Unreviewed, UniProtKB/TrEMBL Q27GS2 (Q27GS2_ACTS5)

Names and origin

Protein names

Submitted name:
    Glycosyltransferase AcbS EMBL CAJ81024.1

Gene names

Name:

acbS EMBL CAJ81024.1

Organism

Actinoplanes sp. (strain 50/110) EMBL CAJ81024.1

Taxonomic identifier

134676 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Actinoplanes

Protein attributes

Sequence length	709 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

Ontologies

Keywords
Molecular function	Transferase EMBL CAJ81024.1
Gene Ontology (GO)
Molecular function	transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q27GS2-1 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 428935F4D1E35041	FASTA	709	79,178
	10 20 30 40 50 60 MHIIETYFEC GGFDHRFIQG GTSVYLWQLS RGLADLGHRV SIVTPAHGRL DDLRRLHEVE 70 80 90 100 110 120 DLPGTDEYEL PLVLDPRVWG ERFPAQMDIA LRTTAHRIRL AGVDLYFLSN ELLDQLPDRF 130 140 150 160 170 180 YPPYESKGVD LVFFKPLAYQ VAAIRFIRSH FGDQRAIVHA HEPFYHYLMP AAFAADPAKH 190 200 210 220 230 240 VVSTVQSNMP INKSVYRAEV ARLLGFLGAP NALPADDPAG SRSPHTVAMS QYQQLTHLHY 250 260 270 280 290 300 EYPPDHVRVY DLVAEHADRI DFLSPGHRDY YTCFADTPFA QLFATLPVSR TVRRNADKTF 310 320 330 340 350 360 VGGCAVGDEW VTGELPPVDR EKVLAGLGLD PDLPAFYHNA RYAVNHKGQV ELIRAVDRVL 370 380 390 400 410 420 SGGVRASFIV RCLSDAGIAD PLFHEVVARH PGRVNLEWHR VPEDQLREYA RAADFCLFPS 430 440 450 460 470 480 KFEMDTFLIA QGEAMAAGAV PIATAQLGMA HFGHVADPLT GPDAATATGF AVNRSFAEDD 490 500 510 520 530 540 PLLVQGLTEQ IRRAVTLWNE QPGQYRRLSA NAVARAREFT WRRAAQAHEA AFAGVWAGRT 550 560 570 580 590 600 PRLPVGDLLR FGWFDELPAD AWTLHRDEIA EVALAHGDAD AYLRCRPDDL DALAALFERA 610 620 630 640 650 660 WARADFPACA RTVELAEEHR QERVPQWRAR LAGRGRIDRD GRLHYRPPSA ERVELVLPDL 670 680 690 700 AEPLRGTVTV TAMAPTGDTF TGQLPAGTRR ADLLLTLSDG RTVWDEVTA

References

[1]	"The AcbC protein from Actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose." Stratmann A., Mahmud T., Lee S., Distler J., Floss H.G., Piepersberg W. J. Biol. Chem. 274:10889-10896(1999) [PubMed: 10196166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81024.1.
[2]	"Identification, cloning, expression, and characterization of the extracellular acarbose-modifying glycosyltransferase, AcbD, from Actinoplanes sp. strain SE50." Hemker M., Stratmann A., Goeke K., Schroder W., Lenz J., Piepersberg W., Pape H. J. Bacteriol. 183:4484-4492(2001) [PubMed: 11443082] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81024.1.
[3]	"Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway." Zhang C.S., Stratmann A., Block O., Bruckner R., Podeschwa M., Altenbach H.J., Wehmeier U.F., Piepersberg W. J. Biol. Chem. 277:22853-22862(2002) [PubMed: 11937512] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81024.1.
[4]	"The acarbose-biosynthetic enzyme AcbO from Actinoplanes sp. SE 50/110 is a 2-epi-5-epi-valiolone-7-phosphate 2-epimerase." Zhang C.S., Podeschwa M., Altenbach H.J., Piepersberg W., Wehmeier U.F. FEBS Lett. 540:47-52(2003) [PubMed: 12681481] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81024.1.
[5]	"The acbH gene of Actinoplanes sp. encodes a solute receptor with binding activities for acarbose and longer homologs." Brunkhorst C., Wehmeier U.F., Piepersberg W., Schneider E. Res. Microbiol. 156:322-327(2005) [PubMed: 15808935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81024.1.
[6]	Stratmann A. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81024.1.
[7]	Wehmeier U.F. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81024.1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y18523 Genomic DNA. Translation: CAJ81024.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT5. Glycosyltransferase Family 5.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

Q27GS2_ACTS5

Accession

Primary (citable) accession number: Q27GS2

Entry history

Integrated into UniProtKB/TrEMBL:	April 4, 2006
Last sequence update:	April 4, 2006
Last modified:	April 14, 2009
This is version 7 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)