Reviewed, UniProtKB/Swiss-Prot Q28041 (ACVR1_BOVIN)

Names and origin

Protein names

Recommended name:
    Activin receptor type-1
    EC=2.7.11.30
Alternative name(s):
    Activin receptor type I
      Short name=ACTR-I
    Serine/threonine-protein kinase receptor R1
      Short name=SKR1

Gene names

Name:	ACVR1
Synonyms:	ACVRLK2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	509 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May also bind activin.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subunit structure	Interacts with FKBP1A By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 GS domain. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Glycoprotein Phosphoprotein
Gene Ontology (GO)
Biological process	determination of left/right symmetry Inferred from sequence or structural similarity. Source: AgBase germ cell development Inferred from sequence or structural similarity. Source: AgBase heart development Inferred from sequence or structural similarity. Source: AgBase in utero embryonic development Inferred from sequence or structural similarity. Source: AgBase neural crest cell migration Inferred from sequence or structural similarity. Source: AgBase transforming growth factor beta receptor signaling pathway Inferred from sequence or structural similarity. Source: AgBase urogenital system development Inferred from sequence or structural similarity. Source: AgBase
Cellular component	activin receptor complex Inferred from sequence or structural similarity. Source: AgBase
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW activin receptor activity, type I Inferred from sequence or structural similarity. Source: AgBase magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW transforming growth factor beta binding Inferred from sequence or structural similarity. Source: AgBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	By similarity
	Chain	21 – 509	489	Activin receptor type-1		PRO_0000024393
Regions
	Topological domain	21 – 123	103	Extracellular Potential
	Transmembrane	124 – 146	23	Potential
	Topological domain	147 – 509	363	Cytoplasmic Potential
	Domain	178 – 207	30	GS
	Domain	208 – 502	295	Protein kinase
	Nucleotide binding	214 – 222	9	ATP By similarity
Sites
	Active site	336	1	Proton acceptor By similarity
	Binding site	235	1	ATP By similarity
Amino acid modifications
	Modified residue	226	1	Phosphoserine By similarity
	Modified residue	501	1	Phosphoserine By similarity
	Glycosylation	102	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q28041-1 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 365B9D4A518773FB	FASTA	509	57,190
	10 20 30 40 50 60 MVDGVMILPV LVMIAFPFPS MEDEKPKVNP KLYMCVCEGL SCGDEAHCEG QQCFSSLSIN 70 80 90 100 110 120 DGFHVYQKGC FQVYEQGKMT CKTPPSPGQA VECCQGDWCN RNITAQLPTK GKSFPGTQNF 130 140 150 160 170 180 HLEVGLIILS VVFAVCLLAC LLGVALRKFK RRNQERLNPR DVEYGTIEGL ITTNVGDSTL 190 200 210 220 230 240 ADLLDHSCTS GSGSGLPFLV QRTVARQITL LECVGKGRYG EVWRGSWQGE NVAVKIFSSR 250 260 270 280 290 300 DEKSWFRETE LYNTVMLRHE NILGFIASDM TSRHSSTQLW LITHYHEMGS LYDYLQLTTL 310 320 330 340 350 360 DTVSCLRIVL SIASGLAHLH IEIFGTQGKP AIAHRDLKSK NILVKKNGQC CIADLGLAVM 370 380 390 400 410 420 HSQSTNQLDV GNNPRVGTKR YMAPEVLDET IQVDCFDSYK RVDIWAFGLV LWEVARRMVS 430 440 450 460 470 480 NGIVEDYKPP FYDVVPNDPS FEDMRKVVCV DQQRPNIPNR WFSDPTLTSL AKLMKECWYQ 490 500 NPSARLTALR IKKTLTKIDN SLDKLKTDC

References

[1]	"Bovine activin receptor type I can be expressed as a kinase-domain truncated receptor." Ethier J.-F., Lussier J.G., Daneau I., Silversides D.W. Submitted (JUN-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	U58095 mRNA. Translation: AAB02696.1.
IPI	IPI00695437.
UniGene	Bt.16020
3D structure databases
SMR	Q28041. Positions 33-108, 178-498.
ModBase	Search...
Protein-protein interaction databases
STRING	Q28041.
Genome annotation databases
Ensembl	ENSBTAT00000015797; ENSBTAP00000015797; ENSBTAG00000011909; Bos taurus. [Genome view]
Phylogenomic databases
eggNOG	maNOG07226.
HOVERGEN	Q28041.
InParanoid	Q28041.
Enzyme and pathway databases
BRENDA	2.7.11.30. 251.
Family and domain databases
InterPro	IPR000333. Activin_II_recpt. IPR000472. Activin_rcpt. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_prot_kinase-like_dom. IPR008271. Ser/Thr_prot_kinase_AS. IPR003605. TGF_beta_rcpt_GS. [Graphical view]
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. PF08515. TGF_beta_GS. 1 hit. [Graphical view]
PRINTS	PR00653. ACTIVIN2R.
SMART	SM00467. GS. 1 hit. [Graphical view]
PROSITE	PS51256. GS. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACVR1_BOVIN

Accession

Primary (citable) accession number: Q28041

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	February 9, 2010
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)