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Protein

Histone H2B 2

Gene

his-4

more
Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H2B 2
Gene namesi
Name:his-4
ORF Names:T10C6.11
AND
Name:his-8
ORF Names:F45F2.12
AND
Name:his-20
ORF Names:K06C4.4
AND
Name:his-22
ORF Names:K06C4.12
AND
Name:his-52
ORF Names:F07B7.4
AND
Name:his-54
ORF Names:F07B7.11
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome V

Organism-specific databases

WormBaseiF07B7.11; CE26800; WBGene00001928; his-54.
F07B7.4; CE10538; WBGene00001926; his-52.
F45F2.12; CE10538; WBGene00001882; his-8.
K06C4.12; CE10538; WBGene00001896; his-22.
K06C4.4; CE10538; WBGene00001894; his-20.
T10C6.11; CE10538; WBGene00001878; his-4.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000718682 – 123Histone H2B 2Add BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110O-linked (GlcNAc) serineBy similarity1
Cross-linki118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Monoubiquitination of Lys-118 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.By similarity
GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ27894.
PaxDbiQ27894.
PeptideAtlasiQ27894.
PRIDEiQ27894.

Expressioni

Gene expression databases

BgeeiWBGene00001878.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi45063. 2 interactors.
56171. 1 interactor.
DIPiDIP-26826N.
MINTiMINT-1130213.
STRINGi6239.T10C6.11.

Structurei

3D structure databases

ProteinModelPortaliQ27894.
SMRiQ27894.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2B family.Curated

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00870000136414.
HOGENOMiHOG000231213.
InParanoidiQ27894.
KOiK11252.
OrthoDBiEOG091G0XGD.
PhylomeDBiQ27894.

Family and domain databases

InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PRINTSiPR00621. HISTONEH2B.
SMARTiView protein in SMART
SM00427. H2B. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS00357. HISTONE_H2B. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q27894-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPPKPSAKG AKKAAKTVTK PKDGKKRRHA RKESYSVYIY RVLKQVHPDT
60 70 80 90 100
GVSSKAMSIM NSFVNDVFER IAAEASRLAH YNKRSTISSR EIQTAVRLIL
110 120
PGELAKHAVS EGTKAVTKYT SSK
Length:123
Mass (Da):13,572
Last modified:January 23, 2007 - v3
Checksum:iA1260A21A632940D
GO

Sequence cautioni

The sequence CCD68873 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti28 – 29RH → KK AA sequence (PubMed:3753445).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081059 Genomic DNA. Translation: CCD68867.2.
FO081059 Genomic DNA. Translation: CCD68873.1. Different initiation.
FO081551 Genomic DNA. Translation: CCD72362.1.
FO081551 Genomic DNA. Translation: CCD72372.1.
FO081223 Genomic DNA. Translation: CCD70026.1.
Z93388 Genomic DNA. Translation: CAB07654.2.
PIRiT24788.
T30054. HSKW22.
RefSeqiNP_505197.1. NM_072796.1.
NP_505278.2. NM_072877.2.
NP_505279.1. NM_072878.1.
NP_505294.1. NM_072893.1.
NP_505295.1. NM_072894.1.
NP_507031.2. NM_074630.3.
UniGeneiCel.21445.
Cel.29298.
Cel.3207.
Cel.33086.

Genome annotation databases

EnsemblMetazoaiF07B7.4; F07B7.4; WBGene00001926.
F45F2.12; F45F2.12; WBGene00001882.
K06C4.12; K06C4.12; WBGene00001896.
K06C4.4; K06C4.4; WBGene00001894.
T10C6.11; T10C6.11; WBGene00001878.
GeneIDi179262.
179266.
180072.
184117.
191670.
191675.
KEGGicel:CELE_F07B7.11.
cel:CELE_F07B7.4.
cel:CELE_F45F2.12.
cel:CELE_K06C4.12.
cel:CELE_K06C4.4.
cel:CELE_T10C6.11.
UCSCiF45F2.12. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
FO081059 Genomic DNA. Translation: CCD68867.2.
FO081059 Genomic DNA. Translation: CCD68873.1. Different initiation.
FO081551 Genomic DNA. Translation: CCD72362.1.
FO081551 Genomic DNA. Translation: CCD72372.1.
FO081223 Genomic DNA. Translation: CCD70026.1.
Z93388 Genomic DNA. Translation: CAB07654.2.
PIRiT24788.
T30054. HSKW22.
RefSeqiNP_505197.1. NM_072796.1.
NP_505278.2. NM_072877.2.
NP_505279.1. NM_072878.1.
NP_505294.1. NM_072893.1.
NP_505295.1. NM_072894.1.
NP_507031.2. NM_074630.3.
UniGeneiCel.21445.
Cel.29298.
Cel.3207.
Cel.33086.

3D structure databases

ProteinModelPortaliQ27894.
SMRiQ27894.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi45063. 2 interactors.
56171. 1 interactor.
DIPiDIP-26826N.
MINTiMINT-1130213.
STRINGi6239.T10C6.11.

Proteomic databases

EPDiQ27894.
PaxDbiQ27894.
PeptideAtlasiQ27894.
PRIDEiQ27894.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF07B7.4; F07B7.4; WBGene00001926.
F45F2.12; F45F2.12; WBGene00001882.
K06C4.12; K06C4.12; WBGene00001896.
K06C4.4; K06C4.4; WBGene00001894.
T10C6.11; T10C6.11; WBGene00001878.
GeneIDi179262.
179266.
180072.
184117.
191670.
191675.
KEGGicel:CELE_F07B7.11.
cel:CELE_F07B7.4.
cel:CELE_F45F2.12.
cel:CELE_K06C4.12.
cel:CELE_K06C4.4.
cel:CELE_T10C6.11.
UCSCiF45F2.12. c. elegans.

Organism-specific databases

CTDi179262.
179266.
180072.
184117.
191670.
191675.
WormBaseiF07B7.11; CE26800; WBGene00001928; his-54.
F07B7.4; CE10538; WBGene00001926; his-52.
F45F2.12; CE10538; WBGene00001882; his-8.
K06C4.12; CE10538; WBGene00001896; his-22.
K06C4.4; CE10538; WBGene00001894; his-20.
T10C6.11; CE10538; WBGene00001878; his-4.

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00870000136414.
HOGENOMiHOG000231213.
InParanoidiQ27894.
KOiK11252.
OrthoDBiEOG091G0XGD.
PhylomeDBiQ27894.

Miscellaneous databases

PROiPR:Q27894.

Gene expression databases

BgeeiWBGene00001878.

Family and domain databases

InterProiView protein in InterPro
IPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiView protein in Pfam
PF00125. Histone. 1 hit.
PRINTSiPR00621. HISTONEH2B.
SMARTiView protein in SMART
SM00427. H2B. 1 hit.
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiView protein in PROSITE
PS00357. HISTONE_H2B. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiH2B2_CAEEL
AccessioniPrimary (citable) accession number: Q27894
Secondary accession number(s): Q95NR2, Q9U373
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: January 23, 2007
Last modified: May 10, 2017
This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.