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Protein

Histone-lysine N-methyltransferase

Gene

SUV39H2

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

S-adenosyl-L-methionineSAAS annotation

Enzyme and pathway databases

ReactomeiREACT_290103. PKMTs methylate histone lysines.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferaseSAAS annotation (EC:2.1.1.43SAAS annotation)
Gene namesi
Name:SUV39H2Imported
Synonyms:Suv39h2Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componenti: Chromosome 10

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

ChromosomeSAAS annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011784.

Structurei

3D structure databases

ProteinModelPortaliQ27I49.
SMRiQ27I49. Positions 64-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation
Contains 1 pre-SET domain.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00780000121845.
HOVERGENiHBG055621.
InParanoidiQ27I49.
KOiK11419.
OMAiAWCVPCL.
OrthoDBiEOG7RJPR0.
TreeFamiTF106452.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR011381. Histone_H3-K9_MeTrfase.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF009343. SUV39_SET. 1 hit.
SMARTiSM00298. CHROMO. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51579. SAM_MT43_SUVAR39_3. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27I49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYYLVKWKG WPDSTNTWEP LQNLKCPLLL QQFCNDKHNY LSQVKKGKAI
60 70 80 90 100
TLKENHRALK PAIAEYIVKK AKQRIALQRW QDELNRRKNH KGMIFVENTV
110 120 130 140 150
DLEGPPSDFY YINEYKPAPG ISLVNEATFG CSCTDCFHEK CCPAEAGVLL
160 170 180 190 200
AYNKNQQIKI PPGTPIYECN SRCQCGPDCP NRIVQKGTQY SLCIFRTSNG
210 220 230 240 250
CGWGVKTLVK IKRMSFVMEY VGEVITSEEA ERRGQLYDNK GITYLFDLDY
260 270 280 290 300
ESDEFTVDAA RYGNVSHFVN HSCDPNLQVF NVFIDNLDTR LPRIALFSTR
310 320 330 340 350
TINAGEELTF DYQMKGSGDI SSDSIDHSPA KKRARTVCKC GAVTCRGYLN
Length:350
Mass (Da):39,889
Last modified:April 4, 2006 - v1
Checksum:i841C83C1FDBE67D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU929591 Genomic DNA. No translation available.
DQ400534 mRNA. Translation: ABD62994.1.
EU219913 mRNA. Translation: ABX10188.1.
RefSeqiNP_001034836.1. NM_001039747.1.
XP_005658692.1. XM_005658635.1.
XP_005668176.1. XM_005668119.1.
UniGeneiSsc.24424.

Genome annotation databases

EnsembliENSSSCT00000012092; ENSSSCP00000011784; ENSSSCG00000011048.
ENSSSCT00000031746; ENSSSCP00000025189; ENSSSCG00000023928.
GeneIDi100738592.
664651.
KEGGissc:100738592.
ssc:664651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU929591 Genomic DNA. No translation available.
DQ400534 mRNA. Translation: ABD62994.1.
EU219913 mRNA. Translation: ABX10188.1.
RefSeqiNP_001034836.1. NM_001039747.1.
XP_005658692.1. XM_005658635.1.
XP_005668176.1. XM_005668119.1.
UniGeneiSsc.24424.

3D structure databases

ProteinModelPortaliQ27I49.
SMRiQ27I49. Positions 64-350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000011784.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000012092; ENSSSCP00000011784; ENSSSCG00000011048.
ENSSSCT00000031746; ENSSSCP00000025189; ENSSSCG00000023928.
GeneIDi100738592.
664651.
KEGGissc:100738592.
ssc:664651.

Organism-specific databases

CTDi79723.

Phylogenomic databases

GeneTreeiENSGT00780000121845.
HOVERGENiHBG055621.
InParanoidiQ27I49.
KOiK11419.
OMAiAWCVPCL.
OrthoDBiEOG7RJPR0.
TreeFamiTF106452.

Enzyme and pathway databases

ReactomeiREACT_290103. PKMTs methylate histone lysines.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR011381. Histone_H3-K9_MeTrfase.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF009343. SUV39_SET. 1 hit.
SMARTiSM00298. CHROMO. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51579. SAM_MT43_SUVAR39_3. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sus scrofa suppressor of variegation 3-9 homolog 2 (Drosophila)."
    Jiang S., Peng J.
    Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Cloning, characterization and prokaryotic expression of porcine suppressor of variegation 3-9 homolog 2 (Suv39h2) gene."
    Liu L., Jiang S.
    Submitted (SEP-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Porcine genome sequencing project
    Submitted (OCT-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Ensembl
    Submitted (APR-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  5. Ensembl
    Submitted (APR-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ27I49_PIG
AccessioniPrimary (citable) accession number: Q27I49
Secondary accession number(s): F1RW84
Entry historyi
Integrated into UniProtKB/TrEMBL: April 4, 2006
Last sequence update: April 4, 2006
Last modified: April 1, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.