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Protein

Integrin beta pat-3

Gene

pat-3

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possible role in cell-cell interactions. Integrin alpha pat-1/beta pat-3 is a receptor for laminin. Integrin alpha pat-2/beta pat-3 recognizes the sequence R-G-D in its ligands (By similarity). During gonad morphogenesis, involved in distal tip cell (DTC)-mediated guidance of gonad elongation, in maintaining their sharp tapering morphology and in their migration (PubMed:19023419). Plays a role in the clearance of apoptotic cells during mid-embryogenesis (PubMed:20226672).By similarity2 Publications

GO - Biological processi

  • cell adhesion Source: UniProtKB-KW
  • integrin-mediated signaling pathway Source: UniProtKB-KW
  • muscle cell development Source: WormBase
  • positive regulation of distal tip cell migration Source: UniProtKB
  • positive regulation of locomotion Source: WormBase
  • positive regulation of myosin II filament organization Source: UniProtKB
  • positive regulation of ovulation Source: UniProtKB
  • positive regulation of smooth muscle contraction Source: UniProtKB
  • regulation of actin cytoskeleton organization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Integrin, Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-CEL-114608. Platelet degranulation.
R-CEL-1236973. Cross-presentation of particulate exogenous antigens (phagosomes).
R-CEL-1566948. Elastic fibre formation.
R-CEL-216083. Integrin cell surface interactions.
R-CEL-3000170. Syndecan interactions.
R-CEL-354192. Integrin alphaIIb beta3 signaling.
R-CEL-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-CEL-445144. Signal transduction by L1.
R-CEL-445355. Smooth Muscle Contraction.
R-CEL-446107. Type I hemidesmosome assembly.
R-CEL-446343. Localization of the PINCH-ILK-PARVIN complex to focal adhesions.
R-CEL-6798695. Neutrophil degranulation.
SignaLinkiQ27874.

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin beta pat-3
Alternative name(s):
Paralyzed arrest at two-fold protein 3
Gene namesi
Name:pat-3
ORF Names:ZK1058.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiZK1058.2; CE01102; WBGene00003930; pat-3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 737ExtracellularSequence analysisAdd BLAST718
Transmembranei738 – 758HelicalSequence analysisAdd BLAST21
Topological domaini759 – 809CytoplasmicSequence analysisAdd BLAST51

GO - Cellular componenti

  • cell surface Source: WormBase
  • integrin complex Source: WormBase
  • M band Source: WormBase
  • neuronal cell body Source: WormBase
  • neuron projection Source: WormBase
  • striated muscle dense body Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

RNAi-mediated knockdown in distal tip cell (DTC) causes DTC migration and guidance defects during the second phase of gonad elongation resulting in a triangular shaped gonad (PubMed:19023419). Embryos at the comma and 1.5-fold stages have increased number of cell corpses (PubMed:20226672).1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000001635820 – 809Integrin beta pat-3Add BLAST790

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...)Sequence analysis1
Glycosylationi141N-linked (GlcNAc...)2 Publications1
Glycosylationi269N-linked (GlcNAc...)2 Publications1
Glycosylationi373N-linked (GlcNAc...)Sequence analysis1
Glycosylationi400N-linked (GlcNAc...)2 Publications1
Glycosylationi530N-linked (GlcNAc...)1 Publication1
Glycosylationi672N-linked (GlcNAc...)1 Publication1
Glycosylationi693N-linked (GlcNAc...)Sequence analysis1
Glycosylationi721N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ27874.
PaxDbiQ27874.
PeptideAtlasiQ27874.
PRIDEiQ27874.

Expressioni

Gene expression databases

BgeeiWBGene00003930.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. Beta pat-3 associates with either alpha pat-1 or alpha pat-2.

Protein-protein interaction databases

BioGridi40742. 11 interactors.
DIPiDIP-27060N.
IntActiQ27874. 3 interactors.
MINTiMINT-1114713.
STRINGi6239.ZK1058.2.

Structurei

3D structure databases

ProteinModelPortaliQ27874.
SMRiQ27874.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini153 – 352VWFAAdd BLAST200

Sequence similaritiesi

Belongs to the integrin beta chain family.Curated
Contains 1 VWFA domain.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
InParanoidiQ27874.
KOiK05719.
OMAiGRGVCNC.
OrthoDBiEOG091G029W.
PhylomeDBiQ27874.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR033760. Integin_beta_N.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR012896. Integrin_bsu_tail.
IPR002369. Integrin_bsu_VWA.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PfamiPF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
PF17205. PSI_integrin. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q27874-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPSTSLLLL AALLPFALPA SDWKTGEVTG KVVEKSEFPC YSLSRDNYTC
60 70 80 90 100
SACIQYHESC AWCGAPMFDE KKPYARCDSR AKLMEHGCPN SYIEDPATKL
110 120 130 140 150
DITEDSKLSD QGQVESEEEA VQIKPQEMYV EIRPKSRVRF NVTYRQAVDY
160 170 180 190 200
PVDLYYLMDL SYSMKDDKQK LSELGDLLAE RMRTVTKNFR LGFGSFIDKK
210 220 230 240 250
LMPFIDPRIE KQLSPCPTPC AEPYGFKHQM SLTTNTAKFK AEVDKAEISG
260 270 280 290 300
NLDAPEGGFD AVVQALACNK TIGWRERARK MIVFSTDAGF HFAGDGRLAG
310 320 330 340 350
VVEPNDGTCH LDREGYYTET LNQDYPSIAL LHQMIKDRKA NVIFAVTKNN
360 370 380 390 400
QDLYTQLSNA LPDVSSSVGV LANDSRNIVD LIEKEYLKIS EKIIMVDNAN
410 420 430 440 450
ASEGLKLTYR SMCLDGTTLK DTNVCEGIRV GDEVQFEVTL ENTHCIDKRD
460 470 480 490 500
FVLRIGPSGL DETLIVNVKV LCDCDCERQD RIVTNSADCN GGDMVCGVCR
510 520 530 540 550
CKGGNVGKYC ECNRPGMSTA ALNEKCKRTN ESAICEGRGV CNCGRCECNP
560 570 580 590 600
RANPEEQISG EFCECDNFNC PRHDRKICAE HGECNCGKCI CAPGWTGRAC
610 620 630 640 650
ECPISTDSCL SANGKICNGK GECICGRCRC FDSPDGNRYS GAKCEICPTC
660 670 680 690 700
PTKCVEYKNC VMCQQWQTGP LNETACDQCE FKVIPVEELP NLNETTPCQF
710 720 730 740 750
VDPADDCTFY YLYYYDEATD NATVWVRKHK DCPPPVPVLA IVLGVIAGIV
760 770 780 790 800
ILGILLLLLW KLLTVLHDRS EYATFNNERL MAKWDTNENP IYKQATTTFK

NPVYAGKAN
Length:809
Mass (Da):90,138
Last modified:November 1, 1996 - v1
Checksum:i70C4AB01C8FE9189
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19744 Genomic DNA. Translation: AAA85704.1.
Z35604 Genomic DNA. Translation: CAA84677.1.
PIRiA57283.
RefSeqiNP_497787.1. NM_065386.5.
UniGeneiCel.5347.

Genome annotation databases

EnsemblMetazoaiZK1058.2; ZK1058.2; WBGene00003930.
GeneIDi175504.
KEGGicel:CELE_ZK1058.2.
UCSCiZK1058.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19744 Genomic DNA. Translation: AAA85704.1.
Z35604 Genomic DNA. Translation: CAA84677.1.
PIRiA57283.
RefSeqiNP_497787.1. NM_065386.5.
UniGeneiCel.5347.

3D structure databases

ProteinModelPortaliQ27874.
SMRiQ27874.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi40742. 11 interactors.
DIPiDIP-27060N.
IntActiQ27874. 3 interactors.
MINTiMINT-1114713.
STRINGi6239.ZK1058.2.

Proteomic databases

EPDiQ27874.
PaxDbiQ27874.
PeptideAtlasiQ27874.
PRIDEiQ27874.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiZK1058.2; ZK1058.2; WBGene00003930.
GeneIDi175504.
KEGGicel:CELE_ZK1058.2.
UCSCiZK1058.2. c. elegans.

Organism-specific databases

CTDi175504.
WormBaseiZK1058.2; CE01102; WBGene00003930; pat-3.

Phylogenomic databases

eggNOGiKOG1226. Eukaryota.
ENOG410XP60. LUCA.
GeneTreeiENSGT00760000119064.
HOGENOMiHOG000252936.
InParanoidiQ27874.
KOiK05719.
OMAiGRGVCNC.
OrthoDBiEOG091G029W.
PhylomeDBiQ27874.

Enzyme and pathway databases

ReactomeiR-CEL-114608. Platelet degranulation.
R-CEL-1236973. Cross-presentation of particulate exogenous antigens (phagosomes).
R-CEL-1566948. Elastic fibre formation.
R-CEL-216083. Integrin cell surface interactions.
R-CEL-3000170. Syndecan interactions.
R-CEL-354192. Integrin alphaIIb beta3 signaling.
R-CEL-354194. GRB2:SOS provides linkage to MAPK signaling for Integrins.
R-CEL-445144. Signal transduction by L1.
R-CEL-445355. Smooth Muscle Contraction.
R-CEL-446107. Type I hemidesmosome assembly.
R-CEL-446343. Localization of the PINCH-ILK-PARVIN complex to focal adhesions.
R-CEL-6798695. Neutrophil degranulation.
SignaLinkiQ27874.

Miscellaneous databases

PROiQ27874.

Gene expression databases

BgeeiWBGene00003930.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR013111. EGF_extracell.
IPR033760. Integin_beta_N.
IPR015812. Integrin_bsu.
IPR014836. Integrin_bsu_cyt_dom.
IPR012896. Integrin_bsu_tail.
IPR002369. Integrin_bsu_VWA.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PANTHERiPTHR10082. PTHR10082. 1 hit.
PfamiPF07974. EGF_2. 1 hit.
PF08725. Integrin_b_cyt. 1 hit.
PF07965. Integrin_B_tail. 1 hit.
PF00362. Integrin_beta. 1 hit.
PF17205. PSI_integrin. 1 hit.
[Graphical view]
PIRSFiPIRSF002512. Integrin_B. 1 hit.
PRINTSiPR01186. INTEGRINB.
SMARTiSM00187. INB. 1 hit.
SM01241. Integrin_b_cyt. 1 hit.
SM01242. Integrin_B_tail. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 1 hit.
SSF69687. SSF69687. 1 hit.
PROSITEiPS00022. EGF_1. 2 hits.
PS01186. EGF_2. 1 hit.
PS00243. INTEGRIN_BETA. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPAT3_CAEEL
AccessioniPrimary (citable) accession number: Q27874
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.