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Protein

Probable histone H2B 4

Gene

his-48

more
Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-212300 PRC2 methylates histones and DNA
R-CEL-2299718 Condensation of Prophase Chromosomes
R-CEL-2559580 Oxidative Stress Induced Senescence
R-CEL-3214815 HDACs deacetylate histones
R-CEL-427359 SIRT1 negatively regulates rRNA expression
R-CEL-5578749 Transcriptional regulation by small RNAs
R-CEL-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
R-CEL-5689880 Ub-specific processing proteases
R-CEL-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-CEL-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-CEL-9018519 Estrogen-dependent gene expression

Names & Taxonomyi

Protein namesi
Recommended name:
Probable histone H2B 4
Gene namesi
Name:his-48
ORF Names:B0035.8
AND
Name:his-58
ORF Names:F54E12.4
AND
Name:his-62
ORF Names:F55G1.3
AND
Name:his-66
ORF Names:H02I12.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiB0035.8 ; CE05165 ; WBGene00001922 ; his-48
F54E12.4 ; CE05165 ; WBGene00001932 ; his-58
F55G1.3 ; CE05165 ; WBGene00001936 ; his-62
H02I12.6 ; CE05165 ; WBGene00001940 ; his-66

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000718702 – 123Probable histone H2B 4Add BLAST122

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110O-linked (GlcNAc) serineBy similarity1
Cross-linki118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Monoubiquitination of Lys-118 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.By similarity
GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ27876
PaxDbiQ27876
PeptideAtlasiQ27876
PRIDEiQ27876

Expressioni

Gene expression databases

BgeeiWBGene00001922

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi43148, 1 interactor
51070, 1 interactor
51393, 1 interactor
STRINGi6239.H02I12.6

Structurei

3D structure databases

ProteinModelPortaliQ27876
SMRiQ27876
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2B family.Curated

Phylogenomic databases

eggNOGiKOG1744 Eukaryota
ENOG4111NV5 LUCA
GeneTreeiENSGT00760000118976
HOGENOMiHOG000231213
InParanoidiQ27876
KOiK11252
OMAiSKEMSIM
OrthoDBiEOG091G0XGD
PhylomeDBiQ27876

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR007125 Histone_H2A/H2B/H3
IPR000558 Histone_H2B
PANTHERiPTHR23428 PTHR23428, 1 hit
PfamiView protein in Pfam
PF00125 Histone, 1 hit
PRINTSiPR00621 HISTONEH2B
SMARTiView protein in SMART
SM00427 H2B, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
PROSITEiView protein in PROSITE
PS00357 HISTONE_H2B, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q27876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKPSAKGA KKAAKTVVAK PKDGKKRRHA RKESYSVYIY RVLKQVHPDT
60 70 80 90 100
GVSSKAMSIM NSFVNDVFER IASEASRLAH YNKRSTISSR EIQTAVRLIL
110 120
PGELAKHAVS EGTKAVTKYT SSK
Length:123
Mass (Da):13,586
Last modified:January 23, 2007 - v3
Checksum:i9300DE62E1CD517D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82271 Genomic DNA Translation: CAB05211.1
FO081135 Genomic DNA Translation: CCD69391.1
Z73102 Genomic DNA Translation: CAA97413.1
Z92789 Genomic DNA Translation: CAB07220.1
PIRiF88730
RefSeqiNP_501202.1, NM_068801.1
NP_502132.1, NM_069731.4
NP_502140.1, NM_069739.5
NP_502149.1, NM_069748.1
UniGeneiCel.12764
Cel.21613
Cel.27008
Cel.32639

Genome annotation databases

EnsemblMetazoaiB0035.8; B0035.8; WBGene00001922
F54E12.4; F54E12.4; WBGene00001932
F55G1.3; F55G1.3; WBGene00001936
H02I12.6; H02I12.6; WBGene00001940
GeneIDi178049
186251
186326
186670
KEGGicel:CELE_B0035.8
cel:CELE_F54E12.4
cel:CELE_F55G1.3
cel:CELE_H02I12.6
UCSCiF55G1.3 c. elegans

Similar proteinsi

Entry informationi

Entry nameiH2B4_CAEEL
AccessioniPrimary (citable) accession number: Q27876
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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