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Protein

Unconventional myosin-Ic

Gene

MYO1C

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes (By similarity).By similarity
Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei88 – 881ATPBy similarity
Binding sitei96 – 961ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi139 – 14810ATPBy similarity
Nucleotide bindingi192 – 1965ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Myosin

Keywords - Biological processi

mRNA transport, Protein transport, Translocation, Transport

Keywords - Ligandi

Actin-binding, ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-BTA-5250924. B-WICH complex positively regulates rRNA expression.

Names & Taxonomyi

Protein namesi
Recommended name:
Unconventional myosin-Ic
Alternative name(s):
Myosin I beta
Short name:
MMI-beta
Short name:
MMIb
Gene namesi
Name:MYO1C
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Chromosome 19

Subcellular locationi

Isoform 3 :
  • Nucleusnucleolus By similarity
  • Nucleusnucleoplasm By similarity
  • Nucleusnuclear pore complex By similarity

  • Note: In the nucleolus, is localized predominantly in dense fibrillar component (DFC) and in granular component (GC). Accumulates strongly in DFC and GC during activation of transcription. Colocalizes with transcription sites. Colocalizes in the granular cortex at the periphery of the nucleolus with RPS6. Colocalizes in nucleoplasm with RPS6 and actin that are in contact with RNP particles. Colocalizes with RPS6 at the nuclear pore level. Colocalizes with RNA polymerase II in the nucleus. Colocalizes with RNA polymerase I in nucleoli (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane, Nuclear pore complex, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10631063Unconventional myosin-IcPRO_0000226048Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei383 – 3831N6-methyllysineBy similarity
Modified residuei408 – 4081PhosphoserineBy similarity
Modified residuei486 – 4861N6-acetyllysineBy similarity
Modified residuei536 – 5361PhosphoserineBy similarity
Modified residuei864 – 8641PhosphoserineBy similarity
Modified residuei1041 – 10411PhosphoserineBy similarity
Isoform 2 (identifier: Q27966-2)
Modified residuei1 – 11N-acetylmethionineBy similarity

Post-translational modificationi

Isoform 2 contains a N-acetylmethionine at position 1.By similarity

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ27966.
PeptideAtlasiQ27966.
PRIDEiQ27966.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiENSBTAG00000001332.

Interactioni

Subunit structurei

Interacts with RPS6 and actin. Interacts (via its IQ motifs) with CABP1 and CIB1; the interaction with CABP1 and CIB1 is calcium-dependent. Interacts (via tail domain) with PLEKHB1 (via PH domain); the interaction is not affected by the presence or absence of calcium and CALM. Interacts with POLR1A and POLR2A. Component of the B-WICH complex, at least composed of SMARCA5/SNF2H, BAZ1B/WSTF, SF3B1, DEK, MYO1C, ERCC6, MYBBP1A and DDX21. Interacts with YWHAB; this precludes interaction with CALM. Likewise, interaction with CALM precludes interaction with YWHAB (By similarity). Interacts (via its IQ motifs) with CALM.By similarity2 Publications

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029554.

Structurei

3D structure databases

ProteinModelPortaliQ27966.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 731685Myosin motorAdd
BLAST
Domaini734 – 75724IQ 1PROSITE-ProRule annotationAdd
BLAST
Domaini758 – 78629IQ 2PROSITE-ProRule annotationAdd
BLAST
Domaini885 – 1059175TH1PROSITE-ProRule annotationAdd
BLAST

Domaini

Binds directly to large unilamellar vesicles (LUVs) containing phosphatidylinositol 4,5-bisphosphate (PIP2) or inositol 1,4,5-trisphosphate (InsP3). The PIP2-binding site corresponds to the myosin tail domain (PH-like) present in its tail domain (By similarity).By similarity

Sequence similaritiesi

Contains 2 IQ domains.PROSITE-ProRule annotation
Contains 1 myosin motor domain.Curated
Contains 1 TH1 (class I myosin tail homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOGENOMiHOG000260264.
InParanoidiQ27966.
KOiK10356.
OMAiELCIKNM.
OrthoDBiEOG091G0136.
TreeFamiTF312960.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 2 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 2 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q27966-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALQVELIPT GEIIRVVHPH RPCKLALGSD GVRVTMESAL TARDRVGVQD
60 70 80 90 100
FVLLENFTSE AAFIENLRRR FRENLIYTYI GPVLVSVNPY RDLQIYSRQH
110 120 130 140 150
MERYRGVSFY EVPPHLFAVA DTVYRALRTE RRDQAVMISG ESGAGKTEAT
160 170 180 190 200
KRLLQFYAET CPAPERGGAV RDRLLQSNPV LEAFGNAKTL RNDNSSRFGK
210 220 230 240 250
YMDVQFDFKG APVGGHILSY LLEKSRVVHQ NHGERNFHIF YQLLEGGEEE
260 270 280 290 300
TLRRLGLERN PQSYLYLVKG QCAKVSSIND KSDWKVVRKA LTVIDFTEDE
310 320 330 340 350
VEDLLSIVAS VLHLGNTHFA ADEESNAQVT TENQLKYLTR LLGVEGSTLR
360 370 380 390 400
EALTHRKIIA KGEELLSPLN LEQAAYARDA LAKAVYSRTF TWLVAKINRS
410 420 430 440 450
LASKDAESPS WRSTTVLGLL DIYGFEVFQH NSFEQFCINY CNEKLQQLFI
460 470 480 490 500
ELTLKSEQEE YEAEGIAWEP VQYFNNKIIC DLVEEKFKGI ISILDEECLR
510 520 530 540 550
PGEATDLTFL EKLEDTIKQH PHFLTHKLAD QRTRKSLDRG EFRLLHYAGE
560 570 580 590 600
VTYNVTGFLD KNNDLLFRNL KETMCSSENP ILGQCFDRSE LSDKKRPETV
610 620 630 640 650
ATQFKMSLLE LVEILKSKEP AYVRCIKPND SKQPGRFDEV LIRHQVKYLG
660 670 680 690 700
LMENLRVRRA GFAYRRKYEA FLQRYKSLCP ETWPTWTGRP QDGVTVLVRH
710 720 730 740 750
LGYKPEEYKM GRTKIFIRFP KTLFATEDAL EIRRQSLATK IQATWRGFHC
760 770 780 790 800
RQKFLRVKRS AICIQSWWRG TLGRRKAAKR KWAAQTIRRL IQGFILRHAP
810 820 830 840 850
RCPENAFFVD HVRTSFLLNL RRQLPRNILD TSWPTPPPAL REASELLREL
860 870 880 890 900
CRKNMVWKYC RSISPEWKQQ LQQKAVASEI FKGKKDNYPQ SVPRLFISTR
910 920 930 940 950
LGADEINPRV LQALGSEPIQ YAVPVVKYDR KGYKPRSRQL LLTPNAVVIV
960 970 980 990 1000
EDAKVKQRIE YTNLTGISVS SLSDSLFVLH VQREDNKQKG DVVLQSDHVI
1010 1020 1030 1040 1050
ETLTKTALSA DRVNNININQ GSITFAGGPG RDGIIDFTPG SELLITKAKN
1060
GHLAVVAPRL NSR
Length:1,063
Mass (Da):121,936
Last modified:April 14, 2009 - v3
Checksum:i682486667418FA51
GO
Isoform 2 (identifier: Q27966-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-35: Missing.

Show »
Length:1,028
Mass (Da):118,147
Checksum:i0D9BE483963A6477
GO
Isoform 3 (identifier: Q27966-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-25: MALQVELIPTGEIIRVVHPHRPCKL → MRYRAS

Note: Gene prediction based on EST data.
Show »
Length:1,044
Mass (Da):119,868
Checksum:iECC5B8288E82A161
GO

Sequence cautioni

The sequence AAI40535 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti42 – 421A → C in CAA80476 (PubMed:8022785).Curated
Sequence conflicti132 – 1321R → G in AAA17565 (PubMed:8313976).Curated
Sequence conflicti355 – 3551H → N in CAA80476 (PubMed:8022785).Curated
Sequence conflicti398 – 3981N → K in CAA80476 (PubMed:8022785).Curated
Sequence conflicti421 – 4211D → G in AAA17565 (PubMed:8313976).Curated
Sequence conflicti579 – 5791N → I in CAA80476 (PubMed:8022785).Curated
Sequence conflicti585 – 5851C → F in CAA80476 (PubMed:8022785).Curated
Sequence conflicti593 – 5931D → S in AAA17565 (PubMed:8313976).Curated
Sequence conflicti690 – 6901P → R in AAA17565 (PubMed:8313976).Curated
Sequence conflicti747 – 7471G → A in CAA80476 (PubMed:8022785).Curated
Sequence conflicti757 – 7571V → L in CAA80476 (PubMed:8022785).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3535Missing in isoform 2. 1 PublicationVSP_036860Add
BLAST
Alternative sequencei1 – 2525MALQV…RPCKL → MRYRAS in isoform 3. 1 PublicationVSP_036859Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03420 mRNA. Translation: AAA17565.1.
BC140534 mRNA. Translation: AAI40535.1. Different initiation.
EG705719 mRNA. No translation available.
Z22852 mRNA. Translation: CAA80476.1.
PIRiS41749.
RefSeqiNP_776821.3. NM_174396.3. [Q27966-1]
XP_005220121.1. XM_005220064.1. [Q27966-3]
XP_005220122.1. XM_005220065.2. [Q27966-2]
UniGeneiBt.4957.

Genome annotation databases

EnsembliENSBTAT00000029554; ENSBTAP00000029553; ENSBTAG00000001332. [Q27966-3]
ENSBTAT00000029555; ENSBTAP00000029554; ENSBTAG00000001332. [Q27966-1]
GeneIDi281937.
KEGGibta:281937.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03420 mRNA. Translation: AAA17565.1.
BC140534 mRNA. Translation: AAI40535.1. Different initiation.
EG705719 mRNA. No translation available.
Z22852 mRNA. Translation: CAA80476.1.
PIRiS41749.
RefSeqiNP_776821.3. NM_174396.3. [Q27966-1]
XP_005220121.1. XM_005220064.1. [Q27966-3]
XP_005220122.1. XM_005220065.2. [Q27966-2]
UniGeneiBt.4957.

3D structure databases

ProteinModelPortaliQ27966.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000029554.

Proteomic databases

PaxDbiQ27966.
PeptideAtlasiQ27966.
PRIDEiQ27966.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000029554; ENSBTAP00000029553; ENSBTAG00000001332. [Q27966-3]
ENSBTAT00000029555; ENSBTAP00000029554; ENSBTAG00000001332. [Q27966-1]
GeneIDi281937.
KEGGibta:281937.

Organism-specific databases

CTDi4641.

Phylogenomic databases

eggNOGiKOG0164. Eukaryota.
COG5022. LUCA.
GeneTreeiENSGT00840000129697.
HOGENOMiHOG000260264.
InParanoidiQ27966.
KOiK10356.
OMAiELCIKNM.
OrthoDBiEOG091G0136.
TreeFamiTF312960.

Enzyme and pathway databases

ReactomeiR-BTA-5250924. B-WICH complex positively regulates rRNA expression.

Gene expression databases

BgeeiENSBTAG00000001332.

Family and domain databases

InterProiIPR000048. IQ_motif_EF-hand-BS.
IPR001609. Myosin_head_motor_dom.
IPR010926. Myosin_TH1.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00612. IQ. 2 hits.
PF00063. Myosin_head. 1 hit.
PF06017. Myosin_TH1. 1 hit.
[Graphical view]
PRINTSiPR00193. MYOSINHEAVY.
SMARTiSM00015. IQ. 2 hits.
SM00242. MYSc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50096. IQ. 2 hits.
PS51456. MYOSIN_MOTOR. 1 hit.
PS51757. TH1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYO1C_BOVIN
AccessioniPrimary (citable) accession number: Q27966
Secondary accession number(s): A5D7F3, Q28138
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: April 14, 2009
Last modified: September 7, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Represents an unconventional myosin. This protein should not be confused with the conventional myosin-1 (MYH1).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.