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Protein

Protein disulfide-isomerase

Gene
N/A
Organism
Strongylocentrotus purpuratus (Purple sea urchin)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Catalyzes the rearrangement of -S-S- bonds in proteins.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationImported

Names & Taxonomyi

Protein namesi
Recommended name:
Protein disulfide-isomeraseUniRule annotation (EC:5.3.4.1UniRule annotation)
OrganismiStrongylocentrotus purpuratus (Purple sea urchin)Imported
Taxonomic identifieri7668 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaStrongylocentrotidaeStrongylocentrotus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17UniRule annotationAdd BLAST17
ChainiPRO_500514288818 – 496Protein disulfide-isomeraseUniRule annotationAdd BLAST479

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 57Redox-activeUniRule annotation
Disulfide bondi391 ↔ 394Redox-activeUniRule annotation

Keywords - PTMi

Disulfide bondUniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ27780.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 132ThioredoxinInterPro annotationAdd BLAST129
Domaini340 – 468ThioredoxinInterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the protein disulfide isomerase family.UniRule annotationSAAS annotation

Keywords - Domaini

Redox-active centerUniRule annotationSAAS annotation, RepeatSAAS annotation, SignalUniRule annotation

Phylogenomic databases

KOiK09580.

Family and domain databases

InterProiView protein in InterPro
IPR005788. Disulphide_isomerase.
IPR005792. Prot_disulphide_isomerase.
IPR036249. Thioredoxin-like_sf.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
PfamiView protein in Pfam
PF00085. Thioredoxin. 2 hits.
SUPFAMiSSF52833. SSF52833. 4 hits.
TIGRFAMsiTIGR01130. ER_PDI_fam. 1 hit.
TIGR01126. pdi_dom. 2 hits.
PROSITEiView protein in PROSITE
PS00194. THIOREDOXIN_1. 2 hits.
PS51352. THIOREDOXIN_2. 2 hits.

Sequencei

Sequence statusi: Complete.

Q27780-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKYLALCFIA LACAVHAAVE VEIEEDVAVL TDAAFADYVA ENEFVLVEFY
60 70 80 90 100
APWCGHCKSL APQYSIAAKT LKDSGSSIKL AKVDATVETQ LPGKYGVRGY
110 120 130 140 150
PTLKFFRSGK DSEYAGGRTG PEIVAWLNKK TGPPAATIAS VEDAEAFLAD
160 170 180 190 200
KEVAVIGFFK DVPQTFLDVA VNIDDIPFAI VSDDAVISNY EAKDGSIILF
210 220 230 240 250
KKFDEGKNVF EGELTSEDLT SFVRKNSLSV VTEFGEETAS KIFGGEIKIH
260 270 280 290 300
NLLFVKKDSD DFKTIYDQFY AAATTFKGEV LFVLIDAAAE SNSRILEYFG
310 320 330 340 350
LGDEEVPTVR LITLDGDMKK YKPTVPELTT ESLSQFVIDF KDGKLKPHLM
360 370 380 390 400
SESVPEDWNA NPVTILVGEN FAEVALDPTK DVLVEFYAPW CGHCKQLAPI
410 420 430 440 450
YEELGEHFKE REDVVIAKVD STKNEVEDAV VRSFPTLKFW KKGENEMVDY
460 470 480 490
SGDRTLEAMI QFVESGGEII AEVDDEDMEE DEEMDEGAED QAKDEL
Length:496
Mass (Da):54,918
Last modified:November 1, 1996 - v1
Checksum:i0F01F887588AF7E5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06484 mRNA. Translation: AAA57472.1.
PIRiA54757.
RefSeqiNP_999697.1. NM_214532.1.
UniGeneiSpu.1.
Spu.1256.

Genome annotation databases

GeneIDi373305.
KEGGispu:373305.

Similar proteinsi

Entry informationi

Entry nameiQ27780_STRPU
AccessioniPrimary (citable) accession number: Q27780
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 25, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)