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Protein

CTP synthase

Gene
N/A
Organism
Plasmodium falciparum
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.UniRule annotation

Catalytic activityi

ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.UniRule annotation

Pathwayi: CTP biosynthesis via de novo pathway

This protein is involved in step 2 of the subpathway that synthesizes CTP from UDP.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. CTP synthase
This subpathway is part of the pathway CTP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CTP from UDP, the pathway CTP biosynthesis via de novo pathway and in Pyrimidine metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Pyrimidine biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00159; UER00277.

Protein family/group databases

MEROPSiC26.A29.

Names & Taxonomyi

Protein namesi
Recommended name:
CTP synthaseUniRule annotation (EC:6.3.4.2UniRule annotation)
Alternative name(s):
UTP--ammonia ligaseUniRule annotation
OrganismiPlasmodium falciparumImported
Taxonomic identifieri5833 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

PTM / Processingi

Proteomic databases

PaxDbiQ27725.

Interactioni

Protein-protein interaction databases

STRINGi5833.PF14_0100.

Structurei

3D structure databases

ProteinModelPortaliQ27725.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini401 – 575Glutamine amidotransferase type-1InterPro annotationAdd BLAST175

Sequence similaritiesi

Belongs to the CTP synthase family.UniRule annotation
Contains 2 glutamine amidotransferase type-1 domains.UniRule annotation

Keywords - Domaini

Glutamine amidotransferaseUniRule annotation

Phylogenomic databases

eggNOGiKOG2387. Eukaryota.
COG0504. LUCA.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.880. 3 hits.
InterProiIPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11550. PTHR11550. 3 hits.
PfamiPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 2 hits.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27725-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSVDDEKPI IKYIIVTGGN MSGLGKGTAA MSRYGCIIVN KKHFINNNKV
60 70 80 90 100
DPYLNIDAGT MSPYEHGEVY VLEDGGEVDL DLGNYERFLN IRLTYKNNIT
110 120 130 140 150
SGKIYEEVIK KERKGEYLGK TVQVVPHVTD AIQKWIKDVI DENIKKMKKE
160 170 180 190 200
YNIDSFNKIP CMCLIEVGGT VGDIESAVYL EALQQLINNL NNDDVCLCHL
210 220 230 240 250
SYVPIIGNLR EQKTKPTQHS VKILREAGLK PDFIFCRCEE PLTQEAIKKI
260 270 280 290 300
ALFSQVKNEH VISLHDTSNV YKVPLILDKQ NVCMNVLKKL NLENVVLNNK
310 320 330 340 350
LQISPYSFNI WKQLADRYES SSEQVVIGIV GKYTASNDTY LSIISSLVHA
360 370 380 390 400
CLECGFKLVI KYINSSHLSL KQKKQKKNMD WKKKARKYSY ENFHENSSTE
410 420 430 440 450
KIIFVDDTTS DEDYDKKRRI KYEKAWETLK SVDGVLVPGG FGTRGIEGKY
460 470 480 490 500
LSSKYCRLHN IPYLGICLGM QIAVIDVARE YLNVNANSEE FEDTTEMQYT
510 520 530 540 550
SHENNIADSD NYNKDDNNND NNQHAKKNPN VTNCTYNEKE KKEKKDKKEN
560 570 580 590 600
IINLENLENV ENVENVENVE NVNKTSVHIN EICSQDTTAS CISIKTNSSH
610 620 630 640 650
NPKELASYTE RQKHDNINNL KKEIHFDDNI STAIINDDIN IENSIYSKYQ
660 670 680 690 700
DTYMTDKNTY DDTDPMFDGK EYLKSQSLIL REKCIEDIPK KLSEESIKEK
710 720 730 740 750
IKLIGIESYY KSIEEIDNNN VIISMSEFKG DDNKGGTMRL GVKQSKIIDK
760 770 780 790 800
DSLTYKAYDE ELYIYERHRH RYEINTKYVP LLEAVGLTFV AKDIHSVPRM
810 820 830 840 850
EICEIKNLDF YVGVQFHPEF TSRPFKSNPL FLAFVLASKK KLKDRLNKYG
860
NKLCSGILYK
Length:860
Mass (Da):98,848
Last modified:November 1, 1996 - v1
Checksum:i952032F6EEA6E950
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51645 Genomic DNA. Translation: AAC36385.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51645 Genomic DNA. Translation: AAC36385.1.

3D structure databases

ProteinModelPortaliQ27725.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5833.PF14_0100.

Protein family/group databases

MEROPSiC26.A29.

Proteomic databases

PaxDbiQ27725.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG2387. Eukaryota.
COG0504. LUCA.

Enzyme and pathway databases

UniPathwayiUPA00159; UER00277.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.880. 3 hits.
InterProiIPR029062. Class_I_gatase-like.
IPR004468. CTP_synthase.
IPR017456. CTP_synthase_N.
IPR017926. GATASE.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR11550. PTHR11550. 3 hits.
PfamiPF06418. CTP_synth_N. 1 hit.
PF00117. GATase. 2 hits.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 2 hits.
SSF52540. SSF52540. 1 hit.
PROSITEiPS51273. GATASE_TYPE_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ27725_PLAFA
AccessioniPrimary (citable) accession number: Q27725
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 6, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.