Q27745 (Q27745_PLAFA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Peptidyl-prolyl cis-trans isomerase RuleBase RU000493
EC=5.2.1.8 RuleBase RU000493

Gene names

Name:

CyP gene EMBL CAA59933.1

Organism

Plasmodium falciparum EMBL CAA59933.1

Taxonomic identifier

5833 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Alveolata › Apicomplexa › Aconoidasida › Haemosporida › Plasmodium › Plasmodium (Laverania)

Protein attributes

Sequence length	195 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	PPIases accelerate the folding of proteins By similarity. RuleBase RU000493 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity. RuleBase RU004223
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0). RuleBase RU000493 SAAS SAAS020892
Sequence similarities	Belongs to the cyclophilin-type PPIase family. RuleBase RU004223 Contains 1 PPIase cyclophilin-type domain. SAAS SAAS020892 RuleBase RU003420

Ontologies

Keywords
Domain	Signal EMBL CAA59933.1
Molecular function	Isomerase Rotamase SAAS SAAS020892 RuleBase RU003420
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW protein peptidyl-prolyl isomerization Inferred from electronic annotation. Source: GOC
Molecular_function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential EMBL CAA59933.1
	Chain	23 – 195	173	Potential EMBL CAA59933.1		PRO_5000146461

Sequences

	Sequence		Length	Mass (Da)
	Q27745 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 59569520AC9288B9	FASTA	195	21,731
	10 20 30 40 50 60 MNKLVSIILV IFFLFHKYAL CAEEHEITHK TYFDITIDDK PLGRIVFGLY GKVAPKTVEN 70 80 90 100 110 120 FVSICKGTVV DGKMLHYTNS IFHRIIPNFM AQGGDITNFN GTGGLSIYGK KFEDENFKVN 130 140 150 160 170 180 HSKRGLLSMA NAGKNTNGSQ FFILFIPTPW LDGRHVVFGE VVEGLDKLVH IEAVGTDSGE 190 PLKRVLVKES GELPL

References

[1]

"Molecular and biochemical characterization of a Plasmodium falciparum cyclophilin containing a cleavable signal sequence." Hirtzlin J., Farber P.M., Franklin R.M., Bell A. Eur. J. Biochem. 232:765-772(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: K1 EMBL CAA59933.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X85956 mRNA. Translation: CAA59933.1.
PIR	S52760. S68357.
3D structure databases
HSSP	HSSP built from PDB template 1E3B based on UniProtKB P52011.
ProteinModelPortal	Q27745.
SMR	Q27745. Positions 24-193.
ModBase	Search...
Proteomic databases
PRIDE	Q27745.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
eggNOG	COG0652.
Family and domain databases
InterPro	IPR002130. Cyclophilin-like_PPIase_dom. IPR024936. Cyclophilin-type_PPIase. IPR020892. Cyclophilin-type_PPIase_CS. [Graphical view]
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PIRSF	PIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTS	PR00153. CSAPPISMRASE.
SUPFAM	SSF50891. CSA_PPIase. 1 hit.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q27745_PLAFA

Accession

Primary (citable) accession number: Q27745

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)