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Q27712

- CP2L1_PANAR

UniProt

Q27712 - CP2L1_PANAR

Protein

Cytochrome P450 2L1

Gene

CYP2L1

Organism
Panulirus argus (Caribbean spiny lobster) (Palinurus argus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Efficient in catalyzing the monooxygenation of benzphetamine, aminopyrine, benzo(a)pyrene, progesterone, and testosterone.

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi436 – 4361Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 2L1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIIL1
    Gene namesi
    Name:CYP2L1
    OrganismiPanulirus argus (Caribbean spiny lobster) (Palinurus argus)
    Taxonomic identifieri6737 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaPleocyemataAchelataPalinuroideaPalinuridaePanulirus

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 492492Cytochrome P450 2L1PRO_0000051776Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ27712.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q27712-1 [UniParc]FASTAAdd to Basket

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    MLTGALLLLL LVVIVYLLDK KPSGLPPGIW GWPLVGRMPS RSKHLADQVK    50
    QLRKKYGDII TWRIGTRVNV FLCNFKLVKT ALSKFECSDR PDFYTFKLFG 100
    EGNDVGVVFS NGVMWQTHRR FILRQLRDLG MGKSRLEAAI QHEAACLVQE 150
    LKKHTDQPMP LPKSINLAVL NVIWKLVADH RYSLQDQEGQ YFTQLLTTTT 200
    DNMQGFALNL FNYLPWLLMI TPDFVKNWMG VRVLRDGVCE LKDYMKTFIK 250
    EHQATLDPSN PKDLLDAYLI DLQERKEDPL STMNIETVRA VIMDLFGAGT 300
    ETTSTMIRWT ILYLMKYPEV QAKIQREIDA AVPRGTLPSL EHKDKLAYFE 350
    ATIHEVHRIV SLVPLGVSHY TNQDTELAGY RLPKGTVVMS HLECCHRDPS 400
    YWEKPNEFYP EHFLDDQGKF VKREHLVNFS VGRRVCVGES LARMELFVFL 450
    SAILQNFTFS APKGEVLHTE KDPQQMLFSF PKPYQVIIRE RE 492
    Length:492
    Mass (Da):56,767
    Last modified:November 1, 1996 - v1
    Checksum:iF27EE702DD09D5EE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U44826 mRNA. Translation: AAB03106.1.
    PIRiS68856.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U44826 mRNA. Translation: AAB03106.1 .
    PIRi S68856.

    3D structure databases

    ProteinModelPortali Q27712.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA and protein sequence of a major form of P450, CYP2L, in the hepatopancreas of the spiny lobster, Panulirus argus."
      James M.O., Boyle S.M., Trapido-Rosenthal H.G., Smith W.C., Greenberg R.M., Shiverick K.T.
      Arch. Biochem. Biophys. 329:31-38(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
      Tissue: Hepatopancreas.

    Entry informationi

    Entry nameiCP2L1_PANAR
    AccessioniPrimary (citable) accession number: Q27712
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3