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Q27902

- CP6B4_PAPGL

UniProt

Q27902 - CP6B4_PAPGL

Protein

Cytochrome P450 6B4

Gene

CYP6B4

Organism
Papilio glaucus (Eastern tiger swallowtail butterfly) (Pterourus glaucus)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Enables the insect to feed on furanocoumarin-producing plants and evolved as an adaptation for detoxification of xanthotoxin and other furanocoumarins. This isozyme metabolizes isopimpinellin, imperatorin, and bergapten at high rates, xanthotoxin and psoralen at intermediate rates and angelicin, sphondin, and trioxsalen only at very low rates.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi443 – 4431Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 6B4 (EC:1.14.14.1)
    Alternative name(s):
    CYP6B4v1/CYP6B4v2
    CYPVIB4
    Gene namesi
    Name:CYP6B4
    OrganismiPapilio glaucus (Eastern tiger swallowtail butterfly) (Pterourus glaucus)
    Taxonomic identifieri45779 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaPapilionoideaPapilionidaePapilioninaePapilio

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500Cytochrome P450 6B4PRO_0000051896Add
    BLAST

    Expressioni

    Inductioni

    By furnocoumarin.

    Structurei

    3D structure databases

    ProteinModelPortaliQ27902.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q27902-1 [UniParc]FASTAAdd to Basket

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    MLTIFIVTAT LFAILYFYFT RNFNYWKDRN VVGPEPTVFF GNIMESVIRR    50
    KHLIMIYKDI YEAFPKEKVV GIYRMTTPCL LLRDLDVIKH VMIKDFDLFN 100
    DRGVEFSEEG LGLNIFHADG DRWRVLRQCF TPLFTSGKLK NMLNLMSDRG 150
    DKFIKMVEKF CDKEPEQQII PLVRKFTMAS ITTCAFGMEL DEEMIETLDK 200
    LDSLIFTTSY GNEIDMMYPG ILKKLNSSIF SKMIAPFFDN LTKTIIEQRG 250
    GKPTNRKDLM DLILELRQKK AIEPMKKTHD EQVTTLELTD SVIAAQTFIF 300
    YAAGYETSAS TMSFLLFELA ENPDIQEKVI AEVDETLKRH NGEITYDTLS 350
    EMTYLTQVFH ETLRKYPVAD ILLRNAKADY AVPGTNVTLK KGQTVVVSGF 400
    GIHYDPKYYP DPEKFDPERF SPENVRNRHP CAYIPFGAGQ RKCLGMRFGQ 450
    WQVQVCIIKL LSKFRFEPST KTMSEFNYDP KRLLVYPKSG IFLNIIPRNY 500
    Length:500
    Mass (Da):58,046
    Last modified:November 1, 1996 - v1
    Checksum:iF6042D7E196029E2
    GO

    Polymorphismi

    The sequence shown is that of 6B4-1, 6B4-2 seems to differ in 7 positions and is probably an allele.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti17 – 171F → L in 6B4-2.
    Natural varianti160 – 1601F → I in 6B4-2.
    Natural varianti229 – 2291I → L in 6B4-2.
    Natural varianti286 – 2861L → F in 6B4-2.
    Natural varianti477 – 4771N → S in 6B4-2.
    Natural varianti481 – 4811K → T in 6B4-2.
    Natural varianti496 – 4961I → L in 6B4-2.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U47059 mRNA. Translation: AAB05892.1.
    U65489 Genomic DNA. Translation: AAB06742.1.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U47059 mRNA. Translation: AAB05892.1 .
    U65489 Genomic DNA. Translation: AAB06742.1 .

    3D structure databases

    ProteinModelPortali Q27902.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of CYP6B4, a furanocoumarin-inducible cytochrome P450 from a polyphagous caterpillar (Lepidoptera: Papilionidae)."
      Hung C.F., Berenbaum M.R., Schuler M.A.
      Insect Biochem. Mol. Biol. 27:377-385(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

    Entry informationi

    Entry nameiCP6B4_PAPGL
    AccessioniPrimary (citable) accession number: Q27902
    Secondary accession number(s): Q95035
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3