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Q27712

- CP2L1_PANAR

UniProt

Q27712 - CP2L1_PANAR

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Protein

Cytochrome P450 2L1

Gene

CYP2L1

Organism
Panulirus argus (Caribbean spiny lobster) (Palinurus argus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Efficient in catalyzing the monooxygenation of benzphetamine, aminopyrine, benzo(a)pyrene, progesterone, and testosterone.

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi436 – 4361Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2L1 (EC:1.14.14.1)
Alternative name(s):
CYPIIL1
Gene namesi
Name:CYP2L1
OrganismiPanulirus argus (Caribbean spiny lobster) (Palinurus argus)
Taxonomic identifieri6737 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAchelataPalinuroideaPalinuridaePanulirus

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 492492Cytochrome P450 2L1PRO_0000051776Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ27712.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27712-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLTGALLLLL LVVIVYLLDK KPSGLPPGIW GWPLVGRMPS RSKHLADQVK
60 70 80 90 100
QLRKKYGDII TWRIGTRVNV FLCNFKLVKT ALSKFECSDR PDFYTFKLFG
110 120 130 140 150
EGNDVGVVFS NGVMWQTHRR FILRQLRDLG MGKSRLEAAI QHEAACLVQE
160 170 180 190 200
LKKHTDQPMP LPKSINLAVL NVIWKLVADH RYSLQDQEGQ YFTQLLTTTT
210 220 230 240 250
DNMQGFALNL FNYLPWLLMI TPDFVKNWMG VRVLRDGVCE LKDYMKTFIK
260 270 280 290 300
EHQATLDPSN PKDLLDAYLI DLQERKEDPL STMNIETVRA VIMDLFGAGT
310 320 330 340 350
ETTSTMIRWT ILYLMKYPEV QAKIQREIDA AVPRGTLPSL EHKDKLAYFE
360 370 380 390 400
ATIHEVHRIV SLVPLGVSHY TNQDTELAGY RLPKGTVVMS HLECCHRDPS
410 420 430 440 450
YWEKPNEFYP EHFLDDQGKF VKREHLVNFS VGRRVCVGES LARMELFVFL
460 470 480 490
SAILQNFTFS APKGEVLHTE KDPQQMLFSF PKPYQVIIRE RE
Length:492
Mass (Da):56,767
Last modified:November 1, 1996 - v1
Checksum:iF27EE702DD09D5EE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44826 mRNA. Translation: AAB03106.1.
PIRiS68856.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44826 mRNA. Translation: AAB03106.1 .
PIRi S68856.

3D structure databases

ProteinModelPortali Q27712.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "cDNA and protein sequence of a major form of P450, CYP2L, in the hepatopancreas of the spiny lobster, Panulirus argus."
    James M.O., Boyle S.M., Trapido-Rosenthal H.G., Smith W.C., Greenberg R.M., Shiverick K.T.
    Arch. Biochem. Biophys. 329:31-38(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
    Tissue: Hepatopancreas.

Entry informationi

Entry nameiCP2L1_PANAR
AccessioniPrimary (citable) accession number: Q27712
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3