Unreviewed, UniProtKB/TrEMBL Q27IU2 (Q27IU2_DROME)

Names and origin

Protein names

Submitted name:
    Dicer-1 EMBL ABD61608.1

Gene names

Name:	Dcr-1 FlyBase FBgn0039016
Synonyms:	Dcr1 EMBL ABD61608.1

Organism

Drosophila melanogaster (Fruit fly) EMBL ABD61608.1

Taxonomic identifier

7227 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora

Protein attributes

Sequence length	2043 AA.
Sequence status	Fragment.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

Ontologies

Gene Ontology (GO)
Biological process	RNA interference, production of siRNA Inferred from direct assay. Source: FlyBase RNA interference, siRNA loading onto RISC Inferred from mutant phenotype. Source: FlyBase germ-line stem cell division Inferred from mutant phenotype. Source: FlyBase mitotic cell cycle, embryonic Inferred from mutant phenotype. Source: FlyBase pole cell formation Inferred from mutant phenotype. Source: FlyBase pre-microRNA processing Inferred from direct assay. Source: FlyBase segment polarity determination Inferred from genetic interaction. Source: FlyBase
Cellular component	RNA-induced silencing complex Inferred from direct assay. Source: FlyBase cytoplasm Inferred from direct assay. Source: FlyBase
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro RNA binding Inferred from electronic annotation. Source: InterPro bidentate ribonuclease III activity Inferred from direct assay. Source: FlyBase helicase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: FlyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL ABD61608.1
	Non-terminal residue	2043	1	EMBL ABD61608.1

Sequences

	Sequence		Length	Mass (Da)
	Q27IU2-1 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 5249E8DA6F39648E	FASTA	2,043	231,827
	10 20 30 40 50 60 ARRHGRVSVY LSCEVGTSTE PCSIYTMLTH LTDLRVWQEQ PDIQIPFDHC WTDYHVSILR 70 80 90 100 110 120 PEGFLYLLET RELLLSRVEL IVLEDCHDSA VYQRIRPLFE NHIMPAPPAD RPRILGLAGP 130 140 150 160 170 180 LHSAGCELQQ LSAMLATLEQ SVLCQIETAS DIVTVLRYCS RPHEYIVQCA PFEMDELSLV 190 200 210 220 230 240 LADVLNTHKS FLLDHRYDPY EIYGTDQFMD ELKDIPDPKV DPLNVINSLL VVLHEMGPWC 250 260 270 280 290 300 TQRAAHHFYQ CNEKLKVKTP HERHYLLYCL VSTALIQLYS LCEHAFHRHL GSGSDSRQTI 310 320 330 340 350 360 ERYSSPKVRR LLQTLRCFKP EEVHTQADGL RRMRHQVDQA DFNRLSHTLE SKCRMVDQLD 370 380 390 400 410 420 QPPTETRALV ATLEQILHTT EDRQTNRSAA RVTPTPTPAH AKPKPSSGAN TAQPRTRRRV 430 440 450 460 470 480 YTRRHHRDHN DGSDTLCALI YCNQNHTARV LFELLAEISR RDPDLKFLRC QYTTDRVADP 490 500 510 520 530 540 TTEPKEAELE HRRQEEVLKR FRMHDCNVLI GTSVLEEGID VPKCNLVVRW DPPTTYRSYV 550 560 570 580 590 600 QCKGRARAAP AYHVILVAPS YKSPTVGSVQ LTDRSHRYIC ATGDTTEADS DSDDSAMPNS 610 620 630 640 650 660 SGSDPYTFGT ARGTVKILNP EVFSKQPPTA CDIKLQEIQD ELPAAAQLDT SNSSDEAVSM 670 680 690 700 710 720 SNTSPSESST EQKSRRFQCE LSSLTEPEDT SDTTAEIDTA HSLASTTKDL VHQMAQYREI 730 740 750 760 770 780 EQMLLSKCAN TEPPEQEQSE AERFSACLAA YRPKPHLLTG ASVDLGSAIA LVNKYCARLP 790 800 810 820 830 840 SDTFTKLTAL WRCTRNERAG VTLFQYTLRL PINSPLKHDI VGLPMPTQTL ARRLAALQAC 850 860 870 880 890 900 VELHRIGELD DQLQPIGKEG FRALEPDWEC FELEPEDEQI VQLSDEPRPG TTKRRQYYYK 910 920 930 940 950 960 RIASEFCDCR PVAGAPCYLY FIQLTLQCPI PEEQNTRGRK IYPPEDAQQG FGILTTKRIP 970 980 990 1000 1010 1020 KLSAFSIFTR SGEVKVSLEL AKERVILTSE QIVCINGFLN YTFTNVLRLQ KFLMLFDPDS 1030 1040 1050 1060 1070 1080 TENCVFIVPT VKAPAGGKHI DWQFLELIQA NGNTMPRAVP DKERQAQPFD PQRFQDAVVM 1090 1100 1110 1120 1130 1140 PWYRNQDQPQ YFYVAEICPH LSPLSCFPGD NYRTFKHYYL VKYGLTIQNT SQPLLDVDHT 1150 1160 1170 1180 1190 1200 SARLNFLTPR YVNRKGVALP TSSEETKRAK RENLEQKQIL VPELCTVHPF PASLWRTAVC 1210 1220 1230 1240 1250 1260 LPCILYRING LLLADDIRKQ VSADLGLGRQ QIEDEDFEWP MLDFGWSLSE VLKKSRXXXX 1270 1280 1290 1300 1310 1320 XESLKDDTIN GKDLADVEKK PTSEETQLDK DSKDDKVEKS AIELIIEGEE KLQEADDFIE 1330 1340 1350 1360 1370 1380 IGTWSNDMAD DIASFNQEDD DEDDAFHLPV LPANVKFCDQ QTRYGSPTFW DVSNGESGFK 1390 1400 1410 1420 1430 1440 GPKSSQNKQG GKGKAKGPAK PTFNYYDSDN SLGSSYDDDD NAGPLNYMHH NYSSDDDDVA 1450 1460 1470 1480 1490 1500 DDIDAGRIAF TSKNEAETIE TAQEVEKRQK QLSIIQATNA NERQYQQTKN LLIGFNFKHE 1510 1520 1530 1540 1550 1560 DQKEPATIRY EESIAKLKTE IESGGMLVPH DQQLVLKRSD AAEAQVAKVS MMKLLKQLLP 1570 1580 1590 1600 1610 1620 YVNEDVLAKK LGDRRELLLS DLVELNADWV ARHEQETYNV MGCGDSFDNY NDHHRLNLDE 1630 1640 1650 1660 1670 1680 KQLKLQYERI EIEPPTSTKA ITSAILPAGF SFDRQPDLVG HPGPSPSIIL QALTMSNAND 1690 1700 1710 1720 1730 1740 GINLERLETI GDSFLKYAIT TYLYITYENV HEGKLSHLRS KQVANLNLYR LGRRKRLGEY 1750 1760 1770 1780 1790 1800 MIATKFEPHD NWLPPCYYVP KELEKALIEA KIPTHHWKLA DLLDIKNLSS VQICEMVREK 1810 1820 1830 1840 1850 1860 ADALGLEQNG GAQNGQLDDS NDSCNDFSCF IPYNLVSQHS IPDKSIADCV EALIGAYLIE 1870 1880 1890 1900 1910 1920 CGPRGALLFM AWLGVRVLPI TRQLDGGNQE QRIPGSTKPN AENVVTVYGA WPTPRSPLLH 1930 1940 1950 1960 1970 1980 FAPNATEELD HLLSGFEEFE ESLGYKFRDR SYLLQAMTHA SYTPNRLTDC YQRLEFLGDA 1990 2000 2010 2020 2030 2040 VLDYLITRHL YEDPRQHSPG ALTDLRSALV NNTIFASLAV RHGFHKFFRH LSPGLNDVID RFV

References

[1]	"Natural selection drives extremely rapid evolution in antiviral RNAi genes." Obbard D.J., Jiggins F.M., Halligan D.L., Little T.J. Curr. Biol. 16:580-585(2006) [PubMed: 16546082] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: G196 EMBL ABD61608.1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ398892 Genomic DNA. Translation: ABD61608.1.
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q27IU2.
Genome annotation databases
Ensembl	FBgn0039016. Drosophila melanogaster. [Contig view]
Organism-specific databases
FlyBase	FBgn0039016. Dcr-1.
Gene expression databases
ArrayExpress	Q27IU2.
Family and domain databases
InterPro	IPR005034. Dicer_dsRNA_binding_fold. IPR001650. DNA/RNA_helicase_C. IPR003100. PAZ. IPR000999. RNase_III. [Graphical view]
Gene3D	G3DSA:1.10.1520.10. RNase_III. 2 hits.
Pfam	PF03368. dsRNA_bind. 1 hit. PF00271. Helicase_C. 1 hit. PF02170. PAZ. 1 hit. PF00636. Ribonuclease_3. 2 hits. [Graphical view]
SMART	SM00490. HELICc. 1 hit. SM00535. RIBOc. 2 hits. [Graphical view]
PROSITE	PS51327. DICER_DSRBF. 1 hit. PS51194. HELICASE_CTER. 1 hit. PS50821. PAZ. 1 hit. PS00517. RNASE_3_1. 1 hit. PS50142. RNASE_3_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q27IU2_DROME

Accession

Primary (citable) accession number: Q27IU2

Entry history

Integrated into UniProtKB/TrEMBL:	April 4, 2006
Last sequence update:	April 4, 2006
Last modified:	June 16, 2009
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)