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Q27712 (CP2L1_PANAR) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome P450 2L1

EC=1.14.14.1
Alternative name(s):
CYPIIL1
Gene names
Name:CYP2L1
OrganismPanulirus argus (Caribbean spiny lobster) (Palinurus argus)
Taxonomic identifier6737 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAchelataPalinuroideaPalinuridaePanulirus

Protein attributes

Sequence length492 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Efficient in catalyzing the monooxygenation of benzphetamine, aminopyrine, benzo(a)pyrene, progesterone, and testosterone.

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane; Peripheral membrane protein By similarity. Microsome membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the cytochrome P450 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
Membrane
Microsome
   LigandHeme
Iron
Metal-binding
   Molecular functionMonooxygenase
Oxidoreductase
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Cellular_componentendoplasmic reticulum membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaromatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

heme binding

Inferred from electronic annotation. Source: InterPro

iron ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 492492Cytochrome P450 2L1
PRO_0000051776

Sites

Metal binding4361Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q27712 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: F27EE702DD09D5EE

FASTA49256,767
        10         20         30         40         50         60 
MLTGALLLLL LVVIVYLLDK KPSGLPPGIW GWPLVGRMPS RSKHLADQVK QLRKKYGDII 

        70         80         90        100        110        120 
TWRIGTRVNV FLCNFKLVKT ALSKFECSDR PDFYTFKLFG EGNDVGVVFS NGVMWQTHRR 

       130        140        150        160        170        180 
FILRQLRDLG MGKSRLEAAI QHEAACLVQE LKKHTDQPMP LPKSINLAVL NVIWKLVADH 

       190        200        210        220        230        240 
RYSLQDQEGQ YFTQLLTTTT DNMQGFALNL FNYLPWLLMI TPDFVKNWMG VRVLRDGVCE 

       250        260        270        280        290        300 
LKDYMKTFIK EHQATLDPSN PKDLLDAYLI DLQERKEDPL STMNIETVRA VIMDLFGAGT 

       310        320        330        340        350        360 
ETTSTMIRWT ILYLMKYPEV QAKIQREIDA AVPRGTLPSL EHKDKLAYFE ATIHEVHRIV 

       370        380        390        400        410        420 
SLVPLGVSHY TNQDTELAGY RLPKGTVVMS HLECCHRDPS YWEKPNEFYP EHFLDDQGKF 

       430        440        450        460        470        480 
VKREHLVNFS VGRRVCVGES LARMELFVFL SAILQNFTFS APKGEVLHTE KDPQQMLFSF 

       490 
PKPYQVIIRE RE 

« Hide

References

[1]"cDNA and protein sequence of a major form of P450, CYP2L, in the hepatopancreas of the spiny lobster, Panulirus argus."
James M.O., Boyle S.M., Trapido-Rosenthal H.G., Smith W.C., Greenberg R.M., Shiverick K.T.
Arch. Biochem. Biophys. 329:31-38(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
Tissue: Hepatopancreas.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U44826 mRNA. Translation: AAB03106.1.
PIRS68856.

3D structure databases

ProteinModelPortalQ27712.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP2L1_PANAR
AccessionPrimary (citable) accession number: Q27712
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: December 11, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families