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Protein

Probable histone H2B 4

Gene

his-48

more
Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable histone H2B 4
Gene namesi
Name:his-48
ORF Names:B0035.8
AND
Name:his-58
ORF Names:F54E12.4
AND
Name:his-62
ORF Names:F55G1.3
AND
Name:his-66
ORF Names:H02I12.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiB0035.8; CE05165; WBGene00001922; his-48.
F54E12.4; CE05165; WBGene00001932; his-58.
F55G1.3; CE05165; WBGene00001936; his-62.
H02I12.6; CE05165; WBGene00001940; his-66.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 123122Probable histone H2B 4PRO_0000071870Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi110 – 1101O-linked (GlcNAc)By similarity
Cross-linki118 – 118Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Monoubiquitination of Lys-118 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation.By similarity
GlcNAcylation at Ser-110 promotes monoubiquitination of Lys-118. It fluctuates in response to extracellular glucose, and associates with transcribed genes (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ27876.
PaxDbiQ27876.
PRIDEiQ27876.

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.

Protein-protein interaction databases

BioGridi43148. 1 interaction.
51070. 1 interaction.
51393. 1 interaction.
STRINGi6239.H02I12.6.

Structurei

3D structure databases

ProteinModelPortaliQ27876.
SMRiQ27876. Positions 31-122.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H2B family.Curated

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00840000129751.
HOGENOMiHOG000231213.
InParanoidiQ27876.
KOiK11252.
OMAiNETYSIY.
OrthoDBiEOG72VH8J.
PhylomeDBiQ27876.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
[Graphical view]
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00357. HISTONE_H2B. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q27876-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKPSAKGA KKAAKTVVAK PKDGKKRRHA RKESYSVYIY RVLKQVHPDT
60 70 80 90 100
GVSSKAMSIM NSFVNDVFER IASEASRLAH YNKRSTISSR EIQTAVRLIL
110 120
PGELAKHAVS EGTKAVTKYT SSK
Length:123
Mass (Da):13,586
Last modified:January 23, 2007 - v3
Checksum:i9300DE62E1CD517D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82271 Genomic DNA. Translation: CAB05211.1.
FO081135 Genomic DNA. Translation: CCD69391.1.
Z73102 Genomic DNA. Translation: CAA97413.1.
Z92789 Genomic DNA. Translation: CAB07220.1.
PIRiF88730.
RefSeqiNP_501202.1. NM_068801.1.
NP_502132.1. NM_069731.4.
NP_502140.1. NM_069739.5.
NP_502149.1. NM_069748.1.
UniGeneiCel.12764.
Cel.21613.
Cel.27008.
Cel.32639.

Genome annotation databases

EnsemblMetazoaiB0035.8; B0035.8; WBGene00001922.
F54E12.4; F54E12.4; WBGene00001932.
F55G1.3; F55G1.3; WBGene00001936.
H02I12.6; H02I12.6; WBGene00001940.
GeneIDi178049.
186251.
186326.
186670.
KEGGicel:CELE_B0035.8.
cel:CELE_F54E12.4.
cel:CELE_F55G1.3.
cel:CELE_H02I12.6.
UCSCiF55G1.3. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z82271 Genomic DNA. Translation: CAB05211.1.
FO081135 Genomic DNA. Translation: CCD69391.1.
Z73102 Genomic DNA. Translation: CAA97413.1.
Z92789 Genomic DNA. Translation: CAB07220.1.
PIRiF88730.
RefSeqiNP_501202.1. NM_068801.1.
NP_502132.1. NM_069731.4.
NP_502140.1. NM_069739.5.
NP_502149.1. NM_069748.1.
UniGeneiCel.12764.
Cel.21613.
Cel.27008.
Cel.32639.

3D structure databases

ProteinModelPortaliQ27876.
SMRiQ27876. Positions 31-122.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi43148. 1 interaction.
51070. 1 interaction.
51393. 1 interaction.
STRINGi6239.H02I12.6.

Proteomic databases

EPDiQ27876.
PaxDbiQ27876.
PRIDEiQ27876.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiB0035.8; B0035.8; WBGene00001922.
F54E12.4; F54E12.4; WBGene00001932.
F55G1.3; F55G1.3; WBGene00001936.
H02I12.6; H02I12.6; WBGene00001940.
GeneIDi178049.
186251.
186326.
186670.
KEGGicel:CELE_B0035.8.
cel:CELE_F54E12.4.
cel:CELE_F55G1.3.
cel:CELE_H02I12.6.
UCSCiF55G1.3. c. elegans.

Organism-specific databases

CTDi178049.
186251.
186326.
186670.
WormBaseiB0035.8; CE05165; WBGene00001922; his-48.
F54E12.4; CE05165; WBGene00001932; his-58.
F55G1.3; CE05165; WBGene00001936; his-62.
H02I12.6; CE05165; WBGene00001940; his-66.

Phylogenomic databases

eggNOGiKOG1744. Eukaryota.
ENOG4111NV5. LUCA.
GeneTreeiENSGT00840000129751.
HOGENOMiHOG000231213.
InParanoidiQ27876.
KOiK11252.
OMAiNETYSIY.
OrthoDBiEOG72VH8J.
PhylomeDBiQ27876.

Miscellaneous databases

NextBioi899510.
PROiQ27876.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR007125. Histone_H2A/H2B/H3.
IPR000558. Histone_H2B.
[Graphical view]
PANTHERiPTHR23428. PTHR23428. 1 hit.
PfamiPF00125. Histone. 1 hit.
[Graphical view]
PRINTSiPR00621. HISTONEH2B.
SMARTiSM00427. H2B. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
PROSITEiPS00357. HISTONE_H2B. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiH2B4_CAEEL
AccessioniPrimary (citable) accession number: Q27876
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: January 23, 2007
Last modified: May 11, 2016
This is version 120 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.