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Q27746

- DNMT1_PARLI

UniProt

Q27746 - DNMT1_PARLI

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Protein

DNA (cytosine-5)-methyltransferase PliMCI

Gene
DNMT, PLIMCIM
Organism
Paracentrotus lividus (Common sea urchin)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Methylates CpG residues.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1218 – 12181 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri626 – 67247CXXC-typeAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: InterPro
  2. DNA (cytosine-5-)-methyltransferase activity Source: UniProtKB-EC
  3. DNA binding Source: UniProtKB-KW
  4. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

Protein family/group databases

REBASEi2961. M.PliMCDnmt1.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA (cytosine-5)-methyltransferase PliMCI (EC:2.1.1.37)
Alternative name(s):
DNA methyltransferase PliMCI
Short name:
DNA MTase PliMCI
Short name:
M.PliMCI
Dnmt1
MCMT
Gene namesi
Name:DNMT
Synonyms:PLIMCIM
OrganismiParacentrotus lividus (Common sea urchin)
Taxonomic identifieri7656 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaEchinidaeParacentrotus

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16121612DNA (cytosine-5)-methyltransferase PliMCIPRO_0000088038Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ27746.
SMRiQ27746. Positions 628-677.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 12475DMAP-interactionAdd
BLAST
Domaini743 – 871129BAH 1Add
BLAST
Domaini967 – 1089123BAH 2Add
BLAST
Domaini1131 – 1590460SAM-dependent MTase C5-typeAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi172 – 1787Poly-Lys
Compositional biasi288 – 2914Poly-Glu
Compositional biasi303 – 3086Poly-Glu
Compositional biasi712 – 7154Poly-Lys

Sequence similaritiesi

Contains 2 BAH domains.

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri626 – 67247CXXC-typeAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR010506. DMAP1-bd.
IPR017198. DNA_C5-MeTrfase_1_euk.
IPR029063. SAM-dependent_MTases-like.
IPR002857. Znf_CXXC.
[Graphical view]
PANTHERiPTHR10629. PTHR10629. 1 hit.
PfamiPF01426. BAH. 2 hits.
PF06464. DMAP_binding. 2 hits.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
PIRSFiPIRSF037404. DNMT1. 1 hit.
PRINTSiPR00105. C5METTRFRASE.
SMARTiSM00439. BAH. 2 hits.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
PS51058. ZF_CXXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27746-1 [UniParc]FASTAAdd to Basket

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MPSKTICDQV IPPNVRDRVQ ELDGDLNDGL ITEKGYVKKK SKILFEHLSP     50
DIQTKLKGLE DELKDEELTE KGYLNKVQSI LAKFIETCSP VNGDTKEEAS 100
SNGKDDEKAE STVANGTTSN GSTTNGSSGS SKANGHTNGG YVQSSSQEET 150
GTSQSEEEMD MDTPTSGKGG SKKKKKSKGS GGGDAGKGRK RKVLGDDERD 200
GVEKKEGEKK DVEGEEGEEA KEESATPDEK TLRTSKRKRS PKADAKQPSI 250
MSMFTKKPAK KEEEKMEESS SMEVDKKEME NGDNGKKEEE EPSGPGGKRI 300
KKEEEEEEKA KVEPMSPSRD LRHKANHETA ESKQPPLRCK ECRQLLDDPD 350
LKIFPGDPED AREEYITLTD PRLSLLTGDE GDAMSYDERL QHKITNFCVY 400
DKSTHICAFD RGMIEKNKEL YFSGYVKPIY DDNPSTEGGI PTKRIGPINE 450
WYTTGFDGGH KALIGFSTAF AEYIVMSPSE EYKPFWTAVQ EKIYMSKILI 500
EFLQNNVDPV YEDLLTQIET TVPPEGCNRF TEDSLLRHAQ FVVEQVESYD 550
DAADRDEVLL ITMPCMRDLI KLAGVTLGKR RAARKAAAVK KDKKPVFTMA 600
TVTPLVSHIF DAIFKDQIAD EMKAAASERK KRCGVCEICQ APDCGKCTAC 650
KDMIKFGGSG KAKQACKDRR CPNMAVQEAD ENDIDEMDNS SNKENKDEKK 700
AKKGRKLETP LKKKKRAKVT WLDEPTEVTE ERAYYKAAML DDEKIEIGDC 750
VLIHPDDPTK PLFMARVIYM WQESQGEMMF HAQWFVYGSE TVLGETSDPL 800
EVFPIDECQD TYLGSVNAKC TVIYKAPPND WSMIGGIDDP ETDHVIKEDD 850
GKTFFYQKWY DPELARFEDY EVLMAPDDIP AHRFCSCCLK NERAQEKETA 900
RPGAKLEDQD DSSKVLYSSW HYKGNEFQIG DGVYLLPEVF SFNIKQKVVT 950
KKPVSKKDVD EDLYPENYRK SSEYVKGSNL ECPEPFRIGK IISIYTTKSN 1000
STVRLRVNKM YRPEDTHKGR TAAYQADLNV LYWSEEEAVT ELEVVQGKCS 1050
VVCAEDLNVS TDEYSAGGPH KFYFREAYDS ERKCFEDPPS KSRSTRMKGK 1100
GKGKGKGKAK GKIAVEKEEE KESTETPFNK LKCLDVFAGC GGLSEGFHQA 1150
GICESSWAIE KEEPAAQAYR LNNPGSTVFS DDCNELLRLV MQGEKTSRTG 1200
QKLPQKGDVE LLCGGPPCQG FSGMNRFNSR EYSKFKNSLI SSYLSYCDYY 1250
RPRFFLLENV RNFVSYKKNM VLKLALRCLI RMGYQCTFGI LQAGQYGVPQ 1300
TRRRAIILAA APGEKLPFYP EPLHVFSSRA CSLSVMIGEK KIESNNQWCL 1350
SAPYRTITVR DTMSDLPTIN NGAQKLEISY DGEPQSDFQK KIRGNQYQPI 1400
LRDHICKDMS SLVAARMKHI PLAPGSDWRD LPNIPVTLKD GTTCRKLRYT 1450
HKDKKNGKSS TGALRGVCSC AEGDACDPSD RQFSTLIPWC LPHTGNRHNN 1500
WAGLYGRLEW DGFFSTTVTN PEPMGKQGRV LHPEQHRVVS VRECARSQGF 1550
PDTYRFFGSI LDKHRQIGNA VPPPMAAAIG MEIKVCLQTK TKRDQERAAL 1600
EPVKEETEES MD 1612
Length:1,612
Mass (Da):181,219
Last modified:November 1, 1996 - v1
Checksum:i0CB3853FB565CF50
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z50183 mRNA. Translation: CAA90563.1.
PIRiJC5210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z50183 mRNA. Translation: CAA90563.1 .
PIRi JC5210.

3D structure databases

ProteinModelPortali Q27746.
SMRi Q27746. Positions 628-677.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

REBASEi 2961. M.PliMCDnmt1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR010506. DMAP1-bd.
IPR017198. DNA_C5-MeTrfase_1_euk.
IPR029063. SAM-dependent_MTases-like.
IPR002857. Znf_CXXC.
[Graphical view ]
PANTHERi PTHR10629. PTHR10629. 1 hit.
Pfami PF01426. BAH. 2 hits.
PF06464. DMAP_binding. 2 hits.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view ]
PIRSFi PIRSF037404. DNMT1. 1 hit.
PRINTSi PR00105. C5METTRFRASE.
SMARTi SM00439. BAH. 2 hits.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 2 hits.
TIGRFAMsi TIGR00675. dcm. 1 hit.
PROSITEi PS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
PS51058. ZF_CXXC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Isolation of cDNA clones encoding DNA methyltransferase of sea urchin P. lividus: expression during embryonic development."
    Aniello F., Locascio A., Fucci L., Geraci G., Branno M.
    Gene 178:57-61(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiDNMT1_PARLI
AccessioniPrimary (citable) accession number: Q27746
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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