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Protein

Chondroadherin

Gene

CHAD

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha2beta1. May play an important role in the regulation of chondrocyte growth and proliferation.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroadherin
Alternative name(s):
38 kDa bone protein
Cartilage leucine-rich protein
Cleaved into the following chain:
Gene namesi
Name:CHAD
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Or 23; in some isoform(s)1 PublicationAdd BLAST24
ChainiPRO_000003277125 – 361ChondroadherinAdd BLAST337
ChainiPRO_000003277225 – 352Chondroadherin minor formAdd BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 40By similarity
Glycosylationi146O-linked (GalNAc...) serineSequence analysis1
Disulfide bondi306 ↔ 348
Disulfide bondi308 ↔ 328

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ27972
PRIDEiQ27972

Expressioni

Tissue specificityi

Cartilage.

Interactioni

Subunit structurei

Mostly monomeric. Interacts with collagen type II (By similarity).By similarity

Protein-protein interaction databases

IntActiQ27972, 1 interactor
STRINGi9913.ENSBTAP00000028386

Structurei

3D structure databases

ProteinModelPortaliQ27972
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 54LRRNTAdd BLAST30
Repeati78 – 99LRR 1Add BLAST22
Repeati102 – 123LRR 2Add BLAST22
Repeati126 – 147LRR 3Add BLAST22
Repeati150 – 171LRR 4Add BLAST22
Repeati174 – 195LRR 5Add BLAST22
Repeati198 – 219LRR 6Add BLAST22
Repeati222 – 243LRR 7Add BLAST22
Repeati247 – 268LRR 8Add BLAST22
Repeati271 – 292LRR 9Add BLAST22
Domaini302 – 350LRRCTAdd BLAST49

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
HOGENOMiHOG000013150
HOVERGENiHBG005324
InParanoidiQ27972
KOiK06248

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 3 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 9 hits
SM00082 LRRCT, 1 hit
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 10 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q27972-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARPMLLLXL SLGLLASLLP ALAACPQNCH CHSDLQHVIC DKVGLQKIPK
60 70 80 90 100
VSEKTKLLNL QRNNFPVLAT NSFRAMPNLV SLHLQHCQIR EVAAGAFRGL
110 120 130 140 150
KQLIYLYLSH NDIRVLRAGA FDDLTELTYL YLDHNKVTEL PRGLLSPLVN
160 170 180 190 200
LFILQLNNNK IRELRSGAFQ GAKDLRWLYL SENSLSSLQP GALDDVENLA
210 220 230 240 250
KFYLDRNQLS SYPSAALSKL RVVEELKLSH NPLKSIPDNA FQSFGRYLET
260 270 280 290 300
LWLDNTNLEK FSDGAFLGVT TLKHVHLENN RLHQLPSNFP FDSLETLTLT
310 320 330 340 350
NNPWKCTCQL RGLRRWLEAK TSRPDATCAS PAKFRGQHIR DTDAFRGCKF
360
PTKRSKKAGR H
Length:361
Mass (Da):40,885
Last modified:November 1, 1996 - v1
Checksum:iDA79DC98AD3DD1F8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25C → Y AA sequence (PubMed:7814406).Curated1
Sequence conflicti29C → W AA sequence (PubMed:7814406).Curated1
Sequence conflicti31C → H AA sequence (PubMed:7814406).Curated1
Sequence conflicti40C → L AA sequence (PubMed:7814406).Curated1
Sequence conflicti52S → R AA sequence (PubMed:7814406).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08018 mRNA Translation: AAA21330.1
PIRiA53860
RefSeqiNP_776444.1, NM_174019.2
UniGeneiBt.91648

Genome annotation databases

GeneIDi281069
KEGGibta:281069

Similar proteinsi

Entry informationi

Entry nameiCHAD_BOVIN
AccessioniPrimary (citable) accession number: Q27972
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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