Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein S100-A7

Gene

S100A7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi18ZincBy similarity1
Metal bindingi25ZincBy similarity1
Metal bindingi87ZincBy similarity1
Metal bindingi91ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi63 – 742; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-BTA-6798695. Neutrophil degranulation.
R-BTA-6799990. Metal sequestration by antimicrobial proteins.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A7
Alternative name(s):
Calcium-binding protein in amniotic fluid 2
Short name:
CAAF2
Dander minor allergen BDA11
Dermal allergen BDA11
S100 calcium-binding protein A7
Allergen: Bos d 3
Gene namesi
Name:S100A7
Synonyms:CAAF2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

  • Cytoplasm By similarity
  • Secreted By similarity

  • Note: Secreted by a non-classical secretory pathway.By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Minor allergen of bovine dander.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei162. Bos d 3.
3164. Bos d 3.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001439892 – 101Protein S100-A7Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ28050.
PeptideAtlasiQ28050.
PRIDEiQ28050.

Interactioni

Subunit structurei

Interacts with RANBP9.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010838.

Structurei

3D structure databases

ProteinModelPortaliQ28050.
SMRiQ28050.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 42EF-hand 1PROSITE-ProRule annotationAdd BLAST35
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JEQ8. Eukaryota.
ENOG41114XT. LUCA.
GeneTreeiENSGT00390000017320.
HOGENOMiHOG000154231.
HOVERGENiHBG095357.
InParanoidiQ28050.
OMAiSHGAPAC.
OrthoDBiEOG091G0Y5T.
TreeFamiTF341148.

Family and domain databases

CDDicd00213. S-100. 1 hit.
InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR034325. S-100_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
PfamiView protein in Pfam
PF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00303. S100_CABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28050-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSQLEQAI TDLINLFHKY SGSDDTIEKE DLLRLMKDNF PNFLGACEKR
60 70 80 90 100
GRDYLSNIFE KQDKNKDRKI DFSEFLSLLA DIATDYHNHS HGAQLCSGGN

Q
Length:101
Mass (Da):11,544
Last modified:November 1, 1997 - v1
Checksum:i1D8E4E5D56661AFA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38D → E AA sequence (PubMed:7594639).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39834 mRNA. Translation: AAA91101.1.
D49550 mRNA. Translation: BAA08498.1.
BC142114 mRNA. Translation: AAI42115.1.
RefSeqiNP_777021.1. NM_174596.2.
UniGeneiBt.358.

Genome annotation databases

EnsembliENSBTAT00000010838; ENSBTAP00000010838; ENSBTAG00000008238.
GeneIDi282344.
KEGGibta:282344.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiS10A7_BOVIN
AccessioniPrimary (citable) accession number: Q28050
Secondary accession number(s): A5PJH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 10, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families