST
Domaini688 – 74558Sushi 12PROSITE-ProRule annotationAdd
BLAST
Domaini750 – 80455Sushi 13PROSITE-ProRule annotationAdd
BLAST
Domaini809 – 86658Sushi 14PROSITE-ProRule annotationAdd
BLAST
Domaini868 – 93669Sushi 15PROSITE-ProRule annotationAdd
BLAST
Domaini937 – 99458Sushi 16PROSITE-ProRule annotationAdd
BLAST
Domaini995 – 105359Sushi 17PROSITE-ProRule annotationAdd
BLAST
Domaini1054 – 111158Sushi 18PROSITE-ProRule annotationAdd
BLAST
Domaini1114 – 117259Sushi 19PROSITE-ProRule annotationAdd
BLAST
Domaini1173 – 123563Sushi 20PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 20 Sushi (CCP/SCR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Sushi

Phylogenomic databases

eggNOGiENOG410IVQ9. Eukaryota.
ENOG410YBAR. LUCA.
HOGENOMiHOG000049040.
HOVERGENiHBG005665.
InParanoidiQ28085.
KOiK04004.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 18 hits.
[Graphical view]
SMARTiSM00032. CCP. 19 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 19 hits.
PROSITEiPS50923. SUSHI. 16 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28085-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFPAKIVWL VLWTVCVAED CKEPPPRKET EILSGSWTEQ TYQEGTQATY
60 70 80 90 100
KCRPGYRTLG SIVMMCRGGK WVSLHPSRIC RKKPCAHPGD TPFGSFHLAE
110 120 130 140 150
GTQFEYGAKV VYTCDEGYQM VGEMNFRECD TNGWTNDIPI CEVVKCLPVT
160 170 180 190 200
EPENGKIFSD ALEPDQEYTY GQVVQFECNS GYMLDGPKQI HCSAGGVWSA
210 220 230 240 250
ETPKCVEIFC KTPVILNGQA VLPKATYKAN ERVQYRCAAG FEYGQRGDTI
260 270 280 290 300
CTKSGWTPAP TCIEITCDPP RIPNGVYRPE LSKYRGQDKI TYECKKGFFP
310 320 330 340 350
EIRGTDATCT RDGWVPVPRC AWKPCSYPVI KHGRLYYSYR GYFPARVNQQ
360 370 380 390 400
FVYSCDHHFV PPSQRSWDHL TCTAEGWSPE EPCLRQCIFN YLENGHTPYR
410 420 430 440 450
EEKYLQGETV RVRCYEGYSL QNDQNTMTCT ESGWSPPPRC IRVKTCSKSN
460 470 480 490 500
IRIENGFLSE STFTYPLNKQ TEYKCKPGYV TADGKTSGLI TCLKNGWSAQ
510 520 530 540 550
PVCIKSCDRP VFEKARVKSD GTWFRLNDRL DYECVDGYEN RDGRTTGSIV
560 570 580 590 600
CGQDGWSDKA ACYERECSIP EMDPYLNAYP RKETYKVGDV LKFSCSQGRI
610 620 630 640 650
MVGADSVQCY HFGWSPKLPT CKVKKVKSCA LPPELPNGKR KEIHKEEYAH
660 670 680 690 700
NEVVEYACNP RFLMKGSHKI QCVDGEWTAL PVCIEEERTC GNIPDLDHGD
710 720 730 740 750
VKPSVPPYHH GDSVEFSCRE AFTMIGPRFI TCISGEWTQP PQCIATDELR
760 770 780 790 800
KCKGSTLFPP EGRQAHKIEY DHNTNKSYQC RGKSEHKHSI CINGEWDPKV
810 820 830 840 850
DCNEEAKIQL CPPPPQVPNA CDMTTTVNYQ DGEKISILCK ENYLIQDAEE
860 870 880 890 900
IVCKDGRWQS IPRCIEKIGC SQPPQIDHGT ISSSSSAEER REIHEQRLYA
910 920 930 940 950
HGTKLSYTCE EGFEISENNV IICHMGKWSS PPQCVGLPCG LPPYVQNGVV
960 970 980 990 1000
SHKKDRYQYG EEVTYDCDEG FGTDGPASIR CLGGEWSRPQ DCISTNCVNL
1010 1020 1030 1040 1050
PTFEDAVLTD REKDFYRSGE QVAFKCLSYY QLDGSNTIQC IKSKWIGRPA
1060 1070 1080 1090 1100
CRDVSCGNPP QVENAIIHNQ KSKYQSEERA RYECIGNYDL FGEMEVVCLN
1110 1120 1130 1140 1150
GTWTEPPQCK DSQGKCGPPP PIDNGDITSL LQSVYPPGMI VEYRCQAYYE
1160 1170 1180 1190 1200
LRGNKNVVCR NGEWSQLPKC LEACVISEET MRKHHIQLRW KHDKKIYSKT
1210 1220 1230
EDTIEFMCQH GYRQLTPKHT FRATCREGKV VYPRCG
Length:1,236
Mass (Da):140,374
Last modified:May 30, 2006 - v3
Checksum:i5F8B1AE1825B020E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti92 – 932PF → VS in CAA67257 (PubMed:8615824).Curated
Sequence conflicti96 – 961F → P in CAA67257 (PubMed:8615824).Curated
Sequence conflicti102 – 1021T → N in CAA67257 (PubMed:8615824).Curated
Sequence conflicti212 – 2121T → P in CAA67257 (PubMed:8615824).Curated
Sequence conflicti229 – 2291A → Q in CAA67257 (PubMed:8615824).Curated
Sequence conflicti250 – 2501I → V in CAA67257 (PubMed:8615824).Curated
Sequence conflicti371 – 3711T → A in CAA67257 (PubMed:8615824).Curated
Sequence conflicti397 – 3993TPY → NQH in CAA67257 (PubMed:8615824).Curated
Sequence conflicti413 – 4131R → H in CAA67257 (PubMed:8615824).Curated
Sequence conflicti661 – 6611R → K in CAA67257 (PubMed:8615824).Curated
Sequence conflicti677 – 6771W → S in CAA67257 (PubMed:8615824).Curated
Sequence conflicti691 – 6944GNIP → EIS in CAA67257 (PubMed:8615824).Curated
Sequence conflicti708 – 7081Y → I in CAA67257 (PubMed:8615824).Curated
Sequence conflicti759 – 7613PPE → FLL in CAA67257 (PubMed:8615824).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105258 mRNA. Translation: AAI05259.1.
X98697 mRNA. Translation: CAA67257.1.
PIRiS65551.
RefSeqiNP_001029108.1. NM_001033936.1.
UniGeneiBt.68530.

Genome annotation databases

GeneIDi280816.
KEGGibta:280816.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC105258 mRNA. Translation: AAI05259.1.
X98697 mRNA. Translation: CAA67257.1.
PIRiS65551.
RefSeqiNP_001029108.1. NM_001033936.1.
UniGeneiBt.68530.

3D structure databases

ProteinModelPortaliQ28085.
SMRiQ28085. Positions 20-206, 866-993.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029340.

Proteomic databases

PaxDbiQ28085.
PRIDEiQ28085.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi280816.
KEGGibta:280816.

Organism-specific databases

CTDi3075.

Phylogenomic databases

eggNOGiENOG410IVQ9. Eukaryota.
ENOG410YBAR. LUCA.
HOGENOMiHOG000049040.
HOVERGENiHBG005665.
InParanoidiQ28085.
KOiK04004.

Family and domain databases

InterProiIPR000436. Sushi_SCR_CCP_dom.
[Graphical view]
PfamiPF00084. Sushi. 18 hits.
[Graphical view]
SMARTiSM00032. CCP. 19 hits.
[Graphical view]
SUPFAMiSSF57535. SSF57535. 19 hits.
PROSITEiPS50923. SUSHI. 16 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCFAH_BOVIN
AccessioniPrimary (citable) accession number: Q28085
Secondary accession number(s): Q3MHF3, Q9TQZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: May 30, 2006
Last modified: September 7, 2016
This is version 95 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.