Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Amyloid beta A4 protein

Gene

APP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functional neuronal receptor which couples to intracellular signaling pathway through the GTP-binding protein G(O).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid beta A4 protein
Alternative name(s):
ABPP
Short name:
APP
Alzheimer disease amyloid A4 protein homolog
Amyloid precursor proteinCurated
Beta-amyloid precursor proteinCurated
Cleaved into the following 6 chains:
Soluble APP-beta
Short name:
S-APP-beta
Alternative name(s):
Beta-APP42
Alternative name(s):
Beta-APP40
Alternative name(s):
Gamma-CTF(59)
Alternative name(s):
Gamma-CTF(57)
Gene namesi
Name:APP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini‹1 – 34ExtracellularSequence analysisAdd BLAST›34
Transmembranei35 – 58HelicalSequence analysisAdd BLAST24
Topological domaini59CytoplasmicSequence analysis›1

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000000064‹1 – 6Soluble APP-betaBy similarity›6
ChainiPRO_00000000657 – ›59CTF-alphaBy similarityAdd BLAST›53
ChainiPRO_00000000667 – 48Beta-amyloid protein 42By similarityAdd BLAST42
ChainiPRO_00000000677 – 46Beta-amyloid protein 40By similarityAdd BLAST40
ChainiPRO_000000006847 – ›59Gamma-secretase C-terminal fragment 59By similarityAdd BLAST›13
ChainiPRO_000000006949 – ›59Gamma-secretase C-terminal fragment 57By similarityAdd BLAST›11

Proteomic databases

PaxDbiQ28053.
PRIDEiQ28053.

Expressioni

Gene expression databases

BgeeiENSBTAG00000017753.

Interactioni

Subunit structurei

Interacts with SORL1. Interacts with VDAC1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045951.

Structurei

3D structure databases

ProteinModelPortaliQ28053.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the APP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3540. Eukaryota.
ENOG410ZW2A. LUCA.
HOGENOMiHOG000232190.
InParanoidiQ28053.

Family and domain databases

Gene3Di4.10.230.10. 1 hit.
InterProiIPR013803. Amyloid_glyco_Abeta.
IPR028866. APP.
[Graphical view]
PANTHERiPTHR23103:SF7. PTHR23103:SF7. 1 hit.
PfamiPF03494. Beta-APP. 1 hit.
[Graphical view]
PRINTSiPR00204. BETAAMYLOID.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ISEVKMDAEF RHDSGYEVHH QKLVFFAEDV GSNKGAIIGL MVGGVVIATV

IVITLVMLK
Length:59
Mass (Da):6,414
Last modified:November 1, 1997 - v1
Checksum:iF43469D488A2E12D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei591

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56124 mRNA. Translation: CAA39589.1.
X56126 mRNA. Translation: CAA39591.1.
UniGeneiBt.40062.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56124 mRNA. Translation: CAA39589.1.
X56126 mRNA. Translation: CAA39591.1.
UniGeneiBt.40062.

3D structure databases

ProteinModelPortaliQ28053.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045951.

Proteomic databases

PaxDbiQ28053.
PRIDEiQ28053.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3540. Eukaryota.
ENOG410ZW2A. LUCA.
HOGENOMiHOG000232190.
InParanoidiQ28053.

Gene expression databases

BgeeiENSBTAG00000017753.

Family and domain databases

Gene3Di4.10.230.10. 1 hit.
InterProiIPR013803. Amyloid_glyco_Abeta.
IPR028866. APP.
[Graphical view]
PANTHERiPTHR23103:SF7. PTHR23103:SF7. 1 hit.
PfamiPF03494. Beta-APP. 1 hit.
[Graphical view]
PRINTSiPR00204. BETAAMYLOID.
ProtoNetiSearch...

Entry informationi

Entry nameiA4_BOVIN
AccessioniPrimary (citable) accession number: Q28053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 5, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.