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Protein

Protein S100-A7

Gene

S100A7

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi18 – 181ZincBy similarity
Metal bindingi25 – 251ZincBy similarity
Metal bindingi87 – 871ZincBy similarity
Metal bindingi91 – 911ZincBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi63 – 74122; high affinityPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A7
Alternative name(s):
Calcium-binding protein in amniotic fluid 2
Short name:
CAAF2
Dander minor allergen BDA11
Dermal allergen BDA11
S100 calcium-binding protein A7
Allergen: Bos d 3
Gene namesi
Name:S100A7
Synonyms:CAAF2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 3

Subcellular locationi

  • Cytoplasm By similarity
  • Secreted By similarity

  • Note: Secreted by a non-classical secretory pathway.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Minor allergen of bovine dander.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei162. Bos d 3.
3164. Bos d 3.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 101100Protein S100-A7PRO_0000143989Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ28050.
PeptideAtlasiQ28050.
PRIDEiQ28050.

Interactioni

Subunit structurei

Interacts with RANBP9.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010838.

Structurei

3D structure databases

ProteinModelPortaliQ28050.
SMRiQ28050. Positions 2-101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 4235EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini50 – 8536EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410JEQ8. Eukaryota.
ENOG41114XT. LUCA.
GeneTreeiENSGT00390000017320.
HOGENOMiHOG000154231.
HOVERGENiHBG095357.
InParanoidiQ28050.
OMAiSHGAPAC.
OrthoDBiEOG7RZ5SH.
TreeFamiTF341148.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028477. S100A7.
[Graphical view]
PANTHERiPTHR11639:SF67. PTHR11639:SF67. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28050-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSSQLEQAI TDLINLFHKY SGSDDTIEKE DLLRLMKDNF PNFLGACEKR
60 70 80 90 100
GRDYLSNIFE KQDKNKDRKI DFSEFLSLLA DIATDYHNHS HGAQLCSGGN

Q
Length:101
Mass (Da):11,544
Last modified:November 1, 1997 - v1
Checksum:i1D8E4E5D56661AFA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti38 – 381D → E AA sequence (PubMed:7594639).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39834 mRNA. Translation: AAA91101.1.
D49550 mRNA. Translation: BAA08498.1.
BC142114 mRNA. Translation: AAI42115.1.
RefSeqiNP_777021.1. NM_174596.2.
UniGeneiBt.358.

Genome annotation databases

EnsembliENSBTAT00000010838; ENSBTAP00000010838; ENSBTAG00000008238.
GeneIDi282344.
KEGGibta:282344.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39834 mRNA. Translation: AAA91101.1.
D49550 mRNA. Translation: BAA08498.1.
BC142114 mRNA. Translation: AAI42115.1.
RefSeqiNP_777021.1. NM_174596.2.
UniGeneiBt.358.

3D structure databases

ProteinModelPortaliQ28050.
SMRiQ28050. Positions 2-101.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000010838.

Protein family/group databases

Allergomei162. Bos d 3.
3164. Bos d 3.0101.

Proteomic databases

PaxDbiQ28050.
PeptideAtlasiQ28050.
PRIDEiQ28050.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000010838; ENSBTAP00000010838; ENSBTAG00000008238.
GeneIDi282344.
KEGGibta:282344.

Organism-specific databases

CTDi6278.

Phylogenomic databases

eggNOGiENOG410JEQ8. Eukaryota.
ENOG41114XT. LUCA.
GeneTreeiENSGT00390000017320.
HOGENOMiHOG000154231.
HOVERGENiHBG095357.
InParanoidiQ28050.
OMAiSHGAPAC.
OrthoDBiEOG7RZ5SH.
TreeFamiTF341148.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028477. S100A7.
[Graphical view]
PANTHERiPTHR11639:SF67. PTHR11639:SF67. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and protein analysis of a bovine dermal allergen with homology to psoriasin."
    Rautiainen J., Rytkoenen M., Parkkinen S., Pentikaeinen J., Linnala-Kankkunen A., Virtanen T., Pelkonen J., Maentyjaervi R.
    J. Invest. Dermatol. 105:660-663(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 20-33; 38-49 AND 70-101.
    Tissue: Skin.
  2. "Characterization of a new calcium-binding protein abundant in amniotic fluid, CAAF2, which is produced by fetal epidermal keratinocytes during embryogenesis."
    Hitomi J., Maruyama K., Kikuchi Y., Nagasaki K., Yamaguchi K.
    Biochem. Biophys. Res. Commun. 228:757-763(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skin.
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Thymus.

Entry informationi

Entry nameiS10A7_BOVIN
AccessioniPrimary (citable) accession number: Q28050
Secondary accession number(s): A5PJH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.