Q27975 (HS71A_BOVIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Heat shock 70 kDa protein 1A

Alternative name(s):
Heat shock 70 kDa protein 1
Short name=HSP70.1

Gene names

Name:	HSPA1A
Synonyms:	HSP70-1

Organism

Bos taurus (Bovine)

Taxonomic identifier

9913 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos

Protein attributes

Sequence length	641 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage By similarity.
Subunit structure	Interacts with IRAK1BP1, DNAAF2 and TSC2 By similarity. Interacts with TERT; the interaction occurs in the absence of the RNA component, TERC, and dissociates once the TERT complex has formed By similarity.
Induction	By heat shock.
Sequence similarities	Belongs to the heat shock protein 70 family.

Ontologies

Keywords
Biological process	Stress response
Ligand	ATP-binding Nucleotide-binding
Molecular function	Chaperone
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	response to stress Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 641	641	Heat shock 70 kDa protein 1A		PRO_0000078245
Experimental info
	Sequence conflict	57	1	N → S in AAT75223. Ref.3
	Sequence conflict	89	1	H → E in AAA73914. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q27975 [UniParc]. Last modified December 21, 2004. Version 2. Checksum: 6FAC1F30540E80F9	FASTA	641	70,259
	10 20 30 40 50 60 MAKNMAIGID LGTTYSCVGV FQHGKVEIIA NDQGNRTTPS YVAFTDTERL IGDAAKNQVA 70 80 90 100 110 120 LNPQNTVFDA KRLIGRKFGD PVVQSDMKHW PFRVINDGDK PKVQVSYKGE TKAFYPEEIS 130 140 150 160 170 180 SMVLTKMKEI AEAYLGHPVT NAVITVPAYF NDSQRQATKD AGVIAGLNVL RIINEPTAAA 190 200 210 220 230 240 IAYGLDRTGK GERNVLIFDL GGGTFDVSIL TIDDGIFEVK ATAGDTHLGG EDFDNRLVNH 250 260 270 280 290 300 FVEEFKRKHK KDISQNKRAV RRLRTACERA KRTLSSSTQA SLEIDSLFEG IDFYTSITRA 310 320 330 340 350 360 RFEELCSDLF RSTLEPVEKA LRDAKLDKAQ IHDLVLVGGS TRIPKVQKLL QDFFNGRDLN 370 380 390 400 410 420 KSINPDEAVA YGAAVQAAIL MGDKSENVQD LLLLDVAPLS LGLETAGGVM TALIKRNSTI 430 440 450 460 470 480 PTKQTQIFTT YSDNQPGVLI QVYEGERAMT RDNNLLGRFE LSGIPPAPRG VPQIEVTFDI 490 500 510 520 530 540 DANGILNVTA TDKSTGKANK ITITNDKGRL SKEEIERMVQ EAEKYKAEDE VQRERVSAKN 550 560 570 580 590 600 ALESYAFNMK SAVEDEGLKG KISEADKKKV LDKCQEVISW LDANTLAEKD EFEHKRKELE 610 620 630 640 QVCNPIISRL YQGAGGPGAG GFGAQGPKGG SGSGPTIEEV D

References

[1]	"Chemical modifications of a recombinant bovine stress-inducible 70 kDa heat-shock protein (Hsp70) mimics Hsp70 isoforms from tissues." Gutierrez J.A., Guerriero V. Biochem. J. 305:197-203(1995) [PubMed: 7826329] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skeletal muscle.
[2]	"Deletion of one of the duplicated Hsp70 genes causes hereditary myopathy of diaphragmatic muscles in Holstein-Friesian cattle." Sugimoto M., Furuoka H., Sugimoto Y. Anim. Genet. 34:191-197(2003) [PubMed: 12755819] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: Holstein-Friesian.
[3]	"Molecular cloning of bovine cardiac muscle heat-shock protein 70 kDa and its phosphorylation by cAMP-dependent protein kinase in vitro." Lakshmikuttyamma A., Selvakumar P., Anderson D.H., Datla R.S., Sharma R.K. Biochemistry 43:13340-13347(2004) [PubMed: 15491140] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart muscle.
[4]	"An AluI polymorphism at the bovine 70 kD heat-shock protein-1 (HSP70-1) locus." Grosz M.D., Skow L.C., Stone R.T. Anim. Genet. 25:196-196(1994) [PubMed: 7943958] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 212-641. Strain: Angus.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U09861 mRNA. Translation: AAA73914.1. AY149618 Genomic DNA. Translation: AAN78092.1. AY149619 Genomic DNA. Translation: AAN78094.1. AY662497 mRNA. Translation: AAT75223.1. U02891 Unassigned DNA. Translation: AAA03450.1.
IPI	IPI00711031.
PIR	S53357.
RefSeq	NP_776975.1. NM_174550.1.
UniGene	Bt.49659.
3D structure databases
ProteinModelPortal	Q27975.
SMR	Q27975. Positions 1-619.
ModBase	Search...
Protein-protein interaction databases
STRING	Q27975.
Proteomic databases
PRIDE	Q27975.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSBTAT00000017500; ENSBTAP00000017500; ENSBTAG00000025441.
GeneID	281825.
KEGG	bta:281825.
Organism-specific databases
CTD	3303.
Phylogenomic databases
eggNOG	maNOG16200.
GeneTree	ENSGT00550000074467.
HOVERGEN	HBG051845.
InParanoid	Q27975.
OMA	MAKSTAI.
OrthoDB	EOG4W6NVK.
PhylomeDB	Q27975.
Family and domain databases
InterPro	IPR018181. Heat_shock_70_CS. IPR001023. Hsp70. IPR013126. Hsp_70. [Graphical view]
KO	K03283.
PANTHER	PTHR19375. Hsp70. 1 hit.
Pfam	PF00012. HSP70. 1 hit. [Graphical view]
PRINTS	PR00301. HEATSHOCK70.
PROSITE	PS00297. HSP70_1. 1 hit. PS00329. HSP70_2. 1 hit. PS01036. HSP70_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HS71A_BOVIN

Accession

Primary (citable) accession number: Q27975
Secondary accession number(s): Q27964, Q6DLW1, Q7YQF7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	December 21, 2004
Last modified:	November 16, 2011
This is version 71 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program