Q27J10 (Q27J10_DROME) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Lozenge splice variant EMBL ABD59005.1

Submitted name:
Lozenge, isoform B EMBL ABW09367.1

Gene names

Name:	lz FlyBase FBgn0002576
Synonyms:	Lozenge EMBL ABD59005.1
ORF Names:	Dmel_CG1689 EMBL ABW09367.1

Organism

Drosophila melanogaster (Fruit fly) EMBL ABD59005.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	705 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	R7 cell development Inferred from mutant phenotype. Source: FlyBase antennal development Traceable author statement. Source: FlyBase compound eye cone cell differentiation Inferred from mutant phenotype. Source: FlyBase embryonic crystal cell differentiation Inferred from mutant phenotype. Source: FlyBase imaginal disc-derived female genitalia development Inferred from mutant phenotype. Source: FlyBase lymph gland crystal cell differentiation Traceable author statement. Source: FlyBase negative regulation of transcription from RNA polymerase II promoter Traceable author statement. Source: FlyBase oogenesis Traceable author statement. Source: FlyBase positive regulation of transcription from RNA polymerase II promoter Traceable author statement. Source: FlyBase scab formation Inferred from mutant phenotype. Source: FlyBase sensory organ precursor cell fate determination Traceable author statement. Source: FlyBase signal transduction Non-traceable author statement. Source: FlyBase spermathecum morphogenesis Traceable author statement. Source: FlyBase
Cellular component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding Inferred from direct assay. Source: FlyBase sequence-specific distal enhancer binding RNA polymerase II transcription factor activity Non-traceable author statement. Source: FlyBase
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q27J10 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: E6E5440A9AEFC63C	FASTA	705	73,187
	10 20 30 40 50 60 MHLHLLAAEK TPPSPSPNPT PTPSASPSGH TGAAGESQLD LASQTESQLQ LGLPLASGYG 70 80 90 100 110 120 LGLGLGLGLG LGLGQELVAD HSTTVAPVSV AGPGRLGRSI NGSGGSHHHH HLHHHYSPYH 130 140 150 160 170 180 HAHPYHPPHP HAPHHHHHHH PPYPYPPAGP HPPAMVTSSS TSPTGNGWSS STGDFKGITA 190 200 210 220 230 240 VATATGGGVG GATQGATAST GATAAEVLAV SSSASVGSSS PTGGASNGTA HSGHSGHTGG 250 260 270 280 290 300 HSSSTASNNN NNGASNSNSN NNNAVHQDLL WMERLVQKRQ QEHPGELVRT SNPYFLCSAL 310 320 330 340 350 360 PAHWRSNKTL PMAFKVVALA EVGDGTYVTI RAGNDENCCA ELRNFTTQMK NDVAKFNDLR 370 380 390 400 410 420 FVGRSGRGKS FTLTITVATS PPQVATYAKA IKVTVDGPRE PRSKTTAEMM GAGEWTNGSS 430 440 450 460 470 480 SSAAAYYHSH AHHPHAHHAH AHLQHQMALP PPPPPPAAAP VSVGVGGNGA TMGMGMGVGV 490 500 510 520 530 540 GMGMNHYGGG YDSANSLEAG QYAAHLPAVL PEMHGHGFAT DPYQTAGYGG GNTGGGSASK 550 560 570 580 590 600 SELDYGGSYN QAWSNGYQNY QYGSCLATAQ YGPQAAPPPQ PPPPPPVVLC PQLYSTVNQN 610 620 630 640 650 660 QIHLHLHSSE KLEQYLGTAT SADHLTIGSL TGSSRSSIEI GQDQYHQQVH HAQQQQQQQQ 670 680 690 700 QQQQVHHPQQ QQVESAGEVG GSGAGGVESA REEDVGDLSQ VWRPY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome sequence of Drosophila melanogaster." Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D. , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L., Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C. Science 287:2185-2195(2000) [PubMed: 10731132] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Berkeley.
[2]	"Alternative splicing removes an Ets interaction domain from Lozenge during Drosophila eye development." Jackson Behan K., Fair J., Singh S., Bogwitz M., Perry T., Grubor V., Cunningham F., Nichols C.D., Cheung T.L., Batterham P., Pollock J.A. Dev. Genes Evol. 215:423-435(2005) [PubMed: 15868204] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Annotation of the Drosophila melanogaster euchromatic genome: a systematic review." Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S., Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E., Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P., Bettencourt B.R., Celniker S.E., de Grey A.D.N.J. , Drysdale R.A., Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E. Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002) [PubMed: 12537572] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Berkeley.
[4]	Pollock J.A., Behan K.J., Nichols C.D., Fair J., Batterham P. Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ397338 mRNA. Translation: ABD59005.1. AE014298 Genomic DNA. Translation: ABW09367.1.
RefSeq	NP_001096919.1. NM_001103449.1.
UniGene	Dm.2929.
3D structure databases
ProteinModelPortal	Q27J10.
SMR	Q27J10. Positions 282-402.
ModBase	Search...
Protein-protein interaction databases
STRING	Q27J10.
Proteomic databases
PRIDE	Q27J10.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	FBtr0112814; FBpp0111726; FBgn0002576.
GeneID	31883.
KEGG	dme:Dmel_CG1689.
UCSC	CG1689-RA. d. melanogaster.
Organism-specific databases
CTD	17106.
FlyBase	FBgn0002576. lz.
Phylogenomic databases
GeneTree	EMGT00050000001331.
InParanoid	Q27J10.
Gene expression databases
Bgee	Q27J10.
Family and domain databases
InterPro	IPR013524. AML1/Runt_N. IPR000040. AML1_Runt. IPR008967. p53-like_TF_DNA-bd. IPR012346. p53/RUNT-type_TF_DNA-bd. [Graphical view]
Gene3D	G3DSA:2.60.40.720. p53_RUNT_DNA_bd. 1 hit.
KO	K09280.
PANTHER	PTHR11950. AML1_Runt. 1 hit.
Pfam	PF00853. Runt. 1 hit. [Graphical view]
PRINTS	PR00967. ONCOGENEAML1.
SUPFAM	SSF49417. P53_like_DNA_bnd. 1 hit.
PROSITE	PS51062. RUNT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	775784.

Entry information

Entry name

Q27J10_DROME

Accession

Primary (citable) accession number: Q27J10

Entry history

Integrated into UniProtKB/TrEMBL:	April 4, 2006
Last sequence update:	April 4, 2006
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)