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Protein

Vitamin D3 receptor

Gene

VDR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431Vitamin D3By similarity
Binding sitei304 – 3041Vitamin D3By similarity
Binding sitei396 – 3961Vitamin D3By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi21 – 9676Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri24 – 4421NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri60 – 8425NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin D3 receptor
Short name:
VDR
Alternative name(s):
1,25-dihydroxyvitamin D3 receptor
Nuclear receptor subfamily 1 group I member 1
Gene namesi
Name:VDR
Synonyms:NR1I1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3452.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 426426Vitamin D3 receptorPRO_0000053541Add
BLAST

Proteomic databases

PaxDbiQ28037.
PRIDEiQ28037.

Expressioni

Tissue specificityi

Mammary gland, expression increases during lactation. Also found in colon, expression is down-regulated at parturition.2 Publications

Interactioni

Subunit structurei

Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts (in a ligand-dependent manner) with BAZ1B/WSTF. Interacts with SNW1. Interacts with IRX4, the interaction doesn't affect its transactivation activity (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021832.

Chemistry

BindingDBiQ28037.

Structurei

3D structure databases

ProteinModelPortaliQ28037.
SMRiQ28037. Positions 21-422.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 19195HingeAdd
BLAST
Regioni192 – 426235Ligand-bindingAdd
BLAST
Regioni225 – 23511Vitamin D3 bindingBy similarityAdd
BLAST
Regioni244 – 26219Interaction with coactivator LXXLL motifBy similarityAdd
BLAST
Regioni269 – 2768Vitamin D3 bindingBy similarity

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.By similarity

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri24 – 4421NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri60 – 8425NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000220844.
HOVERGENiHBG108655.
InParanoidiQ28037.
KOiK08539.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000324. VitD_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00350. VITAMINDR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28037-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEATAASTSL PDPGDFDRNV PRICGVCGDR ATGFHFNAMT CEGCKGFFRR
60 70 80 90 100
SMKRKALFTC PFNGDCRITK DNRRHCQACR LKRCIDIGMM KEFILTDEEV
110 120 130 140 150
QRKREMILKR KEEEALKDSL RPKLSEEQQR IITTLLEAHH KTYDDTYSDF
160 170 180 190 200
SQFRPPVRNS EDEGNRPLRS ILTPSFSGNS SSSCSDHCTS SPDTMEPTSF
210 220 230 240 250
SNQDLNEEDS DDPSVTLDLS QLSMLPHLAD LVSYSIQKVI GFAKMIPGFR
260 270 280 290 300
DLTPEDQIVL LKSSAIEVIM LRSNQSFTLD DDMSWTCGSP DYKYQVSDVT
310 320 330 340 350
RAGHSLELIE PLIKFQVGLK KLNLHEEEHV LLMAICIVSP DRPGVQDAAL
360 370 380 390 400
VEAIQDRLSN TLQTYIRCRH PPPGSHLLYA KMIQKLADLR SLNEEHSKQY
410 420
RCLSFQPESS MKLTPLLFEV FGNEIS
Length:426
Mass (Da):48,318
Last modified:December 4, 2007 - v2
Checksum:i1A0E76ABE461EBF1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03056593 Genomic DNA. No translation available.
RefSeqiNP_001161404.1. NM_001167932.1.
UniGeneiBt.61412.

Genome annotation databases

GeneIDi533656.
KEGGibta:533656.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFC03056593 Genomic DNA. No translation available.
RefSeqiNP_001161404.1. NM_001167932.1.
UniGeneiBt.61412.

3D structure databases

ProteinModelPortaliQ28037.
SMRiQ28037. Positions 21-422.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000021832.

Chemistry

BindingDBiQ28037.
ChEMBLiCHEMBL3452.

Proteomic databases

PaxDbiQ28037.
PRIDEiQ28037.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi533656.
KEGGibta:533656.

Organism-specific databases

CTDi7421.

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
HOGENOMiHOG000220844.
HOVERGENiHBG108655.
InParanoidiQ28037.
KOiK08539.

Miscellaneous databases

PROiQ28037.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR000324. VitD_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
PR00350. VITAMINDR.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Nucleotide sequence of the bovine vitamin D3 receptor."
    Neibergs H.L., Bosworth B.T., Reinhardt T.A.
    J. Dairy Sci. 79:1313-1315(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE.
  2. "The genome sequence of taurine cattle: a window to ruminant biology and evolution."
    The bovine genome sequencing and analysis consortium
    Science 324:522-528(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Hereford.
  3. "Specific binding protein for 1,25-dihydroxyvitamin D3 in bovine mammary gland."
    Reinhardt T.A., Conrad H.R.
    Arch. Biochem. Biophys. 203:108-116(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  4. "Milk fever and dietary cation-anion balance effects on concentration of vitamin D receptor in tissue of periparturient dairy cows."
    Goff J.P., Reinhardt T.A., Horst R.L.
    J. Dairy Sci. 78:2388-2394(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiVDR_BOVIN
AccessioniPrimary (citable) accession number: Q28037
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 4, 2007
Last modified: June 8, 2016
This is version 122 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.