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Q28039

- SC6A9_BOVIN

UniProt

Q28039 - SC6A9_BOVIN

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Protein
Sodium- and chloride-dependent glycine transporter 1
Gene
SLC6A9
Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission By similarity.

GO - Molecular functioni

  1. neurotransmitter:sodium symporter activity Source: InterPro
  2. sodium:amino acid symporter activity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Amino-acid transport, Neurotransmitter transport, Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent glycine transporter 1
Short name:
GlyT-1
Short name:
GlyT1
Alternative name(s):
Solute carrier family 6 member 9
Gene namesi
Name:SLC6A9
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei41 – 6121Helical; Name=1; Reviewed prediction
Add
BLAST
Transmembranei69 – 8820Helical; Name=2; Reviewed prediction
Add
BLAST
Transmembranei112 – 13221Helical; Name=3; Reviewed prediction
Add
BLAST
Topological domaini133 – 21987Extracellular Reviewed prediction
Add
BLAST
Transmembranei220 – 23819Helical; Name=4; Reviewed prediction
Add
BLAST
Transmembranei247 – 26418Helical; Name=5; Reviewed prediction
Add
BLAST
Transmembranei300 – 31718Helical; Name=6; Reviewed prediction
Add
BLAST
Transmembranei329 – 35022Helical; Name=7; Reviewed prediction
Add
BLAST
Transmembranei383 – 40220Helical; Name=8; Reviewed prediction
Add
BLAST
Transmembranei431 – 44919Helical; Name=9; Reviewed prediction
Add
BLAST
Transmembranei465 – 48521Helical; Name=10; Reviewed prediction
Add
BLAST
Transmembranei506 – 52520Helical; Name=11; Reviewed prediction
Add
BLAST
Transmembranei544 – 56219Helical; Name=12; Reviewed prediction
Add
BLAST
Topological domaini563 – 63876Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 638638Sodium- and chloride-dependent glycine transporter 1
PRO_0000214779Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi169 – 1691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi172 – 1721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi182 – 1821N-linked (GlcNAc...) Reviewed prediction
Glycosylationi188 – 1881N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000007938.

Structurei

3D structure databases

ProteinModelPortaliQ28039.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0733.
HOGENOMiHOG000116406.
HOVERGENiHBG071421.
InParanoidiQ28039.
KOiK05038.

Family and domain databases

InterProiIPR000175. Na/ntran_symport.
IPR003028. Na/ntran_symport_glycine_GLY1.
[Graphical view]
PANTHERiPTHR11616. PTHR11616. 1 hit.
PfamiPF00209. SNF. 1 hit.
[Graphical view]
PRINTSiPR01204. GLY1TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEiPS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q28039-1) [UniParc]FASTAAdd to Basket

Also known as: GlyT-1B

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAAQGPVAP SSLEQNGAVP SEATKKDQNL KRGNWGNQIE FVLTSVGYAV    50
GLGNVWRFPY LCYRNGGGAF MFPYFIMLIF CGIPLFFMEL SFGQFASQGC 100
LGVWRISPMF KGVGYGMMVV STYIGIYYNV VICIAFYYFF SSMTPVLPWT 150
YCNNPWNTPD CMSVLDNPNI TNGSQPPALP GNVSQALNQT LKRTSPSEEY 200
WRLYVLKLSD DIGNFGEVRL PLLGCLGVSW VVVFLCLIRG VKSSGKVVYF 250
TATFPYVVLT ILFIRGVTLE GAFTGIMYYL TPQWDKILEA KVWGDAASQI 300
FYSLGCAWGG LVTMASYNKF HNNCYRDSVI ISITNCATSV YAGFVIFSIL 350
GFMANHLGVD VSRVADHGPG LAFVAYPEAL TLLPISPLWS LLFFFMLILL 400
GLGTQFCLLE TLVTAIVDEV GNEWILQKKT YVTLGVAVAG FLLGIPLTSQ 450
AGIYWLLLMD NYAASFSLVI ISCIMCVSIM YIYGHQNYFQ DIQMMLGFPP 500
PLFFQICWRF VSPAIIFFIL IFSVIQYQPI TYNQYQYPSW RVRIGFLMAL 550
SSVICIPLYA LFQFCRTDGD TLLHRLKNAT KPSRDWGPAL LEHRTRRYAP 600
TTTPSPEDGL EVQPLHPDKA QIPMVGSNGS SRFQDSRI 638
Length:638
Mass (Da):71,318
Last modified:November 1, 1997 - v1
Checksum:i97ADDBF28EC2A443
GO
Isoform 2 (identifier: Q28039-2) [UniParc]FASTAAdd to Basket

Also known as: GlyT-1A

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MAAAQGPVAPSSLE → MVGKGAKGM

Show »
Length:633
Mass (Da):70,868
Checksum:iA13C9CEA2F7A382F
GO
Isoform 3 (identifier: Q28039-3) [UniParc]FASTAAdd to Basket

Also known as: GlyT-1F

The sequence of this isoform differs from the canonical sequence as follows:
     537-638: YPSWRVRIGF...GSSRFQDSRI → SSQTGLPLFT...SPGRAASNPL

Show »
Length:593
Mass (Da):65,672
Checksum:i9FC3DEA290A118B2
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1414MAAAQ…PSSLE → MVGKGAKGM in isoform 2.
VSP_006268Add
BLAST
Alternative sequencei537 – 638102YPSWR…QDSRI → SSQTGLPLFTCQIAPAHVPQ PLSGARTPSPKPWSVRVSVL RAPLCSDSPGRAASNPL in isoform 3.
VSP_006269Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U52687 mRNA. Translation: AAB01158.1.
U52688 mRNA. Translation: AAB01159.1.
U52689 mRNA. Translation: AAB01160.1.
U52690 mRNA. Translation: AAB01161.1.
RefSeqiNP_001229271.1. NM_001242342.1.
NP_001229272.1. NM_001242343.1.
UniGeneiBt.4855.

Genome annotation databases

GeneIDi282368.
KEGGibta:282368.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U52687 mRNA. Translation: AAB01158.1 .
U52688 mRNA. Translation: AAB01159.1 .
U52689 mRNA. Translation: AAB01160.1 .
U52690 mRNA. Translation: AAB01161.1 .
RefSeqi NP_001229271.1. NM_001242342.1.
NP_001229272.1. NM_001242343.1.
UniGenei Bt.4855.

3D structure databases

ProteinModelPortali Q28039.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000007938.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 282368.
KEGGi bta:282368.

Organism-specific databases

CTDi 6536.

Phylogenomic databases

eggNOGi COG0733.
HOGENOMi HOG000116406.
HOVERGENi HBG071421.
InParanoidi Q28039.
KOi K05038.

Miscellaneous databases

NextBioi 20806160.

Family and domain databases

InterProi IPR000175. Na/ntran_symport.
IPR003028. Na/ntran_symport_glycine_GLY1.
[Graphical view ]
PANTHERi PTHR11616. PTHR11616. 1 hit.
Pfami PF00209. SNF. 1 hit.
[Graphical view ]
PRINTSi PR01204. GLY1TRNSPORT.
PR00176. NANEUSMPORT.
PROSITEi PS00610. NA_NEUROTRAN_SYMP_1. 1 hit.
PS00754. NA_NEUROTRAN_SYMP_2. 1 hit.
PS50267. NA_NEUROTRAN_SYMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Jones E.M.C.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3).

Entry informationi

Entry nameiSC6A9_BOVIN
AccessioniPrimary (citable) accession number: Q28039
Secondary accession number(s): Q28040, Q29420
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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