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Protein

Enolase

Gene

ENO

Organism
Plasmodium falciparum
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

2-phospho-D-glycerate = phosphoenolpyruvate + H2O.

Cofactori

Mg2+By similarityNote: Mg2+ is required for catalysis and for stabilizing the dimer.By similarity

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase, Glyceraldehyde-3-phosphate dehydrogenase, Glyceraldehyde-3-phosphate dehydrogenase
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Enolase (ENO)
  5. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei166SubstrateBy similarity1
Binding sitei175SubstrateBy similarity1
Active sitei218Proton donorBy similarity1
Metal bindingi253MagnesiumBy similarity1
Metal bindingi304MagnesiumBy similarity1
Binding sitei304SubstrateBy similarity1
Metal bindingi331MagnesiumBy similarity1
Binding sitei331SubstrateBy similarity1
Active sitei356Proton acceptorBy similarity1
Binding sitei407SubstrateBy similarity1

GO - Molecular functioni

  • magnesium ion binding Source: CAFA
  • phosphopyruvate hydratase activity Source: CAFA
  • protein homodimerization activity Source: CAFA

GO - Biological processi

  • entry into host cell Source: CAFA
  • glycolytic process Source: UniProtKB-UniPathway
  • symbiont process Source: CAFA

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BRENDAi4.2.1.11 4889
SABIO-RKiQ27727
UniPathwayiUPA00109; UER00187

Protein family/group databases

MoonProtiQ27727

Names & Taxonomyi

Protein namesi
Recommended name:
Enolase (EC:4.2.1.11)
Alternative name(s):
2-phospho-D-glycerate hydro-lyase
2-phosphoglycerate dehydratase
Gene namesi
Name:ENO
OrganismiPlasmodium falciparum
Taxonomic identifieri5833 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: CAFA
  • pellicle Source: CAFA
  • phosphopyruvate hydratase complex Source: CAFA

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001340901 – 446EnolaseAdd BLAST446

Proteomic databases

PRIDEiQ27727

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

  • protein homodimerization activity Source: CAFA

Structurei

3D structure databases

ProteinModelPortaliQ27727
SMRiQ27727
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni383 – 386Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the enolase family.Curated

Phylogenomic databases

eggNOGiKOG2670 Eukaryota
COG0148 LUCA

Family and domain databases

CDDicd03313 enolase, 1 hit
Gene3Di3.20.20.1201 hit
3.30.390.101 hit
HAMAPiMF_00318 Enolase, 1 hit
InterProiView protein in InterPro
IPR000941 Enolase
IPR036849 Enolase-like_C_sf
IPR029017 Enolase-like_N
IPR034390 Enolase-like_superfamily
IPR020810 Enolase_C
IPR020809 Enolase_CS
IPR020811 Enolase_N
PANTHERiPTHR11902 PTHR11902, 1 hit
PfamiView protein in Pfam
PF00113 Enolase_C, 1 hit
PF03952 Enolase_N, 1 hit
PIRSFiPIRSF001400 Enolase, 1 hit
PRINTSiPR00148 ENOLASE
SFLDiSFLDG00178 enolase, 1 hit
SFLDS00001 Enolase, 1 hit
SMARTiView protein in SMART
SM01192 Enolase_C, 1 hit
SM01193 Enolase_N, 1 hit
SUPFAMiSSF51604 SSF51604, 1 hit
TIGRFAMsiTIGR01060 eno, 1 hit
PROSITEiView protein in PROSITE
PS00164 ENOLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q27727-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHVITRINA REILDSRGNP TVEVDLETNL GIFRAAVPSG ASTGIYEALE
60 70 80 90 100
LRDNDKSRYL GKGVQKAIKN INEIIAPKLI GMNCTEQKKI DNLMVEELDG
110 120 130 140 150
SKNEWGWSKS KLGANAILAI SMAVCRAGAA PNKVSLYKYL AQLAGKKSDQ
160 170 180 190 200
MVLPVPCLNV INGGSHAGNK LSFQEFMIVP VGAPSFKEAL RYGAEVYHTL
210 220 230 240 250
KSEIKKKYGI DATNVGDEGG FAPNILNANE ALDLLVTAIK SAGYEGKVKI
260 270 280 290 300
AMDVAASEFY NSENKTYDLD FKTPNNDKSL VKTGAQLVDL YIDLVKKYPI
310 320 330 340 350
VSIEDPFDQD DWENYAKLTA AIGKDVQIVG DDLLVTNPTR ITKALEKNAC
360 370 380 390 400
NALLLKVNQI GSITEAIEAC LLSQKNNWGV MVSHRSGETE DVFIADLVVA
410 420 430 440
LRTGQIKTGA PCRSERNAKY NQLLRIEESL GNNAVFAGEK FRLQLN
Length:446
Mass (Da):48,704
Last modified:November 1, 1996 - v1
Checksum:iC738905EAFB009A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00152 Unassigned DNA Translation: AAA18634.1
PIRiS42206

Similar proteinsi

Entry informationi

Entry nameiENO_PLAFA
AccessioniPrimary (citable) accession number: Q27727
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)