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Protein

Sodium- and chloride-dependent glycine transporter 1

Gene

SLC6A9

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission (By similarity).By similarity

GO - Molecular functioni

Keywordsi

Biological processAmino-acid transport, Neurotransmitter transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent glycine transporter 1
Short name:
GlyT-1
Short name:
GlyT1
Alternative name(s):
Solute carrier family 6 member 9
Gene namesi
Name:SLC6A9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40CytoplasmicSequence analysisAdd BLAST40
Transmembranei41 – 61Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei69 – 88Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei112 – 132Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini133 – 219ExtracellularSequence analysisAdd BLAST87
Transmembranei220 – 238Helical; Name=4Sequence analysisAdd BLAST19
Transmembranei247 – 264Helical; Name=5Sequence analysisAdd BLAST18
Transmembranei300 – 317Helical; Name=6Sequence analysisAdd BLAST18
Transmembranei329 – 350Helical; Name=7Sequence analysisAdd BLAST22
Transmembranei383 – 402Helical; Name=8Sequence analysisAdd BLAST20
Transmembranei431 – 449Helical; Name=9Sequence analysisAdd BLAST19
Transmembranei465 – 485Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei506 – 525Helical; Name=11Sequence analysisAdd BLAST20
Transmembranei544 – 562Helical; Name=12Sequence analysisAdd BLAST19
Topological domaini563 – 638CytoplasmicSequence analysisAdd BLAST76

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3638333

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002147791 – 638Sodium- and chloride-dependent glycine transporter 1Add BLAST638

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi169N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi182N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei603PhosphothreonineBy similarity1
Modified residuei605PhosphoserineBy similarity1
Modified residuei630PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ28039
PRIDEiQ28039

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007938

Chemistry databases

BindingDBiQ28039

Structurei

3D structure databases

ProteinModelPortaliQ28039
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
HOGENOMiHOG000116406
HOVERGENiHBG071421
InParanoidiQ28039
KOiK05038

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR003028 Na/ntran_symport_glycine_GLY1
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR01204 GLY1TRNSPORT
PR00176 NANEUSMPORT
SUPFAMiSSF161070 SSF161070, 2 hits
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q28039-1) [UniParc]FASTAAdd to basket
Also known as: GlyT-1B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAQGPVAP SSLEQNGAVP SEATKKDQNL KRGNWGNQIE FVLTSVGYAV
60 70 80 90 100
GLGNVWRFPY LCYRNGGGAF MFPYFIMLIF CGIPLFFMEL SFGQFASQGC
110 120 130 140 150
LGVWRISPMF KGVGYGMMVV STYIGIYYNV VICIAFYYFF SSMTPVLPWT
160 170 180 190 200
YCNNPWNTPD CMSVLDNPNI TNGSQPPALP GNVSQALNQT LKRTSPSEEY
210 220 230 240 250
WRLYVLKLSD DIGNFGEVRL PLLGCLGVSW VVVFLCLIRG VKSSGKVVYF
260 270 280 290 300
TATFPYVVLT ILFIRGVTLE GAFTGIMYYL TPQWDKILEA KVWGDAASQI
310 320 330 340 350
FYSLGCAWGG LVTMASYNKF HNNCYRDSVI ISITNCATSV YAGFVIFSIL
360 370 380 390 400
GFMANHLGVD VSRVADHGPG LAFVAYPEAL TLLPISPLWS LLFFFMLILL
410 420 430 440 450
GLGTQFCLLE TLVTAIVDEV GNEWILQKKT YVTLGVAVAG FLLGIPLTSQ
460 470 480 490 500
AGIYWLLLMD NYAASFSLVI ISCIMCVSIM YIYGHQNYFQ DIQMMLGFPP
510 520 530 540 550
PLFFQICWRF VSPAIIFFIL IFSVIQYQPI TYNQYQYPSW RVRIGFLMAL
560 570 580 590 600
SSVICIPLYA LFQFCRTDGD TLLHRLKNAT KPSRDWGPAL LEHRTRRYAP
610 620 630
TTTPSPEDGL EVQPLHPDKA QIPMVGSNGS SRFQDSRI
Length:638
Mass (Da):71,318
Last modified:November 1, 1997 - v1
Checksum:i97ADDBF28EC2A443
GO
Isoform 2 (identifier: Q28039-2) [UniParc]FASTAAdd to basket
Also known as: GlyT-1A

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MAAAQGPVAPSSLE → MVGKGAKGM

Show »
Length:633
Mass (Da):70,868
Checksum:iA13C9CEA2F7A382F
GO
Isoform 3 (identifier: Q28039-3) [UniParc]FASTAAdd to basket
Also known as: GlyT-1F

The sequence of this isoform differs from the canonical sequence as follows:
     537-638: YPSWRVRIGF...GSSRFQDSRI → SSQTGLPLFT...SPGRAASNPL

Show »
Length:593
Mass (Da):65,672
Checksum:i9FC3DEA290A118B2
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0062681 – 14MAAAQ…PSSLE → MVGKGAKGM in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_006269537 – 638YPSWR…QDSRI → SSQTGLPLFTCQIAPAHVPQ PLSGARTPSPKPWSVRVSVL RAPLCSDSPGRAASNPL in isoform 3. 1 PublicationAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52687 mRNA Translation: AAB01158.1
U52688 mRNA Translation: AAB01159.1
U52689 mRNA Translation: AAB01160.1
U52690 mRNA Translation: AAB01161.1
RefSeqiNP_001229271.1, NM_001242342.1
NP_001229272.1, NM_001242343.1
UniGeneiBt.4855

Genome annotation databases

GeneIDi282368
KEGGibta:282368

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSC6A9_BOVIN
AccessioniPrimary (citable) accession number: Q28039
Secondary accession number(s): Q28040, Q29420
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 25, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health