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Q28071 (CD28_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
T-cell-specific surface glycoprotein CD28
Alternative name(s):
CD_antigen=CD28
Gene names
Name:CD28
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length219 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Possibly involved in T-cell activation.

Subunit structure

Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein.

Sequence similarities

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 219201T-cell-specific surface glycoprotein CD28
PRO_0000014651

Regions

Topological domain19 – 151133Extracellular Potential
Transmembrane152 – 17827Helical; Potential
Topological domain179 – 21941Cytoplasmic Potential
Domain28 – 136109Ig-like V-type

Amino acid modifications

Modified residue1881Phosphoserine By similarity
Modified residue1901Phosphotyrosine By similarity
Modified residue2081Phosphotyrosine By similarity
Modified residue2171Phosphotyrosine By similarity
Glycosylation371N-linked (GlcNAc...) Potential
Glycosylation711N-linked (GlcNAc...) Potential
Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation911N-linked (GlcNAc...) Potential
Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1281N-linked (GlcNAc...) Potential
Disulfide bond40 ↔ 111 By similarity
Disulfide bond66 ↔ 85 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q28071 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 85B5C650E96634AA

FASTA21925,143
        10         20         30         40         50         60 
MLRLLLALNF FPSIQVAENK ILVKQSPMLV VNDNEVNLSC KYTYNLFSKE FRASLYKGAD 

        70         80         90        100        110        120 
SAVEVCAVNG NHSHPLQSTN KEFNCTVKVG NETVTFYLQD LYVNQTDIYF CKLEVLYPPP 

       130        140        150        160        170        180 
YIDNEKSNGT IIHVKEKHLC PSPRSPESSK PFWALVVVNG VLVFYSLLVT VALSNCWMKN 

       190        200        210 
KRNRMLQSDY MNMTPRRPGP TRRHYQPYAP ARDFAAYRS

« Hide

References

[1]"Cattle CTLA-4, CD28 and chicken CD28 bind CD86: MYPPPY is not conserved in cattle CD28."
Parsons K.R., Young J.R., Collins R.A., Howard C.J.
Immunogenetics 43:388-391(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X93304 mRNA. Translation: CAA63707.1.
IPIIPI00710319.
RefSeqNP_851347.1. NM_181004.1.
UniGeneBt.48.

3D structure databases

ProteinModelPortalQ28071.
SMRQ28071. Positions 19-135.
ModBaseSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000049878.

Proteomic databases

PRIDEQ28071.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID281050.
KEGGbta:281050.

Organism-specific databases

CTD940.

Phylogenomic databases

eggNOGNOG48152.
HOGENOMHOG000276892.
HOVERGENHBG004094.
KOK06470.
OrthoDBEOG498V1S.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR008093. CD28.
IPR013783. Ig-like_fold.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
PRINTSPR01717. CD28ANTIGEN.
PROSITEPS50835. IG_LIKE. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio20805134.

Entry information

Entry nameCD28_BOVIN
AccessionPrimary (citable) accession number: Q28071
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 3, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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