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Protein

Phospholipid-transporting ATPase

Gene
N/A
Organism
Plasmodium falciparum
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + H2O + phospholipid(Side 1) = ADP + phosphate + phospholipid(Side 2).UniRule annotationSAAS annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid-transporting ATPaseUniRule annotation (EC:3.6.3.1UniRule annotation)
OrganismiPlasmodium falciparumImported
Taxonomic identifieri5833 [NCBI]
Taxonomic lineageiEukaryotaAlveolataApicomplexaAconoidasidaHaemosporidaPlasmodiidaePlasmodiumPlasmodium (Laverania)

Subcellular locationi

  • Membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei383 – 40523HelicalUniRule annotationAdd
BLAST
Transmembranei426 – 45530HelicalUniRule annotationAdd
BLAST
Transmembranei1094 – 111421HelicalUniRule annotationAdd
BLAST
Transmembranei1219 – 124022HelicalUniRule annotationAdd
BLAST
Transmembranei1252 – 127221HelicalUniRule annotationAdd
BLAST
Transmembranei1302 – 132726HelicalUniRule annotationAdd
BLAST
Transmembranei1339 – 136022HelicalUniRule annotationAdd
BLAST
Transmembranei1372 – 139524HelicalUniRule annotationAdd
BLAST
Transmembranei1401 – 142323HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ27720.

Interactioni

Protein-protein interaction databases

STRINGi5833.PFL0950c.

Structurei

3D structure databases

ProteinModelPortaliQ27720.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 3333PhoLip_ATPase_NInterPro annotationAdd
BLAST
Domaini1189 – 1438250PhoLip_ATPase_CInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
COG0474. LUCA.

Family and domain databases

Gene3Di2.70.150.10. 3 hits.
3.40.1110.10. 3 hits.
3.40.50.1000. 3 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 6 hits.
PfamiPF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27720-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYEQFHKISN VYFFFIGILQ VIPQFTATNG IPTVFFPLLI VLTANAIKDA
60 70 80 90 100
FEDWNRHKTD KIENNRMCYG IVSEEEKKIY QEKSNKKNIF KKLKRYFFGN
110 120 130 140 150
RKICNTENYY DEDDMCDDEI TDINDYINNY EDNLENIEGT VKKRWKDIKA
160 170 180 190 200
GDIILCRRSE FFCADILLLC TSHKNGIAFV ETSSLDGETN LKVKEANTFL
210 220 230 240 250
FNILGNDRNS AIDNVKNLKG FILSDKPNKD LSTMYGTIYF EKDKKIDVEN
260 270 280 290 300
IGIQELLKKT TEEIEYRKKR LSSVDLSKSS SAIGSNLCNN NNKSDSKSDI
310 320 330 340 350
KNYNKDDDDF DDMDENNILK NDNYIRIPFD EKQFVLRGCK LKNTDWIMGI
360 370 380 390 400
VIYVGRETKI QMNSSKSIKK TSKLEILTNK MTIIIWVIQM IICLISAYYN
410 420 430 440 450
AIIVSSSRKN RFRYLPFNLE KAKKPYIVGI ISFFSWVVIT GNFVPISLIV
460 470 480 490 500
TMSFVKVVQA YFISCDKNMI HKVQADVPSF GEQKEIPNIP KDDISSDADV
510 520 530 540 550
IKRMRTKKIA DSSLLHIDEN QTEEDNMDMK SDCIAFKNNS SHQNINGNNK
560 570 580 590 600
QYSSSSLGII SNAPKREISS RVISFKDSKE KNYIYFNAVP RTSSLIEELG
610 620 630 640 650
QIEYIFSDKT GTLTCNIMEF RKCAINGISY GKGLTEIKRN ILKKKNLEIP
660 670 680 690 700
VEPTMKFKKK TPHVNIIDND IINHLKDPNH FNHVNLINFF LHLAINHAVI
710 720 730 740 750
CEKDKEGVTT YSSSSPDEEA LVNAAKHFDI TFLYRREGKY GISIFGKIYE
760 770 780 790 800
IDTLATIEFT SKRKMSSVIC RIPVINPDYN HPTDAKSSNM DKKKNNMDDH
810 820 830 840 850
LVVGKNEEKE ETDDLNVYPP KKEAHSKLNN NNNNNNNIRI DNLYDDKNNF
860 870 880 890 900
NIIYNHNEGR TPEVITCKNS KNSKIMLFCK GAGSIILKKL AKRTDIDEIT
910 920 930 940 950
IEHMETYADE GLRTLCIAQR ELSEESFAEW YHLYKEASLS IKDREEKLES
960 970 980 990 1000
VAEYIENDLI LQGITGIEDK LQEGVSSTIE DLRMAGIHIW MLTGDKIETA
1010 1020 1030 1040 1050
MNIGIAANLI DNYSEQFIYT EEYIESEEAL IKKIDDDILM VEKSLNIPHY
1060 1070 1080 1090 1100
NFDDENNNVE DEKRKTFFRN NFIKNFFCAK NKSGLLLNPD KYNMLINTLN
1110 1120 1130 1140 1150
YVLVVDGSVI DLLLSEKMER KFFYLADKCS SVICGRVSPY QKGAIVSSAN
1160 1170 1180 1190 1200
RLLNKITLAI GDGANDRNMI NTANIGIGIR GQEGVQAFNS SDYGISQFRF
1210 1220 1230 1240 1250
LKNLLLVHGR LSYRRISKLV VYMFYKNMVL IFPLFIFGSI SLYSGQKIYF
1260 1270 1280 1290 1300
EFLLHLFNVL FTAIPVVIHA VLDQDISLNT AMEKPNLYKL GIHHYYFNIR
1310 1320 1330 1340 1350
TFISWVMNSL FHGSVVFLIP LYFLSYYNIP TSDGIPYDIW TVGCATYFLT
1360 1370 1380 1390 1400
VLIVNFKILF ETYYLNILPI SGIALSIFSF VLLVTAFSFM CVGSIHLLGT
1410 1420 1430 1440 1450
IVYLVQSLRF WLVVILGLFT ALLRDYVFKV YKRNFNPEIY HLLLDQENAK
1460 1470 1480 1490 1500
IGMNDVIDQL KLNEFDKDDD IRIEKSKSLG YAFSEADPAC IQLIRKQDNM

I
Length:1,501
Mass (Da):172,849
Last modified:November 1, 1996 - v1
Checksum:i809451D6DB42168D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16955 Genomic DNA. Translation: AAA67064.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16955 Genomic DNA. Translation: AAA67064.1.

3D structure databases

ProteinModelPortaliQ27720.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5833.PFL0950c.

Proteomic databases

PaxDbiQ27720.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiKOG0206. Eukaryota.
COG0474. LUCA.

Family and domain databases

Gene3Di2.70.150.10. 3 hits.
3.40.1110.10. 3 hits.
3.40.50.1000. 3 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR006539. P-type_ATPase_IV.
IPR032631. P-type_ATPase_N.
IPR001757. P_typ_ATPase.
IPR032630. P_typ_ATPase_c.
[Graphical view]
PANTHERiPTHR24092. PTHR24092. 6 hits.
PfamiPF16212. PhoLip_ATPase_C. 1 hit.
PF16209. PhoLip_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ27720_PLAFA
AccessioniPrimary (citable) accession number: Q27720
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 11, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.