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Protein
Submitted name:

Endothelin converting enzyme-1a

Gene

ECE-1a

Organism
Bos taurus (Bovine)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Endothelin converting enzyme-1aImported
Gene namesi
Name:ECE-1aImported
OrganismiBos taurus (Bovine)Imported
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei57 – 7923HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ28010.
PRIDEiQ28010.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055669.

Structurei

3D structure databases

ProteinModelPortaliQ28010.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini109 – 495387Peptidase_M13_NInterPro annotationAdd
BLAST
Domaini554 – 757204Peptidase_M13InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3624. Eukaryota.
COG3590. LUCA.
HOGENOMiHOG000245574.
HOVERGENiHBG005554.
KOiK01415.

Family and domain databases

Gene3Di3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PfamiPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.

Sequencei

Sequence statusi: Complete.

Q28010-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPRGQDLLR SPLLLGSEAP GLTSSPFRLP PSLQVNFRGP RNGQRCWAAR
60 70 80 90 100
TPVEKRLVVL VALLAAALVA CLAVLGIQYQ TRTPSVCLSE GCISVTSSIL
110 120 130 140 150
SSMDPTVDPC QDFFTYACGG WIKANPVPDG HSRWGTFSNL WEHNQAIIKH
160 170 180 190 200
LLENSTASVS EAERKAQVYY RACMNETRIE ELKAKPLMEL IEKLGGWNIT
210 220 230 240 250
GPWDKDNFQD TLQVVTSHYH TSPFFSVYVS ADSKNSNSNV IQVDQSGLGL
260 270 280 290 300
PSRDYYLNKT ENEKVLTGYL NYMVQLGKLL GGGAEDTIRP QMQQILDFET
310 320 330 340 350
ALANITIPQE KRRDEELIYH KVTAAELQTL APAINWLPFL NTIFYPVEIN
360 370 380 390 400
ESEPIVIYDK EYLSKVSTLI NSTDKCLLNN YMIWNLVRKT SSFLDQRFQD
410 420 430 440 450
ADEKFMEVMY GTKKTCLPRW KFCVSDTENT LGFALGPMFV KATFAEDSKN
460 470 480 490 500
IASEIILEIK KAFEESLSTL KWMDEDTRKS AKEKADAIYN MIGYPNFIMD
510 520 530 540 550
PKELDKVFND YTAVPDLYFE NAMRFFNFSW RVTADQLRKA PNRDQWSMTP
560 570 580 590 600
PMVNAYYSPT KNEIVFPAGI LQAPFYTRSS PNALNFGGIG VVVGHELTHA
610 620 630 640 650
FDDQGREYDK DGNLRPWWKN SSVEAFKQQT ACMVEQYGNY SVNGEPVNGR
660 670 680 690 700
HTLGENIADN GGLKAAYRAY QNWVKKNGAE QTLPTLGLTN NQLFFLSFGQ
710 720 730 740 750
VWCSVRTPES SHEGLITDPH SPSRFRVIGS ISNSKEFSEH FHCPPGSPMN

PHHKCEVW
Length:758
Mass (Da):85,620
Last modified:November 1, 1996 - v1
Checksum:i39DCB702099F40A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27342 mRNA. Translation: AAA82928.1.
PIRiA54667.
RefSeqiNP_851352.1. NM_181009.2.
UniGeneiBt.4378.

Genome annotation databases

GeneIDi281133.
KEGGibta:281133.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U27342 mRNA. Translation: AAA82928.1.
PIRiA54667.
RefSeqiNP_851352.1. NM_181009.2.
UniGeneiBt.4378.

3D structure databases

ProteinModelPortaliQ28010.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055669.

Proteomic databases

PaxDbiQ28010.
PRIDEiQ28010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281133.
KEGGibta:281133.

Organism-specific databases

CTDi1889.

Phylogenomic databases

eggNOGiKOG3624. Eukaryota.
COG3590. LUCA.
HOGENOMiHOG000245574.
HOVERGENiHBG005554.
KOiK01415.

Miscellaneous databases

NextBioi20805200.

Family and domain databases

Gene3Di3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR018497. Peptidase_M13_C.
IPR008753. Peptidase_M13_N.
[Graphical view]
PfamiPF01431. Peptidase_M13. 1 hit.
PF05649. Peptidase_M13_N. 1 hit.
[Graphical view]
PRINTSiPR00786. NEPRILYSIN.
ProtoNetiSearch...

Publicationsi

  1. "ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1."
    Xu D., Emoto N., Giaid A., Slaughter C., Kaw S., deWit D., Yanagisawa M.
    Cell 78:473-485(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Yanagisawa M.
    Submitted (MAY-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ28010_BOVIN
AccessioniPrimary (citable) accession number: Q28010
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.