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Protein

Protein disulfide-isomerase

Gene
N/A
Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomeraseUniRule annotation (EC:5.3.4.1UniRule annotation)
OrganismiStrongylocentrotus purpuratus (Purple sea urchin)Imported
Taxonomic identifieri7668 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17UniRule annotationAdd BLAST17
ChainiPRO_500514288818 – 496Protein disulfide-isomeraseUniRule annotationAdd BLAST479

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ27780.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 132ThioredoxinInterPro annotationAdd BLAST129
Domaini340 – 468ThioredoxinInterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.UniRule annotationSAAS annotation
Contains 2 thioredoxin domains.UniRule annotation

Keywords - Domaini

Redox-active centerSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation

Phylogenomic databases

KOiK09580.

Family and domain databases

Gene3Di3.40.30.10. 4 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEiPS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27780-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYLALCFIA LACAVHAAVE VEIEEDVAVL TDAAFADYVA ENEFVLVEFY
60 70 80 90 100
APWCGHCKSL APQYSIAAKT LKDSGSSIKL AKVDATVETQ LPGKYGVRGY
110 120 130 140 150
PTLKFFRSGK DSEYAGGRTG PEIVAWLNKK TGPPAATIAS VEDAEAFLAD
160 170 180 190 200
KEVAVIGFFK DVPQTFLDVA VNIDDIPFAI VSDDAVISNY EAKDGSIILF
210 220 230 240 250
KKFDEGKNVF EGELTSEDLT SFVRKNSLSV VTEFGEETAS KIFGGEIKIH
260 270 280 290 300
NLLFVKKDSD DFKTIYDQFY AAATTFKGEV LFVLIDAAAE SNSRILEYFG
310 320 330 340 350
LGDEEVPTVR LITLDGDMKK YKPTVPELTT ESLSQFVIDF KDGKLKPHLM
360 370 380 390 400
SESVPEDWNA NPVTILVGEN FAEVALDPTK DVLVEFYAPW CGHCKQLAPI
410 420 430 440 450
YEELGEHFKE REDVVIAKVD STKNEVEDAV VRSFPTLKFW KKGENEMVDY
460 470 480 490
SGDRTLEAMI QFVESGGEII AEVDDEDMEE DEEMDEGAED QAKDEL
Length:496
Mass (Da):54,918
Last modified:November 1, 1996 - v1
Checksum:i0F01F887588AF7E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06484 mRNA. Translation: AAA57472.1.
PIRiA54757.
RefSeqiNP_999697.1. NM_214532.1.
UniGeneiSpu.1.
Spu.1256.

Genome annotation databases

GeneIDi373305.
KEGGispu:373305.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06484 mRNA. Translation: AAA57472.1.
PIRiA54757.
RefSeqiNP_999697.1. NM_214532.1.
UniGeneiSpu.1.
Spu.1256.

3D structure databases

ProteinModelPortaliQ27780.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373305.
KEGGispu:373305.

Organism-specific databases

CTDi373305.

Phylogenomic databases

KOiK09580.

Family and domain databases

Gene3Di3.40.30.10. 4 hits.
InterProiIPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PfamiPF00085. Thioredoxin. 2 hits.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 4 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEiPS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ27780_STRPU
AccessioniPrimary (citable) accession number: Q27780
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.