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Protein

Amyloid-beta A4 protein

Gene

APP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functional neuronal receptor which couples to intracellular signaling pathway through the GTP-binding protein G(O).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid-beta A4 protein
Alternative name(s):
ABPP
Short name:
APP
Alzheimer disease amyloid A4 protein homolog
Amyloid precursor proteinCurated
Amyloid-beta precursor proteinCurated
Cleaved into the following 6 chains:
Soluble APP-beta
Short name:
S-APP-beta
Amyloid-beta protein 42
Short name:
Abeta42
Alternative name(s):
Beta-APP42
Amyloid-beta protein 40
Short name:
Abeta40
Alternative name(s):
Beta-APP40
Alternative name(s):
Gamma-CTF(59)
Alternative name(s):
Gamma-CTF(57)
Gene namesi
Name:APP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini‹1 – 34ExtracellularSequence analysisAdd BLAST›34
Transmembranei35 – 58HelicalSequence analysisAdd BLAST24
Topological domaini59CytoplasmicSequence analysis›1

Keywords - Cellular componenti

Amyloid, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000000064‹1 – 6Soluble APP-betaBy similarity›6
ChainiPRO_00000000657 – ›59CTF-alphaBy similarityAdd BLAST›53
ChainiPRO_00000000667 – 48Amyloid-beta protein 42By similarityAdd BLAST42
ChainiPRO_00000000677 – 46Amyloid-beta protein 40By similarityAdd BLAST40
ChainiPRO_000000006847 – ›59Gamma-secretase C-terminal fragment 59By similarityAdd BLAST›13
ChainiPRO_000000006949 – ›59Gamma-secretase C-terminal fragment 57By similarityAdd BLAST›11

Proteomic databases

PaxDbiQ28053.
PRIDEiQ28053.

Interactioni

Subunit structurei

Interacts with SORL1. Interacts with VDAC1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045951.

Structurei

3D structure databases

ProteinModelPortaliQ28053.
SMRiQ28053.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the APP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3540. Eukaryota.
ENOG410ZW2A. LUCA.
HOGENOMiHOG000232190.
InParanoidiQ28053.

Family and domain databases

Gene3Di4.10.230.10. 1 hit.
InterProiView protein in InterPro
IPR013803. Amyloid_glyco_Abeta.
IPR028866. APP.
PANTHERiPTHR23103:SF17. PTHR23103:SF17. 1 hit.
PfamiView protein in Pfam
PF03494. Beta-APP. 1 hit.
PRINTSiPR00204. BETAAMYLOID.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ISEVKMDAEF RHDSGYEVHH QKLVFFAEDV GSNKGAIIGL MVGGVVIATV

IVITLVMLK
Length:59
Mass (Da):6,414
Last modified:November 1, 1997 - v1
Checksum:iF43469D488A2E12D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei591

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56124 mRNA. Translation: CAA39589.1.
X56126 mRNA. Translation: CAA39591.1.
UniGeneiBt.40062.

Similar proteinsi

Entry informationi

Entry nameiA4_BOVIN
AccessioniPrimary (citable) accession number: Q28053
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 27, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families