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Protein

L-lactate dehydrogenase

Gene

ldh-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh-1), L-lactate dehydrogenase (ldh-1)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99NADBy similarity1
Binding sitei106SubstrateBy similarity1
Binding sitei138NAD or substrateBy similarity1
Binding sitei169SubstrateBy similarity1
Active sitei193Proton acceptorBy similarity1
Binding sitei249SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 57NADBy similarityAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-CEL-70268. Pyruvate metabolism.
UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase (EC:1.1.1.27)
Short name:
LDH
Gene namesi
Name:ldh-1
ORF Names:F13D12.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF13D12.2; CE02181; WBGene00002262; ldh-1.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001684931 – 333L-lactate dehydrogenaseAdd BLAST333

Proteomic databases

EPDiQ27888.
PaxDbiQ27888.
PeptideAtlasiQ27888.
PRIDEiQ27888.

Expressioni

Gene expression databases

BgeeiWBGene00002262.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ27888. 1 interactor.
STRINGi6239.F13D12.2.2.

Structurei

3D structure databases

ProteinModelPortaliQ27888.
SMRiQ27888.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.Curated

Phylogenomic databases

eggNOGiKOG1495. Eukaryota.
COG0039. LUCA.
GeneTreeiENSGT00550000074541.
HOGENOMiHOG000213793.
InParanoidiQ27888.
KOiK00016.
OMAiRQPGQTR.
OrthoDBiEOG091G0HME.
PhylomeDBiQ27888.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR018177. L-lactate_DH_AS.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.
PROSITEiView protein in PROSITE
PS00064. L_LDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q27888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTIKEVFA EIAAPVENSH GKVTVVGVGQ VGMACAYSIL QQNLANELCL
60 70 80 90 100
VDVVADKLKG EMMDLQHGLA FTRHCTVKAD TDYSITAGSK LCVVTAGARQ
110 120 130 140 150
REGETRLSLV QRNVEIFKGI IPQLVKYSPD TCILVVSNPV DVLTYVTWKL
160 170 180 190 200
SGLPRERVFG SGTNLDSARF RFLLSEKLNI APSSCHGWII GEHGDSSVAV
210 220 230 240 250
WSGVNVAGVT LHEIKPDIGE KTDNEHWEAE IHKKVVDSAY EIIKLKGYTS
260 270 280 290 300
WAIGLSVAKI AQGIFSNSRN VFALSTNVKG FHGINDDVYL SLPVVLGSAG
310 320 330
LTHVVKQQLT EAEVQKLHNS AKALLEVQNG IVM
Length:333
Mass (Da):36,065
Last modified:November 1, 1996 - v1
Checksum:iB9CA8A6BB0E84007
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15420 mRNA. Translation: AAA67063.1.
L43563 Genomic DNA. Translation: AAC41613.1.
Z49127 Genomic DNA. Translation: CAA88944.1.
PIRiJC2432.
RefSeqiNP_496503.1. NM_064102.5.
UniGeneiCel.22829.

Genome annotation databases

EnsemblMetazoaiF13D12.2; F13D12.2; WBGene00002262.
GeneIDi174798.
KEGGicel:CELE_F13D12.2.
UCSCiF13D12.2. c. elegans.

Similar proteinsi

Entry informationi

Entry nameiLDH_CAEEL
AccessioniPrimary (citable) accession number: Q27888
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families