Q28030 (AT1B2_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Sodium/potassium-transporting ATPase subunit beta-2

Alternative name(s):
Sodium/potassium-dependent ATPase subunit beta-2

Gene names

Name:

ATP1B2

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	290 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-2 subunit is not known.
Subunit structure	Composed of three subunits: alpha (catalytic), beta and gamma.
Subcellular location	Membrane; Single-pass type II membrane protein.
Sequence similarities	Belongs to the X(+)/potassium ATPases subunit beta family.

Ontologies

Keywords
Biological process	Ion transport Potassium transport Sodium transport Sodium/potassium transport Transport
Cellular component	Membrane
Domain	Signal-anchor Transmembrane Transmembrane helix
Ligand	Potassium Sodium
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sodium:potassium-exchanging ATPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 290	290	Sodium/potassium-transporting ATPase subunit beta-2		PRO_0000219103
Regions
	Topological domain	1 – 39	39	Cytoplasmic Potential
	Transmembrane	40 – 67	28	Helical; Signal-anchor for type II membrane protein; Potential
	Topological domain	68 – 290	223	Extracellular Potential
Amino acid modifications
	Glycosylation	96	1	N-linked (GlcNAc...) Potential
	Glycosylation	118	1	N-linked (GlcNAc...) Potential
	Glycosylation	153	1	N-linked (GlcNAc...) Potential
	Glycosylation	193	1	N-linked (GlcNAc...) Potential
	Glycosylation	197	1	N-linked (GlcNAc...) Potential
	Glycosylation	238	1	N-linked (GlcNAc...) Potential
	Glycosylation	250	1	N-linked (GlcNAc...) Potential
	Disulfide bond	129 ↔ 150		By similarity
	Disulfide bond	160 ↔ 177		By similarity
	Disulfide bond	200 ↔ 261		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q28030 [UniParc]. Last modified November 1, 1997. Version 1. Checksum: 5B21764A0DFB0B86	FASTA	290	33,401
	10 20 30 40 50 60 MVIQKEKKSC GQVVEEWKEF VWNPRTHQFM GRTGTSWAFI LLFYLVFYGF LTAMFTLTMW 70 80 90 100 110 120 VMLQTVSDHT PKYQDRLATP GLMIRPKTEN LDVIVNVSDT ESWDQHVQKL NKFLEPYNDS 130 140 150 160 170 180 IQAQKNDVCR PGRYYEQPDN GVLNYPKRAC QFNRTQLGDC SGIGDPTHYG YSTGQPCVFI 190 200 210 220 230 240 KMNRVISFYA GANQSMNVTC VGKRDEDAEN LGNFVMFPAN GNIDLIYFPY YGKKFHVNYT 250 260 270 280 290 QPLVAVKFLN VTPNVEVNVE CRINAANIAT DDERDKFAPR VAFKLRINKT

References

[1]	"Expression and synthesis of the Na,K-ATPase beta 2 subunit in human retinal pigment epithelium." Ruiz A.C., Bhat S.P., Bok D. Gene 176:237-242(1996) [PubMed: 8918259] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-94. Tissue: Retinal pigment epithelium.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U45944 mRNA. Translation: AAC48681.1.
IPI	IPI00704082.
PIR	JC5108.
RefSeq	NP_777102.1. NM_174677.2.
UniGene	Bt.91787.
3D structure databases
ProteinModelPortal	Q28030.
SMR	Q28030. Positions 33-78.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	282562.
KEGG	bta:282562.
Organism-specific databases
CTD	482.
Phylogenomic databases
eggNOG	maNOG16450.
GeneTree	ENSGT00550000074530.
HOVERGEN	HBG050603.
InParanoid	Q28030.
OrthoDB	EOG46144C.
Family and domain databases
InterPro	IPR000402. ATPase_P-typ_cation-exchng_bsu. [Graphical view]
KO	K01540.
PANTHER	PTHR11523. ATPase_H_Na/K_b. 1 hit.
Pfam	PF00287. Na_K-ATPase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01107. Na_K_ATPase_bet. 1 hit.
PROSITE	PS00390. ATPASE_NA_K_BETA_1. 1 hit. PS00391. ATPASE_NA_K_BETA_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AT1B2_BOVIN

Accession

Primary (citable) accession number: Q28030

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	November 1, 1997
Last modified:	November 16, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program