Q27GR1 (Q27GR1_ACTS5) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Putative galactocerebrosidase EMBL CAJ81035.1

Gene names

Name:

asp3.1 EMBL CAJ81035.1

Organism

Actinoplanes sp. (strain 50/110) EMBL CAJ81035.1

Taxonomic identifier

134676 [NCBI]

Taxonomic lineage

Bacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Micromonosporineae › Micromonosporaceae › Actinoplanes

Protein attributes

Sequence length	785 AA.
Sequence status	Complete.
Protein existence	Predicted

Ontologies

Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro galactosylceramide catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	cation binding Inferred from electronic annotation. Source: InterPro galactosylceramidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q27GR1 [UniParc]. Last modified April 4, 2006. Version 1. Checksum: 6FF242B2C7CE6CEE	FASTA	785	82,815
	10 20 30 40 50 60 MRHLLMVAVT AAAIGTLAAP APAAAATTVA LNGGIVGRAF DGVGAISGGG GNSRLLIDYP 70 80 90 100 110 120 EPQRGQILDY LFKPGYGAAV QLLKLEIGGD ANSTDGSEPS HQHVRGDINC NAGYEFWLGE 130 140 150 160 170 180 QAVARNPGIR LVALPWAAPG WIGGGSFWST DMINYDVSWL NCARQYGLTI SYLGGWNERG 190 200 210 220 230 240 HDSTWYKNLR TGLDNAGYSA VQIVGDDSGW GMADEFAADP TLKNAVGVLG NHYVCGYLSQ 250 260 270 280 290 300 ADSCSTTGNA RSSGKPLWAS EFGSQDDNAG VVPYIRTVNR GYLDAEISGY MNWPLIAAIT 310 320 330 340 350 360 PNLPFATVGL MDAGSPWSGA YRVGRNLWAN AHYAQFTQPG WHYLNSSASG YLGGNRANGS 370 380 390 400 410 420 YVTLKSTNNT DYSTIYETSG STAAQTVNVT VSGGLSTGTV HVWSTDMGSS NSADWFVRQA 430 440 450 460 470 480 DITPVGATYT LNLQPNRIYT VTTTTGQGKG TAAGPAPHGL ALPYSDNFDG YAVRKLPHYS 490 500 510 520 530 540 EDMQGSFETR ACSAGRGGTC LQQVAPLRPI NWQDDSDAFT LFGDTGWTNY TVSLDVNMQQ 550 560 570 580 590 600 AGTVTLLGRA NIQNRPQNRQ AAYQLRVTDN GGWSIVKHTN ADTDTTLVSG TRAALGLNSW 610 620 630 640 650 660 HNLRLGFSGG QITAAIDNTT VGTVTDYAYG AGQAGVGVVG YQTDQFDNLS VTPNSGPALN 670 680 690 700 710 720 TLRGVESGRC ADVPGASQTN GTQLALWDCN GGSNQNFTLT DQKQLLVYGS KCLDVNAGGT 730 740 750 760 770 780 ADGAKVQIWD CHGGTNQQWT LNADGTIVGI GSGKCLDATG HGTANGTLLE IWTCNGGDNQ KWSRS

References

[1]	"The AcbC protein from Actinoplanes species is a C7-cyclitol synthase related to 3-dehydroquinate synthases and is involved in the biosynthesis of the alpha-glucosidase inhibitor acarbose." Stratmann A., Mahmud T., Lee S., Distler J., Floss H.G., Piepersberg W. J. Biol. Chem. 274:10889-10896(1999) [PubMed: 10196166] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81035.1.
[2]	"Identification, cloning, expression, and characterization of the extracellular acarbose-modifying glycosyltransferase, AcbD, from Actinoplanes sp. strain SE50." Hemker M., Stratmann A., Goeke K., Schroder W., Lenz J., Piepersberg W., Pape H. J. Bacteriol. 183:4484-4492(2001) [PubMed: 11443082] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81035.1.
[3]	"Biosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway." Zhang C.S., Stratmann A., Block O., Bruckner R., Podeschwa M., Altenbach H.J., Wehmeier U.F., Piepersberg W. J. Biol. Chem. 277:22853-22862(2002) [PubMed: 11937512] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81035.1.
[4]	"The acarbose-biosynthetic enzyme AcbO from Actinoplanes sp. SE 50/110 is a 2-epi-5-epi-valiolone-7-phosphate 2-epimerase." Zhang C.S., Podeschwa M., Altenbach H.J., Piepersberg W., Wehmeier U.F. FEBS Lett. 540:47-52(2003) [PubMed: 12681481] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81035.1.
[5]	"The acbH gene of Actinoplanes sp. encodes a solute receptor with binding activities for acarbose and longer homologs." Brunkhorst C., Wehmeier U.F., Piepersberg W., Schneider E. Res. Microbiol. 156:322-327(2005) [PubMed: 15808935] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81035.1.
[6]	Stratmann A. Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81035.1.
[7]	Wehmeier U.F. Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: SE50/110 EMBL CAJ81035.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y18523 Genomic DNA. Translation: CAJ81035.1.
3D structure databases
ProteinModelPortal	Q27GR1.
ModBase	Search...
Protein family/group databases
CAZy	CBM13. Carbohydrate-Binding Module Family 13. GH59. Glycoside Hydrolase Family 59.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001286. Glyco_hydro_59. IPR013781. Glyco_hydro_subgr_catalytic. IPR017853. Glycoside_hydrolase_SF. IPR008997. Ricin_B-rel_lectin. IPR000772. Ricin_B_lectin. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 2 hits.
PANTHER	PTHR15172. Glyco_hydro_59. 1 hit.
Pfam	PF02057. Glyco_hydro_59. 1 hit. PF00652. Ricin_B_lectin. 1 hit. [Graphical view]
PRINTS	PR00850. GLHYDRLASE59.
SMART	SM00458. RICIN. 1 hit. [Graphical view]
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit. SSF50370. RicinB_like. 1 hit.
PROSITE	PS50231. RICIN_B_LECTIN. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q27GR1_ACTS5

Accession

Primary (citable) accession number: Q27GR1

Entry history

Integrated into UniProtKB/TrEMBL:	April 4, 2006
Last sequence update:	April 4, 2006
Last modified:	September 21, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)