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Protein

DNA (cytosine-5)-methyltransferase PliMCI

Gene

DNMT

Organism
Paracentrotus lividus (Common sea urchin)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Methylates CpG residues.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1218 – 12181PROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri626 – 67247CXXC-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

DNA-binding, Metal-binding, S-adenosyl-L-methionine, Zinc

Protein family/group databases

REBASEi2961. M.PliMCDnmt1.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA (cytosine-5)-methyltransferase PliMCI (EC:2.1.1.37)
Alternative name(s):
DNA methyltransferase PliMCI
Short name:
DNA MTase PliMCI
Short name:
M.PliMCI
Dnmt1
MCMT
Gene namesi
Name:DNMT
Synonyms:PLIMCIM
OrganismiParacentrotus lividus (Common sea urchin)
Taxonomic identifieri7656 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEchinodermataEleutherozoaEchinozoaEchinoideaEuechinoideaEchinaceaEchinoidaEchinidaeParacentrotus

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 16121612DNA (cytosine-5)-methyltransferase PliMCIPRO_0000088038Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ27746.
SMRiQ27746. Positions 628-677.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini50 – 12475DMAP-interactionAdd
BLAST
Domaini743 – 871129BAH 1PROSITE-ProRule annotationAdd
BLAST
Domaini967 – 1089123BAH 2PROSITE-ProRule annotationAdd
BLAST
Domaini1131 – 1590460SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi172 – 1787Poly-Lys
Compositional biasi288 – 2914Poly-Glu
Compositional biasi303 – 3086Poly-Glu
Compositional biasi712 – 7154Poly-Lys

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation
Contains 2 BAH domains.PROSITE-ProRule annotation
Contains 1 CXXC-type zinc finger.PROSITE-ProRule annotation
Contains 1 DMAP-interaction domain.Curated
Contains 1 SAM-dependent MTase C5-type domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri626 – 67247CXXC-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR010506. DMAP1-bd.
IPR017198. DNMT1_meta.
IPR029063. SAM-dependent_MTases.
IPR002857. Znf_CXXC.
[Graphical view]
PfamiPF01426. BAH. 2 hits.
PF06464. DMAP_binding. 2 hits.
PF12047. DNMT1-RFD. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
PIRSFiPIRSF037404. DNMT1. 1 hit.
PRINTSiPR00105. C5METTRFRASE.
SMARTiSM00439. BAH. 2 hits.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
PS51058. ZF_CXXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27746-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKTICDQV IPPNVRDRVQ ELDGDLNDGL ITEKGYVKKK SKILFEHLSP
60 70 80 90 100
DIQTKLKGLE DELKDEELTE KGYLNKVQSI LAKFIETCSP VNGDTKEEAS
110 120 130 140 150
SNGKDDEKAE STVANGTTSN GSTTNGSSGS SKANGHTNGG YVQSSSQEET
160 170 180 190 200
GTSQSEEEMD MDTPTSGKGG SKKKKKSKGS GGGDAGKGRK RKVLGDDERD
210 220 230 240 250
GVEKKEGEKK DVEGEEGEEA KEESATPDEK TLRTSKRKRS PKADAKQPSI
260 270 280 290 300
MSMFTKKPAK KEEEKMEESS SMEVDKKEME NGDNGKKEEE EPSGPGGKRI
310 320 330 340 350
KKEEEEEEKA KVEPMSPSRD LRHKANHETA ESKQPPLRCK ECRQLLDDPD
360 370 380 390 400
LKIFPGDPED AREEYITLTD PRLSLLTGDE GDAMSYDERL QHKITNFCVY
410 420 430 440 450
DKSTHICAFD RGMIEKNKEL YFSGYVKPIY DDNPSTEGGI PTKRIGPINE
460 470 480 490 500
WYTTGFDGGH KALIGFSTAF AEYIVMSPSE EYKPFWTAVQ EKIYMSKILI
510 520 530 540 550
EFLQNNVDPV YEDLLTQIET TVPPEGCNRF TEDSLLRHAQ FVVEQVESYD
560 570 580 590 600
DAADRDEVLL ITMPCMRDLI KLAGVTLGKR RAARKAAAVK KDKKPVFTMA
610 620 630 640 650
TVTPLVSHIF DAIFKDQIAD EMKAAASERK KRCGVCEICQ APDCGKCTAC
660 670 680 690 700
KDMIKFGGSG KAKQACKDRR CPNMAVQEAD ENDIDEMDNS SNKENKDEKK
710 720 730 740 750
AKKGRKLETP LKKKKRAKVT WLDEPTEVTE ERAYYKAAML DDEKIEIGDC
760 770 780 790 800
VLIHPDDPTK PLFMARVIYM WQESQGEMMF HAQWFVYGSE TVLGETSDPL
810 820 830 840 850
EVFPIDECQD TYLGSVNAKC TVIYKAPPND WSMIGGIDDP ETDHVIKEDD
860 870 880 890 900
GKTFFYQKWY DPELARFEDY EVLMAPDDIP AHRFCSCCLK NERAQEKETA
910 920 930 940 950
RPGAKLEDQD DSSKVLYSSW HYKGNEFQIG DGVYLLPEVF SFNIKQKVVT
960 970 980 990 1000
KKPVSKKDVD EDLYPENYRK SSEYVKGSNL ECPEPFRIGK IISIYTTKSN
1010 1020 1030 1040 1050
STVRLRVNKM YRPEDTHKGR TAAYQADLNV LYWSEEEAVT ELEVVQGKCS
1060 1070 1080 1090 1100
VVCAEDLNVS TDEYSAGGPH KFYFREAYDS ERKCFEDPPS KSRSTRMKGK
1110 1120 1130 1140 1150
GKGKGKGKAK GKIAVEKEEE KESTETPFNK LKCLDVFAGC GGLSEGFHQA
1160 1170 1180 1190 1200
GICESSWAIE KEEPAAQAYR LNNPGSTVFS DDCNELLRLV MQGEKTSRTG
1210 1220 1230 1240 1250
QKLPQKGDVE LLCGGPPCQG FSGMNRFNSR EYSKFKNSLI SSYLSYCDYY
1260 1270 1280 1290 1300
RPRFFLLENV RNFVSYKKNM VLKLALRCLI RMGYQCTFGI LQAGQYGVPQ
1310 1320 1330 1340 1350
TRRRAIILAA APGEKLPFYP EPLHVFSSRA CSLSVMIGEK KIESNNQWCL
1360 1370 1380 1390 1400
SAPYRTITVR DTMSDLPTIN NGAQKLEISY DGEPQSDFQK KIRGNQYQPI
1410 1420 1430 1440 1450
LRDHICKDMS SLVAARMKHI PLAPGSDWRD LPNIPVTLKD GTTCRKLRYT
1460 1470 1480 1490 1500
HKDKKNGKSS TGALRGVCSC AEGDACDPSD RQFSTLIPWC LPHTGNRHNN
1510 1520 1530 1540 1550
WAGLYGRLEW DGFFSTTVTN PEPMGKQGRV LHPEQHRVVS VRECARSQGF
1560 1570 1580 1590 1600
PDTYRFFGSI LDKHRQIGNA VPPPMAAAIG MEIKVCLQTK TKRDQERAAL
1610
EPVKEETEES MD
Length:1,612
Mass (Da):181,219
Last modified:November 1, 1996 - v1
Checksum:i0CB3853FB565CF50
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50183 mRNA. Translation: CAA90563.1.
PIRiJC5210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50183 mRNA. Translation: CAA90563.1.
PIRiJC5210.

3D structure databases

ProteinModelPortaliQ27746.
SMRiQ27746. Positions 628-677.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

REBASEi2961. M.PliMCDnmt1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR010506. DMAP1-bd.
IPR017198. DNMT1_meta.
IPR029063. SAM-dependent_MTases.
IPR002857. Znf_CXXC.
[Graphical view]
PfamiPF01426. BAH. 2 hits.
PF06464. DMAP_binding. 2 hits.
PF12047. DNMT1-RFD. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
PIRSFiPIRSF037404. DNMT1. 1 hit.
PRINTSiPR00105. C5METTRFRASE.
SMARTiSM00439. BAH. 2 hits.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
TIGRFAMsiTIGR00675. dcm. 1 hit.
PROSITEiPS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
PS51058. ZF_CXXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of cDNA clones encoding DNA methyltransferase of sea urchin P. lividus: expression during embryonic development."
    Aniello F., Locascio A., Fucci L., Geraci G., Branno M.
    Gene 178:57-61(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Embryo.

Entry informationi

Entry nameiDNMT1_PARLI
AccessioniPrimary (citable) accession number: Q27746
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 1, 1996
Last modified: April 1, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.