ID Q27I49_PIG Unreviewed; 350 AA. AC Q27I49; F1RW84; DT 04-APR-2006, integrated into UniProtKB/TrEMBL. DT 04-APR-2006, sequence version 1. DT 27-MAR-2024, entry version 136. DE RecName: Full=Histone-lysine N-methyltransferase {ECO:0000256|PIRNR:PIRNR009343}; DE EC=2.1.1.355 {ECO:0000256|PIRNR:PIRNR009343}; GN Name=SUV39H2 {ECO:0000313|Ensembl:ENSSSCP00000055161.1, GN ECO:0000313|VGNC:VGNC:95841}; GN Synonyms=Suv39h2 {ECO:0000313|EMBL:ABX10188.1}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus. OX NCBI_TaxID=9823 {ECO:0000313|EMBL:ABD62994.1}; RN [1] {ECO:0000313|EMBL:ABD62994.1} RP NUCLEOTIDE SEQUENCE. RA Jiang S., Peng J.; RT "Sus scrofa suppressor of variegation 3-9 homolog 2 (Drosophila)."; RL Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases. RN [2] {ECO:0000313|EMBL:ABX10188.1} RP NUCLEOTIDE SEQUENCE. RA Liu L., Jiang S.; RT "Cloning, characterization and prokaryotic expression of porcine suppressor RT of variegation 3-9 homolog 2 (Suv39h2) gene."; RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases. RN [3] {ECO:0000313|Ensembl:ENSSSCP00000055161.1, ECO:0000313|Proteomes:UP000008227} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000055161.1, RC ECO:0000313|Proteomes:UP000008227}; RG Porcine genome sequencing project; RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. RN [4] {ECO:0000313|Ensembl:ENSSSCP00000055161.1} RP IDENTIFICATION. RG Ensembl; RL Submitted (NOV-2023) to UniProtKB. CC -!- CATALYTIC ACTIVITY: CC Reaction=L-lysyl(9)-[histone H3] + 3 S-adenosyl-L-methionine = 3 H(+) + CC N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 3 S-adenosyl-L- CC homocysteine; Xref=Rhea:RHEA:60276, Rhea:RHEA-COMP:15538, Rhea:RHEA- CC COMP:15546, ChEBI:CHEBI:15378, ChEBI:CHEBI:29969, ChEBI:CHEBI:57856, CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61961; EC=2.1.1.355; CC Evidence={ECO:0000256|PIRNR:PIRNR009343}; CC -!- SUBCELLULAR LOCATION: Chromosome, centromere CC {ECO:0000256|ARBA:ARBA00004584}. Nucleus CC {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR009343}. CC -!- SIMILARITY: Belongs to the class V-like SAM-binding methyltransferase CC superfamily. Histone-lysine methyltransferase family. Suvar3-9 CC subfamily. {ECO:0000256|PIRNR:PIRNR009343}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; DQ400534; ABD62994.1; -; mRNA. DR EMBL; EU219913; ABX10188.1; -; mRNA. DR RefSeq; NP_001034836.1; NM_001039747.1. DR RefSeq; XP_005668176.1; XM_005668119.2. DR RefSeq; XP_013835689.1; XM_013980235.1. DR RefSeq; XP_013835690.1; XM_013980236.1. DR RefSeq; XP_013847331.1; XM_013991877.1. DR PaxDb; 9823-ENSSSCP00000011784; -. DR Ensembl; ENSSSCT00000049142.2; ENSSSCP00000055161.1; ENSSSCG00000011048.5. DR GeneID; 664651; -. DR KEGG; ssc:664651; -. DR CTD; 79723; -. DR VGNC; VGNC:95841; SUV39H2. DR GeneTree; ENSGT00940000156788; -. DR HOGENOM; CLU_020840_8_0_1; -. DR OMA; CECADCP; -. DR OrthoDB; 5481936at2759; -. DR TreeFam; TF106452; -. DR ChiTaRS; SUV39H2; pig. DR Proteomes; UP000008227; Chromosome 10. DR Bgee; ENSSSCG00000011048; Expressed in oocyte and 46 other cell types or tissues. DR GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0140949; F:histone H3K9 trimethyltransferase activity; IEA:UniProtKB-EC. DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule. DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW. DR CDD; cd10532; SET_SUV39H2; 1. DR Gene3D; 2.40.50.40; -; 1. DR Gene3D; 2.170.270.10; SET domain; 1. DR InterPro; IPR016197; Chromo-like_dom_sf. DR InterPro; IPR000953; Chromo/chromo_shadow_dom. DR InterPro; IPR023780; Chromo_domain. DR InterPro; IPR023779; Chromodomain_CS. DR InterPro; IPR011381; H3-K9_MeTrfase_SUV39H1/2-like. DR InterPro; IPR003616; Post-SET_dom. DR InterPro; IPR007728; Pre-SET_dom. DR InterPro; IPR001214; SET_dom. DR InterPro; IPR046341; SET_dom_sf. DR PANTHER; PTHR46223; HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H; 1. DR PANTHER; PTHR46223:SF2; HISTONE-LYSINE N-METHYLTRANSFERASE SUV39H2; 1. DR Pfam; PF00385; Chromo; 1. DR Pfam; PF05033; Pre-SET; 1. DR Pfam; PF00856; SET; 1. DR PIRSF; PIRSF009343; SUV39_SET; 1. DR SMART; SM00508; PostSET; 1. DR SMART; SM00468; PreSET; 1. DR SMART; SM00317; SET; 1. DR SUPFAM; SSF54160; Chromo domain-like; 1. DR SUPFAM; SSF82199; SET domain; 1. DR PROSITE; PS00598; CHROMO_1; 1. DR PROSITE; PS50013; CHROMO_2; 1. DR PROSITE; PS50868; POST_SET; 1. DR PROSITE; PS50867; PRE_SET; 1. DR PROSITE; PS51579; SAM_MT43_SUVAR39_3; 1. DR PROSITE; PS50280; SET; 1. PE 2: Evidence at transcript level; KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108}; KW Cell cycle {ECO:0000256|ARBA:ARBA00023306}; KW Centromere {ECO:0000256|ARBA:ARBA00023328}; KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853, KW ECO:0000256|PIRNR:PIRNR009343}; Chromosome {ECO:0000256|ARBA:ARBA00022454}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, KW ECO:0000256|PIRNR:PIRNR009343}; KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, KW ECO:0000256|PIRNR:PIRNR009343}; Nucleus {ECO:0000256|PIRNR:PIRNR009343}; KW Reference proteome {ECO:0000313|Proteomes:UP000008227}; KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691, KW ECO:0000256|PIRNR:PIRNR009343}; KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR009343}; KW Zinc {ECO:0000256|PIRNR:PIRNR009343, ECO:0000256|PIRSR:PIRSR009343-2}. FT DOMAIN 1..45 FT /note="Chromo" FT /evidence="ECO:0000259|PROSITE:PS50013" FT DOMAIN 129..187 FT /note="Pre-SET" FT /evidence="ECO:0000259|PROSITE:PS50867" FT DOMAIN 190..313 FT /note="SET" FT /evidence="ECO:0000259|PROSITE:PS50280" FT DOMAIN 334..350 FT /note="Post-SET" FT /evidence="ECO:0000259|PROSITE:PS50868" FT BINDING 131 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="2" FT /evidence="ECO:0000256|PIRSR:PIRSR009343-2" FT BINDING 131 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="1" FT /evidence="ECO:0000256|PIRSR:PIRSR009343-2" FT BINDING 133 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="1" FT /evidence="ECO:0000256|PIRSR:PIRSR009343-2" FT BINDING 136 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="3" FT /evidence="ECO:0000256|PIRSR:PIRSR009343-2" FT BINDING 136 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="1" FT /evidence="ECO:0000256|PIRSR:PIRSR009343-2" FT BINDING 141 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="1" FT /evidence="ECO:0000256|PIRSR:PIRSR009343-2" FT BINDING 142 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="2" FT /evidence="ECO:0000256|PIRSR:PIRSR009343-2" FT BINDING 169 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="3" FT /evidence="ECO:0000256|PIRSR:PIRSR009343-2" FT BINDING 169 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="2" FT /evidence="ECO:0000256|PIRSR:PIRSR009343-2" FT BINDING 173 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="2" FT /evidence="ECO:0000256|PIRSR:PIRSR009343-2" FT BINDING 175 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="3" FT /evidence="ECO:0000256|PIRSR:PIRSR009343-2" FT BINDING 179 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="3" FT /evidence="ECO:0000256|PIRSR:PIRSR009343-2" FT BINDING 273 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="4" FT /evidence="ECO:0000256|PIRSR:PIRSR009343-2" FT BINDING 338 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="4" FT /evidence="ECO:0000256|PIRSR:PIRSR009343-2" FT BINDING 340 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="4" FT /evidence="ECO:0000256|PIRSR:PIRSR009343-2" FT BINDING 345 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /ligand_label="4" FT /evidence="ECO:0000256|PIRSR:PIRSR009343-2" SQ SEQUENCE 350 AA; 39889 MW; 841C83C1FDBE67D0 CRC64; MEYYLVKWKG WPDSTNTWEP LQNLKCPLLL QQFCNDKHNY LSQVKKGKAI TLKENHRALK PAIAEYIVKK AKQRIALQRW QDELNRRKNH KGMIFVENTV DLEGPPSDFY YINEYKPAPG ISLVNEATFG CSCTDCFHEK CCPAEAGVLL AYNKNQQIKI PPGTPIYECN SRCQCGPDCP NRIVQKGTQY SLCIFRTSNG CGWGVKTLVK IKRMSFVMEY VGEVITSEEA ERRGQLYDNK GITYLFDLDY ESDEFTVDAA RYGNVSHFVN HSCDPNLQVF NVFIDNLDTR LPRIALFSTR TINAGEELTF DYQMKGSGDI SSDSIDHSPA KKRARTVCKC GAVTCRGYLN //