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Protein

Protein S100-A7

Gene

S100A7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi18ZincBy similarity1
Metal bindingi25ZincBy similarity1
Metal bindingi87ZincBy similarity1
Metal bindingi91ZincBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi63 – 742; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

Keywordsi

LigandCalcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A7
Alternative name(s):
Calcium-binding protein in amniotic fluid 2
Short name:
CAAF2
Dander minor allergen BDA11
Dermal allergen BDA11
S100 calcium-binding protein A7
Allergen: Bos d 3
Gene namesi
Name:S100A7
Synonyms:CAAF2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Minor allergen of bovine dander.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei162 Bos d 3
3164 Bos d 3.0101

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001439892 – 101Protein S100-A7Add BLAST100

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ28050
PeptideAtlasiQ28050
PRIDEiQ28050

Expressioni

Gene expression databases

BgeeiENSBTAG00000008238

Interactioni

Subunit structurei

Interacts with RANBP9.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010838

Structurei

3D structure databases

ProteinModelPortaliQ28050
SMRiQ28050
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 42EF-hand 1PROSITE-ProRule annotationAdd BLAST35
Domaini50 – 85EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JEQ8 Eukaryota
ENOG41114XT LUCA
GeneTreeiENSGT00910000144342
HOGENOMiHOG000154231
HOVERGENiHBG095357
InParanoidiQ28050
OMAiSHGAPAC
OrthoDBiEOG091G0Y5T
TreeFamiTF341148

Family and domain databases

CDDicd00213 S-100, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR034325 S-100_dom
IPR001751 S100/CaBP-9k_CS
IPR013787 S100_Ca-bd_sub
PfamiView protein in Pfam
PF00036 EF-hand_1, 1 hit
PF01023 S_100, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 1 hit
SM01394 S_100, 1 hit
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 1 hit
PS50222 EF_HAND_2, 2 hits
PS00303 S100_CABP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28050-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSQLEQAI TDLINLFHKY SGSDDTIEKE DLLRLMKDNF PNFLGACEKR
60 70 80 90 100
GRDYLSNIFE KQDKNKDRKI DFSEFLSLLA DIATDYHNHS HGAQLCSGGN

Q
Length:101
Mass (Da):11,544
Last modified:November 1, 1997 - v1
Checksum:i1D8E4E5D56661AFA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti38D → E AA sequence (PubMed:7594639).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39834 mRNA Translation: AAA91101.1
D49550 mRNA Translation: BAA08498.1
BC142114 mRNA Translation: AAI42115.1
RefSeqiNP_777021.1, NM_174596.2
UniGeneiBt.358

Genome annotation databases

EnsembliENSBTAT00000010838; ENSBTAP00000010838; ENSBTAG00000008238
GeneIDi282344
KEGGibta:282344

Similar proteinsi

Entry informationi

Entry nameiS10A7_BOVIN
AccessioniPrimary (citable) accession number: Q28050
Secondary accession number(s): A5PJH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: May 23, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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