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Protein

Glutathione S-transferase A1

Gene

GSTA1

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei9GlutathioneBy similarity1
Binding sitei45GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BRENDAi2.5.1.18. 908.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase A1 (EC:2.5.1.18)
Alternative name(s):
GST class-alpha member 1
Glutathione S-transferase alpha-1
Cleaved into the following chain:
Gene namesi
Name:GSTA1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004217811 – 222Glutathione S-transferase A1Add BLAST222
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00001857802 – 222Glutathione S-transferase A1, N-terminally processedAdd BLAST221

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylalanine; in Glutathione S-transferase A1, N-terminally processedBy similarity1
Modified residuei4N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ28035.
PeptideAtlasiQ28035.
PRIDEiQ28035.

Expressioni

Tissue specificityi

Expressed in corpus luteum, adrenal gland, testis, liver, lung, thyroid and kidney.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005618.

Structurei

3D structure databases

ProteinModelPortaliQ28035.
SMRiQ28035.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 83GST N-terminalAdd BLAST81
Domaini85 – 208GST C-terminalAdd BLAST124

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 55Glutathione bindingBy similarity2
Regioni67 – 68Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated

Phylogenomic databases

eggNOGiKOG1695. Eukaryota.
ENOG4111VAU. LUCA.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiQ28035.
KOiK00799.
TreeFamiTF105321.

Family and domain databases

InterProiView protein in InterPro
IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
PfamiView protein in Pfam
PF14497. GST_C_3. 1 hit.
PF02798. GST_N. 1 hit.
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28035-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGKPTLHYF NGRGRMECIR WLLAAAGVEF EEKFIEKPED LDKLKNDGSL
60 70 80 90 100
MFQQVPMVEI DGMKLVQTRA ILNYIATKYN LYGKDMKERA LIDMYSEGVA
110 120 130 140 150
DLGEMIMHFP LCPPAEKDAK LTLIREKTTN RYLPAFENVL KSHGQDYLVG
160 170 180 190 200
NKLSRADIHL VELLYYVEEL DPSLLANFPL LKALKARVSN IPAVKKFLQP
210 220
GSQRKPPTDE KKIEEARKVF KF
Length:222
Mass (Da):25,452
Last modified:January 23, 2007 - v3
Checksum:iF2708C849CB04655
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti190 – 191NI → SL in AAB72239 (PubMed:10433206).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49179 mRNA. Translation: AAB72239.1.
BC102540 mRNA. Translation: AAI02541.1.
RefSeqiNP_001071617.1. NM_001078149.1.
UniGeneiBt.227.

Genome annotation databases

GeneIDi777644.
KEGGibta:777644.

Similar proteinsi

Entry informationi

Entry nameiGSTA1_BOVIN
AccessioniPrimary (citable) accession number: Q28035
Secondary accession number(s): Q3T072
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families