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Protein

L-lactate dehydrogenase

Gene

ldh-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh-1), L-lactate dehydrogenase (ldh-1)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei99NADBy similarity1
Binding sitei106SubstrateBy similarity1
Binding sitei138NAD or substrateBy similarity1
Binding sitei169SubstrateBy similarity1
Active sitei193Proton acceptorBy similarity1
Binding sitei249SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 57NADBy similarityAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-CEL-70268 Pyruvate metabolism
UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase (EC:1.1.1.27)
Short name:
LDH
Gene namesi
Name:ldh-1
ORF Names:F13D12.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF13D12.2a ; CE02181 ; WBGene00002262 ; ldh-1

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001684931 – 333L-lactate dehydrogenaseAdd BLAST333

Proteomic databases

EPDiQ27888
PaxDbiQ27888
PeptideAtlasiQ27888
PRIDEiQ27888

Expressioni

Gene expression databases

BgeeiWBGene00002262

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ27888, 1 interactor
STRINGi6239.F13D12.2.2

Structurei

3D structure databases

ProteinModelPortaliQ27888
SMRiQ27888
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.Curated

Phylogenomic databases

eggNOGiKOG1495 Eukaryota
COG0039 LUCA
GeneTreeiENSGT00550000074541
HOGENOMiHOG000213793
InParanoidiQ27888
OMAiRQPGQTR
OrthoDBiEOG091G0HME
PhylomeDBiQ27888

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR018177 L-lactate_DH_AS
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit
PROSITEiView protein in PROSITE
PS00064 L_LDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q27888-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASTIKEVFA EIAAPVENSH GKVTVVGVGQ VGMACAYSIL QQNLANELCL
60 70 80 90 100
VDVVADKLKG EMMDLQHGLA FTRHCTVKAD TDYSITAGSK LCVVTAGARQ
110 120 130 140 150
REGETRLSLV QRNVEIFKGI IPQLVKYSPD TCILVVSNPV DVLTYVTWKL
160 170 180 190 200
SGLPRERVFG SGTNLDSARF RFLLSEKLNI APSSCHGWII GEHGDSSVAV
210 220 230 240 250
WSGVNVAGVT LHEIKPDIGE KTDNEHWEAE IHKKVVDSAY EIIKLKGYTS
260 270 280 290 300
WAIGLSVAKI AQGIFSNSRN VFALSTNVKG FHGINDDVYL SLPVVLGSAG
310 320 330
LTHVVKQQLT EAEVQKLHNS AKALLEVQNG IVM
Length:333
Mass (Da):36,065
Last modified:November 1, 1996 - v1
Checksum:iB9CA8A6BB0E84007
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U15420 mRNA Translation: AAA67063.1
L43563 Genomic DNA Translation: AAC41613.1
Z49127 Genomic DNA Translation: CAA88944.1
PIRiJC2432
RefSeqiNP_496503.1, NM_064102.5
UniGeneiCel.22829

Genome annotation databases

EnsemblMetazoaiF13D12.2.1; F13D12.2.1; WBGene00002262
F13D12.2.2; F13D12.2.2; WBGene00002262
GeneIDi174798
UCSCiF13D12.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiLDH_CAEEL
AccessioniPrimary (citable) accession number: Q27888
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

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