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Q27902

- CP6B4_PAPGL

UniProt

Q27902 - CP6B4_PAPGL

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Protein

Cytochrome P450 6B4

Gene
CYP6B4
Organism
Papilio glaucus (Eastern tiger swallowtail butterfly) (Pterourus glaucus)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Enables the insect to feed on furanocoumarin-producing plants and evolved as an adaptation for detoxification of xanthotoxin and other furanocoumarins. This isozyme metabolizes isopimpinellin, imperatorin, and bergapten at high rates, xanthotoxin and psoralen at intermediate rates and angelicin, sphondin, and trioxsalen only at very low rates.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi443 – 4431Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 6B4 (EC:1.14.14.1)
Alternative name(s):
CYP6B4v1/CYP6B4v2
CYPVIB4
Gene namesi
Name:CYP6B4
OrganismiPapilio glaucus (Eastern tiger swallowtail butterfly) (Pterourus glaucus)
Taxonomic identifieri45779 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaPapilionoideaPapilionidaePapilioninaePapilio

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500Cytochrome P450 6B4PRO_0000051896Add
BLAST

Expressioni

Inductioni

By furnocoumarin.

Structurei

3D structure databases

ProteinModelPortaliQ27902.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27902-1 [UniParc]FASTAAdd to Basket

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MLTIFIVTAT LFAILYFYFT RNFNYWKDRN VVGPEPTVFF GNIMESVIRR    50
KHLIMIYKDI YEAFPKEKVV GIYRMTTPCL LLRDLDVIKH VMIKDFDLFN 100
DRGVEFSEEG LGLNIFHADG DRWRVLRQCF TPLFTSGKLK NMLNLMSDRG 150
DKFIKMVEKF CDKEPEQQII PLVRKFTMAS ITTCAFGMEL DEEMIETLDK 200
LDSLIFTTSY GNEIDMMYPG ILKKLNSSIF SKMIAPFFDN LTKTIIEQRG 250
GKPTNRKDLM DLILELRQKK AIEPMKKTHD EQVTTLELTD SVIAAQTFIF 300
YAAGYETSAS TMSFLLFELA ENPDIQEKVI AEVDETLKRH NGEITYDTLS 350
EMTYLTQVFH ETLRKYPVAD ILLRNAKADY AVPGTNVTLK KGQTVVVSGF 400
GIHYDPKYYP DPEKFDPERF SPENVRNRHP CAYIPFGAGQ RKCLGMRFGQ 450
WQVQVCIIKL LSKFRFEPST KTMSEFNYDP KRLLVYPKSG IFLNIIPRNY 500
Length:500
Mass (Da):58,046
Last modified:November 1, 1996 - v1
Checksum:iF6042D7E196029E2
GO

Polymorphismi

The sequence shown is that of 6B4-1, 6B4-2 seems to differ in 7 positions and is probably an allele.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171F → L in 6B4-2.
Natural varianti160 – 1601F → I in 6B4-2.
Natural varianti229 – 2291I → L in 6B4-2.
Natural varianti286 – 2861L → F in 6B4-2.
Natural varianti477 – 4771N → S in 6B4-2.
Natural varianti481 – 4811K → T in 6B4-2.
Natural varianti496 – 4961I → L in 6B4-2.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U47059 mRNA. Translation: AAB05892.1.
U65489 Genomic DNA. Translation: AAB06742.1.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U47059 mRNA. Translation: AAB05892.1 .
U65489 Genomic DNA. Translation: AAB06742.1 .

3D structure databases

ProteinModelPortali Q27902.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation and characterization of CYP6B4, a furanocoumarin-inducible cytochrome P450 from a polyphagous caterpillar (Lepidoptera: Papilionidae)."
    Hung C.F., Berenbaum M.R., Schuler M.A.
    Insect Biochem. Mol. Biol. 27:377-385(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].

Entry informationi

Entry nameiCP6B4_PAPGL
AccessioniPrimary (citable) accession number: Q27902
Secondary accession number(s): Q95035
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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