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Protein

Unconventional myosin-Ic

Gene

MYO1C

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity).By similarity
Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation (By similarity).By similarity

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei88ATPBy similarity1
Binding sitei96ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi139 – 148ATPBy similarity10
Nucleotide bindingi192 – 196ATPBy similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding, Motor protein, Myosin
Biological processmRNA transport, Protein transport, Translocation, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-2029482 Regulation of actin dynamics for phagocytic cup formation
R-BTA-5250924 B-WICH complex positively regulates rRNA expression

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ic
Alternative name(s):
Myosin I beta
Short name:
MMI-beta
Short name:
MMIb
Gene namesi
Name:MYO1C
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Organism-specific databases

VGNCiVGNC:31818 MYO1C

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002260481 – 1063Unconventional myosin-IcAdd BLAST1063

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei383N6-methyllysineBy similarity1
Modified residuei408PhosphoserineBy similarity1
Modified residuei486N6-acetyllysineBy similarity1
Modified residuei536PhosphoserineBy similarity1
Modified residuei864PhosphoserineBy similarity1
Modified residuei1041PhosphoserineBy similarity1
Isoform 2 (identifier: Q27966-2)
Modified residuei1N-acetylmethionineBy similarity1

Post-translational modificationi

Isoform 2 contains a N-acetylmethionine at position 1.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ27966
PeptideAtlasiQ27966
PRIDEiQ27966

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSBTAG00000001332

Interactioni

Subunit structurei

Interacts with RPS6 and actin. Interacts (via its IQ motifs) with CABP1 and CIB1; the interaction with CABP1 and CIB1 is calcium-dependent. Interacts (via tail domain) with PLEKHB1 (via PH domain); the interaction is not affected by the presence or absence of calcium and CALM. Interacts with POLR1A and POLR2A. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Interacts with YWHAB; this precludes interaction with CALM. Likewise, interaction with CALM precludes interaction with YWHAB (By similarity). Interacts (via its IQ motifs) with CALM. Interacts with LLPH (By similarity).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029554

Structurei

3D structure databases

ProteinModelPortaliQ27966
SMRiQ27966
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 731Myosin motorPROSITE-ProRule annotationAdd BLAST685
Domaini734 – 757IQ 1PROSITE-ProRule annotationAdd BLAST24
Domaini758 – 786IQ 2PROSITE-ProRule annotationAdd BLAST29
Domaini885 – 1059TH1PROSITE-ProRule annotationAdd BLAST175

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni608 – 630Actin-bindingPROSITE-ProRule annotationAdd BLAST23

Domaini

Binds directly to large unilamellar vesicles (LUVs) containing phosphatidylinositol 4,5-bisphosphate (PIP2) or inositol 1,4,5-trisphosphate (InsP3). The PIP2-binding site corresponds to the myosin tail domain (PH-like) present in its tail domain (By similarity).By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00900000140778
HOGENOMiHOG000260264
InParanoidiQ27966
KOiK10356
OMAiDAYQAKK
OrthoDBiEOG091G0136
TreeFamiTF312960

Family and domain databases

CDDicd01378 MYSc_Myo1, 1 hit
Gene3Di3.40.850.10, 3 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR036961 Kinesin_motor_dom_sf
IPR001609 Myosin_head_motor_dom
IPR010926 Myosin_TH1
IPR036072 MYSc_Myo1
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00612 IQ, 2 hits
PF00063 Myosin_head, 1 hit
PF06017 Myosin_TH1, 1 hit
PRINTSiPR00193 MYOSINHEAVY
SMARTiView protein in SMART
SM00015 IQ, 2 hits
SM00242 MYSc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 2 hits
PS51456 MYOSIN_MOTOR, 1 hit
PS51757 TH1, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q27966-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALQVELIPT GEIIRVVHPH RPCKLALGSD GVRVTMESAL TARDRVGVQD
60 70 80 90 100
FVLLENFTSE AAFIENLRRR FRENLIYTYI GPVLVSVNPY RDLQIYSRQH
110 120 130 140 150
MERYRGVSFY EVPPHLFAVA DTVYRALRTE RRDQAVMISG ESGAGKTEAT
160 170 180 190 200
KRLLQFYAET CPAPERGGAV RDRLLQSNPV LEAFGNAKTL RNDNSSRFGK
210 220 230 240 250
YMDVQFDFKG APVGGHILSY LLEKSRVVHQ NHGERNFHIF YQLLEGGEEE
260 270 280 290 300
TLRRLGLERN PQSYLYLVKG QCAKVSSIND KSDWKVVRKA LTVIDFTEDE
310 320 330 340 350
VEDLLSIVAS VLHLGNTHFA ADEESNAQVT TENQLKYLTR LLGVEGSTLR
360 370 380 390 400
EALTHRKIIA KGEELLSPLN LEQAAYARDA LAKAVYSRTF TWLVAKINRS
410 420 430 440 450
LASKDAESPS WRSTTVLGLL DIYGFEVFQH NSFEQFCINY CNEKLQQLFI
460 470 480 490 500
ELTLKSEQEE YEAEGIAWEP VQYFNNKIIC DLVEEKFKGI ISILDEECLR
510 520 530 540 550
PGEATDLTFL EKLEDTIKQH PHFLTHKLAD QRTRKSLDRG EFRLLHYAGE
560 570 580 590 600
VTYNVTGFLD KNNDLLFRNL KETMCSSENP ILGQCFDRSE LSDKKRPETV
610 620 630 640 650
ATQFKMSLLE LVEILKSKEP AYVRCIKPND SKQPGRFDEV LIRHQVKYLG
660 670 680 690 700
LMENLRVRRA GFAYRRKYEA FLQRYKSLCP ETWPTWTGRP QDGVTVLVRH
710 720 730 740 750
LGYKPEEYKM GRTKIFIRFP KTLFATEDAL EIRRQSLATK IQATWRGFHC
760 770 780 790 800
RQKFLRVKRS AICIQSWWRG TLGRRKAAKR KWAAQTIRRL IQGFILRHAP
810 820 830 840 850
RCPENAFFVD HVRTSFLLNL RRQLPRNILD TSWPTPPPAL REASELLREL
860 870 880 890 900
CRKNMVWKYC RSISPEWKQQ LQQKAVASEI FKGKKDNYPQ SVPRLFISTR
910 920 930 940 950
LGADEINPRV LQALGSEPIQ YAVPVVKYDR KGYKPRSRQL LLTPNAVVIV
960 970 980 990 1000
EDAKVKQRIE YTNLTGISVS SLSDSLFVLH VQREDNKQKG DVVLQSDHVI
1010 1020 1030 1040 1050
ETLTKTALSA DRVNNININQ GSITFAGGPG RDGIIDFTPG SELLITKAKN
1060
GHLAVVAPRL NSR
Length:1,063
Mass (Da):121,936
Last modified:April 14, 2009 - v3
Checksum:i682486667418FA51
GO
Isoform 2 (identifier: Q27966-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Show »
Length:1,028
Mass (Da):118,147
Checksum:i0D9BE483963A6477
GO
Isoform 3 (identifier: Q27966-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MALQVELIPTGEIIRVVHPHRPCKL → MRYRAS

Note: Gene prediction based on EST data.
Show »
Length:1,044
Mass (Da):119,868
Checksum:iECC5B8288E82A161
GO

Sequence cautioni

The sequence AAI40535 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42A → C in CAA80476 (PubMed:8022785).Curated1
Sequence conflicti132R → G in AAA17565 (PubMed:8313976).Curated1
Sequence conflicti355H → N in CAA80476 (PubMed:8022785).Curated1
Sequence conflicti398N → K in CAA80476 (PubMed:8022785).Curated1
Sequence conflicti421D → G in AAA17565 (PubMed:8313976).Curated1
Sequence conflicti579N → I in CAA80476 (PubMed:8022785).Curated1
Sequence conflicti585C → F in CAA80476 (PubMed:8022785).Curated1
Sequence conflicti593D → S in AAA17565 (PubMed:8313976).Curated1
Sequence conflicti690P → R in AAA17565 (PubMed:8313976).Curated1
Sequence conflicti747G → A in CAA80476 (PubMed:8022785).Curated1
Sequence conflicti757V → L in CAA80476 (PubMed:8022785).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0368601 – 35Missing in isoform 2. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_0368591 – 25MALQV…RPCKL → MRYRAS in isoform 3. 1 PublicationAdd BLAST25

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03420 mRNA Translation: AAA17565.1
BC140534 mRNA Translation: AAI40535.1 Different initiation.
EG705719 mRNA No translation available.
Z22852 mRNA Translation: CAA80476.1
PIRiS41749
RefSeqiNP_776821.3, NM_174396.3 [Q27966-1]
XP_005220121.1, XM_005220064.1 [Q27966-3]
XP_005220122.1, XM_005220065.2 [Q27966-2]
UniGeneiBt.4957

Genome annotation databases

EnsembliENSBTAT00000029554; ENSBTAP00000029553; ENSBTAG00000001332 [Q27966-3]
ENSBTAT00000029555; ENSBTAP00000029554; ENSBTAG00000001332 [Q27966-1]
GeneIDi281937
KEGGibta:281937

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiMYO1C_BOVIN
AccessioniPrimary (citable) accession number: Q27966
Secondary accession number(s): A5D7F3, Q28138
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: April 14, 2009
Last modified: May 23, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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