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Protein

Catalase

Gene

cat

Organism
Onchocerca volvulus endobacterium
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide.

Catalytic activityi

2 H2O2 = O2 + 2 H2O.PROSITE-ProRule annotation

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei55 – 551PROSITE-ProRule annotation
Active sitei128 – 1281PROSITE-ProRule annotation
Metal bindingi338 – 3381Iron (heme axial ligand)By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxide

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Catalase (EC:1.11.1.6)
Gene namesi
Name:cat
OrganismiOnchocerca volvulus endobacterium
Taxonomic identifieri77551 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesAnaplasmataceaeWolbachieaeWolbachia

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 482482CatalasePRO_0000084993Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ27710.
SMRiQ27710. Positions 4-482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.Curated

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q27710-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQNKTLTTA SGPPVADNQN SRSAGPRGPL LLDDFHLIEK LAHFNRENIP
60 70 80 90 100
ERRVHAKGSG AYGTFTVTQD ITQYTSAKLF DSVGKQTPTF LRFSTVGGER
110 120 130 140 150
GSADTERDPR GFALKFYTEE GNWDIVGNNT PVFFIRDPLK FPDFIHTQKR
160 170 180 190 200
LPQSNLKSAQ MMWDFWSHSP EALHQVTILF SDRGIPDGYR HMHGFGSHTY
210 220 230 240 250
SLINAKGERH WVKWHYKTKQ GIKNLAPADA ARLAGTDPDY AQRDLFGAIE
260 270 280 290 300
RGDFPKWRVC IQIMTEAQAN AHYENPFDVT KTWSQKEFPL IEVGELELNR
310 320 330 340 350
NPLNYFAEVE QAAFGPSNMV PGVGLSPDRM LQGRVFAYAD AHRYRVGTNH
360 370 380 390 400
QQLPVNAPRS PVNSYQRDGS MAFGSNGGAA PNYEPNSYAD APKQAPQYAE
410 420 430 440 450
PALALSGAAD RYDHREDTDY YSHAGALFRL MNDEQKALLI NNIAGAMAGV
460 470 480
SSDVVQRQLQ YFFKADPAYG EGIASALGVS LN
Length:482
Mass (Da):53,700
Last modified:November 1, 1996 - v1
Checksum:iB1DA5F49BA39F776
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82176 mRNA. Translation: CAA57666.1.
AF069070 Genomic DNA. Translation: AAC79431.1.
PIRiS49465.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82176 mRNA. Translation: CAA57666.1.
AF069070 Genomic DNA. Translation: AAC79431.1.
PIRiS49465.

3D structure databases

ProteinModelPortaliQ27710.
SMRiQ27710. Positions 4-482.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATA_ONCVE
AccessioniPrimary (citable) accession number: Q27710
Secondary accession number(s): O85499
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: October 14, 2015
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.