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Protein

Chondroadherin

Gene

CHAD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha2beta1. May play an important role in the regulation of chondrocyte growth and proliferation.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroadherin
Alternative name(s):
38 kDa bone protein
Cartilage leucine-rich protein
Cleaved into the following chain:
Gene namesi
Name:CHAD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Or 23; in some isoform(s)1 PublicationAdd BLAST24
ChainiPRO_000003277125 – 361ChondroadherinAdd BLAST337
ChainiPRO_000003277225 – 352Chondroadherin minor formAdd BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 40By similarity
Glycosylationi146O-linked (GalNAc...) serineSequence analysis1
Disulfide bondi306 ↔ 348
Disulfide bondi308 ↔ 328

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ27972.
PRIDEiQ27972.

Expressioni

Tissue specificityi

Cartilage.

Interactioni

Subunit structurei

Mostly monomeric. Interacts with collagen type II (By similarity).By similarity

Protein-protein interaction databases

IntActiQ27972. 1 interactor.
STRINGi9913.ENSBTAP00000028386.

Structurei

3D structure databases

ProteinModelPortaliQ27972.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 54LRRNTAdd BLAST30
Repeati78 – 99LRR 1Add BLAST22
Repeati102 – 123LRR 2Add BLAST22
Repeati126 – 147LRR 3Add BLAST22
Repeati150 – 171LRR 4Add BLAST22
Repeati174 – 195LRR 5Add BLAST22
Repeati198 – 219LRR 6Add BLAST22
Repeati222 – 243LRR 7Add BLAST22
Repeati247 – 268LRR 8Add BLAST22
Repeati271 – 292LRR 9Add BLAST22
Domaini302 – 350LRRCTAdd BLAST49

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000013150.
HOVERGENiHBG005324.
InParanoidiQ27972.
KOiK06248.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
PfamiView protein in Pfam
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 10 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q27972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPMLLLXL SLGLLASLLP ALAACPQNCH CHSDLQHVIC DKVGLQKIPK
60 70 80 90 100
VSEKTKLLNL QRNNFPVLAT NSFRAMPNLV SLHLQHCQIR EVAAGAFRGL
110 120 130 140 150
KQLIYLYLSH NDIRVLRAGA FDDLTELTYL YLDHNKVTEL PRGLLSPLVN
160 170 180 190 200
LFILQLNNNK IRELRSGAFQ GAKDLRWLYL SENSLSSLQP GALDDVENLA
210 220 230 240 250
KFYLDRNQLS SYPSAALSKL RVVEELKLSH NPLKSIPDNA FQSFGRYLET
260 270 280 290 300
LWLDNTNLEK FSDGAFLGVT TLKHVHLENN RLHQLPSNFP FDSLETLTLT
310 320 330 340 350
NNPWKCTCQL RGLRRWLEAK TSRPDATCAS PAKFRGQHIR DTDAFRGCKF
360
PTKRSKKAGR H
Length:361
Mass (Da):40,885
Last modified:November 1, 1996 - v1
Checksum:iDA79DC98AD3DD1F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25C → Y AA sequence (PubMed:7814406).Curated1
Sequence conflicti29C → W AA sequence (PubMed:7814406).Curated1
Sequence conflicti31C → H AA sequence (PubMed:7814406).Curated1
Sequence conflicti40C → L AA sequence (PubMed:7814406).Curated1
Sequence conflicti52S → R AA sequence (PubMed:7814406).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08018 mRNA. Translation: AAA21330.1.
PIRiA53860.
RefSeqiNP_776444.1. NM_174019.2.
UniGeneiBt.91648.

Genome annotation databases

GeneIDi281069.
KEGGibta:281069.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08018 mRNA. Translation: AAA21330.1.
PIRiA53860.
RefSeqiNP_776444.1. NM_174019.2.
UniGeneiBt.91648.

3D structure databases

ProteinModelPortaliQ27972.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ27972. 1 interactor.
STRINGi9913.ENSBTAP00000028386.

Proteomic databases

PaxDbiQ27972.
PRIDEiQ27972.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi281069.
KEGGibta:281069.

Organism-specific databases

CTDi1101.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000013150.
HOVERGENiHBG005324.
InParanoidiQ27972.
KOiK06248.

Family and domain databases

Gene3Di3.80.10.10. 3 hits.
InterProiView protein in InterPro
IPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
PfamiView protein in Pfam
PF00560. LRR_1. 1 hit.
PF13855. LRR_8. 3 hits.
PF01462. LRRNT. 1 hit.
SMARTiView protein in SMART
SM00369. LRR_TYP. 9 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiView protein in PROSITE
PS51450. LRR. 10 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCHAD_BOVIN
AccessioniPrimary (citable) accession number: Q27972
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 10, 2017
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.