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Protein

Calcium-transporting ATPase

Gene

SMA1

Organism
Schistosoma mansoni (Blood fluke)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotationImported

Keywords - Biological processi

Calcium transportUniRule annotation, Ion transport, Transport

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:SMA1Imported
ORF Names:Smp_007260.2Imported
OrganismiSchistosoma mansoni (Blood fluke)Imported
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma
Proteomesi
  • UP000008854 Componenti: Chromosome 1

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei61 – 7919HelicalUniRule annotationAdd
BLAST
Transmembranei85 – 10824HelicalUniRule annotationAdd
BLAST
Transmembranei261 – 27919HelicalUniRule annotationAdd
BLAST
Transmembranei299 – 32224HelicalUniRule annotationAdd
BLAST
Transmembranei762 – 78322HelicalUniRule annotationAdd
BLAST
Transmembranei795 – 81420HelicalUniRule annotationAdd
BLAST
Transmembranei835 – 85925HelicalUniRule annotationAdd
BLAST
Transmembranei930 – 95223HelicalUniRule annotationAdd
BLAST
Transmembranei1000 – 101920HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi6183.Smp_007260.2__mRNA.

Structurei

3D structure databases

SMRiQ27779. Positions 2-992.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7875Cation_ATPase_NInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0202. Eukaryota.
COG0474. LUCA.
HOGENOMiHOG000265621.
OMAiCEVASSI.
PhylomeDBiQ27779.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005782. P-type_ATPase_IIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01116. ATPase-IIA1_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27779-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEEAYSCTV DDILKHYNTN TETGLTKRQI ESSLKEYGYN ELPPEENKPL
60 70 80 90 100
WKLVLGQFDD LLVKILLLAA IISFVLAWFE DSEDATTAFV EPVVIMLILI
110 120 130 140 150
VNAIVGVWQE RNAESAIEAL KEYESDTAKV VRQGYQGVQS VKARELVPGD
160 170 180 190 200
IVEVAVGDRV PADIRIVKIL STTLLIDQSI LTGESVSVSK HSDPISQARA
210 220 230 240 250
VNQDKKNMLF SGTNVASGKC VGIVVGTGLS TEIGKIRDQI MHTEQDKTPL
260 270 280 290 300
GQKIDEFGTQ LSKVITFICI AVWCINIGHF NDPVHGGSWL RGAVYYFKIA
310 320 330 340 350
VALAVAAIPE GLPAVITTCL ALGTRRMARK NAIVRSLPSV ETLGCTTVIC
360 370 380 390 400
SDKTGTLTTN QMTVCRMFTF GNESRIGDAL QLKFDEFEIT GSKYAPEGNV
410 420 430 440 450
HHQGRKVDCS EYPCLVELAQ ICSLCNDSSM EYNESRHAYE KVGEATETAL
460 470 480 490 500
VCLVEKMNVT KVSKSNLTNH QLAMVCNRDI QKMFERKFTL EFSRDRKSMS
510 520 530 540 550
TYVIPQSQIS GSKEKLFVKG APESILDRCT YVRTAGGKLL LTSELKGEVL
560 570 580 590 600
RKIATYATGR ETLRCLALAT RDEPPSHFDL KDPKNFKDYE TELTLVGVVG
610 620 630 640 650
MVDPPRCEVA SSIQACKKAG IRVIVITGDN KATAEAICRR IGLFEDKEDT
660 670 680 690 700
SGKSFTGREF DDLSLEKKKD AVRNGKLFAR VEPAHKSLIV QFLQQDGEIS
710 720 730 740 750
AMTGDGVNDA PALKKAEIGI AMGSGTAVAK SASDMVLADD NFSTIVAAVE
760 770 780 790 800
EGRAIYDNMK QFIRYLISSN IGEVVCIFLT AALGMPEALI PVQLLWVNLV
810 820 830 840 850
TDGLPATALG FNPPDVDIMT KPPRKSKEPL ISGWLFLRYM LIGIYVGCAT
860 870 880 890 900
VGAAAWWFMV YEGGPKVNYY QLTHHLQCQL EPSAFKGVNC SVFASPKPMT
910 920 930 940 950
MALSVLVLIE MFNALNSLSE NQSLVVMPPW HNMWLIAAIC FSMTLHFAIL
960 970 980 990 1000
YINVLANIFQ IAALNIAEWF AVLKISIPVL LLDETQKAIV RSSQRGHSPL
1010 1020
YHMAIPMVMW CVYSAFLAFN PL
Length:1,022
Mass (Da):112,594
Last modified:November 1, 1996 - v1
Checksum:iCD84184F49E4158F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40328 mRNA. Translation: AAA96714.1.
HE601624 Genomic DNA. Translation: CCD75577.1.

Genome annotation databases

EnsemblMetazoaiSmp_007260.2; Smp_007260.2:pep; Smp_007260.
GeneDBiSmp_007260.2:pep.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40328 mRNA. Translation: AAA96714.1.
HE601624 Genomic DNA. Translation: CCD75577.1.

3D structure databases

SMRiQ27779. Positions 2-992.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6183.Smp_007260.2__mRNA.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiSmp_007260.2; Smp_007260.2:pep; Smp_007260.
GeneDBiSmp_007260.2:pep.

Phylogenomic databases

eggNOGiKOG0202. Eukaryota.
COG0474. LUCA.
HOGENOMiHOG000265621.
OMAiCEVASSI.
PhylomeDBiQ27779.

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005782. P-type_ATPase_IIA.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01116. ATPase-IIA1_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a putative calcium-transporting ATPase gene from Schistosoma mansoni."
    de Mendonca R.L., Beck E., Rumjanek F.D., Goffeau A.
    Mol. Biochem. Parasitol. 72:129-139(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Puerto RicanImported.
    Tissue: Whole wormImported.
  2. Aslett M.
    Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Puerto Rico.
  3. "A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni."
    Protasio A.V., Tsai J.I., Babbage A., Nichol S., Hunt M., de Silva N., Anderson T.J.C., Clark R.C., Davidson C., Dillon G.P., Holroyd N., LoVerde P.T., Lloyd C., McQuillan J., Oliveira G., Otto T.D., Parker-Manuel S.J., Quail M.A.
    , Wilson A., Zerlotini A., Dunne D.W., Berriman M.
    Submitted (OCT-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Puerto Rico.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Puerto RicanImported.

Entry informationi

Entry nameiQ27779_SCHMA
AccessioniPrimary (citable) accession number: Q27779
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.