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Protein

Lutropin-choriogonadotropic hormone receptor

Gene

LHCGR

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Lutropin-choriogonadotropic hormone receptor
Short name:
LH/CG-R
Alternative name(s):
Luteinizing hormone receptor
Short name:
LSH-R
Gene namesi
Name:LHCGR
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 365339ExtracellularSequence analysisAdd
BLAST
Transmembranei366 – 38722Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini388 – 39710CytoplasmicSequence analysis
Transmembranei398 – 41821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini419 – 44123ExtracellularSequence analysisAdd
BLAST
Transmembranei442 – 46423Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini465 – 48420CytoplasmicSequence analysisAdd
BLAST
Transmembranei485 – 50723Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini508 – 52720ExtracellularSequence analysisAdd
BLAST
Transmembranei528 – 55124Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini552 – 57221CytoplasmicSequence analysisAdd
BLAST
Transmembranei573 – 59624Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini597 – 60711ExtracellularSequence analysisAdd
BLAST
Transmembranei608 – 62922Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini630 – 70172CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 701675Lutropin-choriogonadotropic hormone receptorPRO_0000012778Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence analysis
Glycosylationi176 – 1761N-linked (GlcNAc...)Sequence analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence analysis
Glycosylationi293 – 2931N-linked (GlcNAc...)Sequence analysis
Glycosylationi301 – 3011N-linked (GlcNAc...)Sequence analysis
Glycosylationi315 – 3151N-linked (GlcNAc...)Sequence analysis
Disulfide bondi441 ↔ 516PROSITE-ProRule annotation
Lipidationi645 – 6451S-palmitoyl cysteineBy similarity
Lipidationi646 – 6461S-palmitoyl cysteineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ28005.
PRIDEiQ28005.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022047.

Structurei

3D structure databases

ProteinModelPortaliQ28005.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati124 – 14926LRR 1Add
BLAST
Repeati151 – 17323LRR 2Add
BLAST
Repeati174 – 19825LRR 3Add
BLAST
Repeati200 – 22223LRR 4Add
BLAST
Repeati223 – 24624LRR 5Add
BLAST
Repeati250 – 27122LRR 6Add
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.PROSITE-ProRule annotation
Contains 6 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2087. Eukaryota.
ENOG410XR1T. LUCA.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
InParanoidiQ28005.
KOiK04248.
TreeFamiTF316814.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR026906. LRR_5.
IPR002273. LSH_rcpt.
[Graphical view]
PANTHERiPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF1. PTHR24372:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF13306. LRR_5. 2 hits.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
PR01144. LSHRECEPTOR.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q28005-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRPSLALRL LLALLLLPPP APLLWALRPA PCPEPCSCPP DGALRCPGPQ
60 70 80 90 100
AGLSRLSLTY LPIKVIPSQA FRGLNEVIKI EISQSDSLEK IEANAFDNLL
110 120 130 140 150
NLSEILIQNT KNLVHIEAGA FTNLPRLKYL SICNTGIHKL PDVTKIFSSE
160 170 180 190 200
FNFILEICDN LHITTIPRNA FQGMNNESIT LKLYGNGFEE IQSHAFNGTT
210 220 230 240 250
LISLELKENA RLEKMHNDAF RGATGPSILD ISSTKLQALP TYGLESIQTL
260 270 280 290 300
IATSSYSLKK LPSREKFTNL LDATLTYPSH CCAFRNLPTN EQNFSFSIFK
310 320 330 340 350
NFSKQCESTA RRPNNETLYS AIFAESELSG WDYDYGFCLP KTLQCAPEPD
360 370 380 390 400
AFNPCEDIMG YNFLRVLIWL INILAITGNV TVLFVLLTSR YKLTVPRFLM
410 420 430 440 450
CNLSFADFCM GLYLLLIASV DAQTKGQYYN HAIDWQTGSG CSAAGFFTVF
460 470 480 490 500
ASELSVYTLT VITLERWHTI TYAIQLDQKL RLKHAIPVML GGWLFSTLIA
510 520 530 540 550
VLPLVGVSNY MKVSICLPMD VESTLSQVYI LTILILNVMA FIIICACYIK
560 570 580 590 600
IYFAVQNPEL MATNKDTKIA KKMAVLIFTD FTCMAPISFF AISAAFKVPL
610 620 630 640 650
ITVTNSKVLL VLFYPVNSCA NPFLYAIFTK AFQRDFFLLL SKFGCCKYRA
660 670 680 690 700
ELYRRKDFSA YISNCKNGFT GSNKPSRSTF KLTTLQCQYS AVLDKTCYKE

C
Length:701
Mass (Da):78,456
Last modified:November 1, 1997 - v1
Checksum:i8CDCE92F59EDBBD7
GO
Isoform Short (identifier: Q28005-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-291: Missing.

Show »
Length:638
Mass (Da):71,468
Checksum:iAC700A40BBB724EA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti235 – 2351K → Q in AAM09535 (Ref. 2) Curated
Sequence conflicti557 – 5571N → D in AAC33486 (PubMed:9532424).Curated
Sequence conflicti577 – 5771I → T in AAC33486 (PubMed:9532424).Curated
Sequence conflicti589 – 5891F → S in AAC33486 (PubMed:9532424).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei229 – 29163Missing in isoform Short. CuratedVSP_001961Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20504 mRNA. Translation: AAC24012.1.
AF491303 mRNA. Translation: AAM09535.1.
U87230 mRNA. Translation: AAC33486.1.
RefSeqiNP_776806.1. NM_174381.1. [Q28005-1]
UniGeneiBt.37.

Genome annotation databases

GeneIDi281900.
KEGGibta:281900.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U20504 mRNA. Translation: AAC24012.1.
AF491303 mRNA. Translation: AAM09535.1.
U87230 mRNA. Translation: AAC33486.1.
RefSeqiNP_776806.1. NM_174381.1. [Q28005-1]
UniGeneiBt.37.

3D structure databases

ProteinModelPortaliQ28005.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000022047.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ28005.
PRIDEiQ28005.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281900.
KEGGibta:281900.

Organism-specific databases

CTDi3973.

Phylogenomic databases

eggNOGiKOG2087. Eukaryota.
ENOG410XR1T. LUCA.
HOGENOMiHOG000045902.
HOVERGENiHBG003521.
InParanoidiQ28005.
KOiK04248.
TreeFamiTF316814.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR002131. Gphrmn_rcpt_fam.
IPR032675. L_dom-like.
IPR026906. LRR_5.
IPR002273. LSH_rcpt.
[Graphical view]
PANTHERiPTHR24372. PTHR24372. 1 hit.
PTHR24372:SF1. PTHR24372:SF1. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
PF13306. LRR_5. 2 hits.
[Graphical view]
PRINTSiPR00373. GLYCHORMONER.
PR00237. GPCRRHODOPSN.
PR01144. LSHRECEPTOR.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Lussier J.G., Houde A., Ethier J.-F., Silversides D.W.
    Submitted (MAR-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
    Strain: Holstein.
    Tissue: Ovary and Testis.
  2. "Expression of a cloned full-length cDNA encoding bovine luteinizing hormone receptor in COS-7 cells."
    Kawate N., Tamada H., Inaba T., Sawada T.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG).
    Strain: Holstein.
    Tissue: Corpus luteum.
  3. "LH receptor mRNA and cytochrome P450 side-chain cleavage expression in bovine theca and granulosa cells luteinized by LH or forskolin."
    Mamluk R., Wolfenson D., Meidan R.
    Domest. Anim. Endocrinol. 15:103-114(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 80-701 (ISOFORM LONG).

Entry informationi

Entry nameiLSHR_BOVIN
AccessioniPrimary (citable) accession number: Q28005
Secondary accession number(s): P79133, Q8SPS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.