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Protein

Myosin-10

Gene

MYH10

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9 (By similarity).By similarity

Caution

Represents a conventional non-muscle myosin. This protein should not be confused with the unconventional myosin-10 (MYO10).Curated

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi178 – 185ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
Biological processCell adhesion, Cell shape
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-5627123 RHO GTPases activate PAKs

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin-10
Alternative name(s):
Cellular myosin heavy chain, type B
Myosin heavy chain 10
Myosin heavy chain, non-muscle IIb
Non-muscle myosin heavy chain B
Short name:
NMMHC-B
Non-muscle myosin heavy chain IIb
Short name:
NMMHC II-b
Short name:
NMMHC-IIB
Gene namesi
Name:MYH10
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:31794 MYH10

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001234201 – 1976Myosin-10Add BLAST1976

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18Omega-N-methylarginineBy similarity1
Modified residuei442N6-acetyllysineBy similarity1
Modified residuei1145PhosphoserineBy similarity1
Modified residuei1241N6-acetyllysineBy similarity1
Modified residuei1301N6-acetyllysineBy similarity1
Modified residuei1645N6-acetyllysineBy similarity1
Modified residuei1930Omega-N-methylarginineBy similarity1
Modified residuei1935PhosphoserineBy similarity1
Modified residuei1937PhosphoserineBy similarity1
Modified residuei1938PhosphoserineBy similarity1
Modified residuei1939PhosphoserineBy similarity1
Modified residuei1940Omega-N-methylarginineBy similarity1
Modified residuei1952PhosphoserineBy similarity1
Modified residuei1956PhosphoserineBy similarity1
Modified residuei1960PhosphothreonineBy similarity1
Modified residuei1975PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by ABL2.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ27991
PeptideAtlasiQ27991
PRIDEiQ27991

Expressioni

Gene expression databases

BgeeiENSBTAG00000021151

Interactioni

Subunit structurei

Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with PLEKHG6. Interacts with ECPAS (By similarity). Interacts with KIF26B (By similarity). Interacts with LARP6. Interacts with MCC. Interacts with C9orf135 homolog (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000028188

Structurei

3D structure databases

ProteinModelPortaliQ27991
SMRiQ27991
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 81Myosin N-terminal SH3-likePROSITE-ProRule annotationAdd BLAST51
Domaini85 – 783Myosin motorPROSITE-ProRule annotationAdd BLAST699
Domaini786 – 815IQPROSITE-ProRule annotationAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni661 – 683Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili845 – 1976Sequence analysisAdd BLAST1132

Domaini

The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils.

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0161 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00760000118919
HOGENOMiHOG000173958
HOVERGENiHBG004704
InParanoidiQ27991
KOiK10352
OMAiRSKWDDE
OrthoDBiEOG091G009J
TreeFamiTF333601

Family and domain databases

Gene3Di2.30.30.360, 1 hit
3.40.850.10, 3 hits
4.10.270.10, 1 hit
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR027401 Myosin_IQ_contain_sf
IPR004009 Myosin_N
IPR008989 Myosin_S1_N
IPR002928 Myosin_tail
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PF00063 Myosin_head, 1 hit
PF02736 Myosin_N, 1 hit
PF01576 Myosin_tail_1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 1 hit
SM00242 MYSc, 1 hit
SUPFAMiSSF50084 SSF50084, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS51456 MYOSIN_MOTOR, 1 hit
PS51844 SH3_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q27991-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQRTGLEDP ERYLFVDRAV IYNPATQADW TAKKLVWIPS ERHGFEAASI
60 70 80 90 100
KEERGDEVLV ELAENGKKAM VNKDDIQKMN PPKFSKVEDM AELTCLNEAS
110 120 130 140 150
VLHNLKDRYY SGLIYTYSGL FCVVINPYKN LPIYSENIIE MYRGKKRHEM
160 170 180 190 200
PPHIYAISES AYRCMLQDRE DQSILCTGES GAGKTENTKK VIQYLAHVAS
210 220 230 240 250
SHKGRKDHNI PGELERQLLQ ANPILESFGN AKTVKNDNSS RFGKFIRINF
260 270 280 290 300
DVTGYIVGAN IETYLLEKSR AVRQAKDERT FHIFYQLLSG AGEHLKSDLL
310 320 330 340 350
LEGFNNYRFL SNGYIPIPGQ QDKDNFQETM EAMHIMGFSH EEILSMLKVV
360 370 380 390 400
SSVLQFGNIS FKKERNTDQA SMPENTVAQK LCHLLGMNVM EFTRAILTPR
410 420 430 440 450
IKVGRDYVQK AQTKEQADFA VEALAKATYE RLFRWLVHRI NKALDRTKRQ
460 470 480 490 500
GASFIGILDI AGFEIFELNS FEQLCINYTN EKLQQLFNHT MFILEQEEYQ
510 520 530 540 550
REGIEWNFID FGLDLQPCID LIERPANPPG VLALLDEECW FPKATDKTFV
560 570 580 590 600
EKLVQEQGSH SKFQKPRQLK DKADFCIIHY AGKVDYKADE WLMKNMDPLN
610 620 630 640 650
DNVATLLHQS SDRFVAELWK DVDRIVGLDQ VTGMTETAFG SAYKTKKGMF
660 670 680 690 700
RTVGQLYKES LTKLMATLRN TNPNFVRCII PNHEKRAGKL DPHLVLDQLR
710 720 730 740 750
CNGVLEGIRI CRQGFPNRIV FQEFRQRYEI LTPNAIPKGF MDGKQACERM
760 770 780 790 800
IRALELDPNL YRIGQSKIFF RAGVLAHLEE ERDLKITDII IFFQAVCRGY
810 820 830 840 850
LARKAFAKKQ QQLSALKVLQ RNCAAYLKLR HWQWWRVFTK VKPLLQVTRQ
860 870 880 890 900
EEELQAKDEE LLKVKEKQTK VEGELEEMER KHQQLLEEKN ILAEQLQAET
910 920 930 940 950
ELFAEAEEMR ARLAAKKQEL EEILHDLESR VEEEEERNQI LQNEKKKMQA
960 970 980 990 1000
HIQDLEEQLD EEEGARQKLQ LEKVTAEAKI KKMEEEILLL EDQNSKFIKE
1010 1020 1030 1040 1050
KKLMEDRIAE CSSQLAEEEE KAKNLAKIRN KQEVMISDLE ERLKKEEKTR
1060 1070 1080 1090 1100
QELEKAKRKL DGETTDLQDQ IAELQAQIDE LKIQVAKKEE ELQGALARGD
1110 1120 1130 1140 1150
DETLHKNNAL KVVRELQAQI AELQEDFESE KASRNKAEKQ KRDLSEELEA
1160 1170 1180 1190 1200
LKTELEDTLD TTAAQQELRT KREQEVAELK KALEEETKSH EAQIQDMRQR
1210 1220 1230 1240 1250
HATALEELSE QLEQAKRFKA NLEKNKQGLE TDNKELACEV KVLQQVKAES
1260 1270 1280 1290 1300
EHKRKKLDAQ VQELHAKVSE GDRLRVELAE KANKLQNELD NVSTLLEEAE
1310 1320 1330 1340 1350
KKGIKFAKDA AGLESQLQDT QELLQEETRQ KLNLSSRIRQ LEEERSSLQE
1360 1370 1380 1390 1400
QQEEEEEARR SLEKQLQALQ AQLTDTKKKV DDDLGTIENL EEAKKKLLKD
1410 1420 1430 1440 1450
VEVLSQRLEE KALAYDKLEK TKTRLQQELD DLLVDLDHQR QIVSNLEKKQ
1460 1470 1480 1490 1500
KKFDQLLAEE KNISARYAEE RDRAEAEARE KETKALSLAR ALEEALEARE
1510 1520 1530 1540 1550
EAERQNKQLR ADMEDLMSSK DDVGKNVHEL EKSKRALEQQ VEEMRTQLEE
1560 1570 1580 1590 1600
LEDELQATED AKLRLEVNMQ AMKAQFERDL QTRDEQNEEK KRLLIKQVRE
1610 1620 1630 1640 1650
LEAELEDERK QRALAVASKK KMEIDLKDLE AQIEAANKAR DEVIKQLRKL
1660 1670 1680 1690 1700
QAQMKDYQRE LEEARASRDE IFAQSKESEK KLKSLEAEIL QLQEELASSE
1710 1720 1730 1740 1750
RARRHAEQER DELADEIANS ASGKSALLDE KRRLEARIAQ LEEELEEEQS
1760 1770 1780 1790 1800
NMELLNDRFR KTTLQVDTLN TELAAERSAA QKSDNARQQL ERQNKELKAK
1810 1820 1830 1840 1850
LQELEGAVKS KFKATISALE AKIGQLEEQL EQEAKERAAA NKLVRRTEKK
1860 1870 1880 1890 1900
LKEIFMQVED ERRHADQYKE QMEKANARMK QLKRQLEEAE EEATRANASR
1910 1920 1930 1940 1950
RKLQRELDDA TEANEGLSRE VSTLKNRLRR GGPISFSSSR SGRRQLHIEG
1960 1970
ASLELSDDDT ESKTSDINET QPPQSE
Length:1,976
Mass (Da):229,099
Last modified:August 1, 1999 - v2
Checksum:i6144354451C0F790
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB022023 mRNA Translation: BAA36494.1
U15716 mRNA Translation: AAA87715.1
RefSeqiNP_777259.1, NM_174834.1
UniGeneiBt.4057
Bt.92698

Genome annotation databases

EnsembliENSBTAT00000028188; ENSBTAP00000028188; ENSBTAG00000021151
GeneIDi317655
KEGGibta:317655

Similar proteinsi

Entry informationi

Entry nameiMYH10_BOVIN
AccessioniPrimary (citable) accession number: Q27991
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: August 1, 1999
Last modified: April 25, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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