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Q28039 (SC6A9_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium- and chloride-dependent glycine transporter 1

Short name=GlyT-1
Short name=GlyT1
Alternative name(s):
Solute carrier family 6 member 9
Gene names
Name:SLC6A9
OrganismBos taurus (Bovine) [Reference proteome]
Taxonomic identifier9913 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Protein attributes

Sequence length638 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily. [View classification]

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q28039-1)

Also known as: GlyT-1B;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q28039-2)

Also known as: GlyT-1A;

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MAAAQGPVAPSSLE → MVGKGAKGM
Isoform 3 (identifier: Q28039-3)

Also known as: GlyT-1F;

The sequence of this isoform differs from the canonical sequence as follows:
     537-638: YPSWRVRIGF...GSSRFQDSRI → SSQTGLPLFT...SPGRAASNPL

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 638638Sodium- and chloride-dependent glycine transporter 1
PRO_0000214779

Regions

Topological domain1 – 4040Cytoplasmic Potential
Transmembrane41 – 6121Helical; Name=1; Potential
Transmembrane69 – 8820Helical; Name=2; Potential
Transmembrane112 – 13221Helical; Name=3; Potential
Topological domain133 – 21987Extracellular Potential
Transmembrane220 – 23819Helical; Name=4; Potential
Transmembrane247 – 26418Helical; Name=5; Potential
Transmembrane300 – 31718Helical; Name=6; Potential
Transmembrane329 – 35022Helical; Name=7; Potential
Transmembrane383 – 40220Helical; Name=8; Potential
Transmembrane431 – 44919Helical; Name=9; Potential
Transmembrane465 – 48521Helical; Name=10; Potential
Transmembrane506 – 52520Helical; Name=11; Potential
Transmembrane544 – 56219Helical; Name=12; Potential
Topological domain563 – 63876Cytoplasmic Potential

Amino acid modifications

Glycosylation1691N-linked (GlcNAc...) Potential
Glycosylation1721N-linked (GlcNAc...) Potential
Glycosylation1821N-linked (GlcNAc...) Potential
Glycosylation1881N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 1414MAAAQ…PSSLE → MVGKGAKGM in isoform 2.
VSP_006268
Alternative sequence537 – 638102YPSWR…QDSRI → SSQTGLPLFTCQIAPAHVPQ PLSGARTPSPKPWSVRVSVL RAPLCSDSPGRAASNPL in isoform 3.
VSP_006269

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (GlyT-1B) [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 97ADDBF28EC2A443

FASTA63871,318
        10         20         30         40         50         60 
MAAAQGPVAP SSLEQNGAVP SEATKKDQNL KRGNWGNQIE FVLTSVGYAV GLGNVWRFPY 

        70         80         90        100        110        120 
LCYRNGGGAF MFPYFIMLIF CGIPLFFMEL SFGQFASQGC LGVWRISPMF KGVGYGMMVV 

       130        140        150        160        170        180 
STYIGIYYNV VICIAFYYFF SSMTPVLPWT YCNNPWNTPD CMSVLDNPNI TNGSQPPALP 

       190        200        210        220        230        240 
GNVSQALNQT LKRTSPSEEY WRLYVLKLSD DIGNFGEVRL PLLGCLGVSW VVVFLCLIRG 

       250        260        270        280        290        300 
VKSSGKVVYF TATFPYVVLT ILFIRGVTLE GAFTGIMYYL TPQWDKILEA KVWGDAASQI 

       310        320        330        340        350        360 
FYSLGCAWGG LVTMASYNKF HNNCYRDSVI ISITNCATSV YAGFVIFSIL GFMANHLGVD 

       370        380        390        400        410        420 
VSRVADHGPG LAFVAYPEAL TLLPISPLWS LLFFFMLILL GLGTQFCLLE TLVTAIVDEV 

       430        440        450        460        470        480 
GNEWILQKKT YVTLGVAVAG FLLGIPLTSQ AGIYWLLLMD NYAASFSLVI ISCIMCVSIM 

       490        500        510        520        530        540 
YIYGHQNYFQ DIQMMLGFPP PLFFQICWRF VSPAIIFFIL IFSVIQYQPI TYNQYQYPSW 

       550        560        570        580        590        600 
RVRIGFLMAL SSVICIPLYA LFQFCRTDGD TLLHRLKNAT KPSRDWGPAL LEHRTRRYAP 

       610        620        630 
TTTPSPEDGL EVQPLHPDKA QIPMVGSNGS SRFQDSRI 

« Hide

Isoform 2 (GlyT-1A) [UniParc].

Checksum: A13C9CEA2F7A382F
Show »

FASTA63370,868
Isoform 3 (GlyT-1F) [UniParc].

Checksum: 9FC3DEA290A118B2
Show »

FASTA59365,672

References

[1]Jones E.M.C.
Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U52687 mRNA. Translation: AAB01158.1.
U52688 mRNA. Translation: AAB01159.1.
U52689 mRNA. Translation: AAB01160.1.
U52690 mRNA. Translation: AAB01161.1.
RefSeqNP_001229271.1. NM_001242342.1.
NP_001229272.1. NM_001242343.1.
UniGeneBt.4855.

3D structure databases

ProteinModelPortalQ28039.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9913.ENSBTAP00000007938.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID282368.
KEGGbta:282368.

Organism-specific databases

CTD6536.

Phylogenomic databases

eggNOGCOG0733.
HOGENOMHOG000116406.
HOVERGENHBG071421.
InParanoidQ28039.
KOK05038.

Family and domain databases

InterProIPR000175. Na/ntran_symport.
IPR003028. Na/ntran_symport_glycine_GLY1.
[Graphical view]
PANTHERPTHR11616. PTHR11616. 1 hit.
PfamPF00209. SNF. 1 hit.
[Graphical view]
PRINTSPR01204. GLY1TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20806160.

Entry information

Entry nameSC6A9_BOVIN
AccessionPrimary (citable) accession number: Q28039
Secondary accession number(s): Q28040, Q29420
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families