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Q27746 (DNMT1_PARLI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA (cytosine-5)-methyltransferase PliMCI
EC=2.1.1.37
Alternative name(s):
DNA methyltransferase PliMCI
Short name=DNA MTase PliMCI
Short name=M.PliMCI
Dnmt1
MCMT
Gene names
Name:DNMT
Synonyms:PLIMCIM
OrganismParacentrotus lividus (Common sea urchin)
Taxonomic identifier7656 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Echinodermata › Eleutherozoa › Echinozoa › Echinoidea › Euechinoidea › Echinacea › Echinoida › Echinidae › Paracentrotus

Protein attributes

Sequence length1612 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Methylates CpG residues.

Catalytic activity

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the C5-methyltransferase family.

Contains 2 BAH domains.

Contains 1 CXXC-type zinc finger.

Ontologies

Keywords
   Cellular componentNucleus
   DomainRepeat
Zinc-finger
   LigandDNA-binding
Metal-binding
S-adenosyl-L-methionine
Zinc
   Molecular functionMethyltransferase
Transferase
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA (cytosine-5-)-methyltransferase activity

Inferred from electronic annotation. Source: EC

DNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 16121612DNA (cytosine-5)-methyltransferase PliMCI
PRO_0000088038

Regions

Domain743 – 871129BAH 1
Domain967 – 1089123BAH 2
Zinc finger626 – 67247CXXC-type
Compositional bias172 – 1787Poly-Lys
Compositional bias288 – 2914Poly-Glu
Compositional bias303 – 3086Poly-Glu
Compositional bias712 – 7154Poly-Lys

Sites

Active site12181 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q27746 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 0CB3853FB565CF50

FASTA1,612181,219
        10         20         30         40         50         60 
MPSKTICDQV IPPNVRDRVQ ELDGDLNDGL ITEKGYVKKK SKILFEHLSP DIQTKLKGLE 

        70         80         90        100        110        120 
DELKDEELTE KGYLNKVQSI LAKFIETCSP VNGDTKEEAS SNGKDDEKAE STVANGTTSN 

       130        140        150        160        170        180 
GSTTNGSSGS SKANGHTNGG YVQSSSQEET GTSQSEEEMD MDTPTSGKGG SKKKKKSKGS 

       190        200        210        220        230        240 
GGGDAGKGRK RKVLGDDERD GVEKKEGEKK DVEGEEGEEA KEESATPDEK TLRTSKRKRS 

       250        260        270        280        290        300 
PKADAKQPSI MSMFTKKPAK KEEEKMEESS SMEVDKKEME NGDNGKKEEE EPSGPGGKRI 

       310        320        330        340        350        360 
KKEEEEEEKA KVEPMSPSRD LRHKANHETA ESKQPPLRCK ECRQLLDDPD LKIFPGDPED 

       370        380        390        400        410        420 
AREEYITLTD PRLSLLTGDE GDAMSYDERL QHKITNFCVY DKSTHICAFD RGMIEKNKEL 

       430        440        450        460        470        480 
YFSGYVKPIY DDNPSTEGGI PTKRIGPINE WYTTGFDGGH KALIGFSTAF AEYIVMSPSE 

       490        500        510        520        530        540 
EYKPFWTAVQ EKIYMSKILI EFLQNNVDPV YEDLLTQIET TVPPEGCNRF TEDSLLRHAQ 

       550        560        570        580        590        600 
FVVEQVESYD DAADRDEVLL ITMPCMRDLI KLAGVTLGKR RAARKAAAVK KDKKPVFTMA 

       610        620        630        640        650        660 
TVTPLVSHIF DAIFKDQIAD EMKAAASERK KRCGVCEICQ APDCGKCTAC KDMIKFGGSG 

       670        680        690        700        710        720 
KAKQACKDRR CPNMAVQEAD ENDIDEMDNS SNKENKDEKK AKKGRKLETP LKKKKRAKVT 

       730        740        750        760        770        780 
WLDEPTEVTE ERAYYKAAML DDEKIEIGDC VLIHPDDPTK PLFMARVIYM WQESQGEMMF 

       790        800        810        820        830        840 
HAQWFVYGSE TVLGETSDPL EVFPIDECQD TYLGSVNAKC TVIYKAPPND WSMIGGIDDP 

       850        860        870        880        890        900 
ETDHVIKEDD GKTFFYQKWY DPELARFEDY EVLMAPDDIP AHRFCSCCLK NERAQEKETA 

       910        920        930        940        950        960 
RPGAKLEDQD DSSKVLYSSW HYKGNEFQIG DGVYLLPEVF SFNIKQKVVT KKPVSKKDVD 

       970        980        990       1000       1010       1020 
EDLYPENYRK SSEYVKGSNL ECPEPFRIGK IISIYTTKSN STVRLRVNKM YRPEDTHKGR 

      1030       1040       1050       1060       1070       1080 
TAAYQADLNV LYWSEEEAVT ELEVVQGKCS VVCAEDLNVS TDEYSAGGPH KFYFREAYDS 

      1090       1100       1110       1120       1130       1140 
ERKCFEDPPS KSRSTRMKGK GKGKGKGKAK GKIAVEKEEE KESTETPFNK LKCLDVFAGC 

      1150       1160       1170       1180       1190       1200 
GGLSEGFHQA GICESSWAIE KEEPAAQAYR LNNPGSTVFS DDCNELLRLV MQGEKTSRTG 

      1210       1220       1230       1240       1250       1260 
QKLPQKGDVE LLCGGPPCQG FSGMNRFNSR EYSKFKNSLI SSYLSYCDYY RPRFFLLENV 

      1270       1280       1290       1300       1310       1320 
RNFVSYKKNM VLKLALRCLI RMGYQCTFGI LQAGQYGVPQ TRRRAIILAA APGEKLPFYP 

      1330       1340       1350       1360       1370       1380 
EPLHVFSSRA CSLSVMIGEK KIESNNQWCL SAPYRTITVR DTMSDLPTIN NGAQKLEISY 

      1390       1400       1410       1420       1430       1440 
DGEPQSDFQK KIRGNQYQPI LRDHICKDMS SLVAARMKHI PLAPGSDWRD LPNIPVTLKD 

      1450       1460       1470       1480       1490       1500 
GTTCRKLRYT HKDKKNGKSS TGALRGVCSC AEGDACDPSD RQFSTLIPWC LPHTGNRHNN 

      1510       1520       1530       1540       1550       1560 
WAGLYGRLEW DGFFSTTVTN PEPMGKQGRV LHPEQHRVVS VRECARSQGF PDTYRFFGSI 

      1570       1580       1590       1600       1610 
LDKHRQIGNA VPPPMAAAIG MEIKVCLQTK TKRDQERAAL EPVKEETEES MD

« Hide

References

[1]"Isolation of cDNA clones encoding DNA methyltransferase of sea urchin P. lividus: expression during embryonic development."
Aniello F., Locascio A., Fucci L., Geraci G., Branno M.
Gene 178:57-61(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Embryo.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z50183 mRNA. Translation: CAA90563.1.
PIRJC5210.

3D structure databases

ProteinModelPortalQ27746.
SMRQ27746. Positions 628-677.
ModBaseSearch...

Protein family/group databases

REBASE2961. M.PliMCDnmt1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR010506. DMAP1-bd.
IPR017198. DNA_C5-MeTrfase_1_euk.
IPR002857. Znf_CXXC.
[Graphical view]
PANTHERPTHR10629. PTHR10629. 1 hit.
PfamPF01426. BAH. 2 hits.
PF06464. DMAP_binding. 2 hits.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
PIRSFPIRSF037404. DNMT1. 1 hit.
PRINTSPR00105. C5METTRFRASE.
SMARTSM00439. BAH. 2 hits.
[Graphical view]
TIGRFAMsTIGR00675. dcm. 1 hit.
PROSITEPS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51058. ZF_CXXC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDNMT1_PARLI
AccessionPrimary (citable) accession number: Q27746
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1996
Last modified: April 3, 2013
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

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