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Protein

C-X-C chemokine receptor type 2

Gene

CXCR2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 2
Short name:
CXC-R2
Short name:
CXCR-2
Alternative name(s):
High affinity interleukin-8 receptor B
Short name:
IL-8R B
CD_antigen: CD182
Gene namesi
Name:CXCR2
Synonyms:IL8RB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 48ExtracellularSequence analysisAdd BLAST48
Transmembranei49 – 75Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini76 – 84CytoplasmicSequence analysis9
Transmembranei85 – 105Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini106 – 120ExtracellularSequence analysisAdd BLAST15
Transmembranei121 – 142Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini143 – 163CytoplasmicSequence analysisAdd BLAST21
Transmembranei164 – 183Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini184 – 208ExtracellularSequence analysisAdd BLAST25
Transmembranei209 – 231Helical; Name=5Sequence analysisAdd BLAST23
Topological domaini232 – 251CytoplasmicSequence analysisAdd BLAST20
Transmembranei252 – 273Helical; Name=6Sequence analysisAdd BLAST22
Topological domaini274 – 294ExtracellularSequence analysisAdd BLAST21
Transmembranei295 – 315Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini316 – 360CytoplasmicSequence analysisAdd BLAST45

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693341 – 360C-X-C chemokine receptor type 2Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi119 ↔ 196PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated upon ligand binding; which is required for desensitization.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ28003.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000056463.

Structurei

3D structure databases

ProteinModelPortaliQ28003.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEHI. Eukaryota.
ENOG410Y9Y6. LUCA.
HOVERGENiHBG106917.
InParanoidiQ28003.
KOiK04175.

Family and domain databases

CDDicd15178. 7tmA_CXCR1_2. 1 hit.
InterProiView protein in InterPro
IPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00572. INTRLEUKN8AR.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q28003-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIILKDLSN SSILWEGFED EFGNYSGTPP TEDYDYSPCE ISTETLNKYA
60 70 80 90 100
VVVIDALVFL LSLLGNSLVM LVILYSRIGR SVTDVYLLNL AMADLLFAMT
110 120 130 140 150
LPIWTASKAK GWVFGTPLCK VVSLLKEVNF YSGILLLACI SMDRYLAIVH
160 170 180 190 200
ATRTLTQKWH WVKFICLGIW ALSVILALPI FIFREAYQPP YSDLVCYEDL
210 220 230 240 250
GANTTKWRMI MRVLPQTFGF LLPLLVMLFC YGFTLRTLFS AQMGHKHRAM
260 270 280 290 300
RVIFAVVLVF LLCWLPYNLV LIADTLMRAH VIAETCQRRN DIGRALDATE
310 320 330 340 350
ILGFLHSCLN PLIYVFIGQK FRHGLLKIMA IHGLISKEFL AKDGRPSFVG
360
SSSGNTSTTL
Length:360
Mass (Da):40,625
Last modified:November 1, 1997 - v1
Checksum:i9A7F70C982A632D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19947 mRNA. Translation: AAA84996.1.
RefSeqiNP_776785.1. NM_174360.2.
UniGeneiBt.111573.
Bt.4208.

Genome annotation databases

GeneIDi281863.
KEGGibta:281863.

Similar proteinsi

Entry informationi

Entry nameiCXCR2_BOVIN
AccessioniPrimary (citable) accession number: Q28003
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: August 30, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families