ID SC6A9_BOVIN Reviewed; 638 AA. AC Q28039; Q28040; Q29420; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1997, sequence version 1. DT 24-JAN-2024, entry version 120. DE RecName: Full=Sodium- and chloride-dependent glycine transporter 1; DE Short=GlyT-1; DE Short=GlyT1; DE AltName: Full=Solute carrier family 6 member 9; GN Name=SLC6A9; OS Bos taurus (Bovine). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; OC Bovinae; Bos. OX NCBI_TaxID=9913; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3). RA Jones E.M.C.; RL Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases. CC -!- FUNCTION: Sodium- and chloride-dependent glycine transporter which is CC essential for regulating glycine concentrations at inhibitory CC glycinergic synapses. {ECO:0000250|UniProtKB:P28571}. CC -!- CATALYTIC ACTIVITY: CC Reaction=chloride(out) + glycine(out) + 2 Na(+)(out) = chloride(in) + CC glycine(in) + 2 Na(+)(in); Xref=Rhea:RHEA:70691, ChEBI:CHEBI:17996, CC ChEBI:CHEBI:29101, ChEBI:CHEBI:57305; CC Evidence={ECO:0000250|UniProtKB:P28571}; CC -!- SUBUNIT: Interacts with EXOC1; interaction increases the transporter CC capacity of SLC6A9 probably by promoting its insertion into the cell CC membrane (By similarity). Interacts with EXOC3 and EXOC4 (By CC similarity). {ECO:0000250|UniProtKB:P28572}. CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P28572}; CC Multi-pass membrane protein {ECO:0000255}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; Synonyms=GlyT-1B; CC IsoId=Q28039-1; Sequence=Displayed; CC Name=2; Synonyms=GlyT-1A; CC IsoId=Q28039-2; Sequence=VSP_006268; CC Name=3; Synonyms=GlyT-1F; CC IsoId=Q28039-3; Sequence=VSP_006269; CC -!- SIMILARITY: Belongs to the sodium:neurotransmitter symporter (SNF) CC (TC 2.A.22) family. SLC6A9 subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; U52687; AAB01158.1; -; mRNA. DR EMBL; U52688; AAB01159.1; -; mRNA. DR EMBL; U52689; AAB01160.1; -; mRNA. DR EMBL; U52690; AAB01161.1; -; mRNA. DR RefSeq; NP_001229271.1; NM_001242342.1. DR RefSeq; NP_001229272.1; NM_001242343.1. DR AlphaFoldDB; Q28039; -. DR SMR; Q28039; -. DR STRING; 9913.ENSBTAP00000073186; -. DR BindingDB; Q28039; -. DR ChEMBL; CHEMBL3638333; -. DR GlyCosmos; Q28039; 4 sites, No reported glycans. DR PaxDb; 9913-ENSBTAP00000007938; -. DR GeneID; 282368; -. DR KEGG; bta:282368; -. DR CTD; 6536; -. DR eggNOG; KOG3660; Eukaryota. DR InParanoid; Q28039; -. DR OrthoDB; 3084493at2759; -. DR Proteomes; UP000009136; Unplaced. DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB. DR GO; GO:0045202; C:synapse; IEA:GOC. DR GO; GO:0015375; F:glycine:sodium symporter activity; ISS:UniProtKB. DR GO; GO:1903804; P:glycine import across plasma membrane; IBA:GO_Central. DR GO; GO:0006836; P:neurotransmitter transport; IEA:UniProtKB-KW. DR GO; GO:0060092; P:regulation of synaptic transmission, glycinergic; ISS:UniProtKB. DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central. DR GO; GO:0060012; P:synaptic transmission, glycinergic; IBA:GO_Central. DR CDD; cd11498; SLC6sbd_GlyT1; 1. DR InterPro; IPR000175; Na/ntran_symport. DR InterPro; IPR003028; Na/ntran_symport_glycine_GLY1. DR InterPro; IPR037272; SNS_sf. DR PANTHER; PTHR11616:SF263; SODIUM- AND CHLORIDE-DEPENDENT GLYCINE TRANSPORTER 1; 1. DR PANTHER; PTHR11616; SODIUM/CHLORIDE DEPENDENT TRANSPORTER; 1. DR Pfam; PF00209; SNF; 1. DR PRINTS; PR01204; GLY1TRNSPORT. DR PRINTS; PR00176; NANEUSMPORT. DR SUPFAM; SSF161070; SNF-like; 1. DR PROSITE; PS00610; NA_NEUROTRAN_SYMP_1; 1. DR PROSITE; PS00754; NA_NEUROTRAN_SYMP_2; 1. DR PROSITE; PS50267; NA_NEUROTRAN_SYMP_3; 1. PE 2: Evidence at transcript level; KW Alternative splicing; Amino-acid transport; Cell membrane; Glycoprotein; KW Membrane; Neurotransmitter transport; Phosphoprotein; Reference proteome; KW Symport; Transmembrane; Transmembrane helix; Transport. FT CHAIN 1..638 FT /note="Sodium- and chloride-dependent glycine transporter FT 1" FT /id="PRO_0000214779" FT TOPO_DOM 1..40 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 41..61 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TRANSMEM 69..88 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TRANSMEM 112..132 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 133..219 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 220..238 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TRANSMEM 247..264 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TRANSMEM 300..317 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TRANSMEM 329..350 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TRANSMEM 383..402 FT /note="Helical; Name=8" FT /evidence="ECO:0000255" FT TRANSMEM 431..449 FT /note="Helical; Name=9" FT /evidence="ECO:0000255" FT TRANSMEM 465..485 FT /note="Helical; Name=10" FT /evidence="ECO:0000255" FT TRANSMEM 506..525 FT /note="Helical; Name=11" FT /evidence="ECO:0000255" FT TRANSMEM 544..562 FT /note="Helical; Name=12" FT /evidence="ECO:0000255" FT TOPO_DOM 563..638 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT REGION 1..29 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 597..638 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 627..638 FT /note="Essential for interaction with EXOC1" FT /evidence="ECO:0000250|UniProtKB:P28572" FT COMPBIAS 9..23 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 624..638 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT MOD_RES 603 FT /note="Phosphothreonine" FT /evidence="ECO:0000250|UniProtKB:P28571" FT MOD_RES 605 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P28571" FT MOD_RES 630 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P48067" FT CARBOHYD 169 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 172 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 182 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 188 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT VAR_SEQ 1..14 FT /note="MAAAQGPVAPSSLE -> MVGKGAKGM (in isoform 2)" FT /evidence="ECO:0000303|Ref.1" FT /id="VSP_006268" FT VAR_SEQ 537..638 FT /note="YPSWRVRIGFLMALSSVICIPLYALFQFCRTDGDTLLHRLKNATKPSRDWGP FT ALLEHRTRRYAPTTTPSPEDGLEVQPLHPDKAQIPMVGSNGSSRFQDSRI -> SSQTG FT LPLFTCQIAPAHVPQPLSGARTPSPKPWSVRVSVLRAPLCSDSPGRAASNPL (in FT isoform 3)" FT /evidence="ECO:0000303|Ref.1" FT /id="VSP_006269" SQ SEQUENCE 638 AA; 71318 MW; 97ADDBF28EC2A443 CRC64; MAAAQGPVAP SSLEQNGAVP SEATKKDQNL KRGNWGNQIE FVLTSVGYAV GLGNVWRFPY LCYRNGGGAF MFPYFIMLIF CGIPLFFMEL SFGQFASQGC LGVWRISPMF KGVGYGMMVV STYIGIYYNV VICIAFYYFF SSMTPVLPWT YCNNPWNTPD CMSVLDNPNI TNGSQPPALP GNVSQALNQT LKRTSPSEEY WRLYVLKLSD DIGNFGEVRL PLLGCLGVSW VVVFLCLIRG VKSSGKVVYF TATFPYVVLT ILFIRGVTLE GAFTGIMYYL TPQWDKILEA KVWGDAASQI FYSLGCAWGG LVTMASYNKF HNNCYRDSVI ISITNCATSV YAGFVIFSIL GFMANHLGVD VSRVADHGPG LAFVAYPEAL TLLPISPLWS LLFFFMLILL GLGTQFCLLE TLVTAIVDEV GNEWILQKKT YVTLGVAVAG FLLGIPLTSQ AGIYWLLLMD NYAASFSLVI ISCIMCVSIM YIYGHQNYFQ DIQMMLGFPP PLFFQICWRF VSPAIIFFIL IFSVIQYQPI TYNQYQYPSW RVRIGFLMAL SSVICIPLYA LFQFCRTDGD TLLHRLKNAT KPSRDWGPAL LEHRTRRYAP TTTPSPEDGL EVQPLHPDKA QIPMVGSNGS SRFQDSRI //