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Q27788

- KPYK_TRYBO

UniProt

Q27788 - KPYK_TRYBO

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Protein

Pyruvate kinase

Gene
PYK
Organism
Trypanoplasma borreli
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Magnesium.
Potassium.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei53 – 531Substrate By similarity
Metal bindingi55 – 551Potassium By similarity
Metal bindingi57 – 571Potassium By similarity
Metal bindingi87 – 871Potassium By similarity
Metal bindingi88 – 881Potassium; via carbonyl oxygen By similarity
Sitei238 – 2381Transition state stabilizer By similarity
Metal bindingi240 – 2401Magnesium By similarity
Binding sitei263 – 2631Substrate; via amide nitrogen By similarity
Metal bindingi264 – 2641Magnesium By similarity
Binding sitei264 – 2641Substrate; via amide nitrogen By similarity
Binding sitei296 – 2961Substrate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Name:PYK
OrganismiTrypanoplasma borreli
Taxonomic identifieri5710 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaBodonidaeTrypanoplasma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498Pyruvate kinasePRO_0000112105Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ27788.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27788-1 [UniParc]FASTAAdd to Basket

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MMRKSQLQFN TELRVHHPPA LFRSNKIICT IGPSSQSVEV LKDLMKAGLN    50
VARMNFSHGT YEYHQKTIDN VRKAASELGI HVGIALDTKG PEIRTGLFPA 100
GDVVIEAHKT VILTTDETFK EKGTAEKFYV DYMNITKVVP VGGHIFVDDG 150
LLDLIVVKIS GKDIECVAQN THTISNRKGI NLPNADVDLP AVSEKDLMDL 200
QFGAKNRVDF VFASFIRNAD QVNEVRQAFG GKIAVIAKIE NYQGIDNIDA 250
IIDAADGIMV ARGDLGVEIP AEKVVIAQKM IMSKCNKVGK TVICATQMLD 300
SMTHGPRPTR AEVSDVAKSV LDGADCVMLS GETAKGKYPV ETVVYMSRIC 350
CETQVTMWNM AAFEAIKNLQ SFPLIPEEAI CSSAVNSIFE LHAKAILVLT 400
NTGRSAHMVS KYRPPVPIIC ASQELDVCRL LSITRGTIPV YYDTEKLGPD 450
YDREKRVGLA IDVGKQMGVF KEGDVVVAVH ADHHTKGFAN QIRAIYIK 498
Length:498
Mass (Da):54,634
Last modified:November 1, 1996 - v1
Checksum:i7C5882430B93DE21
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77255 Genomic DNA. Translation: CAA54472.1.
X77255 Genomic DNA. Translation: CAA54473.1.
PIRiJC2456.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X77255 Genomic DNA. Translation: CAA54472.1 .
X77255 Genomic DNA. Translation: CAA54473.1 .
PIRi JC2456.

3D structure databases

ProteinModelPortali Q27788.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and sequence analysis of the gene encoding pyruvate kinase in Trypanoplasma borelli."
    Ernest I., Opperdoes F.R., Michels P.A.M.
    Biochem. Biophys. Res. Commun. 201:727-732(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiKPYK_TRYBO
AccessioniPrimary (citable) accession number: Q27788
Secondary accession number(s): Q27789
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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