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Protein

C-type lectin domain family 3 member A

Gene

CLEC3A

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Promotes cell adhesion to laminin and fibronectin.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

Lectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 3 member A
Alternative name(s):
C-type lectin superfamily member 1
Cartilage-derived C-type lectin
Gene namesi
Name:CLEC3A
Synonyms:CLECSF1
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 18

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001737325 – 197C-type lectin domain family 3 member AAdd BLAST173

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi68 ↔ 78PROSITE-ProRule annotation
Disulfide bondi95 ↔ 191PROSITE-ProRule annotation
Disulfide bondi167 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ28008.
PRIDEiQ28008.

Expressioni

Gene expression databases

BgeeiENSBTAG00000046772.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000054542.

Structurei

3D structure databases

ProteinModelPortaliQ28008.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini74 – 192C-type lectinPROSITE-ProRule annotationAdd BLAST119

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00610000086061.
HOGENOMiHOG000060248.
HOVERGENiHBG108270.
InParanoidiQ28008.
KOiK17519.
OMAiKWSDEAC.
OrthoDBiEOG091G0NMQ.
TreeFamiTF330481.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q28008-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKNGLVIYI LVITLLLDQT SCHASKFKAR KHSKRRVKEK DGDLKTQVEK
60 70 80 90 100
LWREVNALKE MQALQTVCLR GTKFHKKCYL AAEGLKHFHE ANEDCISKGG
110 120 130 140 150
TLVVPRSADE INALRDYGKR SLPGVNDFWL GINDMVAEGK FVDINGLAIS
160 170 180 190
FLNWDQAQPN GGKRENCALF SQSAQGKWSD EACHSSKRYI CEFTIPQ
Length:197
Mass (Da):22,216
Last modified:November 1, 1996 - v1
Checksum:iAAAC4280F41AC0F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22298 mRNA. Translation: AAC18614.1.
RefSeqiNP_777058.1. NM_174633.2.
UniGeneiBt.33.

Genome annotation databases

EnsembliENSBTAT00000064491; ENSBTAP00000054542; ENSBTAG00000046772.
GeneIDi282415.
KEGGibta:282415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22298 mRNA. Translation: AAC18614.1.
RefSeqiNP_777058.1. NM_174633.2.
UniGeneiBt.33.

3D structure databases

ProteinModelPortaliQ28008.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000054542.

Proteomic databases

PaxDbiQ28008.
PRIDEiQ28008.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000064491; ENSBTAP00000054542; ENSBTAG00000046772.
GeneIDi282415.
KEGGibta:282415.

Organism-specific databases

CTDi10143.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00610000086061.
HOGENOMiHOG000060248.
HOVERGENiHBG108270.
InParanoidiQ28008.
KOiK17519.
OMAiKWSDEAC.
OrthoDBiEOG091G0NMQ.
TreeFamiTF330481.

Gene expression databases

BgeeiENSBTAG00000046772.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCLC3A_BOVIN
AccessioniPrimary (citable) accession number: Q28008
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.