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Unreviewed, UniProtKB/TrEMBL Q27HK5 (Q27HK5_HUMAN)

Last modified January 19, 2010. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesRecommended name:
    Cellular tumor antigen p53 RuleBase RU003304V0
OrganismHomo sapiens (Human) EMBL ABD62752.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length112 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression By similarity. RuleBase RU003304V0

Subunit structure

Binds DNA as a homotetramer By similarity. RuleBase RU003304V0

Subcellular location

Cytoplasm. Nucleus By similarity RuleBase RU003304V0.

Sequence similarities

Belongs to the p53 family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL ABD62752.1
Non-terminal residue1121 EMBL ABD62752.1

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Sequences

Sequence LengthMass (Da)Tools
Q27HK5-1 [UniParc].

Last modified April 4, 2006. Version 1.
Checksum: F16986BBAC4AAA5E

FASTA11212,713
        10         20         30         40         50         60 
FRVTAMEEPQ SDPSVEPPLS QETFSDLWKL LPENNVLYSP ALNKMFCQLA KTCPVQLWVD 

        70         80         90        100        110 
STPPPGTRVR AMAIYKQSQH MTEVVRRCPH HERCSDSDGL APPQHLIRVE GN

« Hide

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References

[1]"p53 isoforms in testis."
Venables J.P.
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		DQ401704 mRNA. Translation: ABD62752.1.
IPIIPI00796188.
UniGeneHs.654481

3D structure databases

SMRQ27HK5. Positions 38-112.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ27HK5.

Organism-specific databases

HGNCHGNC:11998. TP53.

Phylogenomic databases

HOVERGENQ27HK5.

Family and domain databases

InterProIPR008967. p53-like_TF_DNA-bd.
IPR012346. p53/RUNT-type_TF_DNA_bd.
IPR011615. p53_DNA_bd.
IPR013872. p53_transactivation_domain.
IPR002117. p53_tumour_Ag.
IPR015551. Trp53.
[Graphical view]
Gene3DG3DSA:2.60.40.720. p53_RUNT_DNA_bd. 1 hit.
PANTHERPTHR11447. Trp53. 1 hit.
PfamPF00870. P53. 1 hit.
PF08563. P53_TAD. 1 hit.
[Graphical view]
PRINTSPR00386. P53SUPPRESSR.
ProtoNetSearch...

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Entry information

Entry nameQ27HK5_HUMAN
AccessionPrimary (citable) accession number: Q27HK5
Entry history
Integrated into UniProtKB/TrEMBL: April 4, 2006
Last sequence update: April 4, 2006
Last modified: January 19, 2010
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information