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Q28043

- AVR2A_BOVIN

UniProt

Q28043 - AVR2A_BOVIN

Protein

Activin receptor type-2A

Gene

ACVR2A

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei219 – 2191ATPPROSITE-ProRule annotation
    Active sitei322 – 3221Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi198 – 2069ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. activin-activated receptor activity Source: Ensembl
    2. ATP binding Source: UniProtKB-KW
    3. coreceptor activity Source: Ensembl
    4. metal ion binding Source: UniProtKB-KW
    5. receptor signaling protein serine/threonine kinase activity Source: InterPro
    6. transforming growth factor beta-activated receptor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. BMP signaling pathway Source: Ensembl
    3. determination of left/right symmetry Source: Ensembl
    4. embryonic skeletal system development Source: Ensembl
    5. gastrulation with mouth forming second Source: Ensembl
    6. mesoderm development Source: Ensembl
    7. penile erection Source: Ensembl
    8. positive regulation of activin receptor signaling pathway Source: Ensembl
    9. positive regulation of bone mineralization Source: Ensembl
    10. positive regulation of erythrocyte differentiation Source: Ensembl
    11. positive regulation of osteoblast differentiation Source: Ensembl
    12. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
    13. regulation of BMP signaling pathway Source: Ensembl
    14. regulation of nitric-oxide synthase activity Source: Ensembl
    15. Sertoli cell proliferation Source: Ensembl
    16. spermatogenesis Source: Ensembl
    17. sperm ejaculation Source: Ensembl

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BRENDAi2.7.10.2. 908.
    ReactomeiREACT_211837. Signaling by BMP.
    REACT_223290. Regulation of signaling by NODAL.
    REACT_223651. Signaling by NODAL.
    REACT_224587. Signaling by Activin.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Activin receptor type-2A (EC:2.7.11.30)
    Alternative name(s):
    Activin receptor type IIA
    Short name:
    ACTR-IIA
    Gene namesi
    Name:ACVR2A
    Synonyms:ACTRII, ACVR2
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Chromosome 2

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. cytoplasm Source: Ensembl
    3. inhibin-betaglycan-ActRII complex Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 513494Activin receptor type-2APRO_0000024397Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 60By similarity
    Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi50 ↔ 78By similarity
    Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi85 ↔ 104By similarity
    Disulfide bondi91 ↔ 103By similarity
    Disulfide bondi105 ↔ 110By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ28043.

    Interactioni

    Subunit structurei

    Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ28043.
    SMRiQ28043. Positions 26-119, 192-484.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini20 – 135116ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini162 – 513352CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei136 – 16126HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini192 – 485294Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00560000076906.
    HOGENOMiHOG000231495.
    HOVERGENiHBG054502.
    InParanoidiQ28043.
    KOiK04670.
    OMAiEDPGNWI.
    OrthoDBiEOG7JHM5B.
    TreeFamiTF352876.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    PRINTSiPR00653. ACTIVIN2R.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q28043-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAAAKLAFA VFLISCSSGA ILGRSETQEC IFYNANWERD RTNRTGVESC    50
    YGDKDKRRHC FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV 100
    YFCCCEGNMC NERFSYFPEM EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI 150
    AGIVICAFWV YRHHKMAYPP VLVPTQDPGP PPPSPLLGLK PLQLLEVKAR 200
    GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG MKHENILQFI 250
    GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 300
    AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG 350
    KSAGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR 400
    CTAADGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG 450
    MAMLCETIEE CWDHDAEARL SAGCVGERIT QMQRLTNIIT TEDIVTVVTM 500
    VTNVDFPPKE SSL 513
    Length:513
    Mass (Da):57,952
    Last modified:November 1, 1997 - v1
    Checksum:iC2969A54CF00617B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L21717 mRNA. Translation: AAA74597.1.
    U43208 mRNA. Translation: AAC48694.1.
    BC140605 mRNA. Translation: AAI40606.1.
    PIRiI45850.
    RefSeqiNP_776652.1. NM_174227.3.
    UniGeneiBt.513.

    Genome annotation databases

    EnsembliENSBTAT00000024108; ENSBTAP00000024108; ENSBTAG00000018114.
    GeneIDi281598.
    KEGGibta:281598.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L21717 mRNA. Translation: AAA74597.1 .
    U43208 mRNA. Translation: AAC48694.1 .
    BC140605 mRNA. Translation: AAI40606.1 .
    PIRi I45850.
    RefSeqi NP_776652.1. NM_174227.3.
    UniGenei Bt.513.

    3D structure databases

    ProteinModelPortali Q28043.
    SMRi Q28043. Positions 26-119, 192-484.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q28043.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSBTAT00000024108 ; ENSBTAP00000024108 ; ENSBTAG00000018114 .
    GeneIDi 281598.
    KEGGi bta:281598.

    Organism-specific databases

    CTDi 92.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00560000076906.
    HOGENOMi HOG000231495.
    HOVERGENi HBG054502.
    InParanoidi Q28043.
    KOi K04670.
    OMAi EDPGNWI.
    OrthoDBi EOG7JHM5B.
    TreeFami TF352876.

    Enzyme and pathway databases

    BRENDAi 2.7.10.2. 908.
    Reactomei REACT_211837. Signaling by BMP.
    REACT_223290. Regulation of signaling by NODAL.
    REACT_223651. Signaling by NODAL.
    REACT_224587. Signaling by Activin.

    Miscellaneous databases

    NextBioi 20805541.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PRINTSi PR00653. ACTIVIN2R.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bovine activin receptor type II cDNA: cloning and tissue expression."
      Ethier J.-F., Houde A., Lussier J.G., Silversides D.W.
      Mol. Cell. Endocrinol. 106:1-8(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Holstein.
      Tissue: Testis.
    2. "Fluorescent in situ localization of the bovine activin receptor type IIA locus on chromosome 2 (2q2.3-2.4)."
      Monteagudo L.V., Heriz A., Flavin N., Rogers M., Ennis S., Arruga M.V.
      Mamm. Genome 7:869-869(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.
    3. NIH - Mammalian Gene Collection (MGC) project
      Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: Hereford.
      Tissue: Fetal muscle.

    Entry informationi

    Entry nameiAVR2A_BOVIN
    AccessioniPrimary (citable) accession number: Q28043
    Secondary accession number(s): A5D7L7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3