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Protein

C-X-C chemokine receptor type 2

Gene

CXCR2

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Chemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 2
Short name:
CXC-R2
Short name:
CXCR-2
Alternative name(s):
High affinity interleukin-8 receptor B
Short name:
IL-8R B
CD_antigen: CD182
Gene namesi
Name:CXCR2
Synonyms:IL8RB
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4848ExtracellularSequence analysisAdd
BLAST
Transmembranei49 – 7527Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini76 – 849CytoplasmicSequence analysis
Transmembranei85 – 10521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini106 – 12015ExtracellularSequence analysisAdd
BLAST
Transmembranei121 – 14222Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini143 – 16321CytoplasmicSequence analysisAdd
BLAST
Transmembranei164 – 18320Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini184 – 20825ExtracellularSequence analysisAdd
BLAST
Transmembranei209 – 23123Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini232 – 25120CytoplasmicSequence analysisAdd
BLAST
Transmembranei252 – 27322Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini274 – 29421ExtracellularSequence analysisAdd
BLAST
Transmembranei295 – 31521Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini316 – 36045CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 360360C-X-C chemokine receptor type 2PRO_0000069334Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi10 – 101N-linked (GlcNAc...)Sequence analysis
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence analysis
Disulfide bondi119 ↔ 196PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated upon ligand binding; which is required for desensitization.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ28003.
PRIDEiQ28003.

Interactioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000056463.

Structurei

3D structure databases

ProteinModelPortaliQ28003.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEHI. Eukaryota.
ENOG410Y9Y6. LUCA.
HOVERGENiHBG106917.
InParanoidiQ28003.
KOiK04175.

Family and domain databases

InterProiIPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00572. INTRLEUKN8AR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q28003-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIILKDLSN SSILWEGFED EFGNYSGTPP TEDYDYSPCE ISTETLNKYA
60 70 80 90 100
VVVIDALVFL LSLLGNSLVM LVILYSRIGR SVTDVYLLNL AMADLLFAMT
110 120 130 140 150
LPIWTASKAK GWVFGTPLCK VVSLLKEVNF YSGILLLACI SMDRYLAIVH
160 170 180 190 200
ATRTLTQKWH WVKFICLGIW ALSVILALPI FIFREAYQPP YSDLVCYEDL
210 220 230 240 250
GANTTKWRMI MRVLPQTFGF LLPLLVMLFC YGFTLRTLFS AQMGHKHRAM
260 270 280 290 300
RVIFAVVLVF LLCWLPYNLV LIADTLMRAH VIAETCQRRN DIGRALDATE
310 320 330 340 350
ILGFLHSCLN PLIYVFIGQK FRHGLLKIMA IHGLISKEFL AKDGRPSFVG
360
SSSGNTSTTL
Length:360
Mass (Da):40,625
Last modified:November 1, 1997 - v1
Checksum:i9A7F70C982A632D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19947 mRNA. Translation: AAA84996.1.
RefSeqiNP_776785.1. NM_174360.2.
UniGeneiBt.111573.
Bt.4208.

Genome annotation databases

GeneIDi281863.
KEGGibta:281863.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19947 mRNA. Translation: AAA84996.1.
RefSeqiNP_776785.1. NM_174360.2.
UniGeneiBt.111573.
Bt.4208.

3D structure databases

ProteinModelPortaliQ28003.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000056463.

Protein family/group databases

GPCRDBiSearch...

Proteomic databases

PaxDbiQ28003.
PRIDEiQ28003.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281863.
KEGGibta:281863.

Organism-specific databases

CTDi3577.

Phylogenomic databases

eggNOGiENOG410IEHI. Eukaryota.
ENOG410Y9Y6. LUCA.
HOVERGENiHBG106917.
InParanoidiQ28003.
KOiK04175.

Miscellaneous databases

NextBioi20805766.

Family and domain databases

InterProiIPR001355. Chemokine_CXCR1.
IPR000174. Chemokine_CXCR_1/2.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR00427. INTRLEUKIN8R.
PR00572. INTRLEUKN8AR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Li Y., Feng J., Templeton J.W.
    Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCXCR2_BOVIN
AccessioniPrimary (citable) accession number: Q28003
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 13, 2016
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.