Unreviewed, UniProtKB/TrEMBL Q27GR9 (Q27GR9_ACTS5)

Names and origin

Protein names

Submitted name:
    Glycosyltransferase AcbI EMBL CAJ81027.1

Gene names

Name:

acbI EMBL CAJ81027.1

Organism

Actinoplanes sp. (strain 50/110) EMBL CAJ81027.1

Taxonomic identifier

134676 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Actinoplanes

Protein attributes

Sequence length	734 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Predicted.

Ontologies

Keywords
Molecular function	Transferase EMBL CAJ81027.1
Gene Ontology (GO)
Molecular function	transferase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q27GR9-1 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 68B2B05E426E3DDA	FASTA	734	80,889
	10 20 30 40 50 60 MHVVSFAFEA LAFDVGMMRG GLAPLAWELA RHYAAQGHRS SIVTPAHGRL PYLAERYDLV 70 80 90 100 110 120 ELDYRDEHVV PVVPDPDVWA GQPRELGLPL VTRAHLLRHE GVDIYLLSDE YLDLLPERLY 130 140 150 160 170 180 PAGTSEGSDL AYFKPLVFQV GGLRFLQSRL AGDEPAVVQA YEPYYHYLLP PVLAGDPRFR 190 200 210 220 230 240 VMSTVASSMP IDLGVYRPQV DRLLEHFGAG TDLDRYVESP VAAGADHPAA TREAALGAAM 250 260 270 280 290 300 AGYLPTTRLS SGRRRADYVG LFALITDHCD TVDFLTPGQR RFYSTFRDTP YEAAFRRTAV 310 320 330 340 350 360 ARVVRENAAK QFVGGCALPE NWLRRDPAEV DRAAYLSGLG LDPALPTFYH VGRYSPHHKG 370 380 390 400 410 420 QVELFRAVER ILATDTRVNF VLRCATSAGG GGARIGDPAF QAVADRHPGQ VRLFWTMADE 430 440 450 460 470 480 DELFTEAVAA DFGLFPSKYE LDTFLTAQGQ LCACGAVPIG TAQESTRHYR HQLATDHPLA 490 500 510 520 530 540 TGFALPRSFT PDDERLTGAL VRTMREALRM YRDEPGEYRR LAGNAAELAR TFRYAEVSRR 550 560 570 580 590 600 RLAHFAKLLD GTPTAADPEH VIGCGWFDQL DAAQWAAHLP QIRREAIRLG DLETLRRCGP 610 620 630 640 650 660 VDPGALGALY EAAYRRADFD RCVRVAELLG DRGSEAVSLR RRCRVRPHEQ GWEIQYRAPG 670 680 690 700 710 720 AEQVALVVGG TAHRMHGSAG RFSTVLPTVP MPSPVFLLTL ASGRYAWDAP PATAHLADLA 730 GQPHPAQPVG AGGR

References

[1]	"The AcbC protein from Actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose." Stratmann A., Mahmud T., Lee S., Distler J., Floss H.G., Piepersberg W. J. Biol. Chem. 274:10889-10896(1999) [PubMed: 10196166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81027.1.
[2]	"Identification, cloning, expression, and characterization of the extracellular acarbose-modifying glycosyltransferase, AcbD, from Actinoplanes sp. strain SE50." Hemker M., Stratmann A., Goeke K., Schroder W., Lenz J., Piepersberg W., Pape H. J. Bacteriol. 183:4484-4492(2001) [PubMed: 11443082] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81027.1.
[3]	"Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway." Zhang C.S., Stratmann A., Block O., Bruckner R., Podeschwa M., Altenbach H.J., Wehmeier U.F., Piepersberg W. J. Biol. Chem. 277:22853-22862(2002) [PubMed: 11937512] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81027.1.
[4]	"The acarbose-biosynthetic enzyme AcbO from Actinoplanes sp. SE 50/110 is a 2-epi-5-epi-valiolone-7-phosphate 2-epimerase." Zhang C.S., Podeschwa M., Altenbach H.J., Piepersberg W., Wehmeier U.F. FEBS Lett. 540:47-52(2003) [PubMed: 12681481] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81027.1.
[5]	"The acbH gene of Actinoplanes sp. encodes a solute receptor with binding activities for acarbose and longer homologs." Brunkhorst C., Wehmeier U.F., Piepersberg W., Schneider E. Res. Microbiol. 156:322-327(2005) [PubMed: 15808935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81027.1.
[6]	Stratmann A. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81027.1.
[7]	Wehmeier U.F. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81027.1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y18523 Genomic DNA. Translation: CAJ81027.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT5. Glycosyltransferase Family 5.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

Q27GR9_ACTS5

Accession

Primary (citable) accession number: Q27GR9

Entry history

Integrated into UniProtKB/TrEMBL:	April 4, 2006
Last sequence update:	April 4, 2006
Last modified:	April 14, 2009
This is version 7 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)