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Q28039

- SC6A9_BOVIN

UniProt

Q28039 - SC6A9_BOVIN

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Protein

Sodium- and chloride-dependent glycine transporter 1

Gene

SLC6A9

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission (By similarity).By similarity

GO - Molecular functioni

  1. neurotransmitter:sodium symporter activity Source: InterPro
  2. sodium:amino acid symporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Neurotransmitter transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent glycine transporter 1
Short name:
GlyT-1
Short name:
GlyT1
Alternative name(s):
Solute carrier family 6 member 9
Gene namesi
Name:SLC6A9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei41 – 6121Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei69 – 8820Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei112 – 13221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini133 – 21987ExtracellularSequence AnalysisAdd
BLAST
Transmembranei220 – 23819Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei247 – 26418Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei300 – 31718Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei329 – 35022Helical; Name=7Sequence AnalysisAdd
BLAST
Transmembranei383 – 40220Helical; Name=8Sequence AnalysisAdd
BLAST
Transmembranei431 – 44919Helical; Name=9Sequence AnalysisAdd
BLAST
Transmembranei465 – 48521Helical; Name=10Sequence AnalysisAdd
BLAST
Transmembranei506 – 52520Helical; Name=11Sequence AnalysisAdd
BLAST
Transmembranei544 – 56219Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini563 – 63876CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 638638Sodium- and chloride-dependent glycine transporter 1PRO_0000214779Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi169 – 1691N-linked (GlcNAc...)Sequence Analysis
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi182 – 1821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi188 – 1881N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007938.

Structurei

3D structure databases

ProteinModelPortaliQ28039.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ28039.
KOiK05038.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR003028. Na/ntran_symport_glycine_GLY1.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR01204. GLY1TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q28039-1) [UniParc]FASTAAdd to Basket

Also known as: GlyT-1B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAQGPVAP SSLEQNGAVP SEATKKDQNL KRGNWGNQIE FVLTSVGYAV
60 70 80 90 100
GLGNVWRFPY LCYRNGGGAF MFPYFIMLIF CGIPLFFMEL SFGQFASQGC
110 120 130 140 150
LGVWRISPMF KGVGYGMMVV STYIGIYYNV VICIAFYYFF SSMTPVLPWT
160 170 180 190 200
YCNNPWNTPD CMSVLDNPNI TNGSQPPALP GNVSQALNQT LKRTSPSEEY
210 220 230 240 250
WRLYVLKLSD DIGNFGEVRL PLLGCLGVSW VVVFLCLIRG VKSSGKVVYF
260 270 280 290 300
TATFPYVVLT ILFIRGVTLE GAFTGIMYYL TPQWDKILEA KVWGDAASQI
310 320 330 340 350
FYSLGCAWGG LVTMASYNKF HNNCYRDSVI ISITNCATSV YAGFVIFSIL
360 370 380 390 400
GFMANHLGVD VSRVADHGPG LAFVAYPEAL TLLPISPLWS LLFFFMLILL
410 420 430 440 450
GLGTQFCLLE TLVTAIVDEV GNEWILQKKT YVTLGVAVAG FLLGIPLTSQ
460 470 480 490 500
AGIYWLLLMD NYAASFSLVI ISCIMCVSIM YIYGHQNYFQ DIQMMLGFPP
510 520 530 540 550
PLFFQICWRF VSPAIIFFIL IFSVIQYQPI TYNQYQYPSW RVRIGFLMAL
560 570 580 590 600
SSVICIPLYA LFQFCRTDGD TLLHRLKNAT KPSRDWGPAL LEHRTRRYAP
610 620 630
TTTPSPEDGL EVQPLHPDKA QIPMVGSNGS SRFQDSRI
Length:638
Mass (Da):71,318
Last modified:November 1, 1997 - v1
Checksum:i97ADDBF28EC2A443
GO
Isoform 2 (identifier: Q28039-2) [UniParc]FASTAAdd to Basket

Also known as: GlyT-1A

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MAAAQGPVAPSSLE → MVGKGAKGM

Show »
Length:633
Mass (Da):70,868
Checksum:iA13C9CEA2F7A382F
GO
Isoform 3 (identifier: Q28039-3) [UniParc]FASTAAdd to Basket

Also known as: GlyT-1F

The sequence of this isoform differs from the canonical sequence as follows:
     537-638: YPSWRVRIGF...GSSRFQDSRI → SSQTGLPLFT...SPGRAASNPL

Show »
Length:593
Mass (Da):65,672
Checksum:i9FC3DEA290A118B2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1414MAAAQ…PSSLE → MVGKGAKGM in isoform 2. 1 PublicationVSP_006268Add
BLAST
Alternative sequencei537 – 638102YPSWR…QDSRI → SSQTGLPLFTCQIAPAHVPQ PLSGARTPSPKPWSVRVSVL RAPLCSDSPGRAASNPL in isoform 3. 1 PublicationVSP_006269Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52687 mRNA. Translation: AAB01158.1.
U52688 mRNA. Translation: AAB01159.1.
U52689 mRNA. Translation: AAB01160.1.
U52690 mRNA. Translation: AAB01161.1.
RefSeqiNP_001229271.1. NM_001242342.1.
NP_001229272.1. NM_001242343.1.
UniGeneiBt.4855.

Genome annotation databases

GeneIDi282368.
KEGGibta:282368.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U52687 mRNA. Translation: AAB01158.1 .
U52688 mRNA. Translation: AAB01159.1 .
U52689 mRNA. Translation: AAB01160.1 .
U52690 mRNA. Translation: AAB01161.1 .
RefSeqi NP_001229271.1. NM_001242342.1.
NP_001229272.1. NM_001242343.1.
UniGenei Bt.4855.

3D structure databases

ProteinModelPortali Q28039.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000007938.

Chemistry

BindingDBi Q28039.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 282368.
KEGGi bta:282368.

Organism-specific databases

CTDi 6536.

Phylogenomic databases

eggNOGi COG0733.
HOGENOMi HOG000116406.
HOVERGENi HBG071421.
InParanoidi Q28039.
KOi K05038.

Miscellaneous databases

NextBioi 20806160.

Family and domain databases

InterProi IPR000175. Na/ntran_symport.
IPR003028. Na/ntran_symport_glycine_GLY1.
[Graphical view ]
PANTHERi PTHR11616. PTHR11616. 1 hit.
Pfami PF00209. SNF. 1 hit.
[Graphical view ]
PRINTSi PR01204. GLY1TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Jones E.M.C.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).

Entry informationi

Entry nameiSC6A9_BOVIN
AccessioniPrimary (citable) accession number: Q28039
Secondary accession number(s): Q28040, Q29420
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3