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Q27746

- DNMT1_PARLI

UniProt

Q27746 - DNMT1_PARLI

Protein

DNA (cytosine-5)-methyltransferase PliMCI

Gene

DNMT

Organism
Paracentrotus lividus (Common sea urchin)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Methylates CpG residues.

    Catalytic activityi

    S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1218 – 12181PROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri626 – 67247CXXC-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: InterPro
    2. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
    3. DNA binding Source: UniProtKB-KW
    4. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Ligandi

    DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

    Protein family/group databases

    REBASEi2961. M.PliMCDnmt1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA (cytosine-5)-methyltransferase PliMCI (EC:2.1.1.37)
    Alternative name(s):
    DNA methyltransferase PliMCI
    Short name:
    DNA MTase PliMCI
    Short name:
    M.PliMCI
    Dnmt1
    MCMT
    Gene namesi
    Name:DNMT
    Synonyms:PLIMCIM
    OrganismiParacentrotus lividus (Common sea urchin)
    Taxonomic identifieri7656 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaEchinidaeParacentrotus

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 16121612DNA (cytosine-5)-methyltransferase PliMCIPRO_0000088038Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ27746.
    SMRiQ27746. Positions 628-677.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini50 – 12475DMAP-interactionAdd
    BLAST
    Domaini743 – 871129BAH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini967 – 1089123BAH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1131 – 1590460SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi172 – 1787Poly-Lys
    Compositional biasi288 – 2914Poly-Glu
    Compositional biasi303 – 3086Poly-Glu
    Compositional biasi712 – 7154Poly-Lys

    Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
    Contains 2 BAH domains.PROSITE-ProRule annotation
    Contains 1 CXXC-type zinc finger.PROSITE-ProRule annotation
    Contains 1 DMAP-interaction domain.Curated
    Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri626 – 67247CXXC-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR001025. BAH_dom.
    IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR022702. Cytosine_MeTrfase1_RFD.
    IPR010506. DMAP1-bd.
    IPR017198. DNA_C5-MeTrfase_1_euk.
    IPR029063. SAM-dependent_MTases-like.
    IPR002857. Znf_CXXC.
    [Graphical view]
    PANTHERiPTHR10629. PTHR10629. 1 hit.
    PfamiPF01426. BAH. 2 hits.
    PF06464. DMAP_binding. 2 hits.
    PF00145. DNA_methylase. 1 hit.
    PF12047. DNMT1-RFD. 1 hit.
    PF02008. zf-CXXC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037404. DNMT1. 1 hit.
    PRINTSiPR00105. C5METTRFRASE.
    SMARTiSM00439. BAH. 2 hits.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 2 hits.
    TIGRFAMsiTIGR00675. dcm. 1 hit.
    PROSITEiPS51038. BAH. 2 hits.
    PS00094. C5_MTASE_1. 1 hit.
    PS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    PS51058. ZF_CXXC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q27746-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSKTICDQV IPPNVRDRVQ ELDGDLNDGL ITEKGYVKKK SKILFEHLSP     50
    DIQTKLKGLE DELKDEELTE KGYLNKVQSI LAKFIETCSP VNGDTKEEAS 100
    SNGKDDEKAE STVANGTTSN GSTTNGSSGS SKANGHTNGG YVQSSSQEET 150
    GTSQSEEEMD MDTPTSGKGG SKKKKKSKGS GGGDAGKGRK RKVLGDDERD 200
    GVEKKEGEKK DVEGEEGEEA KEESATPDEK TLRTSKRKRS PKADAKQPSI 250
    MSMFTKKPAK KEEEKMEESS SMEVDKKEME NGDNGKKEEE EPSGPGGKRI 300
    KKEEEEEEKA KVEPMSPSRD LRHKANHETA ESKQPPLRCK ECRQLLDDPD 350
    LKIFPGDPED AREEYITLTD PRLSLLTGDE GDAMSYDERL QHKITNFCVY 400
    DKSTHICAFD RGMIEKNKEL YFSGYVKPIY DDNPSTEGGI PTKRIGPINE 450
    WYTTGFDGGH KALIGFSTAF AEYIVMSPSE EYKPFWTAVQ EKIYMSKILI 500
    EFLQNNVDPV YEDLLTQIET TVPPEGCNRF TEDSLLRHAQ FVVEQVESYD 550
    DAADRDEVLL ITMPCMRDLI KLAGVTLGKR RAARKAAAVK KDKKPVFTMA 600
    TVTPLVSHIF DAIFKDQIAD EMKAAASERK KRCGVCEICQ APDCGKCTAC 650
    KDMIKFGGSG KAKQACKDRR CPNMAVQEAD ENDIDEMDNS SNKENKDEKK 700
    AKKGRKLETP LKKKKRAKVT WLDEPTEVTE ERAYYKAAML DDEKIEIGDC 750
    VLIHPDDPTK PLFMARVIYM WQESQGEMMF HAQWFVYGSE TVLGETSDPL 800
    EVFPIDECQD TYLGSVNAKC TVIYKAPPND WSMIGGIDDP ETDHVIKEDD 850
    GKTFFYQKWY DPELARFEDY EVLMAPDDIP AHRFCSCCLK NERAQEKETA 900
    RPGAKLEDQD DSSKVLYSSW HYKGNEFQIG DGVYLLPEVF SFNIKQKVVT 950
    KKPVSKKDVD EDLYPENYRK SSEYVKGSNL ECPEPFRIGK IISIYTTKSN 1000
    STVRLRVNKM YRPEDTHKGR TAAYQADLNV LYWSEEEAVT ELEVVQGKCS 1050
    VVCAEDLNVS TDEYSAGGPH KFYFREAYDS ERKCFEDPPS KSRSTRMKGK 1100
    GKGKGKGKAK GKIAVEKEEE KESTETPFNK LKCLDVFAGC GGLSEGFHQA 1150
    GICESSWAIE KEEPAAQAYR LNNPGSTVFS DDCNELLRLV MQGEKTSRTG 1200
    QKLPQKGDVE LLCGGPPCQG FSGMNRFNSR EYSKFKNSLI SSYLSYCDYY 1250
    RPRFFLLENV RNFVSYKKNM VLKLALRCLI RMGYQCTFGI LQAGQYGVPQ 1300
    TRRRAIILAA APGEKLPFYP EPLHVFSSRA CSLSVMIGEK KIESNNQWCL 1350
    SAPYRTITVR DTMSDLPTIN NGAQKLEISY DGEPQSDFQK KIRGNQYQPI 1400
    LRDHICKDMS SLVAARMKHI PLAPGSDWRD LPNIPVTLKD GTTCRKLRYT 1450
    HKDKKNGKSS TGALRGVCSC AEGDACDPSD RQFSTLIPWC LPHTGNRHNN 1500
    WAGLYGRLEW DGFFSTTVTN PEPMGKQGRV LHPEQHRVVS VRECARSQGF 1550
    PDTYRFFGSI LDKHRQIGNA VPPPMAAAIG MEIKVCLQTK TKRDQERAAL 1600
    EPVKEETEES MD 1612
    Length:1,612
    Mass (Da):181,219
    Last modified:November 1, 1996 - v1
    Checksum:i0CB3853FB565CF50
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z50183 mRNA. Translation: CAA90563.1.
    PIRiJC5210.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z50183 mRNA. Translation: CAA90563.1 .
    PIRi JC5210.

    3D structure databases

    ProteinModelPortali Q27746.
    SMRi Q27746. Positions 628-677.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    REBASEi 2961. M.PliMCDnmt1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR001025. BAH_dom.
    IPR018117. C5_DNA_meth_AS.
    IPR001525. C5_MeTfrase.
    IPR022702. Cytosine_MeTrfase1_RFD.
    IPR010506. DMAP1-bd.
    IPR017198. DNA_C5-MeTrfase_1_euk.
    IPR029063. SAM-dependent_MTases-like.
    IPR002857. Znf_CXXC.
    [Graphical view ]
    PANTHERi PTHR10629. PTHR10629. 1 hit.
    Pfami PF01426. BAH. 2 hits.
    PF06464. DMAP_binding. 2 hits.
    PF00145. DNA_methylase. 1 hit.
    PF12047. DNMT1-RFD. 1 hit.
    PF02008. zf-CXXC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037404. DNMT1. 1 hit.
    PRINTSi PR00105. C5METTRFRASE.
    SMARTi SM00439. BAH. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 2 hits.
    TIGRFAMsi TIGR00675. dcm. 1 hit.
    PROSITEi PS51038. BAH. 2 hits.
    PS00094. C5_MTASE_1. 1 hit.
    PS00095. C5_MTASE_2. 1 hit.
    PS51679. SAM_MT_C5. 1 hit.
    PS51058. ZF_CXXC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of cDNA clones encoding DNA methyltransferase of sea urchin P. lividus: expression during embryonic development."
      Aniello F., Locascio A., Fucci L., Geraci G., Branno M.
      Gene 178:57-61(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryo.

    Entry informationi

    Entry nameiDNMT1_PARLI
    AccessioniPrimary (citable) accession number: Q27746
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3