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Q28039

- SC6A9_BOVIN

UniProt

Q28039 - SC6A9_BOVIN

Protein

Sodium- and chloride-dependent glycine transporter 1

Gene

SLC6A9

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission By similarity.By similarity

    GO - Molecular functioni

    1. neurotransmitter:sodium symporter activity Source: InterPro
    2. sodium:amino acid symporter activity Source: InterPro

    Keywords - Biological processi

    Amino-acid transport, Neurotransmitter transport, Symport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium- and chloride-dependent glycine transporter 1
    Short name:
    GlyT-1
    Short name:
    GlyT1
    Alternative name(s):
    Solute carrier family 6 member 9
    Gene namesi
    Name:SLC6A9
    OrganismiBos taurus (Bovine)
    Taxonomic identifieri9913 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
    ProteomesiUP000009136: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: InterPro

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 638638Sodium- and chloride-dependent glycine transporter 1PRO_0000214779Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Interactioni

    Protein-protein interaction databases

    STRINGi9913.ENSBTAP00000007938.

    Structurei

    3D structure databases

    ProteinModelPortaliQ28039.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4040CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini133 – 21987ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini563 – 63876CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6121Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei69 – 8820Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei112 – 13221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei220 – 23819Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei247 – 26418Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei300 – 31718Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei329 – 35022Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei383 – 40220Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei431 – 44919Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei465 – 48521Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei506 – 52520Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei544 – 56219Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0733.
    HOGENOMiHOG000116406.
    HOVERGENiHBG071421.
    InParanoidiQ28039.
    KOiK05038.

    Family and domain databases

    InterProiIPR000175. Na/ntran_symport.
    IPR003028. Na/ntran_symport_glycine_GLY1.
    [Graphical view]
    PANTHERiPTHR11616. PTHR11616. 1 hit.
    PfamiPF00209. SNF. 1 hit.
    [Graphical view]
    PRINTSiPR01204. GLY1TRNSPORT.
    PR00176. NANEUSMPORT.
    PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q28039-1) [UniParc]FASTAAdd to Basket

    Also known as: GlyT-1B

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAQGPVAP SSLEQNGAVP SEATKKDQNL KRGNWGNQIE FVLTSVGYAV    50
    GLGNVWRFPY LCYRNGGGAF MFPYFIMLIF CGIPLFFMEL SFGQFASQGC 100
    LGVWRISPMF KGVGYGMMVV STYIGIYYNV VICIAFYYFF SSMTPVLPWT 150
    YCNNPWNTPD CMSVLDNPNI TNGSQPPALP GNVSQALNQT LKRTSPSEEY 200
    WRLYVLKLSD DIGNFGEVRL PLLGCLGVSW VVVFLCLIRG VKSSGKVVYF 250
    TATFPYVVLT ILFIRGVTLE GAFTGIMYYL TPQWDKILEA KVWGDAASQI 300
    FYSLGCAWGG LVTMASYNKF HNNCYRDSVI ISITNCATSV YAGFVIFSIL 350
    GFMANHLGVD VSRVADHGPG LAFVAYPEAL TLLPISPLWS LLFFFMLILL 400
    GLGTQFCLLE TLVTAIVDEV GNEWILQKKT YVTLGVAVAG FLLGIPLTSQ 450
    AGIYWLLLMD NYAASFSLVI ISCIMCVSIM YIYGHQNYFQ DIQMMLGFPP 500
    PLFFQICWRF VSPAIIFFIL IFSVIQYQPI TYNQYQYPSW RVRIGFLMAL 550
    SSVICIPLYA LFQFCRTDGD TLLHRLKNAT KPSRDWGPAL LEHRTRRYAP 600
    TTTPSPEDGL EVQPLHPDKA QIPMVGSNGS SRFQDSRI 638
    Length:638
    Mass (Da):71,318
    Last modified:November 1, 1997 - v1
    Checksum:i97ADDBF28EC2A443
    GO
    Isoform 2 (identifier: Q28039-2) [UniParc]FASTAAdd to Basket

    Also known as: GlyT-1A

    The sequence of this isoform differs from the canonical sequence as follows:
         1-14: MAAAQGPVAPSSLE → MVGKGAKGM

    Show »
    Length:633
    Mass (Da):70,868
    Checksum:iA13C9CEA2F7A382F
    GO
    Isoform 3 (identifier: Q28039-3) [UniParc]FASTAAdd to Basket

    Also known as: GlyT-1F

    The sequence of this isoform differs from the canonical sequence as follows:
         537-638: YPSWRVRIGF...GSSRFQDSRI → SSQTGLPLFT...SPGRAASNPL

    Show »
    Length:593
    Mass (Da):65,672
    Checksum:i9FC3DEA290A118B2
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1414MAAAQ…PSSLE → MVGKGAKGM in isoform 2. 1 PublicationVSP_006268Add
    BLAST
    Alternative sequencei537 – 638102YPSWR…QDSRI → SSQTGLPLFTCQIAPAHVPQ PLSGARTPSPKPWSVRVSVL RAPLCSDSPGRAASNPL in isoform 3. 1 PublicationVSP_006269Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U52687 mRNA. Translation: AAB01158.1.
    U52688 mRNA. Translation: AAB01159.1.
    U52689 mRNA. Translation: AAB01160.1.
    U52690 mRNA. Translation: AAB01161.1.
    RefSeqiNP_001229271.1. NM_001242342.1.
    NP_001229272.1. NM_001242343.1.
    UniGeneiBt.4855.

    Genome annotation databases

    GeneIDi282368.
    KEGGibta:282368.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U52687 mRNA. Translation: AAB01158.1 .
    U52688 mRNA. Translation: AAB01159.1 .
    U52689 mRNA. Translation: AAB01160.1 .
    U52690 mRNA. Translation: AAB01161.1 .
    RefSeqi NP_001229271.1. NM_001242342.1.
    NP_001229272.1. NM_001242343.1.
    UniGenei Bt.4855.

    3D structure databases

    ProteinModelPortali Q28039.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9913.ENSBTAP00000007938.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 282368.
    KEGGi bta:282368.

    Organism-specific databases

    CTDi 6536.

    Phylogenomic databases

    eggNOGi COG0733.
    HOGENOMi HOG000116406.
    HOVERGENi HBG071421.
    InParanoidi Q28039.
    KOi K05038.

    Miscellaneous databases

    NextBioi 20806160.

    Family and domain databases

    InterProi IPR000175. Na/ntran_symport.
    IPR003028. Na/ntran_symport_glycine_GLY1.
    [Graphical view ]
    PANTHERi PTHR11616. PTHR11616. 1 hit.
    Pfami PF00209. SNF. 1 hit.
    [Graphical view ]
    PRINTSi PR01204. GLY1TRNSPORT.
    PR00176. NANEUSMPORT.
    PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
    PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
    PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Jones E.M.C.
      Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).

    Entry informationi

    Entry nameiSC6A9_BOVIN
    AccessioniPrimary (citable) accession number: Q28039
    Secondary accession number(s): Q28040, Q29420
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3