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Protein

Solute carrier family 2, facilitated glucose transporter member 4

Gene

SLC2A4

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Insulin-regulated facilitative glucose transporter.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei333 – 3331MonosaccharideBy similarity
Binding sitei404 – 4041MonosaccharideBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-BTA-428790. Facilitative Na+-independent glucose transporters.
R-BTA-70153. Glucose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 4
Alternative name(s):
Glucose transporter type 4, insulin-responsive
Short name:
GLUT-4
Gene namesi
Name:SLC2A4
Synonyms:GLUT4
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424CytoplasmicSequence analysisAdd
BLAST
Transmembranei25 – 4521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini46 – 8136ExtracellularSequence analysisAdd
BLAST
Transmembranei82 – 10221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini103 – 1119CytoplasmicSequence analysis
Transmembranei112 – 13221Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini133 – 14210ExtracellularSequence analysis
Transmembranei143 – 16321Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini164 – 1718CytoplasmicSequence analysis
Transmembranei172 – 19221Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini193 – 2008ExtracellularSequence analysis
Transmembranei201 – 22121Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini222 – 28766CytoplasmicSequence analysisAdd
BLAST
Transmembranei288 – 30821Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini309 – 32315ExtracellularSequence analysisAdd
BLAST
Transmembranei324 – 34421Helical; Name=8Sequence analysisAdd
BLAST
Topological domaini345 – 3539CytoplasmicSequence analysis
Transmembranei354 – 37421Helical; Name=9Sequence analysisAdd
BLAST
Topological domaini375 – 38410ExtracellularSequence analysis
Transmembranei385 – 40521Helical; Name=10Sequence analysisAdd
BLAST
Topological domaini406 – 41712CytoplasmicSequence analysisAdd
BLAST
Transmembranei418 – 43821Helical; Name=11Sequence analysisAdd
BLAST
Topological domaini439 – 4457ExtracellularSequence analysis
Transmembranei446 – 46621Helical; Name=12Sequence analysisAdd
BLAST
Topological domaini467 – 50943CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Solute carrier family 2, facilitated glucose transporter member 4PRO_0000050361Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101PhosphoserineBy similarity
Glycosylationi57 – 571N-linked (GlcNAc...)Sequence analysis
Modified residuei274 – 2741Phosphoserine; by SGK1By similarity
Modified residuei486 – 4861PhosphothreonineBy similarity
Modified residuei488 – 4881PhosphoserineBy similarity

Post-translational modificationi

Sumoylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ27994.
PRIDEiQ27994.

Interactioni

Subunit structurei

Binds to DAXX. Interacts via its N-terminus with SRFBP1. Interacts with NDUFA9 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012109.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni7 – 137SRFBP1-bindingBy similarity
Regioni298 – 3047Monosaccharide bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi489 – 4902Dileucine internalization motifSequence analysis

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiQ27994.
KOiK07191.
OMAiSHTHRQP.
OrthoDBiEOG7QVM2R.
TreeFamiTF313762.

Family and domain databases

InterProiIPR002441. Glc_transpt_4.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01193. GLUCTRSPORT4.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27994-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSGFQQIGS EDGEPPRQRV TGTLVLAVFS AVLGSLQFGY NIGVINAPQK
60 70 80 90 100
VIEQSYNETW LGRQGPEGPG SIPPGTLTTL WALSVAIFSV GGMISSFLIG
110 120 130 140 150
IISQWLGRKR AMLFNNALAV LGGTLMGLAK AAASYEMLIL GRFFIGAYSG
160 170 180 190 200
LTSGLVPMYV GEIAPTHLRG ALGTLNQLAI VTGILIAQVL GLESMLGTAT
210 220 230 240 250
LWPLLLGITV LPALLQMVLL PLCPESPRYL YIIRNLEGPA RKSLKRLTGW
260 270 280 290 300
ADVSEVLAEL KEEKRKLERE RPLSLLQLLG SHTHRQPLVI AIVLQLSQQL
310 320 330 340 350
SGINAVFYYS TSIFESAGVE KPAYATIGAG VVNTVFTLVS VFLVERAGRR
360 370 380 390 400
TLHLLGLAGM CGCAILMTVA LLLLERVPAM SYVSIVAIFG FVAFFEIGPG
410 420 430 440 450
PIPWFIVAEL FSQGPRPAAM AVAGFSNWTC NFIIGMGFQY VADAMGPYVF
460 470 480 490 500
LLFAVLLLGF FIFTFLKVPE TRGRTFDQIS AVFHRTPSLL EQEVKPSTEL

EYLGPDEHD
Length:509
Mass (Da):55,084
Last modified:May 1, 2007 - v2
Checksum:iD5BC14E2B78B4D01
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti27 – 271A → G in BAA21105 (PubMed:9027564).Curated
Sequence conflicti115 – 1151N → S in BAA21105 (PubMed:9027564).Curated
Sequence conflicti181 – 1811V → D in AAB04950 (PubMed:8925410).Curated
Sequence conflicti272 – 2721P → S in BAA21105 (PubMed:9027564).Curated
Sequence conflicti293 – 2931V → M in AAR24285 (Ref. 2) Curated
Sequence conflicti349 – 3491R → H in BAA21105 (PubMed:9027564).Curated
Sequence conflicti362 – 3621G → A in BAA21105 (PubMed:9027564).Curated
Sequence conflicti404 – 4041W → C in BAA21105 (PubMed:9027564).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63150 mRNA. Translation: BAA21105.1.
AY458600 mRNA. Translation: AAR24285.1.
BC114082 mRNA. Translation: AAI14083.1.
U18105 mRNA. Translation: AAB04950.1.
RefSeqiNP_777029.1. NM_174604.1.
UniGeneiBt.4391.

Genome annotation databases

EnsembliENSBTAT00000012109; ENSBTAP00000012109; ENSBTAG00000009190.
GeneIDi282359.
KEGGibta:282359.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63150 mRNA. Translation: BAA21105.1.
AY458600 mRNA. Translation: AAR24285.1.
BC114082 mRNA. Translation: AAI14083.1.
U18105 mRNA. Translation: AAB04950.1.
RefSeqiNP_777029.1. NM_174604.1.
UniGeneiBt.4391.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000012109.

Proteomic databases

PaxDbiQ27994.
PRIDEiQ27994.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000012109; ENSBTAP00000012109; ENSBTAG00000009190.
GeneIDi282359.
KEGGibta:282359.

Organism-specific databases

CTDi6517.

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiQ27994.
KOiK07191.
OMAiSHTHRQP.
OrthoDBiEOG7QVM2R.
TreeFamiTF313762.

Enzyme and pathway databases

ReactomeiR-BTA-428790. Facilitative Na+-independent glucose transporters.
R-BTA-70153. Glucose transport.

Family and domain databases

InterProiIPR002441. Glc_transpt_4.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport_like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01193. GLUCTRSPORT4.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and mRNA expression of the bovine insulin-responsive glucose transporter (GLUT4)."
    Abe H., Morimatsu M., Nikami H., Miyashige T., Saito M.
    J. Anim. Sci. 75:182-188(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Holstein.
    Tissue: White adipose tissue.
  2. Kang M.-J., Jeong Y.H., Lee S.M., Park H.Y., Yang J.M., Mun S.C., Yoon D.H., Kim D.M.
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Korean.
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Heart ventricle.
  4. "Insulin-sensitive glucose transporter transcript levels in calf muscles assessed with a bovine GLUT4 cDNA fragment."
    Hocquette J.F., Graulet B., Castiglia-Delavaud C., Bornes F., Lepetit N., Ferre P.
    Int. J. Biochem. Cell Biol. 28:795-806(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 108-187.
    Tissue: Muscle.

Entry informationi

Entry nameiGTR4_BOVIN
AccessioniPrimary (citable) accession number: Q27994
Secondary accession number(s): P79104, Q29RP5, Q6SI69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 2007
Last modified: June 8, 2016
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.