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Q28035

- GSTA1_BOVIN

UniProt

Q28035 - GSTA1_BOVIN

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Protein

Glutathione S-transferase A1

Gene

GSTA1

Organism
Bos taurus (Bovine)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei9 – 91GlutathioneBy similarity

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB

GO - Biological processi

  1. glutathione metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase A1 (EC:2.5.1.18)
Alternative name(s):
GST class-alpha member 1
Glutathione S-transferase alpha-1
Cleaved into the following chain:
Gene namesi
Name:GSTA1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
ProteomesiUP000009136: Chromosome 23

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Glutathione S-transferase A1PRO_0000185780Add
BLAST
Initiator methioninei1 – 11Removed; alternateBy similarity
Chaini2 – 222221Glutathione S-transferase A1, N-terminally processedPRO_0000421781Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ28035.
PRIDEiQ28035.

Expressioni

Tissue specificityi

Expressed in corpus luteum, adrenal gland, testis, liver, lung, thyroid and kidney.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000005618.

Structurei

3D structure databases

ProteinModelPortaliQ28035.
SMRiQ28035. Positions 2-222.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini3 – 8381GST N-terminalAdd
BLAST
Domaini85 – 208124GST C-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni54 – 552Glutathione bindingBy similarity
Regioni67 – 682Glutathione bindingBy similarity

Sequence similaritiesi

Belongs to the GST superfamily. Alpha family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiNOG266414.
GeneTreeiENSGT00670000097856.
HOGENOMiHOG000115734.
HOVERGENiHBG053749.
InParanoidiQ28035.
KOiK00799.
OrthoDBiEOG79CZ0K.
TreeFamiTF105321.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
PRINTSiPR01266. GSTRNSFRASEA.
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28035-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAGKPTLHYF NGRGRMECIR WLLAAAGVEF EEKFIEKPED LDKLKNDGSL
60 70 80 90 100
MFQQVPMVEI DGMKLVQTRA ILNYIATKYN LYGKDMKERA LIDMYSEGVA
110 120 130 140 150
DLGEMIMHFP LCPPAEKDAK LTLIREKTTN RYLPAFENVL KSHGQDYLVG
160 170 180 190 200
NKLSRADIHL VELLYYVEEL DPSLLANFPL LKALKARVSN IPAVKKFLQP
210 220
GSQRKPPTDE KKIEEARKVF KF
Length:222
Mass (Da):25,452
Last modified:January 23, 2007 - v3
Checksum:iF2708C849CB04655
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti190 – 1912NI → SL in AAB72239. (PubMed:10433206)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49179 mRNA. Translation: AAB72239.1.
BC102540 mRNA. Translation: AAI02541.1.
RefSeqiNP_001071617.1. NM_001078149.1.
UniGeneiBt.227.

Genome annotation databases

EnsembliENSBTAT00000005618; ENSBTAP00000005618; ENSBTAG00000021516.
GeneIDi777644.
KEGGibta:777644.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U49179 mRNA. Translation: AAB72239.1 .
BC102540 mRNA. Translation: AAI02541.1 .
RefSeqi NP_001071617.1. NM_001078149.1.
UniGenei Bt.227.

3D structure databases

ProteinModelPortali Q28035.
SMRi Q28035. Positions 2-222.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9913.ENSBTAP00000005618.

Proteomic databases

PaxDbi Q28035.
PRIDEi Q28035.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSBTAT00000005618 ; ENSBTAP00000005618 ; ENSBTAG00000021516 .
GeneIDi 777644.
KEGGi bta:777644.

Phylogenomic databases

eggNOGi NOG266414.
GeneTreei ENSGT00670000097856.
HOGENOMi HOG000115734.
HOVERGENi HBG053749.
InParanoidi Q28035.
KOi K00799.
OrthoDBi EOG79CZ0K.
TreeFami TF105321.

Miscellaneous databases

NextBioi 20924256.

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR003080. GST_alpha.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view ]
PRINTSi PR01266. GSTRNSFRASEA.
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "High expression of bovine alpha glutathione S-transferase (GSTA1, GSTA2) subunits is mainly associated with steroidogenically active cells and regulated by gonadotropins in bovine ovarian follicles."
    Rabahi F., Brule S., Sirois J., Beckers J.-F.M.P., Silversides D.W., Lussier J.G.
    Endocrinology 140:3507-3517(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Holstein.
    Tissue: Corpus luteum.
  2. NIH - Mammalian Gene Collection (MGC) project
    Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Crossbred X Angus.
    Tissue: Liver.

Entry informationi

Entry nameiGSTA1_BOVIN
AccessioniPrimary (citable) accession number: Q28035
Secondary accession number(s): Q3T072
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 100 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3