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Protein

Calcium-transporting ATPase

Gene

SMA1

Organism
Schistosoma mansoni (Blood fluke)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium.UniRule annotation

Catalytic activityi

ATP + H2O + Ca2+(Side 1) = ADP + phosphate + Ca2+(Side 2).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processCalcium transportUniRule annotation, Ion transport, Transport
LigandATP-bindingUniRule annotationSAAS annotation, Calcium, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-transporting ATPaseUniRule annotation (EC:3.6.3.8UniRule annotation)
Gene namesi
Name:SMA1Imported
ORF Names:Smp_007260.2Imported
OrganismiSchistosoma mansoni (Blood fluke)Imported
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma
Proteomesi
  • UP000008854 Componenti: Chromosome 1

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei61 – 79HelicalUniRule annotationAdd BLAST19
Transmembranei85 – 108HelicalUniRule annotationAdd BLAST24
Transmembranei261 – 279HelicalUniRule annotationAdd BLAST19
Transmembranei299 – 322HelicalUniRule annotationAdd BLAST24
Transmembranei762 – 783HelicalUniRule annotationAdd BLAST22
Transmembranei795 – 814HelicalUniRule annotationAdd BLAST20
Transmembranei835 – 859HelicalUniRule annotationAdd BLAST25
Transmembranei930 – 952HelicalUniRule annotationAdd BLAST23
Transmembranei1000 – 1019HelicalUniRule annotationAdd BLAST20

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

ExpressionAtlasiQ27779. baseline.

Interactioni

Protein-protein interaction databases

STRINGi6183.Smp_007260.2__mRNA.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 78Cation_ATPase_NInterPro annotationAdd BLAST75

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0202. Eukaryota.
COG0474. LUCA.
HOGENOMiHOG000265621.
OMAiDLDIMSR.
OrthoDBiEOG091G01LE.

Family and domain databases

Gene3Di3.40.1110.10. 2 hits.
3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005782. P-type_ATPase_IIA.
IPR001757. P_typ_ATPase.
IPR030330. SERCA3.
PANTHERiPTHR42861:SF23. PTHR42861:SF23. 1 hit.
PfamiView protein in Pfam
PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
SMARTiView protein in SMART
SM00831. Cation_ATPase_N. 1 hit.
SUPFAMiSSF56784. SSF56784. 1 hit.
SSF81653. SSF81653. 1 hit.
SSF81660. SSF81660. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01116. ATPase-IIA1_Ca. 1 hit.
TIGR01494. ATPase_P-type. 3 hits.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q27779-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLEEAYSCTV DDILKHYNTN TETGLTKRQI ESSLKEYGYN ELPPEENKPL
60 70 80 90 100
WKLVLGQFDD LLVKILLLAA IISFVLAWFE DSEDATTAFV EPVVIMLILI
110 120 130 140 150
VNAIVGVWQE RNAESAIEAL KEYESDTAKV VRQGYQGVQS VKARELVPGD
160 170 180 190 200
IVEVAVGDRV PADIRIVKIL STTLLIDQSI LTGESVSVSK HSDPISQARA
210 220 230 240 250
VNQDKKNMLF SGTNVASGKC VGIVVGTGLS TEIGKIRDQI MHTEQDKTPL
260 270 280 290 300
GQKIDEFGTQ LSKVITFICI AVWCINIGHF NDPVHGGSWL RGAVYYFKIA
310 320 330 340 350
VALAVAAIPE GLPAVITTCL ALGTRRMARK NAIVRSLPSV ETLGCTTVIC
360 370 380 390 400
SDKTGTLTTN QMTVCRMFTF GNESRIGDAL QLKFDEFEIT GSKYAPEGNV
410 420 430 440 450
HHQGRKVDCS EYPCLVELAQ ICSLCNDSSM EYNESRHAYE KVGEATETAL
460 470 480 490 500
VCLVEKMNVT KVSKSNLTNH QLAMVCNRDI QKMFERKFTL EFSRDRKSMS
510 520 530 540 550
TYVIPQSQIS GSKEKLFVKG APESILDRCT YVRTAGGKLL LTSELKGEVL
560 570 580 590 600
RKIATYATGR ETLRCLALAT RDEPPSHFDL KDPKNFKDYE TELTLVGVVG
610 620 630 640 650
MVDPPRCEVA SSIQACKKAG IRVIVITGDN KATAEAICRR IGLFEDKEDT
660 670 680 690 700
SGKSFTGREF DDLSLEKKKD AVRNGKLFAR VEPAHKSLIV QFLQQDGEIS
710 720 730 740 750
AMTGDGVNDA PALKKAEIGI AMGSGTAVAK SASDMVLADD NFSTIVAAVE
760 770 780 790 800
EGRAIYDNMK QFIRYLISSN IGEVVCIFLT AALGMPEALI PVQLLWVNLV
810 820 830 840 850
TDGLPATALG FNPPDVDIMT KPPRKSKEPL ISGWLFLRYM LIGIYVGCAT
860 870 880 890 900
VGAAAWWFMV YEGGPKVNYY QLTHHLQCQL EPSAFKGVNC SVFASPKPMT
910 920 930 940 950
MALSVLVLIE MFNALNSLSE NQSLVVMPPW HNMWLIAAIC FSMTLHFAIL
960 970 980 990 1000
YINVLANIFQ IAALNIAEWF AVLKISIPVL LLDETQKAIV RSSQRGHSPL
1010 1020
YHMAIPMVMW CVYSAFLAFN PL
Length:1,022
Mass (Da):112,594
Last modified:November 1, 1996 - v1
Checksum:iCD84184F49E4158F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L40328 mRNA. Translation: AAA96714.1.
HE601624 Genomic DNA. Translation: CCD75577.1.
RefSeqiXP_018648452.1. XM_018793995.1.
UniGeneiSma.14495.

Genome annotation databases

EnsemblMetazoaiSmp_007260.2; Smp_007260.2:pep; Smp_007260.
GeneDBiSmp_007260.2:pep.
GeneIDi8342565.
KEGGismm:Smp_007260.1.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ27779_SCHMA
AccessioniPrimary (citable) accession number: Q27779
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteomeImported