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Q27788

- KPYK_TRYBO

UniProt

Q27788 - KPYK_TRYBO

Protein

Pyruvate kinase

Gene

PYK

Organism
Trypanoplasma borreli
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + pyruvate = ADP + phosphoenolpyruvate.

    Cofactori

    Magnesium.
    Potassium.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei53 – 531SubstrateBy similarity
    Metal bindingi55 – 551PotassiumBy similarity
    Metal bindingi57 – 571PotassiumBy similarity
    Metal bindingi87 – 871PotassiumBy similarity
    Metal bindingi88 – 881Potassium; via carbonyl oxygenBy similarity
    Sitei238 – 2381Transition state stabilizerBy similarity
    Metal bindingi240 – 2401MagnesiumBy similarity
    Binding sitei263 – 2631Substrate; via amide nitrogenBy similarity
    Metal bindingi264 – 2641MagnesiumBy similarity
    Binding sitei264 – 2641Substrate; via amide nitrogenBy similarity
    Binding sitei296 – 2961SubstrateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: InterPro
    3. potassium ion binding Source: InterPro
    4. pyruvate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00188.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate kinase (EC:2.7.1.40)
    Short name:
    PK
    Gene namesi
    Name:PYK
    OrganismiTrypanoplasma borreli
    Taxonomic identifieri5710 [NCBI]
    Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaBodonidaeTrypanoplasma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 498498Pyruvate kinasePRO_0000112105Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ27788.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pyruvate kinase family.Curated

    Family and domain databases

    Gene3Di2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProiIPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view]
    PANTHERiPTHR11817. PTHR11817. 1 hit.
    PfamiPF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view]
    PRINTSiPR01050. PYRUVTKNASE.
    SUPFAMiSSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
    PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q27788-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMRKSQLQFN TELRVHHPPA LFRSNKIICT IGPSSQSVEV LKDLMKAGLN    50
    VARMNFSHGT YEYHQKTIDN VRKAASELGI HVGIALDTKG PEIRTGLFPA 100
    GDVVIEAHKT VILTTDETFK EKGTAEKFYV DYMNITKVVP VGGHIFVDDG 150
    LLDLIVVKIS GKDIECVAQN THTISNRKGI NLPNADVDLP AVSEKDLMDL 200
    QFGAKNRVDF VFASFIRNAD QVNEVRQAFG GKIAVIAKIE NYQGIDNIDA 250
    IIDAADGIMV ARGDLGVEIP AEKVVIAQKM IMSKCNKVGK TVICATQMLD 300
    SMTHGPRPTR AEVSDVAKSV LDGADCVMLS GETAKGKYPV ETVVYMSRIC 350
    CETQVTMWNM AAFEAIKNLQ SFPLIPEEAI CSSAVNSIFE LHAKAILVLT 400
    NTGRSAHMVS KYRPPVPIIC ASQELDVCRL LSITRGTIPV YYDTEKLGPD 450
    YDREKRVGLA IDVGKQMGVF KEGDVVVAVH ADHHTKGFAN QIRAIYIK 498
    Length:498
    Mass (Da):54,634
    Last modified:November 1, 1996 - v1
    Checksum:i7C5882430B93DE21
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77255 Genomic DNA. Translation: CAA54472.1.
    X77255 Genomic DNA. Translation: CAA54473.1.
    PIRiJC2456.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X77255 Genomic DNA. Translation: CAA54472.1 .
    X77255 Genomic DNA. Translation: CAA54473.1 .
    PIRi JC2456.

    3D structure databases

    ProteinModelPortali Q27788.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00188 .

    Family and domain databases

    Gene3Di 2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProi IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view ]
    PANTHERi PTHR11817. PTHR11817. 1 hit.
    Pfami PF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01050. PYRUVTKNASE.
    SUPFAMi SSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
    PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequence analysis of the gene encoding pyruvate kinase in Trypanoplasma borelli."
      Ernest I., Opperdoes F.R., Michels P.A.M.
      Biochem. Biophys. Res. Commun. 201:727-732(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

    Entry informationi

    Entry nameiKPYK_TRYBO
    AccessioniPrimary (citable) accession number: Q27788
    Secondary accession number(s): Q27789
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3