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Protein

Amyloid beta A4 protein

Gene

APP

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Functional neuronal receptor which couples to intracellular signaling pathway through the GTP-binding protein G(O).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Amyloid beta A4 protein
Alternative name(s):
ABPP
Short name:
APP
Alzheimer disease amyloid A4 protein homolog
Amyloid precursor proteinCurated
Beta-amyloid precursor proteinCurated
Cleaved into the following 6 chains:
Soluble APP-beta
Short name:
S-APP-beta
Alternative name(s):
Beta-APP42
Alternative name(s):
Beta-APP40
Alternative name(s):
Gamma-CTF(59)
Alternative name(s):
Gamma-CTF(57)
Gene namesi
Name:APP
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini‹1 – 34›34ExtracellularSequence analysisAdd
BLAST
Transmembranei35 – 5824HelicalSequence analysisAdd
BLAST
Topological domaini59 – ›59›1CytoplasmicSequence analysis

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Amyloid, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 6›6Soluble APP-betaBy similarityPRO_0000000064
Chaini7 – ›59›53CTF-alphaBy similarityPRO_0000000065Add
BLAST
Chaini7 – 4842Beta-amyloid protein 42By similarityPRO_0000000066Add
BLAST
Chaini7 – 4640Beta-amyloid protein 40By similarityPRO_0000000067Add
BLAST
Chaini47 – ›59›13Gamma-secretase C-terminal fragment 59By similarityPRO_0000000068Add
BLAST
Chaini49 – ›59›11Gamma-secretase C-terminal fragment 57By similarityPRO_0000000069Add
BLAST

Proteomic databases

PaxDbiQ28053.
PRIDEiQ28053.

Interactioni

Subunit structurei

Interacts with SORL1. Interacts with VDAC1.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045951.

Chemistry

BindingDBiQ28053.

Structurei

3D structure databases

ProteinModelPortaliQ28053.
SMRiQ28053. Positions 7-48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the APP family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3540. Eukaryota.
ENOG410ZW2A. LUCA.
HOGENOMiHOG000232190.
InParanoidiQ28053.

Family and domain databases

Gene3Di4.10.230.10. 1 hit.
InterProiIPR013803. Amyloid_glyco_Abeta.
IPR028866. APP.
[Graphical view]
PANTHERiPTHR23103:SF7. PTHR23103:SF7. 1 hit.
PfamiPF03494. Beta-APP. 1 hit.
[Graphical view]
PRINTSiPR00204. BETAAMYLOID.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28053-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
ISEVKMDAEF RHDSGYEVHH QKLVFFAEDV GSNKGAIIGL MVGGVVIATV

IVITLVMLK
Length:59
Mass (Da):6,414
Last modified:November 1, 1997 - v1
Checksum:iF43469D488A2E12D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11
Non-terminal residuei59 – 591

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56124 mRNA. Translation: CAA39589.1.
X56126 mRNA. Translation: CAA39591.1.
UniGeneiBt.40062.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X56124 mRNA. Translation: CAA39589.1.
X56126 mRNA. Translation: CAA39591.1.
UniGeneiBt.40062.

3D structure databases

ProteinModelPortaliQ28053.
SMRiQ28053. Positions 7-48.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000045951.

Chemistry

BindingDBiQ28053.

Proteomic databases

PaxDbiQ28053.
PRIDEiQ28053.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG3540. Eukaryota.
ENOG410ZW2A. LUCA.
HOGENOMiHOG000232190.
InParanoidiQ28053.

Family and domain databases

Gene3Di4.10.230.10. 1 hit.
InterProiIPR013803. Amyloid_glyco_Abeta.
IPR028866. APP.
[Graphical view]
PANTHERiPTHR23103:SF7. PTHR23103:SF7. 1 hit.
PfamiPF03494. Beta-APP. 1 hit.
[Graphical view]
PRINTSiPR00204. BETAAMYLOID.
ProtoNetiSearch...

Publicationsi

  1. "Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis."
    Johnstone E.M., Chaney M.O., Norris F.H., Pascual R., Little S.P.
    Brain Res. Mol. Brain Res. 10:299-305(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiA4_BOVIN
AccessioniPrimary (citable) accession number: Q28053
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: February 17, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.