Q28050 (S10A7_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein S100-A7

Alternative name(s):
Calcium-binding protein in amniotic fluid 2
Short name=CAAF2
Dander minor allergen BDA11
Dermal allergen BDA11
S100 calcium-binding protein A7
Allergen=Bos d 3

Gene names

Name:	S100A7
Synonyms:	CAAF2

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	101 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Interacts with RANBP9 By similarity.
Subcellular location	Cytoplasm By similarity. Secreted By similarity. Note: Secreted by a non-classical secretory pathway By similarity.
Allergenic properties	Causes an allergic reaction in human. Minor allergen of bovine dander.
Sequence similarities	Belongs to the S-100 family. Contains 2 EF-hand domains.

Ontologies

Keywords
Cellular component	Cytoplasm Secreted
Disease	Allergen
Domain	Repeat
Ligand	Calcium Metal-binding Zinc
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 101	100	Protein S100-A7		PRO_0000143989
Regions
	Domain	8 – 42	35	EF-hand 1
	Domain	50 – 85	36	EF-hand 2
	Calcium binding	63 – 74	12	2; high affinity Potential
Sites
	Metal binding	18	1	Zinc By similarity
	Metal binding	25	1	Zinc By similarity
	Metal binding	87	1	Zinc By similarity
	Metal binding	91	1	Zinc By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylserine By similarity
Experimental info
	Sequence conflict	38	1	D → E AA sequence Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q28050 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 1D8E4E5D56661AFA	FASTA	101	11,544
	10 20 30 40 50 60 MSSSQLEQAI TDLINLFHKY SGSDDTIEKE DLLRLMKDNF PNFLGACEKR GRDYLSNIFE 70 80 90 100 KQDKNKDRKI DFSEFLSLLA DIATDYHNHS HGAQLCSGGN Q

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA cloning and protein analysis of a bovine dermal allergen with homology to psoriasin." Rautiainen J., Rytkoenen M., Parkkinen S., Pentikaeinen J., Linnala-Kankkunen A., Virtanen T., Pelkonen J., Maentyjaervi R. J. Invest. Dermatol. 105:660-663(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-33; 38-49 AND 70-101. Tissue: Skin.
[2]	"Characterization of a new calcium-binding protein abundant in amniotic fluid, CAAF2, which is produced by fetal epidermal keratinocytes during embryogenesis." Hitomi J., Maruyama K., Kikuchi Y., Nagasaki K., Yamaguchi K. Biochem. Biophys. Res. Commun. 228:757-763(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skin.
[3]	NIH - Mammalian Gene Collection (MGC) project Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Thymus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L39834 mRNA. Translation: AAA91101.1. D49550 mRNA. Translation: BAA08498.1. BC142114 mRNA. Translation: AAI42115.1.
IPI	IPI00699984.
RefSeq	NP_777021.1. NM_174596.2.
UniGene	Bt.358.
3D structure databases
ProteinModelPortal	Q28050.
SMR	Q28050. Positions 2-101.
ModBase	Search...
Protein-protein interaction databases
STRING	9913.ENSBTAP00000044105.
Protein family/group databases
Allergome	162. Bos d 3. 3164. Bos d 3.0101.
Proteomic databases
PRIDE	Q28050.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000010838; ENSBTAP00000010838; ENSBTAG00000008238.
GeneID	282344.
KEGG	bta:282344.
Organism-specific databases
CTD	6278.
Phylogenomic databases
eggNOG	NOG78008.
GeneTree	ENSGT00390000017320.
HOGENOM	HOG000154231.
HOVERGEN	HBG095357.
InParanoid	Q28050.
OMA	SHGAPAC.
OrthoDB	EOG49GKJ6.
Family and domain databases
Gene3D	1.10.238.10. 1 hit.
InterPro	IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR002048. EF_hand_dom. IPR001751. S100/CaBP-9k_CS. IPR013787. S100_Ca-bd_sub. [Graphical view]
Pfam	PF13405. EF_hand_4. 1 hit. PF01023. S_100. 1 hit. [Graphical view]
PROSITE	PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 2 hits. PS00303. S100_CABP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20806139.

Entry information

Entry name

S10A7_BOVIN

Accession

Primary (citable) accession number: Q28050
Secondary accession number(s): A5PJH5

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	May 1, 2013
This is version 88 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program