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Protein
Submitted name:

Suppressor of variegation 3-9-like protein 2

Gene

SUV39H2

Organism
Sus scrofa (Pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].SAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi131 – 1311Zinc 1UniRule annotation
Metal bindingi131 – 1311Zinc 2UniRule annotation
Metal bindingi133 – 1331Zinc 1UniRule annotation
Metal bindingi136 – 1361Zinc 1UniRule annotation
Metal bindingi136 – 1361Zinc 3UniRule annotation
Metal bindingi141 – 1411Zinc 1UniRule annotation
Metal bindingi142 – 1421Zinc 2UniRule annotation
Metal bindingi169 – 1691Zinc 2UniRule annotation
Metal bindingi169 – 1691Zinc 3UniRule annotation
Metal bindingi173 – 1731Zinc 2UniRule annotation
Metal bindingi175 – 1751Zinc 3UniRule annotation
Metal bindingi179 – 1791Zinc 3UniRule annotation
Metal bindingi273 – 2731Zinc 4UniRule annotation
Metal bindingi338 – 3381Zinc 4UniRule annotation
Metal bindingi340 – 3401Zinc 4UniRule annotation
Metal bindingi345 – 3451Zinc 4UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

Metal-bindingUniRule annotation, S-adenosyl-L-methionineSAAS annotation, ZincUniRule annotation

Enzyme and pathway databases

ReactomeiR-SSC-3214841. PKMTs methylate histone lysines.

Names & Taxonomyi

Protein namesi
Submitted name:
Suppressor of variegation 3-9-like protein 2Imported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:SUV39H2Imported
Synonyms:Suv39h2Imported
OrganismiSus scrofa (Pig)Imported
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 10

Subcellular locationi

  • Chromosome SAAS annotation
  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

ChromosomeSAAS annotation, NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000025189.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 4545ChromoInterPro annotationAdd
BLAST
Domaini129 – 18759Pre-SETInterPro annotationAdd
BLAST
Domaini190 – 313124SETInterPro annotationAdd
BLAST
Domaini334 – 35017Post-SETInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SET domain.UniRule annotation
Contains 1 post-SET domain.UniRule annotation
Contains 1 pre-SET domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00780000121845.
HOVERGENiHBG055621.
KOiK11419.
OMAiAWCVPCL.
OrthoDBiEOG7RJPR0.
TreeFamiTF106452.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR011381. Histone_H3-K9_MeTrfase.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF009343. SUV39_SET. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51579. SAM_MT43_SUVAR39_3. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27I49-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYYLVKWKG WPDSTNTWEP LQNLKCPLLL QQFCNDKHNY LSQVKKGKAI
60 70 80 90 100
TLKENHRALK PAIAEYIVKK AKQRIALQRW QDELNRRKNH KGMIFVENTV
110 120 130 140 150
DLEGPPSDFY YINEYKPAPG ISLVNEATFG CSCTDCFHEK CCPAEAGVLL
160 170 180 190 200
AYNKNQQIKI PPGTPIYECN SRCQCGPDCP NRIVQKGTQY SLCIFRTSNG
210 220 230 240 250
CGWGVKTLVK IKRMSFVMEY VGEVITSEEA ERRGQLYDNK GITYLFDLDY
260 270 280 290 300
ESDEFTVDAA RYGNVSHFVN HSCDPNLQVF NVFIDNLDTR LPRIALFSTR
310 320 330 340 350
TINAGEELTF DYQMKGSGDI SSDSIDHSPA KKRARTVCKC GAVTCRGYLN
Length:350
Mass (Da):39,889
Last modified:April 4, 2006 - v1
Checksum:i841C83C1FDBE67D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU929591 Genomic DNA. No translation available.
DQ400534 mRNA. Translation: ABD62994.1.
EU219913 mRNA. Translation: ABX10188.1.
RefSeqiNP_001034836.1. NM_001039747.1.
XP_005668176.1. XM_005668119.2.
XP_013835689.1. XM_013980235.1.
XP_013835690.1. XM_013980236.1.
XP_013847331.1. XM_013991877.1.
UniGeneiSsc.24424.

Genome annotation databases

EnsembliENSSSCT00000012092; ENSSSCP00000011784; ENSSSCG00000011048.
ENSSSCT00000031746; ENSSSCP00000025189; ENSSSCG00000023928.
GeneIDi100738592.
664651.
KEGGissc:100738592.
ssc:664651.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CU929591 Genomic DNA. No translation available.
DQ400534 mRNA. Translation: ABD62994.1.
EU219913 mRNA. Translation: ABX10188.1.
RefSeqiNP_001034836.1. NM_001039747.1.
XP_005668176.1. XM_005668119.2.
XP_013835689.1. XM_013980235.1.
XP_013835690.1. XM_013980236.1.
XP_013847331.1. XM_013991877.1.
UniGeneiSsc.24424.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000025189.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000012092; ENSSSCP00000011784; ENSSSCG00000011048.
ENSSSCT00000031746; ENSSSCP00000025189; ENSSSCG00000023928.
GeneIDi100738592.
664651.
KEGGissc:100738592.
ssc:664651.

Organism-specific databases

CTDi79723.

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG2940. LUCA.
GeneTreeiENSGT00780000121845.
HOVERGENiHBG055621.
KOiK11419.
OMAiAWCVPCL.
OrthoDBiEOG7RJPR0.
TreeFamiTF106452.

Enzyme and pathway databases

ReactomeiR-SSC-3214841. PKMTs methylate histone lysines.

Family and domain databases

InterProiIPR000953. Chromo/shadow_dom.
IPR023780. Chromo_domain.
IPR016197. Chromodomain-like.
IPR023779. Chromodomain_CS.
IPR011381. Histone_H3-K9_MeTrfase.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00385. Chromo. 1 hit.
PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
PIRSFiPIRSF009343. SUV39_SET. 1 hit.
SMARTiSM00508. PostSET. 1 hit.
SM00468. PreSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
SUPFAMiSSF54160. SSF54160. 1 hit.
PROSITEiPS00598. CHROMO_1. 1 hit.
PS50013. CHROMO_2. 1 hit.
PS50868. POST_SET. 1 hit.
PS50867. PRE_SET. 1 hit.
PS51579. SAM_MT43_SUVAR39_3. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sus scrofa suppressor of variegation 3-9 homolog 2 (Drosophila)."
    Jiang S., Peng J.
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "Cloning, characterization and prokaryotic expression of porcine suppressor of variegation 3-9 homolog 2 (Suv39h2) gene."
    Liu L., Jiang S.
    Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  3. Porcine genome sequencing project
    Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DurocImported.
  4. Zha H.-G.
    Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DurocImported.
  5. Ensembl
    Submitted (MAY-2011) to UniProtKB
    Cited for: IDENTIFICATION.
  6. Ensembl
    Submitted (MAY-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiQ27I49_PIG
AccessioniPrimary (citable) accession number: Q27I49
Secondary accession number(s): F1RW84
Entry historyi
Integrated into UniProtKB/TrEMBL: April 4, 2006
Last sequence update: April 4, 2006
Last modified: June 8, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.