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Q27788

- KPYK_TRYBO

UniProt

Q27788 - KPYK_TRYBO

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Protein

Pyruvate kinase

Gene

PYK

Organism
Trypanoplasma borreli
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Protein has several cofactor binding sites:

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531SubstrateBy similarity
Metal bindingi55 – 551PotassiumBy similarity
Metal bindingi57 – 571PotassiumBy similarity
Metal bindingi87 – 871PotassiumBy similarity
Metal bindingi88 – 881Potassium; via carbonyl oxygenBy similarity
Sitei238 – 2381Transition state stabilizerBy similarity
Metal bindingi240 – 2401MagnesiumBy similarity
Binding sitei263 – 2631Substrate; via amide nitrogenBy similarity
Metal bindingi264 – 2641MagnesiumBy similarity
Binding sitei264 – 2641Substrate; via amide nitrogenBy similarity
Binding sitei296 – 2961SubstrateBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:PYK
OrganismiTrypanoplasma borreli
Taxonomic identifieri5710 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaBodonidaeTrypanoplasma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498Pyruvate kinasePRO_0000112105Add
BLAST

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ27788.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.Curated

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27788-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MMRKSQLQFN TELRVHHPPA LFRSNKIICT IGPSSQSVEV LKDLMKAGLN
60 70 80 90 100
VARMNFSHGT YEYHQKTIDN VRKAASELGI HVGIALDTKG PEIRTGLFPA
110 120 130 140 150
GDVVIEAHKT VILTTDETFK EKGTAEKFYV DYMNITKVVP VGGHIFVDDG
160 170 180 190 200
LLDLIVVKIS GKDIECVAQN THTISNRKGI NLPNADVDLP AVSEKDLMDL
210 220 230 240 250
QFGAKNRVDF VFASFIRNAD QVNEVRQAFG GKIAVIAKIE NYQGIDNIDA
260 270 280 290 300
IIDAADGIMV ARGDLGVEIP AEKVVIAQKM IMSKCNKVGK TVICATQMLD
310 320 330 340 350
SMTHGPRPTR AEVSDVAKSV LDGADCVMLS GETAKGKYPV ETVVYMSRIC
360 370 380 390 400
CETQVTMWNM AAFEAIKNLQ SFPLIPEEAI CSSAVNSIFE LHAKAILVLT
410 420 430 440 450
NTGRSAHMVS KYRPPVPIIC ASQELDVCRL LSITRGTIPV YYDTEKLGPD
460 470 480 490
YDREKRVGLA IDVGKQMGVF KEGDVVVAVH ADHHTKGFAN QIRAIYIK
Length:498
Mass (Da):54,634
Last modified:November 1, 1996 - v1
Checksum:i7C5882430B93DE21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77255 Genomic DNA. Translation: CAA54472.1.
X77255 Genomic DNA. Translation: CAA54473.1.
PIRiJC2456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77255 Genomic DNA. Translation: CAA54472.1 .
X77255 Genomic DNA. Translation: CAA54473.1 .
PIRi JC2456.

3D structure databases

ProteinModelPortali Q27788.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequence analysis of the gene encoding pyruvate kinase in Trypanoplasma borelli."
    Ernest I., Opperdoes F.R., Michels P.A.M.
    Biochem. Biophys. Res. Commun. 201:727-732(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKPYK_TRYBO
AccessioniPrimary (citable) accession number: Q27788
Secondary accession number(s): Q27789
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3