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Protein
Submitted name:

ADAM19

Gene

adam19

Organism
Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi344Zinc; catalyticPROSITE-ProRule annotation1
Active sitei345PROSITE-ProRule annotation1
Metal bindingi348Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi354Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-bindingPROSITE-ProRule annotation, ZincPROSITE-ProRule annotation

Protein family/group databases

MEROPSiM12.214

Names & Taxonomyi

Protein namesi
Submitted name:
ADAM19Imported
Gene namesi
Name:adam19Imported
OrganismiXenopus tropicalis (Western clawed frog) (Silurana tropicalis)Imported
Taxonomic identifieri8364 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusSilurana

Organism-specific databases

XenbaseiXB-GENE-993485 adam19

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei699 – 724HelicalSequence analysisAdd BLAST26

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_500420330928 – 911Sequence analysisAdd BLAST884

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi473 ↔ 493PROSITE-ProRule annotation
Disulfide bondi650 ↔ 660PROSITE-ProRule annotation
Disulfide bondi668 ↔ 677PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ27JK5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini209 – 407Peptidase M12BInterPro annotationAdd BLAST199
Domaini415 – 501DisintegrinInterPro annotationAdd BLAST87
Domaini646 – 678EGF-likeInterPro annotationAdd BLAST33

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3607 Eukaryota
ENOG410XX2M LUCA
HOVERGENiHBG006978
KOiK08608

Family and domain databases

CDDicd04269 ZnMc_adamalysin_II_like, 1 hit
Gene3Di3.40.390.10, 1 hit
4.10.70.10, 1 hit
InterProiView protein in InterPro
IPR033596 ADAM19
IPR006586 ADAM_Cys-rich
IPR018358 Disintegrin_CS
IPR001762 Disintegrin_dom
IPR036436 Disintegrin_dom_sf
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR024079 MetalloPept_cat_dom_sf
IPR001590 Peptidase_M12B
IPR002870 Peptidase_M12B_N
IPR034027 Reprolysin_adamalysin
PANTHERiPTHR11905:SF19 PTHR11905:SF19, 1 hit
PfamiView protein in Pfam
PF08516 ADAM_CR, 1 hit
PF00200 Disintegrin, 1 hit
PF01562 Pep_M12B_propep, 1 hit
PF01421 Reprolysin, 1 hit
PRINTSiPR00289 DISINTEGRIN
SMARTiView protein in SMART
SM00608 ACR, 1 hit
SM00050 DISIN, 1 hit
SUPFAMiSSF57552 SSF57552, 1 hit
PROSITEiView protein in PROSITE
PS50215 ADAM_MEPRO, 1 hit
PS00427 DISINTEGRIN_1, 1 hit
PS50214 DISINTEGRIN_2, 1 hit
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q27JK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGATGLVWI WVGSMTLLAL TVPTSSGNRN QSEHLKDIVE HSEIIEPHWL
60 70 80 90 100
GDFFIGMEAG GKYPEHAELL VKAEGQDLIL SLHRNEQFIH PNYRETHYSL
110 120 130 140 150
NYTRVVRTPN MTEHCYYHGI VQEQDNSSVV ISICSGIRGM ITLSNNLSYI
160 170 180 190 200
VEPLPGEDGR HVIYKAEHLG LSRICHGHSI HFEEKLPTLT SNLSGHHSRV
210 220 230 240 250
RRENVEGERC VELYLVADYA EFQKHDSDLE ETQRKMLEVM NYIDKFYRAL
260 270 280 290 300
NIRIALVGLE VWTAGDKCNV SENPYSTLRA FLSWRRKLLQ HTPHDNAQLI
310 320 330 340 350
TGRSFYGTTI GLAPLQAMCS VYQSGGVNMD HSDNAIGVAA TMAHELGHNF
360 370 380 390 400
GMSHDAAGCC TAKPEEGGCI MAASTGHPFP KVFNACNKQE LDRFFRSGGG
410 420 430 440 450
MCLSNLPDTK TLFGGPRCGN GFLEEGEQCD CGDPEQCNNP CCNATTCTLM
460 470 480 490 500
AGADCAHGAC CLRCKLRPPG FPCRKPSRPC DLPEFCTGQS AVCPPNSFQL
510 520 530 540 550
DGTLCQGEQA FCYNGRCLTH QQQCQQLWGA RSRVAPDLCF ELINVAGDQY
560 570 580 590 600
GNCGRDMSGT YRSCEGRDVM CGKIQCLSQA SKPMESNAVA IDTTITIEGK
610 620 630 640 650
RVQCRGTHIY KEEDDLMDPG LVLTGTKCGL NQICFDGQCR NTSFLQVDEC
660 670 680 690 700
AKKCHGNGMC NNNRNCHCFA GWRPPFCNQT GNGGSIDSGP VPEDGSLALV
710 720 730 740 750
LWICIPLALL AGMALSLAMF FYVFRIRGRQ AKTESCPATC PLHKSDSPTK
760 770 780 790 800
HGVGSTSKQR PQVPMQPKSP PVLYPTLRVE KSQSAASQHH QEQPEGGAAK
810 820 830 840 850
YSSAISHHSN QDLKGGAGKI LHGVSYLQQG GAIKTGYAMR TPPPNRPAPP
860 870 880 890 900
PPALAPTPPA PVPPPPASAP PPPAPKRLER PRRLPLPPPV PPNRTRRKAM
910
DSSFSGPEGT T
Length:911
Mass (Da):99,615
Last modified:April 4, 2006 - v1
Checksum:i73FF6102F8B4875C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ393789 mRNA Translation: ABD52384.1
RefSeqiNP_001035105.1, NM_001040016.1
UniGeneiStr.52121

Genome annotation databases

GeneIDi677730
KEGGixtr:677730

Similar proteinsi

Entry informationi

Entry nameiQ27JK5_XENTR
AccessioniPrimary (citable) accession number: Q27JK5
Entry historyiIntegrated into UniProtKB/TrEMBL: April 4, 2006
Last sequence update: April 4, 2006
Last modified: February 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health