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Q28043

- AVR2A_BOVIN

UniProt

Q28043 - AVR2A_BOVIN

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Protein

Activin receptor type-2A

Gene

ACVR2A

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei219 – 2191ATPPROSITE-ProRule annotation
Active sitei322 – 3221Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi198 – 2069ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. activin-activated receptor activity Source: Ensembl
  2. ATP binding Source: UniProtKB-KW
  3. coreceptor activity Source: Ensembl
  4. metal ion binding Source: UniProtKB-KW
  5. receptor signaling protein serine/threonine kinase activity Source: InterPro
  6. transforming growth factor beta-activated receptor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. BMP signaling pathway Source: Ensembl
  3. cellular response to BMP stimulus Source: Ensembl
  4. determination of left/right symmetry Source: Ensembl
  5. embryonic skeletal system development Source: Ensembl
  6. gastrulation with mouth forming second Source: Ensembl
  7. mesoderm development Source: Ensembl
  8. penile erection Source: Ensembl
  9. positive regulation of activin receptor signaling pathway Source: Ensembl
  10. positive regulation of bone mineralization Source: Ensembl
  11. positive regulation of erythrocyte differentiation Source: Ensembl
  12. positive regulation of osteoblast differentiation Source: Ensembl
  13. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  14. regulation of BMP signaling pathway Source: Ensembl
  15. regulation of nitric-oxide synthase activity Source: Ensembl
  16. Sertoli cell proliferation Source: Ensembl
  17. spermatogenesis Source: Ensembl
  18. sperm ejaculation Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.10.2. 908.
ReactomeiREACT_211837. Signaling by BMP.
REACT_223290. Regulation of signaling by NODAL.
REACT_223651. Signaling by NODAL.
REACT_224587. Signaling by Activin.

Names & Taxonomyi

Protein namesi
Recommended name:
Activin receptor type-2A (EC:2.7.11.30)
Alternative name(s):
Activin receptor type IIA
Short name:
ACTR-IIA
Gene namesi
Name:ACVR2A
Synonyms:ACTRII, ACVR2
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 2

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini20 – 135116ExtracellularSequence AnalysisAdd
BLAST
Transmembranei136 – 16126HelicalSequence AnalysisAdd
BLAST
Topological domaini162 – 513352CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: Ensembl
  2. cytoplasm Source: Ensembl
  3. inhibin-betaglycan-ActRII complex Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 513494Activin receptor type-2APRO_0000024397Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 60By similarity
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi50 ↔ 78By similarity
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi85 ↔ 104By similarity
Disulfide bondi91 ↔ 103By similarity
Disulfide bondi105 ↔ 110By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ28043.

Interactioni

Subunit structurei

Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ28043.
SMRiQ28043. Positions 26-119, 192-484.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini192 – 485294Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000231495.
HOVERGENiHBG054502.
InParanoidiQ28043.
KOiK04670.
OMAiEDPGNWI.
OrthoDBiEOG7JHM5B.
TreeFamiTF352876.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSiPR00653. ACTIVIN2R.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28043-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAAAKLAFA VFLISCSSGA ILGRSETQEC IFYNANWERD RTNRTGVESC
60 70 80 90 100
YGDKDKRRHC FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV
110 120 130 140 150
YFCCCEGNMC NERFSYFPEM EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI
160 170 180 190 200
AGIVICAFWV YRHHKMAYPP VLVPTQDPGP PPPSPLLGLK PLQLLEVKAR
210 220 230 240 250
GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG MKHENILQFI
260 270 280 290 300
GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL
310 320 330 340 350
AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG
360 370 380 390 400
KSAGDTHGQV GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR
410 420 430 440 450
CTAADGPVDE YMLPFEEEIG QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG
460 470 480 490 500
MAMLCETIEE CWDHDAEARL SAGCVGERIT QMQRLTNIIT TEDIVTVVTM
510
VTNVDFPPKE SSL
Length:513
Mass (Da):57,952
Last modified:November 1, 1997 - v1
Checksum:iC2969A54CF00617B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21717 mRNA. Translation: AAA74597.1.
U43208 mRNA. Translation: AAC48694.1.
BC140605 mRNA. Translation: AAI40606.1.
PIRiI45850.
RefSeqiNP_776652.1. NM_174227.3.
UniGeneiBt.513.

Genome annotation databases

EnsembliENSBTAT00000024108; ENSBTAP00000024108; ENSBTAG00000018114.
GeneIDi281598.
KEGGibta:281598.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L21717 mRNA. Translation: AAA74597.1 .
U43208 mRNA. Translation: AAC48694.1 .
BC140605 mRNA. Translation: AAI40606.1 .
PIRi I45850.
RefSeqi NP_776652.1. NM_174227.3.
UniGenei Bt.513.

3D structure databases

ProteinModelPortali Q28043.
SMRi Q28043. Positions 26-119, 192-484.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q28043.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000024108 ; ENSBTAP00000024108 ; ENSBTAG00000018114 .
GeneIDi 281598.
KEGGi bta:281598.

Organism-specific databases

CTDi 92.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000118876.
HOGENOMi HOG000231495.
HOVERGENi HBG054502.
InParanoidi Q28043.
KOi K04670.
OMAi EDPGNWI.
OrthoDBi EOG7JHM5B.
TreeFami TF352876.

Enzyme and pathway databases

BRENDAi 2.7.10.2. 908.
Reactomei REACT_211837. Signaling by BMP.
REACT_223290. Regulation of signaling by NODAL.
REACT_223651. Signaling by NODAL.
REACT_224587. Signaling by Activin.

Miscellaneous databases

NextBioi 20805541.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
PRINTSi PR00653. ACTIVIN2R.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Bovine activin receptor type II cDNA: cloning and tissue expression."
    Ethier J.-F., Houde A., Lussier J.G., Silversides D.W.
    Mol. Cell. Endocrinol. 106:1-8(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Holstein.
    Tissue: Testis.
  2. "Fluorescent in situ localization of the bovine activin receptor type IIA locus on chromosome 2 (2q2.3-2.4)."
    Monteagudo L.V., Heriz A., Flavin N., Rogers M., Ennis S., Arruga M.V.
    Mamm. Genome 7:869-869(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Fetal muscle.

Entry informationi

Entry nameiAVR2A_BOVIN
AccessioniPrimary (citable) accession number: Q28043
Secondary accession number(s): A5D7L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3