Q28043 (AVR2A_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Activin receptor type-2A
EC=2.7.11.30

Alternative name(s):
Activin receptor type IIA
Short name=ACTR-IIA

Gene names

Name:	ACVR2A
Synonyms:	ACTRII, ACVR2

Organism

Bos taurus (Bovine) [Reference proteome]

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	513 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subunit structure	Interacts with AIP1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3 By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	BMP signaling pathway Inferred from electronic annotation. Source: Compara Sertoli cell proliferation Inferred from electronic annotation. Source: Compara anterior/posterior pattern specification Inferred from electronic annotation. Source: Compara determination of left/right symmetry Inferred from electronic annotation. Source: Compara embryonic skeletal system development Inferred from electronic annotation. Source: Compara gastrulation with mouth forming second Inferred from electronic annotation. Source: Compara mesoderm development Inferred from electronic annotation. Source: Compara penile erection Inferred from electronic annotation. Source: Compara positive regulation of activin receptor signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of bone mineralization Inferred from electronic annotation. Source: Compara positive regulation of erythrocyte differentiation Inferred from electronic annotation. Source: Compara positive regulation of osteoblast differentiation Inferred from electronic annotation. Source: Compara positive regulation of pathway-restricted SMAD protein phosphorylation Inferred from electronic annotation. Source: Compara regulation of BMP signaling pathway Inferred from electronic annotation. Source: Compara regulation of nitric-oxide synthase activity Inferred from electronic annotation. Source: Compara signal transduction by phosphorylation Inferred from electronic annotation. Source: GOC sperm ejaculation Inferred from electronic annotation. Source: Compara spermatogenesis Inferred from electronic annotation. Source: Compara
Cellular_component	cell surface Inferred from electronic annotation. Source: Compara cytoplasm Inferred from electronic annotation. Source: Compara inhibin-betaglycan-ActRII complex Inferred from electronic annotation. Source: Compara integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW activin-activated receptor activity Inferred from electronic annotation. Source: Compara coreceptor activity Inferred from electronic annotation. Source: Compara metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW receptor signaling protein serine/threonine kinase activity Inferred from electronic annotation. Source: InterPro transforming growth factor beta-activated receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19	Potential
	Chain	20 – 513	494	Activin receptor type-2A		PRO_0000024397
Regions
	Topological domain	20 – 135	116	Extracellular Potential
	Transmembrane	136 – 161	26	Helical; Potential
	Topological domain	162 – 513	352	Cytoplasmic Potential
	Domain	192 – 485	294	Protein kinase
	Nucleotide binding	198 – 206	9	ATP By similarity
Sites
	Active site	322	1	Proton acceptor By similarity
	Binding site	219	1	ATP By similarity
Amino acid modifications
	Glycosylation	43	1	N-linked (GlcNAc...) Potential
	Glycosylation	66	1	N-linked (GlcNAc...) Potential
	Disulfide bond	30 ↔ 60		By similarity
	Disulfide bond	50 ↔ 78		By similarity
	Disulfide bond	85 ↔ 104		By similarity
	Disulfide bond	91 ↔ 103		By similarity
	Disulfide bond	105 ↔ 110		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q28043 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: C2969A54CF00617B	FASTA	513	57,952
	10 20 30 40 50 60 MGAAAKLAFA VFLISCSSGA ILGRSETQEC IFYNANWERD RTNRTGVESC YGDKDKRRHC 70 80 90 100 110 120 FATWKNISGS IEIVKQGCWL DDINCYDRTD CIEKKDSPEV YFCCCEGNMC NERFSYFPEM 130 140 150 160 170 180 EVTQPTSNPV TPKPPYYNIL LYSLVPLMLI AGIVICAFWV YRHHKMAYPP VLVPTQDPGP 190 200 210 220 230 240 PPPSPLLGLK PLQLLEVKAR GRFGCVWKAQ LLNEYVAVKI FPIQDKQSWQ NEYEVYSLPG 250 260 270 280 290 300 MKHENILQFI GAEKRGTSVD VDLWLITAFH EKGSLSDFLK ANVVSWNELC HIAETMARGL 310 320 330 340 350 360 AYLHEDIPGL KDGHKPAISH RDIKSKNVLL KNNLTACIAD FGLALKFEAG KSAGDTHGQV 370 380 390 400 410 420 GTRRYMAPEV LEGAINFQRD AFLRIDMYAM GLVLWELASR CTAADGPVDE YMLPFEEEIG 430 440 450 460 470 480 QHPSLEDMQE VVVHKKKRPV LRDYWQKHAG MAMLCETIEE CWDHDAEARL SAGCVGERIT 490 500 510 QMQRLTNIIT TEDIVTVVTM VTNVDFPPKE SSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Bovine activin receptor type II cDNA: cloning and tissue expression." Ethier J.-F., Houde A., Lussier J.G., Silversides D.W. Mol. Cell. Endocrinol. 106:1-8(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Holstein. Tissue: Testis.
[2]	"Fluorescent in situ localization of the bovine activin receptor type IIA locus on chromosome 2 (2q2.3-2.4)." Monteagudo L.V., Heriz A., Flavin N., Rogers M., Ennis S., Arruga M.V. Mamm. Genome 7:869-869(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Ovary.
[3]	NIH - Mammalian Gene Collection (MGC) project Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Hereford. Tissue: Fetal muscle.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L21717 mRNA. Translation: AAA74597.1. U43208 mRNA. Translation: AAC48694.1. BC140605 mRNA. Translation: AAI40606.1.
IPI	IPI00708883.
PIR	I45850.
RefSeq	NP_776652.1. NM_174227.3.
UniGene	Bt.513.
3D structure databases
ProteinModelPortal	Q28043.
SMR	Q28043. Positions 26-119, 192-484.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000024108; ENSBTAP00000024108; ENSBTAG00000018114.
GeneID	281598.
KEGG	bta:281598.
Organism-specific databases
CTD	92.
Phylogenomic databases
eggNOG	COG0515.
GeneTree	ENSGT00560000076906.
HOGENOM	HOG000231495.
HOVERGEN	HBG054502.
InParanoid	Q28043.
KO	K04670.
OMA	ERIIQMQ.
OrthoDB	EOG47WNNH.
Enzyme and pathway databases
BRENDA	2.7.10.2. 908.
Family and domain databases
InterPro	IPR000333. Activin_II/TGFBeta-II_recpt. IPR015768. Activin_II_recpt. IPR000472. Activin_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR008271. Ser/Thr_kinase_AS. [Graphical view]
PANTHER	PTHR23255:SF10. PTHR23255:SF10. 1 hit.
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
PRINTS	PR00653. ACTIVIN2R.
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20805541.

Entry information

Entry name

AVR2A_BOVIN

Accession

Primary (citable) accession number: Q28043
Secondary accession number(s): A5D7L7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 106 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program