##gff-version 3
Q27713	UniProtKB	Chain	1	587	.	.	.	ID=PRO_0000186347;Note=Bifunctional dihydrofolate reductase-thymidylate synthase	
Q27713	UniProtKB	Domain	9	237	.	.	.	Note=DHFR	
Q27713	UniProtKB	Region	301	587	.	.	.	Note=Thymidylate synthase	
Q27713	UniProtKB	Active site	469	469	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q27713	UniProtKB	Binding site	36	42	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q27713	UniProtKB	Binding site	51	51	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q27713	UniProtKB	Binding site	108	110	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q27713	UniProtKB	Binding site	129	132	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q27713	UniProtKB	Binding site	173	173	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q27713	UniProtKB	Binding site	174	181	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q27713	UniProtKB	Binding site	179	179	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q27713	UniProtKB	Binding site	194	194	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q27713	UniProtKB	Binding site	324	324	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q27713	UniProtKB	Binding site	470	470	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q27713	UniProtKB	Binding site	488	492	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q27713	UniProtKB	Binding site	500	500	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q27713	UniProtKB	Binding site	530	532	.	.	.	Ontology_term=ECO:0000250;evidence=ECO:0000250	
Q27713	UniProtKB	Natural variant	110	110	.	.	.	Note=In pyrimethamine resistance. S->N	
Q27713	UniProtKB	Natural variant	177	177	.	.	.	Note=In pyrimethamine resistance. S->F