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Protein

Ras GTPase-activating protein 3

Gene

RASA3

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibitory regulator of the Ras-cyclic AMP pathway. May bind inositol tetrakisphosphate (IP4).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri679 – 715Btk-typePROSITE-ProRule annotationAdd BLAST37

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating protein 3
Alternative name(s):
GAP1(IP4BP)
Ins P4-binding protein
Gene namesi
Name:RASA3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000566411 – 834Ras GTPase-activating protein 3Add BLAST834

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66PhosphotyrosineBy similarity1
Modified residuei77PhosphoserineBy similarity1
Modified residuei110PhosphothreonineBy similarity1
Modified residuei809PhosphoserineBy similarity1
Modified residuei833PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ28013.
PRIDEiQ28013.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026598.

Structurei

3D structure databases

ProteinModelPortaliQ28013.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 96C2 1PROSITE-ProRule annotationAdd BLAST96
Domaini132 – 247C2 2PROSITE-ProRule annotationAdd BLAST116
Domaini330 – 524Ras-GAPPROSITE-ProRule annotationAdd BLAST195
Domaini576 – 677PHPROSITE-ProRule annotationAdd BLAST102

Sequence similaritiesi

Contains 1 Btk-type zinc finger.PROSITE-ProRule annotation
Contains 2 C2 domains.PROSITE-ProRule annotation
Contains 1 PH domain.PROSITE-ProRule annotation
Contains 1 Ras-GAP domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri679 – 715Btk-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2059. Eukaryota.
ENOG410Y128. LUCA.
HOGENOMiHOG000007183.
HOVERGENiHBG055643.
InParanoidiQ28013.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR001562. Znf_Btk_motif.
[Graphical view]
PfamiPF00779. BTK. 1 hit.
PF00168. C2. 2 hits.
PF00169. PH. 1 hit.
PF00616. RasGAP. 2 hits.
[Graphical view]
PRINTSiPR00402. TECBTKDOMAIN.
SMARTiSM00107. BTK. 1 hit.
SM00239. C2. 2 hits.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28013-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVEEEGLRV FQSVKIKIGE AKNLPTYPGP NKMRDCYCTV NLDQEEVFRT
60 70 80 90 100
KVVEKSLCPF YGEDFYCEIP RSFRHLSFYI FDRDVFRRDS IIGKVAIKKE
110 120 130 140 150
DLQKYHNRDT WFQLQHVDAD SEVQGKVHLE LRLSEVITDS GVVCHKLATR
160 170 180 190 200
ILECQGLPIV NGQCDPYATV TLAGPCRSEA KKTKVKKKTN NPQFDEVFYF
210 220 230 240 250
EVTRPCSYSR KSHFDFEDED VDKLEIRVDL WNASNLKFGD EFLGELRVPL
260 270 280 290 300
KVLRQSSPHE AWYFLQPRDN GSKSLKPGDL GSLRLNVVYT EDHVFSSDYY
310 320 330 340 350
SPLRDLLLKS ADVEPVSASA AHILGEVCRE KQEAAIPLVR LFLHYGRVVP
360 370 380 390 400
FISAIASAEV RRTQDPNTIF RGNSLTSKCI DETMKLAGMQ YLHVTLKPTI
410 420 430 440 450
EEICQSHKSC EIDPVRLKDG ESLESNMENL RQFVDRVFSV ITKSGVSCPT
460 470 480 490 500
VMCDIFFSLR EAAAKRFQDD LDVRYTAVSS FIFLRFFAPA ILSPNLFQLT
510 520 530 540 550
PHHTDPQTSR TLTLVSKTIQ TLGSLSKSKS ASFKESYMAA FYEFFNEQKY
560 570 580 590 600
ADAVKNFLDL ISSSGRRDPK SVQQPILLKE GFMIKRAQGR KRFGMKNFKK
610 620 630 640 650
RWFRLTNHEF TYQKSKGDPP LYSIPIENIL AVEPLEEESF KMKNMFQVIQ
660 670 680 690 700
PERALYIQAN NCVEAKAWID ILTKVSQCNQ KRLAVYHPSA YLNGHWLCCR
710 720 730 740 750
ASSDTAAGCS PCTGGLPANI QLDIDGDRET ERIYSLSSSY MSKLETMQEA
760 770 780 790 800
CGSRSVYDGP EQEEYSTFII DDPQETYKTL KQVVAGVGAL EQEHAQYKRD
810 820 830
KFRRTKYGSQ EHPIGDKSFQ SYIRQQSETP AHSM
Length:834
Mass (Da):95,386
Last modified:November 1, 1996 - v1
Checksum:iAB996368A27174BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30857 mRNA. Translation: AAC48500.1.
UniGeneiBt.5371.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U30857 mRNA. Translation: AAC48500.1.
UniGeneiBt.5371.

3D structure databases

ProteinModelPortaliQ28013.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000026598.

Proteomic databases

PaxDbiQ28013.
PRIDEiQ28013.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG2059. Eukaryota.
ENOG410Y128. LUCA.
HOGENOMiHOG000007183.
HOVERGENiHBG055643.
InParanoidiQ28013.

Family and domain databases

Gene3Di1.10.506.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 2 hits.
InterProiIPR000008. C2_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR023152. RasGAP_CS.
IPR001936. RasGAP_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR001562. Znf_Btk_motif.
[Graphical view]
PfamiPF00779. BTK. 1 hit.
PF00168. C2. 2 hits.
PF00169. PH. 1 hit.
PF00616. RasGAP. 2 hits.
[Graphical view]
PRINTSiPR00402. TECBTKDOMAIN.
SMARTiSM00107. BTK. 1 hit.
SM00239. C2. 2 hits.
SM00233. PH. 1 hit.
SM00323. RasGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
SSF49562. SSF49562. 2 hits.
SSF50729. SSF50729. 1 hit.
PROSITEiPS50004. C2. 2 hits.
PS50003. PH_DOMAIN. 1 hit.
PS00509. RAS_GTPASE_ACTIV_1. 1 hit.
PS50018. RAS_GTPASE_ACTIV_2. 1 hit.
PS51113. ZF_BTK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRASA3_BOVIN
AccessioniPrimary (citable) accession number: Q28013
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.