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Protein

Histone-lysine N-methyltransferase

Gene

Suv39h2

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].PROSITE-ProRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi131Zinc 1UniRule annotation1
Metal bindingi131Zinc 2UniRule annotation1
Metal bindingi133Zinc 1UniRule annotation1
Metal bindingi136Zinc 1UniRule annotation1
Metal bindingi136Zinc 3UniRule annotation1
Metal bindingi141Zinc 1UniRule annotation1
Metal bindingi142Zinc 2UniRule annotation1
Metal bindingi169Zinc 2UniRule annotation1
Metal bindingi169Zinc 3UniRule annotation1
Metal bindingi173Zinc 2UniRule annotation1
Metal bindingi175Zinc 3UniRule annotation1
Metal bindingi179Zinc 3UniRule annotation1
Metal bindingi273Zinc 4UniRule annotation1
Metal bindingi338Zinc 4UniRule annotation1
Metal bindingi340Zinc 4UniRule annotation1
Metal bindingi345Zinc 4UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferasePROSITE-ProRule annotationSAAS annotation, Transferase
LigandMetal-bindingUniRule annotation, S-adenosyl-L-methioninePROSITE-ProRule annotationSAAS annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-SSC-3214841. PKMTs methylate histone lysines.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferasePROSITE-ProRule annotation (EC:2.1.1.43PROSITE-ProRule annotation)
Gene namesi
Name:Suv39h2Imported
Synonyms:SUV39H2Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

ChromosomeSAAS annotation, NucleusSAAS annotation

Expressioni

Gene expression databases

BgeeiENSSSCG00000011048.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000025189.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 45ChromoInterPro annotationAdd BLAST45
Domaini129 – 187Pre-SETInterPro annotationAdd BLAST59
Domaini190 – 313SETInterPro annotationAdd BLAST124
Domaini334 – 350Post-SETInterPro annotationAdd BLAST17

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00780000121845.
HOVERGENiHBG055621.
KOiK11419.
OMAiAWCVPCL.
OrthoDBiEOG091G0Y4N.
TreeFamiTF106452.

Family and domain databases

InterProiView protein in InterPro
IPR000953. Chromo/chromo_shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR011381. Histone_H3-K9_MeTrfase.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
PfamiView protein in Pfam
PF00385. Chromo. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
PIRSFiPIRSF009343. SUV39_SET. 1 hit.
SMARTiView protein in SMART
SM00508. PostSET. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiView protein in PROSITE
PS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51579. SAM_MT43_SUVAR39_3. 1 hit.
PS50280. SET. 1 hit.

Sequencei

Sequence statusi: Complete.

Q27I49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYYLVKWKG WPDSTNTWEP LQNLKCPLLL QQFCNDKHNY LSQVKKGKAI
60 70 80 90 100
TLKENHRALK PAIAEYIVKK AKQRIALQRW QDELNRRKNH KGMIFVENTV
110 120 130 140 150
DLEGPPSDFY YINEYKPAPG ISLVNEATFG CSCTDCFHEK CCPAEAGVLL
160 170 180 190 200
AYNKNQQIKI PPGTPIYECN SRCQCGPDCP NRIVQKGTQY SLCIFRTSNG
210 220 230 240 250
CGWGVKTLVK IKRMSFVMEY VGEVITSEEA ERRGQLYDNK GITYLFDLDY
260 270 280 290 300
ESDEFTVDAA RYGNVSHFVN HSCDPNLQVF NVFIDNLDTR LPRIALFSTR
310 320 330 340 350
TINAGEELTF DYQMKGSGDI SSDSIDHSPA KKRARTVCKC GAVTCRGYLN
Length:350
Mass (Da):39,889
Last modified:April 4, 2006 - v1
Checksum:i841C83C1FDBE67D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU929591 Genomic DNA. No translation available.
DQ400534 mRNA. Translation: ABD62994.1.
EU219913 mRNA. Translation: ABX10188.1.
RefSeqiNP_001034836.1. NM_001039747.1.
XP_005668176.1. XM_005668119.2.
XP_013835689.1. XM_013980235.1.
XP_013835690.1. XM_013980236.1.
XP_013847331.1. XM_013991877.1.
UniGeneiSsc.24424.

Genome annotation databases

EnsembliENSSSCT00000012092; ENSSSCP00000011784; ENSSSCG00000011048.
ENSSSCT00000031746; ENSSSCP00000025189; ENSSSCG00000023928.
GeneIDi664651.
KEGGissc:100738592.
ssc:664651.

Similar proteinsi

Entry informationi

Entry nameiQ27I49_PIG
AccessioniPrimary (citable) accession number: Q27I49
Secondary accession number(s): F1RW84
Entry historyiIntegrated into UniProtKB/TrEMBL: April 4, 2006
Last sequence update: April 4, 2006
Last modified: September 27, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported