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Protein

Solute carrier family 2, facilitated glucose transporter member 4

Gene

SLC2A4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Insulin-regulated facilitative glucose transporter.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei333MonosaccharideBy similarity1
Binding sitei404MonosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-428790. Facilitative Na+-independent glucose transporters.
R-BTA-70153. Glucose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 4
Alternative name(s):
Glucose transporter type 4, insulin-responsive
Short name:
GLUT-4
Gene namesi
Name:SLC2A4
Synonyms:GLUT4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 24CytoplasmicSequence analysisAdd BLAST24
Transmembranei25 – 45Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini46 – 81ExtracellularSequence analysisAdd BLAST36
Transmembranei82 – 102Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini103 – 111CytoplasmicSequence analysis9
Transmembranei112 – 132Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini133 – 142ExtracellularSequence analysis10
Transmembranei143 – 163Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini164 – 171CytoplasmicSequence analysis8
Transmembranei172 – 192Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini193 – 200ExtracellularSequence analysis8
Transmembranei201 – 221Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini222 – 287CytoplasmicSequence analysisAdd BLAST66
Transmembranei288 – 308Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini309 – 323ExtracellularSequence analysisAdd BLAST15
Transmembranei324 – 344Helical; Name=8Sequence analysisAdd BLAST21
Topological domaini345 – 353CytoplasmicSequence analysis9
Transmembranei354 – 374Helical; Name=9Sequence analysisAdd BLAST21
Topological domaini375 – 384ExtracellularSequence analysis10
Transmembranei385 – 405Helical; Name=10Sequence analysisAdd BLAST21
Topological domaini406 – 417CytoplasmicSequence analysisAdd BLAST12
Transmembranei418 – 438Helical; Name=11Sequence analysisAdd BLAST21
Topological domaini439 – 445ExtracellularSequence analysis7
Transmembranei446 – 466Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini467 – 509CytoplasmicSequence analysisAdd BLAST43

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503611 – 509Solute carrier family 2, facilitated glucose transporter member 4Add BLAST509

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10PhosphoserineBy similarity1
Glycosylationi57N-linked (GlcNAc...)Sequence analysis1
Modified residuei274Phosphoserine; by SGK1By similarity1
Modified residuei486PhosphothreonineBy similarity1
Modified residuei488PhosphoserineBy similarity1

Post-translational modificationi

Sumoylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ27994.
PRIDEiQ27994.

Expressioni

Gene expression databases

BgeeiENSBTAG00000009190.

Interactioni

Subunit structurei

Binds to DAXX. Interacts via its N-terminus with SRFBP1. Interacts with NDUFA9 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012109.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni7 – 13SRFBP1-bindingBy similarity7
Regioni298 – 304Monosaccharide bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi489 – 490Dileucine internalization motifSequence analysis2

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiQ27994.
KOiK07191.
OMAiSHTHRQP.
OrthoDBiEOG091G0A9K.
TreeFamiTF313762.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002441. Glc_transpt_4.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01193. GLUCTRSPORT4.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27994-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSGFQQIGS EDGEPPRQRV TGTLVLAVFS AVLGSLQFGY NIGVINAPQK
60 70 80 90 100
VIEQSYNETW LGRQGPEGPG SIPPGTLTTL WALSVAIFSV GGMISSFLIG
110 120 130 140 150
IISQWLGRKR AMLFNNALAV LGGTLMGLAK AAASYEMLIL GRFFIGAYSG
160 170 180 190 200
LTSGLVPMYV GEIAPTHLRG ALGTLNQLAI VTGILIAQVL GLESMLGTAT
210 220 230 240 250
LWPLLLGITV LPALLQMVLL PLCPESPRYL YIIRNLEGPA RKSLKRLTGW
260 270 280 290 300
ADVSEVLAEL KEEKRKLERE RPLSLLQLLG SHTHRQPLVI AIVLQLSQQL
310 320 330 340 350
SGINAVFYYS TSIFESAGVE KPAYATIGAG VVNTVFTLVS VFLVERAGRR
360 370 380 390 400
TLHLLGLAGM CGCAILMTVA LLLLERVPAM SYVSIVAIFG FVAFFEIGPG
410 420 430 440 450
PIPWFIVAEL FSQGPRPAAM AVAGFSNWTC NFIIGMGFQY VADAMGPYVF
460 470 480 490 500
LLFAVLLLGF FIFTFLKVPE TRGRTFDQIS AVFHRTPSLL EQEVKPSTEL

EYLGPDEHD
Length:509
Mass (Da):55,084
Last modified:May 1, 2007 - v2
Checksum:iD5BC14E2B78B4D01
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti27A → G in BAA21105 (PubMed:9027564).Curated1
Sequence conflicti115N → S in BAA21105 (PubMed:9027564).Curated1
Sequence conflicti181V → D in AAB04950 (PubMed:8925410).Curated1
Sequence conflicti272P → S in BAA21105 (PubMed:9027564).Curated1
Sequence conflicti293V → M in AAR24285 (Ref. 2) Curated1
Sequence conflicti349R → H in BAA21105 (PubMed:9027564).Curated1
Sequence conflicti362G → A in BAA21105 (PubMed:9027564).Curated1
Sequence conflicti404W → C in BAA21105 (PubMed:9027564).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63150 mRNA. Translation: BAA21105.1.
AY458600 mRNA. Translation: AAR24285.1.
BC114082 mRNA. Translation: AAI14083.1.
U18105 mRNA. Translation: AAB04950.1.
RefSeqiNP_777029.1. NM_174604.1.
UniGeneiBt.4391.

Genome annotation databases

EnsembliENSBTAT00000012109; ENSBTAP00000012109; ENSBTAG00000009190.
GeneIDi282359.
KEGGibta:282359.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63150 mRNA. Translation: BAA21105.1.
AY458600 mRNA. Translation: AAR24285.1.
BC114082 mRNA. Translation: AAI14083.1.
U18105 mRNA. Translation: AAB04950.1.
RefSeqiNP_777029.1. NM_174604.1.
UniGeneiBt.4391.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012109.

Proteomic databases

PaxDbiQ27994.
PRIDEiQ27994.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000012109; ENSBTAP00000012109; ENSBTAG00000009190.
GeneIDi282359.
KEGGibta:282359.

Organism-specific databases

CTDi6517.

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiQ27994.
KOiK07191.
OMAiSHTHRQP.
OrthoDBiEOG091G0A9K.
TreeFamiTF313762.

Enzyme and pathway databases

ReactomeiR-BTA-428790. Facilitative Na+-independent glucose transporters.
R-BTA-70153. Glucose transport.

Gene expression databases

BgeeiENSBTAG00000009190.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002441. Glc_transpt_4.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01193. GLUCTRSPORT4.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTR4_BOVIN
AccessioniPrimary (citable) accession number: Q27994
Secondary accession number(s): P79104, Q29RP5, Q6SI69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 2007
Last modified: November 30, 2016
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.